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At least 415 records · Page 23
All sourcesNASA NTRSDOE OSTI
NASA NTRS2004

Short-Duration Spaceflight Does Not Prolong QTc Intervals in Male Astronauts

Although ventricular dysrhythmias are not increased during, and QTc intervals are not prolonged after, short-duration (5 to 16 days) spaceflights, QTc intervals have not previously been reported during these shorter flights. Holter monitor recordings, obtained in 11 male astronauts who flew on shuttle missions ranging from 5 to 10 days, showed that QTc intervals did not change significantly 10 days before launch, on 2 separate days of spaceflight, and 2 days after landing. Taken together, these data and our previous report show that QTc interval prolongation occurs sometime between the 9th and 30th days of spaceflight.

Space Flight↗
NASA NTRS2000

Dose limits for astronauts

Radiation exposures to individuals in space can greatly exceed natural radiation exposure on Earth and possibly normal occupational radiation exposures as well. Consequently, procedures limiting exposures would be necessary. Limitations were proposed by the Radiobiological Advisory Panel of the National Academy of Sciences/National Research Council in 1970. This panel recommended short-term limits to avoid deterministic effects and a single career limit (of 4 Sv) based on a doubling of the cancer risk in men aged 35 to 55. Later, when risk estimates for cancer had increased and were recognized to be age and sex dependent, the NCRP, in Report No. 98 in 1989, recommended a range of career limits based on age and sex from 1 to 4 Sv. NCRP is again in the process of revising recommendations for astronaut exposure, partly because risk estimates have increased further and partly to recognize trends in limiting radiation exposure occupationally on the ground. The result of these considerations is likely to be similar short-term limits for deterministic effects but modified career limits.

Review↗
NASA NTRS1997

Comparison of ground-based and space flight energy expenditure and water turnover in middle-aged healthy male US astronauts

Energy requirements during space flight are poorly defined because they depend on metabolic-balance studies, food disappearance, and dietary records. Water turnover has been estimated by balance methods only. The purpose of this study was to determine energy requirements and water turnover for short-term space flights (8-14 d). Subjects were 13 male astronauts aged 36-51 y with normal body mass indexes (BMIs). Total energy expenditure (TEE) was determined during both a ground-based period and space flight and compared with the World Health Organization (WHO) calculations of energy requirements and dietary intake. TEE was not different for the ground-based and the space-flight periods (12.40 +/- 2.83 and 11.70 +/- 1.89 MJ/d, respectively), and the WHO calculation using the moderate activity correction was a good predictor of TEE during space flight. During the ground-based period, energy intake and TEE did not differ, but during space flight energy intake was significantly lower than TEE; body weight was also less at landing than before flight. Water turnover was lower during space flight than during the ground-based period (2.7 +/- 0.6 compared with 3.8 +/- 0.5 L/d), probably because of lower fluid intakes and perspiration loss during flight. This study confirmed that the WHO calculation can be used for male crew members' energy requirements during short space flights.

STS Shuttle Project↗
NASA NTRS2004

Chromosome aberrations of clonal origin are present in astronauts' blood lymphocytes

Radiation-induced chromosome translocations remain in peripheral blood cells over many years, and can potentially be used to measure retrospective doses or prolonged low-dose rate exposures. However, several recent studies have indicated that some individuals possess clones of cells with balanced chromosome abnormalities, which can result in an overestimation of damage and, therefore, influence the accuracy of dose calculations. We carefully examined the patterns of chromosome damage found in the blood lymphocytes of twelve astronauts, and also applied statistical methods to screen for the presence of potential clones. Cells with clonal aberrations were identified in three of the twelve individuals. These clonal cells were present in samples collected both before and after space flight, and yields are higher than previously reported for healthy individuals in this age range (40-52 years of age). The frequency of clonal damage appears to be even greater in chromosomes prematurely condensed in interphase, when compared with equivalent analysis in metaphase cells. The individuals with clonal aberrations were followed-up over several months and the yields of all clones decreased during this period. Since clonal aberrations may be associated with increased risk of tumorigenesis, it is important to accurately identify cells containing clonal rearrangements for risk assessment as well as biodosimetry. Copyright 2003 S. Karger AG, Basel.

Chromosomes, Human/radiation effects/ultrastructur↗
NASA NTRS2005

The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station

Defining optimal nutrient requirements is critical for ensuring crew health during long-duration space exploration missions. Data pertaining to such nutrient requirements are extremely limited. The primary goal of this study was to better understand nutritional changes that occur during long-duration space flight. We examined body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals in 11 astronauts before and after long-duration (128-195 d) space flight aboard the International Space Station. Dietary intake and limited biochemical measures were assessed during flight. Crew members consumed a mean of 80% of their recommended energy intake, and on landing day their body weight was less (P = 0.051) than before flight. Hematocrit, serum iron, ferritin saturation, and transferrin were decreased and serum ferritin was increased after flight (P < 0.05). The finding that other acute-phase proteins were unchanged after flight suggests that the changes in iron metabolism are not likely to be solely a result of an inflammatory response. Urinary 8-hydroxy-2'-deoxyguanosine concentration was greater and RBC superoxide dismutase was less after flight (P < 0.05), indicating increased oxidative damage. Despite vitamin D supplement use during flight, serum 25-hydroxycholecalciferol was decreased after flight (P < 0.01). Bone resorption was increased after flight, as indicated by several markers. Bone formation, assessed by several markers, did not consistently rise 1 d after landing. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers.

Space Flight↗
NASA NTRS2021

Lunar Surface Operations Modeling Using Digital Astronaut Simulation

During Apollo, crew members experienced a number of falls while engaging in extravehicular activity. The Digital Astronaut Simulation (DAS) expanded human biomechanics modeling tools to begin investigating this prospective mission safety and success challenge for the Artemis program. A core capability was developed to detect if a motion is dynamically feasible in a given gravitational environment. Fed by motion capture and mass properties data, this technology enables observation of whether tasks performed in 1G can be performed the same way in lunar gravity or if they require modifications.

Long Duration Health↗
NASA NTRS2023

Find My Astronaut Photo

An automated localization and georectification pipeline for astronaut photography

Machine Learning↗
NASA NTRS1967

Astronautics and Aeronautics, 1966

At the opening of the tenth year in the era of man’s mobility in outer space, we can look back on 1966 as offering convincing evidence that the United States had gained great competence. This evidence included: five orbital space flights by ten Gemini astronauts; four lunar missions undertaking the orbiting of and soft landing on the moon; numerous contributions to scientific knowledge by unmanned spacecraft and sounding rockets; and further demonstrations of the practical utility of operational space systems, including weather and communications satellites. During 1966, a record 100 American spacecraft were placed into earth orbit or on escape trajectories. Thousands of revealing and useful pictures of the earth were taken from space and of the moon from lunar orbit and on its surface. The Gemini program ended with rendezvous and docking experiments and extravehicular activity by the Gemini test pilots as the Apollo R&D test flights leading to the manned lunar mission came into the schedule. Thirty-five major scientific, technological, and operational milestones were cited for 1966 by the President in his Report to the Congress on aeronautical and space activities of the United States. This was one measure of the American commitment to share in the peaceful exploration of space for all mankind. Another was our support of the final steps toward a United Nations space treaty, undertaken to ensure that the peaceful exploitation of space had juridical basis in international law. Spectacular as some events in the space venture were in 1966, they nonetheless came to have diminished novelty in the eyes of many laymen. The multitude of both important and unspectacular space activities attained almost an accepted and routine place. This volume, as well as its predecessor chronicles, offers a ready reference on the major as well as the less-well known events. Beyond the welter of documented details on the complex nature of aeronautical and space related events and their impact, this volume helps to provide a better perspective upon today as we contemplate tomorrow. Such intent also serves future historians and analysts who cannot be unmindful of what is herein presented. When the Congress created the National Aeronautics and Space Administration in 1958, it charged NASA with the responsibility to “contribute materially to . . . the expansion of human knowledge of phenomena in the atmosphere and space’’ and to “provide for the widest practical and appropriate dissemination of information concerning its activities and results thereof.” NASA has attempted to do this and to include documentation for the historical record. The relating of NASA history begins with this day-by day chronicle and leads to more specialized studies and histories of the unprecedented task of extending man’s mobility and understanding beyond his planet. While a chronology cannot in itself serve as a full-fledged history, the size of this annual volume alone is illustrative of the scope and complexity of the historical task yet to be completed as memories fade and the records disappear.

SPACE PROBE↗
NASA NTRS1968

Astronaut space suit communication antenna

Astronaut space suit communication antenna consists of a spring steel monopole in a blade-type configuration. This antenna is mounted in a copper cup filled with a potting compound that is recessed in the center to facilitate bending the blade flat for stowing when not in use.

Lindsey, J. F., III↗