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NASA NTRS2014

Reliability Growth in Space Life Support Systems

A hardware system's failure rate often increases over time due to wear and aging, but not always. Some systems instead show reliability growth, a decreasing failure rate with time, due to effective failure analysis and remedial hardware upgrades. Reliability grows when failure causes are removed by improved design. A mathematical reliability growth model allows the reliability growth rate to be computed from the failure data. The space shuttle was extensively maintained, refurbished, and upgraded after each flight and it experienced significant reliability growth during its operational life. In contrast, the International Space Station (ISS) is much more difficult to maintain and upgrade and its failure rate has been constant over time. The ISS Carbon Dioxide Removal Assembly (CDRA) reliability has slightly decreased. Failures on ISS and with the ISS CDRA continue to be a challenge.

life support↗

NASA NTRS2014

Birch Stands Growth Increase in Western Siberia

Birch (Betula pendula Roth) growth within the Western Siberia forest-steppe was analyzed based on long-term (1897-2006) inventory data (height, diameter at breast height [dbh], and stand volume). Analysis of biometry parameters showed increased growth at the beginning of twenty-first century compared to similar stands (stands age = 40-60 years) at the end of nineteenth century. Mean height, dbh, and stem volume increased from 14 to 20 m, from 16 to 22 cm, and from approx. 63 to approx. 220 cu m/ha, respectively. Significant correlations were found between the stands mean height, dbh, and volume on the one hand, and vegetation period length (r(sub s) = 0.71 to 0.74), atmospheric CO2 concentration (r(sub s) = 0.71 to 0.76), and drought index (Standardized Precipitation-Evapotranspiration Index, r(sub s) = −0.33 to −0.51) on the other hand. The results obtained have revealed apparent climate-induced impacts (e.g. increase of vegetation period length and birch habitat drying due to drought increase) on the stands growth. Along with this, a high correlation of birch biometric parameters and [CO2] in ambient air indicated an effect of CO2 fertilization. Meanwhile, further drought increase may switch birch stand growth into decline and greater mortality as has already been observed within the Trans-Baikal forest-steppe ecotone.

climate-induced tree growth↗

NASA NTRS2014

Report of the Workshop for Life Detection in Samples from Mars

The question of whether there is or was life on Mars has been one of the most pivotal since Schiaparellis' telescopic observations of the red planet. With the advent of the space age, this question can be addressed directly by exploring the surface of Mars and by bringing samples to Earth for analysis. The latter, however, is not free of problems. Life can be found virtually everywhere on Earth. Hence the potential for contaminating the Mars samples and compromising their scientific integrity is not negligible. Conversely, if life is present in samples from Mars, this may represent a potential source of extraterrestrial biological contamination for Earth. A range of measures and policies, collectively termed 'planetary protection', are employed to minimise risks and thereby prevent undesirable consequences for the terrestrial biosphere. This report documents discussions and conclusions from a workshop held in 2012, which followed a public conference focused on current capabilities for performing life-detection studies on Mars samples. The workshop focused on the evaluation of Mars samples that would maximise scientific productivity and inform decision making in the context of planetary protection. Workshop participants developed a strong consensus that the same measurements could be employed to effectively inform both science and planetary protection, when applied in the context of two competing hypotheses: 1) that there is no detectable life in the samples; or 2) that there is martian life in the samples. Participants then outlined a sequence for sample processing and defined analytical methods that would test these hypotheses. They also identified critical developments to enable the analysis of samples from Mars.

Life Detection↗

NASA NTRS2003

Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapy

OBJECTIVE: To assess the frequency of shedding of polyomavirus JC virus (JCV) genotypes in urine of HIV-infected patients receiving highly active antiretroviral therapy (HAART). METHODS: Single samples of urine and blood were collected prospectively from 70 adult HIV-infected patients and 68 uninfected volunteers. Inclusion criteria for HIV-infected patients included an HIV RNA viral load < 1000 copies, CD4 cell count of 200-700 x 106 cells/l, and stable HAART regimen. PCR assays and sequence analysis were carried out using JCV-specific primers against different regions of the virus genome. RESULTS: JCV excretion in urine was more common in HIV-positive patients but not significantly different from that of the HIV-negative group [22/70 (31%) versus 13/68 (19%); P = 0.09]. HIV-positive patients lost the age-related pattern of JCV shedding (P = 0.13) displayed by uninfected subjects (P = 0.01). Among HIV-infected patients significant differences in JCV shedding were related to CD4 cell counts (P = 0.03). Sequence analysis of the JCV regulatory region from both HIV-infected patients and uninfected volunteers revealed all to be JCV archetypal strains. JCV genotypes 1 (36%) and 4 (36%) were the most common among HIV-infected patients, whereas type 2 (77%) was the most frequently detected among HIV-uninfected volunteers. CONCLUSION: These results suggest that JCV shedding is enhanced by modest depressions in immune function during HIV infection. JCV shedding occurred in younger HIV-positive persons than in the healthy controls. As the common types of JCV excreted varied among ethnic groups, JCV genotypes associated with progressive multifocal leukoencephalopathy may reflect demographics of those infected patient populations.

Non-NASA Center↗

NASA NTRS1994

Gender- and age-related differences in heart rate dynamics: are women more complex than men?

OBJECTIVES. This study aimed to quantify the complex dynamics of beat-to-beat sinus rhythm heart rate fluctuations and to determine their differences as a function of gender and age. BACKGROUND. Recently, measures of heart rate variability and the nonlinear "complexity" of heart rate dynamics have been used as indicators of cardiovascular health. Because women have lower cardiovascular risk and greater longevity than men, we postulated that there are important gender-related differences in beat-to-beat heart rate dynamics. METHODS. We analyzed heart rate dynamics during 8-min segments of continuous electrocardiographic recording in healthy young (20 to 39 years old), middle-aged (40 to 64 years old) and elderly (65 to 90 years old) men (n = 40) and women (n = 27) while they performed spontaneous and metronomic (15 breaths/min) breathing. Relatively high (0.15 to 0.40 Hz) and low (0.01 to 0.15 Hz) frequency components of heart rate variability were computed using spectral analysis. The overall "complexity" of each heart rate time series was quantified by its approximate entropy, a measure of regularity derived from nonlinear dynamics ("chaos" theory). RESULTS. Mean heart rate did not differ between the age groups or genders. High frequency heart rate power and the high/low frequency power ratio decreased with age in both men and women (p < 0.05). The high/low frequency power ratio during spontaneous and metronomic breathing was greater in women than men (p < 0.05). Heart rate approximate entropy decreased with age and was higher in women than men (p < 0.05). CONCLUSIONS. High frequency heart rate spectral power (associated with parasympathetic activity) and the overall complexity of heart rate dynamics are higher in women than men. These complementary findings indicate the need to account for gender-as well as age-related differences in heart rate dynamics. Whether these gender differences are related to lower cardiovascular disease risk and greater longevity in women requires further study.

NASA Discipline Cardiopulmonary↗

NASA NTRSDate not supplied

Elastic-Poroelastic Simulation of Locally Resonant Ultrasound for Aging Li-Metal Batteries

An elastic-poroelastic simulation of ultrasound inspection for lithium-metal batteries is presented and compared to empirical reflection spectra measured during battery cycling. Simulated reflection spectra were obtained using a two-dimensional (2D) plane strain model, comprised of dozens of individual microns-thick layers within a Li-metal pouch cell. The simulated reflection spectra were then compared to ultrasonic reflection spectra measurements taken intermittently during cell cycling. A sensitivity analysis and parameter calibration were performed for the pristine pouch cell simulation prior to cycling, providing a baseline to account for difficult to measure poroelastic material parameters. Then, the reduction in solid Li anode thickness and corresponding growth into a mossy lithium layer was modeled to represent aging conditions. Results from both simulations and empirical inspections show similar trends in through-thickness resonance frequencies due to cell aging.

Battery↗

NASA NTRS1973

Rb-Sr systematics for chemically defined Apollo 15 and 16 materials

Concentrations of Rb and Sr and the Sr87/86 ratios are determined in a large number of Apollo 15 samples, including KREEP basalts, mare basalts, anorthosite breccia clasts, lithic fragments, a spinel-bearing clast, green glass samples, breccia matrix, and soils. Relative concentrations of Sm, Eu, Rb, and Sr are also examined in the samples, with particular attention to Rb/Sr systematics vs other trace element abundances and total chemical compositions of rocks. Analysis of crystalline KREEP samples rich in trace elements indicates that the differentiation of these rocks has extended to -4.25 AE age, a significantly later time than the presumed time of accretion of the moon.

Nyquist, L. E.↗

NASA NTRS1984

Atmospheric methane in the recent and ancient atmospheres Concentrations, trends, and interhemispheric gradient

Rasmussen and Khalil (1981) have shown that the concentration of methane is increasing in the earth's atmosphere. A continuing increase of methane may perturb the global environment in the future by warming the earth and leading to more ozone and carbon monoxide in the atmosphere. It appears that the present concentration of methane may be more than twice as high as the natural levels of 150 years ago. An analysis of air bubbles buried long ago in polar ice makes it possible to deduce the concentrations of methane in the old and ancient atmospheres. The present investigation is concerned with the results of an analysis of more than 80 ice core samples, taking into account both polar regions of the earth. The samples range in age from about 100 to nearly 3000 years old. It is found that the concentration of methane started changing significantly about 150 years ago. These findings suggest that the increase of methane is probably indirectly caused by the rapid increase of human population.

Rasmussen, R. A.↗

NASA NTRS1985

Analysis of data acquired by Shuttle Imaging Radar SIR-A and Landsat Thematic Mapper over Baldwin County, Alabama

Seasonally compatible data collected by SIR-A and by Landsat 4 TM over the lower coastal plain in Alabama were coregistered, forming a SIR-A/TM multichannel data set with 30 m x 30 m pixel size. Spectral signature plots and histogram analysis of the data were used to observe data characteristics. Radar returns from pine forest classes correlated highly with the tree ages, suggesting the potential utility of microwave remote sensing for forest biomass estimation. As compared with the TM-only data set, the use of SIR-A/TM data set improved classification accuracy of the seven land cover types studied. In addition, the SIR-A/TM classified data support previous finding by Engheta and Elachi (1982) that microwave data appear to be correlated with differing bottomland hardwood forest vegetation as associated with varying water regimens (i.e., wet versus dry).

Wu, S.-T.↗

NASA NTRS1994

Prediction of thermal cycling induced cracking in polmer matrix composites

The work done in the period August 1993 through February 1994 on the 'Prediction of Thermal Cycling Induced Cracking In Polymer Matrix Composites' program is summarized. Most of the work performed in this period, as well as the previous one, is described in detail in the attached Master's thesis, 'Analysis of Thermally Induced Damage in Composite Space Structures,' by Cecelia Hyun Seon Park. Work on a small thermal cycling and aging chamber was concluded in this period. The chamber was extensively tested and calibrated. Temperatures can be controlled very precisely, and are very uniform in the test chamber. Based on results obtained in the previous period of this program, further experimental progressive cracking studies were carried out. The laminates tested were selected to clarify the differences between the behaviors of thick and thin ply layers, and to explore other variables such as stacking sequence and scaling effects. Most specimens tested were made available from existing stock at Langley Research Center. One laminate type had to be constructed from available prepreg material at Langley Research Center. Specimens from this laminate were cut and prepared at MIT. Thermal conditioning was carried out at Langley Research Center, and at the newly constructed MIT facility. Specimens were examined by edge inspection and by crack configuration studies, in which specimens were sanded down in order to examine the distribution of cracks within the specimens. A method for predicting matrix cracking due to decreasing temperatures and/or thermal cycling in all plies of an arbitrary laminate was implemented as a computer code. The code also predicts changes in properties due to the cracking. Extensive correlations between test results and code predictions were carried out. The computer code was documented and is ready for distribution.

Mcmanus, Hugh L.↗

NASA NTRS1999

Influence of Transport on Two-Dimensional Model Simulation: 2. Stratospheric Aircraft Perturbations: Stratospheric Aircraft Perturbations - 2

We have adopted the transport scenarios used in Part 1 to examine the sensitivity of stratospheric aircraft perturbations to transport changes in our 2-D model. Changes to the strength of the residual circulation in the upper troposphere and stratosphere and changes to the lower stratospheric K(sub zz) had similar effects in that increasing the transport rates decreased the overall stratospheric residence time and reduced the magnitude of the negative perturbation response in total ozone. Increasing the stratospheric K(sub yy) increased the residence time and enhanced the global scale negative total ozone response. However, increasing K(sub yy) along with self-consistent increases in the corresponding planetary wave drive, which leads to a stronger residual circulation, more than compensates for the K(sub yy)-effect, and results in a significantly weaker perturbation response, relative to the base case, throughout the stratosphere. We found a relatively minor model perturbation response sensitivity to the magnitude of K(sub yy) in the tropical stratosphere, and only a very small sensitivity to the magnitude of the horizontal mixing across the tropopause and to the strength of the mesospheric gravity wave drag and diffusion. These transport simulations also revealed a generally strong correlation between passive NO(sub y) accumulation and age of air throughout the stratosphere, such that faster transport rates resulted in a younger mean age and a smaller NO(y) mass accumulation. However, specific variations in K(sub yy) and mesospheric gravity wave strength exhibited very little NO(sub y)-age correlation in the lower stratosphere, similar to 3-D model simulations performed in the recent NASA "Models and Measurements" II analysis. The base model transport, which gives the most favorable overall comparison with inert tracer observations, simulated a global/annual mean total ozone response of -0.59%, with only a slightly larger response in the northern compared to the southern hemisphere. For transport scenarios which gave tracer simulations within some agreement with measurements, the annual/globally averaged total ozone response ranged from -0.45% to -0.70%. Our previous 1995 model exhibited overly fast transport rates, resulting in a global/annually averaged perturbation total ozone response of -0.25%, which is significantly weaker compared to the 1999 model. This illustrates how transport deficiencies can bias model simulations of stratospheric aircraft.

Fleming, Eric L.↗

NASA NTRS2004

A Gravity Analysis of the Subsurface Structure of the Utopia Impact Basin

The large, shallow, circular depression in Utopia Planitia has been identified as a huge impact basin, based on both geological evidence and detailed analysis of MOLA topography. Its diameter (approximately 3000 km) is equivalent to that of the Hellas basin, as is its inferred age (early Noachian). However, there the similarity ends. Their appearance, both surficially and geophysically, are virtually polar opposites. Whereas Hellas is extremely deep with rough terrain and large slopes, high-precision MOLA measurements were required to unambiguously define the smooth, shallow, almost imperceptible bowl of the Utopia basin. Conversely, Utopia displays one of the largest (non-Tharsis-related) positive geoid anomalies on Mars, in contrast to a more subdued negative anomaly over Hellas. As these two features presumably formed roughly contemporaneously by similar mechanisms, it is reasonable to assume that they were originally quite similar, and that their differences are due largely to different paths of subsequent modification. The obvious source for these differences is in their elevations: Hellas is located in the southern highlands at a rim elevation of about 3km, whereas Utopia is in the lowlying northern plains, at an average elevation of 4 km. Thus Utopia has been in an especially gravitationally favorable position to be subjected to infilling, for example, by lava flows, sedimentation, or water. In fact, its floor was almost certainly the lowest point on the planet at one time, and it would have been the termination point for down-slope drainage from over two-thirds of Mars. Thus the nature of the material filling this basin has strong connections to the sedimentary and/or volcanic processes acting on Mars in the Noachian and Early Hesperian periods. In particular, it may be able to shed some light on amount and persistence of water on early Mars in general and in the Utopia basin in particular. In this study I will use the inferred early correspondence between Hellas and Utopia to investigate Utopia's subsurface structure.

Barnerdt, W. B.↗

NASA NTRSDate not supplied

Exploring Sustained Food Production in the Veggie Vegetable Production System

Since 2014, the Veggie vegetable production system on the International Space Station has intermittently supplied astronaut crews with fresh produce. To assess the potential for continuous crop production in Veggie and develop a baseline for future space crop production systems, a 120-day study was conducted to determine methodology for inputs, optimal yield, food safety standards, and crew involvement. ‘Amara’ mustard and ‘Red Russian’ kale were grown as initial crops, followed by ‘Extra Dwarf’ pakchoi and shungiku as final crops. Previous grow-outs in Veggie have included harvests at 28-35 days after initiation. In this study, a 56-day grow-out with multiple harvests from the same plants was compared to the conventional, single harvest Veggie schedule. Unlike previous Veggie studies which grew all plants simultaneously, this test staggered initiation and harvest, aiming for consistent and increased production. Plant pillows were initiated in pairs weekly and positioned to reduce shading. Completed pillows were immediately replaced with fresh ones. The multi-harvest scheme used fewer pillows, totaling 46% less pillow mass than the single harvest method. Yield varied by crop and harvest scheme, when compared as fresh edible biomass production across 56-day time increments. ‘Red Russian’ kale yielded similarly across harvest schemes. In the multiple-harvest schedule, ‘Amara’ mustard and shungiku yielded 23% to 25% higher, respectively, while ‘Extra Dwarf’ pakchoi had 43% lower yield. Microbial analysis of the plants indicated no culturable human pathogens. Microbial load of a given plant appeared to depend more on system age than plant age; across harvest methods, aerobic plate counts from final crops were higher than those of initial crops. This project also considered the complexity of crew involvement in a continuous production scenario. New crew procedures that periodically remove plant material from the Veggie root mat would be needed under continuous production to prevent potential pathogens and unpleasant odors. This study supports future space crop production scenarios and was funded by NASA’s Human Research Program.

Jess M Bunchek↗

NASA NTRSDate not supplied

Sustained Veggie: A Continuous Food Production Comparison

The International Space Station’s Veggie system intermittently supplies the crew with fresh produce. To assess the potential for continuous crop production in Veggie and develop a baseline for future space crop production systems, a 120-day study was conducted to determine methodology for inputs, optimal yield, and crew involvement. ‘Amara’ mustard and ‘Red Russian’ kale were grown as initial crops, followed by ‘Extra Dwarf’ pak choi and shungiku as final crops. Previous grow-outs in Veggie have included harvests at 28-35days after initiation. In this study, a 56-day grow-out with multiple harvests from the same plants was compared to the conventional, single harvest Veggie schedule. Unlike previous Veggie studies which grew all plants simultaneously, this test staggered initiation and harvest, aiming for consistent and increased production. Plant pillows were initiated in pairs weekly and positioned to reduce shading. Completed pillows were immediately replaced with fresh ones. The multi-harvest scheme used fewer pillows, totaling 46% less pillow mass than the single harvest method. Scaled to 56-day increments, yield varied by crop and harvest scheme. ‘Red Russian’ kale yielded similarly across harvest schemes. In the multiple-harvest schedule, ‘Amara’ mustard and shungiku yielded 23% to 25% higher, respectively, while ‘Extra Dwarf’ pak choi had43% lower yield. Microbial analysis of the plants indicated no culturable human pathogens. Microbial load of a given plant appears to depend more on system age than plant age. Across harvest methods, aerobic plate counts from final crops were higher than those of initial crops. This project also considered the complexity of crew involvement in a continuous production scenario. New crew procedures that periodically remove plant material from the Veggie root mat are needed under continuous production to prevent potential pathogens and unpleasant odors. This study supports future space crop production scenarios and was funded by NASA’s Human Research Program.

Jess M Bunchek↗

NASA NTRS1998

A Photo Album of Earth Scheduling Landsat 7 Mission Daily Activities

Landsat7 is a member of a new generation of Earth observation satellites. Landsat7 will carry on the mission of the aging Landsat 5 spacecraft by acquiring high resolution, multi-spectral images of the Earth surface for strategic, environmental, commercial, agricultural and civil analysis and research. One of the primary mission goals of Landsat7 is to accumulate and seasonally refresh an archive of global images with full coverage of Earth's landmass, less the central portion of Antarctica. This archive will enable further research into seasonal, annual and long-range trending analysis in such diverse research areas as crop yields, deforestation, population growth, and pollution control, to name just a few. A secondary goal of Landsat7 is to fulfill imaging requests from our international partners in the mission. Landsat7 will transmit raw image data from the spacecraft to 25 ground stations in 20 subscribing countries. Whereas earlier Landsat missions were scheduled manually (as are the majority of current low-orbit satellite missions), the task of manually planning and scheduling Landsat7 mission activities would be overwhelmingly complex when considering the large volume of image requests, the limited resources available, spacecraft instrument limitations, and the limited ground image processing capacity, not to mention avoidance of foul weather systems. The Landsat7 Mission Operation Center (MOC) includes an image scheduler subsystem that is designed to automate the majority of mission planning and scheduling, including selection of the images to be acquired, managing the recording and playback of the images by the spacecraft, scheduling ground station contacts for downlink of images, and generating the spacecraft commands for controlling the imager, recorder, transmitters and antennas. The image scheduler subsystem autonomously generates 90% of the spacecraft commanding with minimal manual intervention. The image scheduler produces a conflict-free schedule for acquiring images of the "best" 250 scenes daily for refreshing the global archive. It then equitably distributes the remaining resources for acquiring up to 430 scenes to satisfy requests by international subscribers. The image scheduler selects candidate scenes based on priority and age of the requests, and predicted cloud cover and sun angle at each scene. It also selects these scenes to avoid instrument constraint violations and maximizes efficiency of resource usage by encouraging acquisition of scenes in clusters. Of particular interest to the mission planners, it produces the resulting schedule in a reasonable time, typically within 15 minutes.

Potter, William↗

NASA NTRS1993

Interstitial space and collagen alterations of the developing rat diaphragm

The effect of growth on the relative interstitial space [%total cross-sectional area (CSA)] and collagen content of the rat diaphragm muscle was examined at postnatal ages of 0, 7, 14, and 21 days as well as in adult males. The proportion of interstitial space relative to total muscle CSA was determined by computerized image analysis of lectin-stained cross sections of diaphragm muscle. To assess collagen content and extent of collagen maturation (i.e., cross-linking), high-pressure liquid chromatography analysis was used to measure hydroxyproline concentration and the nonreducible collagen cross-link hydroxylysylpyridinoline (HP), respectively. At birth, interstitial space accounted for approximately 47% of total diaphragm muscle CSA. During postnatal growth, the relative contribution of interstitial space decreased such that by adulthood the interstitial space accounted for approximately 18% of total muscle CSA. The change in relative interstitial space occurred without a concomitant change in hydroxyproline concentration. However, the concentration of HP markedly increased with age such that the adult diaphragm contained approximately 17 times more HP than at birth. These results indicate that during development the relative CSA occupied by interstitial space decreases as muscle fiber size increases. However, the reduction in relative interstitial space is not associated with a change in collagen concentration. Thus collagen density in the interstitial space may increase with age. It is possible that the observed changes in relative interstitial space and collagen influence the passive length-force properties of the diaphragm.

NASA Program Space Physiology and Countermeasures↗

NASA NTRS2011

Orion Absolute Navigation System Progress and Challenges

The Orion spacecraft is being designed as NASA's next-generation exploration vehicle for crewed missions beyond Low-Earth Orbit. The navigation system for the Orion spacecraft is being designed in a Multi-Organizational Design Environment (MODE) team including contractor and NASA personnel. The system uses an Extended Kalman Filter to process measurements and determine the state. The design of the navigation system has undergone several iterations and modifications since its inception, and continues as a work-in-progress. This paper seeks to benchmark the current state of the design and some of the rationale and analysis behind it. There are specific challenges to address when preparing a timely and effective design for the Exploration Flight Test (EFT-1), while still looking ahead and providing software extensibility for future exploration missions. The primary measurements in a Near-Earth or Mid-Earth environment consist of GPS pseudorange and deltarange, but for future explorations missions the use of star-tracker and optical navigation sources need to be considered. Discussions are presented for state size and composition, processing techniques, and consider states. A presentation is given for the processing technique using the computationally stable and robust UDU formulation with an Agee-Turner Rank-One update. This allows for computational savings when dealing with many parameters which are modeled as slowly varying Gauss-Markov processes. Preliminary analysis shows up to a 50% reduction in computation versus a more traditional formulation. Several state elements are discussed and evaluated, including position, velocity, attitude, clock bias/drift, and GPS measurement biases in addition to bias, scale factor, misalignment, and non-orthogonalities of the accelerometers and gyroscopes. Another consideration is the initialization of the EKF in various scenarios. Scenarios such as single-event upset, ground command, pad alignment, cold start are discussed as are strategies for whole and partial state updates as well as covariance considerations. Strategies are given for dealing with latent measurements and high-rate propagation using multi-rate architecture. The details of the rate groups and the data ow between the elements is discussed and evaluated.

Holt, Greg N.↗

NASA NTRS2011

Rapid Detection of the Varicella Zoster Virus

1.Technology Description-Researchers discovered that when the Varicella Zoster Virus (VZV) reactivates from latency in the body, the virus is consistently present in saliva before the appearance of skin lesions. A small saliva sample is mixed with a specialized reagent in a test kit. If the virus is present in the saliva sample, the mixture turns a red color. The sensitivity and specificity emanates from an antibody-antigen reaction. This technology is a rapid, non-invasive, point of-of-care testing kit for detecting the virus from a saliva sample. The device is easy to use and can be used in clinics and in remote locations to quickly detect VZV and begin treatment with antiviral drugs. 2.Market Opportunity- RST Bioscience will be the first and only company to market a rapid, same day test kit for the detection of VZV in saliva. The RST detection test kit will have several advantages over existing, competitive technology. The test kit is self contained and laboratory equipment is not required for analysis of the sample. Only a single saliva sample is required to be taken instead of blood or cerebral spinal fluid. The test kit is portable, sterile and disposable after use. RST detection test kits require no electrical power or expensive storage equipment and can be used in remote locations. 3.Market Analysis- According to the CDC, it is estimated that 1 million cases of shingles occur each year in the U.S. with more than half over the age of sixty. There is a high demand for rapid diagnostics by the public. The point-of-care testing (POCT) market is growing faster than other segments of in vitro diagnostics. According to a July 2007 InteLab Corporation industry report the overall market for POCT was forecast to increase from $10.3 billion in 2005 to $18.7 billion by 2011. The market value of this test kit has not been determined. 4.Competition- The VZV vaccine prevents 50% of cases and reduces neuralgia by 66%. The most popular test detects VZV-specific IgM antibody in blood. Other tests include running a sample in a polymerase chain reaction analyzer, enzyme immunoassay, latex agglutination, indirect fluorescent antibody and fluorescent antibody to membrane antigen assay. These existing tests require laboratory analysis by trained personnel, expensive equipment, invasive procedures and a longer period of time to obtain test results.

Lewis, Michelle P.↗