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At least 397 records · Page 22

The Potential Role of Concentrating Solar Power within the Context of DOE's 2030 Solar Cost Targets

For solar electricity generating technologies to be cost competitive at a large scale with conventionally generated electricity, cost reductions are needed for both concentrating solar power (CSP) and solar photovoltaic (PV) systems. In 2011, the U.S. Department of Energy (DOE) established solar cost targets that corresponded to reducing CSP and PV prices by approximately 75% in order to achieve a levelized cost of electricity (LCOE) of $0.06 per kilowatt-hour (kWh) for both utility-scale PV and high-capacity factor CSP-TES systems in 2020. Utility-scale PV achieved its 2020 cost target in 2017, and recent estimates for the LCOE of CSP-TES with a molten-salt power tower system are approximately $0.10/kWh for projects that are expected to come online in 2020, which represents a substantial reduction since 2010 - when the LCOE for CSP-TES was around $0.21/kWh. To continue the momentum for cost reductions in solar technologies, DOE recently established cost targets for 2030 that would make solar one of the lowest-cost sources of new electricity in the United States. For CSP-based systems, the new targets correspond to an LCOE in 2030 of $0.05/kWh for a dispatchable, high-capacity factor CSP-TES plant configuration. This aggressive target would have been unimaginable a decade ago. However, building on the previously described reduction in CSP-TES costs over the past decade, recent announcements suggest the next phase of projects will continue this downward trend through lower installation costs, attractive financing, longer-duration PPAs, and the ability to capitalize on the value that the flexibility of storage brings CSP. This presentation summarizes a recent report that evaluates the potential impacts of simultaneously achieving the 2030 cost targets for PV and CSP-TES, and it includes a detailed evaluation of the role that CSP-TES could play in realizing those impacts. The scenarios in this analysis are designed to isolate and assess the potential impacts of achieving DOE's 2030 cost targets for CSP-TES and PV, and they do not reflect the potential benefits or system impacts associated with success in other DOE research programs. The low-cost solar scenarios include DOE's 2030 solar cost targets--which are represented via a roughly 50% reduction in LCOE by 2030 (from current levels) with additional cost reductions thereafter representing technology learning and/or improvements that could result from innovation - coupled with a variety of market, technology, and demand assumptions. With these assumptions, the evolution of the contiguous U.S. electricity system is evaluated with NREL's Renewable Energy Deployment System (ReEDS) model, which was specifically designed to represent the temporal and locational value of renewable generation technologies in the U.S. power system. ReEDS relies on system-wide least-cost optimization to estimate the type and location of future generation and transmission capacity. In addition, it accounts for the locational and temporal variations in variable renewable technologies, including the need for new transmission, curtailment, dynamic capacity value, and the need to hold operating reserves to account for the uncertainty and variability of these technologies. This presentation summarizes the key findings that arise from a detailed evaluation of the impacts of achieving DOE's 2030 cost targets for CSP-TES and PV systems, noting again the inherent challenges associated with modeling future scenarios of the large, complex system electricity system in the contiguous United States within the context of various market features.

14 SOLAR ENERGY↗

Methods and systems for evaluating a target using pulsed, energetic particle beams

A method for evaluating a target, the target having a surface, includes pulsing a defined, energetic particle beam through the surface and into the target such that particle energy deposition from the particle beam is concentrated in a subsurface target volume within a target medium of the target. The deposited particle energy induces a thermoelastic expansion of the target medium in the target volume that generates a corresponding acoustic wave. The method further includes detecting the acoustic wave from the target medium.

Hunt, Sean Matthew↗

Demonstration and Automation of Reflected Target Optical Measurement for Heliostats

Accurate optical surfaces are a primary driver of concentrated solar power plant performance. Errors in pointing and tracking mirrors, the canting of individual mirror facets, and the surface slope of the mirror itself can be caused by errors during assembly, transportation, wind loading, gravity, and many other sources. The tools that exist to measure these error sources today largely rely on fringe deflectometry (SOFAST, QDec, others), or photogrammetry with targets attached to the mirror surface. Since 2022, NREL has been developing a measurement method called the Reflected Target Non-intrusive Assessment (ReTNA) system. This system differs from most established methods in that we perform deflectometry with a pattern of coded targets, identified in space with photogrammetry. Reflected target systems have several advantages over traditional fringe deflectometry systems. Firstly, they can be operated in bright or ambient lighting, a challenge for fringe systems that use a projector and screen. Reflected target systems also can use a much lighter and less expensive target than projector-based systems. Lastly, 2D slope measurement can be solved from a single image, which leads to several advantages for accommodating faster measurements and smaller sized targets. These advantages make ReTNA particularly well-suited for applications where there are space or lighting constraints, like performing heliostat quality assurance on an assembly line. It's also useful when a lightweight, flexible system is needed, like for heliostat developers to quickly measure a new heliostat design at different orientations, to observe gravitational effects on the mirror surface shape. In the last year, significant improvements were made to this tool to make it more useful for these applications. These improvements were focused around validation of the ReTNA measurement system, and automation of the setup and measurement process. First, we present an improved ReTNA layout, for use on the heliostat assembly line. Next, we detail the various changes to the ReTNA software and computer vision methods to automate data collection in this new setup, and lessons learned from this process. The goal with this new setup is to perform a full heliostat surface characterization without removing the mirror from the assembly line. Lastly, we share results from several ReTNA validation studies undertaken over the last year. These include repeated ReTNA measurement on demonstration mirror facets, comparisons with other optical measurement tools, and some studies aimed at quantifying the uncertainty of ReTNA measurement under various constraints (mirror-target spacing, camera resolution, etc.). These results are compared with 2024 HelioCon performance targets, and our planned next steps for the ReTNA measurement system are presented.

CSP↗

Properties of vapor-deposited and solution-processed targets for laser-driven inertial confinement fusion experiments

Targets for low-adiabat direct-drive-implosion experiments on OMEGA must meet rigorous specifications and tight tolerances on the diameter, wall thickness, wall-thickness uniformity, and presence of surface features. Of these, restrictions on the size and number of defects (bumps and depressions) on the surface are the most challenging. The properties of targets that are made using vapor-deposition and solution-based microencapsulation techniques are reviewed. Targets were characterized using confocal microscopy, bright- and dark-field microscopy, atomic force microscopy, electron microscopy, and interferometry. Each technique has merits and limitations, and a combination of these techniques is necessary to adequately characterize a target. The main limitation with the glow-discharge polymerization (GDP) method for making targets is that it produces hundreds of domes with a lateral dimension of 0.7–2 μm. Polishing these targets reduces the size of some but not all domes, but it adds scratches and grooves to the surface. Solution-made polystyrene shells lack the dome features of GDP targets but have hundreds of submicrometer-size voids throughout the wall of the target; a few of these voids can be as large as ∼12 μm at the surface.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Optimal conditions for shock ignition of scaled cryogenic deuterium-tritium targets

Within the framework of the shock-ignition (SI) scheme, ignition conditions are reached following the separation of the compression and heating phases. First, the shell is compressed at a sub-ignition implosion velocity; then an intense laser spike is launched at the end of the main drive, leading to the propagation of a strong shock through the precompressed fuel. The minimal laser energy required for ignition of scaled deuterium-tritium (DT) targets is assessed by calculations. A semi-empiric model describing the ignitor shock generation and propagation in the fuel assembly is defined. The minimal power needed in the laser spike pulse to achieve ignition is derived from the hydrodynamic model. Optimal conditions for ignition of scaled targets are explored in terms of laser intensity, shell-implosion velocity, and target scale range for the SI process. Curves of minimal laser requirements for ignition are plotted in the energy-power diagram. The most economic and reliable conditions for ignition of a millimeter DT target are observed in the 240- to 320-km/s implosion velocity range and for the peak laser intensity ranging from {approx}2 Multiplication-Sign 10{sup 15} W/cm{sup 2} up to 5 Multiplication-Sign 10{sup 15} W/cm{sup 2}. These optimal conditions correspond to shock-ignited targets for a laser energy of {approx}250 kJ and a laser power of 100 to 200 TW. Large, self-ignited targets are particularly attractive by offering ignition at a lower implosion velocity and a reduced laser intensity than for conventional ignition. The SI scheme allows for the compression and heating phases of the high power laser energy research facility target to be performed at a peak laser intensity below 10{sup 16} W/cm{sup 2}. A better control of parametric and hydrodynamic instabilities within the SI scheme sets it as an optimal and reliable approach to attain ignition of large targets.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

High quality actinide targets

We prepare high quality actinide targets for studies of neutron-induced and charged-particle-induced fission. I report on our efforts to measure fragment energy loss in the target backings and to diagnose the "crud" problem frequently found in 248 Cm and 252 Cf sources and targets. I discuss the preparation of multi-isotopic targets for the FissionTPC and our efforts to measure the pointing resolution of this device. Furthermore, the issues of target uniformity, chemical composition and radiation stability of the targets are discussed along with problems of high/low specific activity regions in a single target.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

Breast tumor-targeted drug delivery via polymer nanocarriers: Endogenous and exogenous strategies

Breast cancer, one of the most common types of cancer worldwide, has a high degree of malignancy while lacking efficient treatments. The off-target events frequently occurring in drug administration have been a major obstacle, which causes severe side effects to patients and reduces the therapeutic efficacy. An ideal medication should precisely target the specific site with precise control over concentration and duration. In recent years, there has been immense progress in polymer nanocarriers that demonstrate great potential in the targeted delivery. These nanocarriers are constructed from materials sensitive to a wide range of endogenous (e.g., pH, enzyme, redox) and exogenous stimuli (e.g., light, ultrasound, magnetic waves), driving cargo release to the targeted tissue or cells. Here, we elucidate the mechanism of current targeting strategies and the engineering methods to construct these targeting systems or to improve their targeting efficiency. Here we capture the recent progress in the targeted nanocarriers derived from polymers which span hydrogels and micelles, demonstrating their design and applications in chemo, hyperthermia, immuno, and gene therapies.

36 MATERIALS SCIENCE↗

Preparation and characterization of isotopically pure Mo targets for nuclear science measurements

Isotopically pure molybdenum targets are essential in various nuclear science measurements. For studies of cross sections of capture reactions on molybdenum, uniform targets with areal densities of hundreds of g/cm 2 are desired. Mechanical rolling of enriched metal pieces or vacuum sputtering methods used in previous studies to prepare molybdenum targets are challenging and involve labor- and time-intensive processes. Therefore, reliable and straightforward methods to produce molybdenum targets are crucial. We have developed a new double-step method to produce targets meeting these needs. The first step consists of evaporating isotopically enriched MoO 3 onto gold backings. The second step involves the reduction of the oxide layer in a 5% H 2 -Ar environment to obtain molybdenum targets. X-ray fluorescence (XRF) spectroscopy, X-ray Diffraction (XRD), a scanning electron microscope/focused ion beam milling, and energy-dispersive X-ray spectroscopy (EDS) were used to characterize the targets. These methods show that the targets exhibit a uniform coverage of Mo over the gold backings. Furthermore, significant volume shrinkage occurring during the reduction of MoO 3 creates a porous Mo layer where the gold diffuses due to the high processing temperatures, resulting in mixed Mo–Au layers.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The Q weak high performance LH 2 target

A high-power liquid hydrogen target was built for the Jefferson Lab Q weak experiment, which measured the tiny parity-violating asymmetry in $\vec{e}$ p scattering at an incident energy of 1.16 GeV, and a Q 2 = 0.025 GeV 2 . To achieve the luminosity of 1.7 x 10 39 cm -2 s -1 , a 34.5 cm- long target was used with a beam current of 180 μA. The ionization energy-loss deposited by the beam in the target was 2.1 kW. The target temperature was controlled to within ±0.02 K and the target noise (density fluctuations) near the experiment's beam helicity- reversal rate of 960 Hz was only 53 ppm. The 58 liquid liter target achieved a head of 11.4 m (7.6 kPa) and a mass flow of 1.2 ± 0.3 kg/s (corresponding to a volume flow of 17.4 ± 3.8 l/s) at the nominal 29 Hz rotation frequency of the recirculating centrifugal pump. We describe aspects of the design, operation, and performance of this target, the highest power LH2 target ever used in an electron scattering experiment to date.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Measurement of the target current by inductive probe during laser interaction on terawatt laser system PALS

Measurements of the return-current flowing through a solid target irradiated with the sub-nanosecond kJ-class Prague Asterix Laser System is reported. A new inductive target probe was developed which allows us measuring the target current derivative in a kA/ns range. The dependences of the target current on the laser pulse energy for cooper, graphite, and polyethylene targets are reported. The experiment shows that the target current is proportional to the deposited laser energy and is strongly affected by the shot-to-shot fluctuations. The corresponding maximum target charge exceeded a value of 10 μC. A return-current dependence of the electromagnetic pulse produced by the laser-target interaction is presented.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Optimization of the combined proton acceleration regime with a target composition scheme

A target composition scheme to optimize the combined proton acceleration regime is presented and verified by two-dimensional particle-in-cell simulations by using an ultra-intense circularly polarized (CP) laser pulse irradiating an overdense hydrocarbon (CH) target, instead of a pure hydrogen (H) one. The combined acceleration regime is a two-stage proton acceleration scheme combining the radiation pressure dominated acceleration (RPDA) stage and the laser wakefield acceleration (LWFA) stage sequentially together. Protons get pre-accelerated in the first stage when an ultra-intense CP laser pulse irradiating an overdense CH target. The wakefield is driven by the laser pulse after penetrating through the overdense CH target and propagating in the underdense tritium plasma gas. With the pre-accelerate stage, protons can now get trapped in the wakefield and accelerated to much higher energy by LWFA. Finally, protons with higher energies (from about 20 GeV up to about 30 GeV) and lower energy spreads (from about 18% down to about 5% in full-width at half-maximum, or FWHM) are generated, as compared to the use of a pure H target. It is because protons can be more stably pre-accelerated in the first RPDA stage when using CH targets. With the increase of the carbon-to-hydrogen density ratio, the energy spread is lower and the maximum proton energy is higher. It also shows that for the same laser intensity around 10{sup 22} W cm{sup −2}, using the CH target will lead to a higher proton energy, as compared to the use of a pure H target. Additionally, proton energy can be further increased by employing a longitudinally negative gradient of a background plasma density.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

D 2 and D-T Liquid-Layer Target Shots at the National Ignition Facility

Experiments at the National Ignition Facility (NIF) using targets containing a deuterium-tritium (D-T) fuel layer have, until recently, required that a high-quality layer of solid D-T (herein referred to as an ice layer) be formed in the capsule. The development of a process to line the inner surface of a target capsule with a foam layer of a thickness that is typical of ice layers has resulted in the ability to field targets with liquid layers wetting the foam. Successful fielding of liquid-layer targets on NIF required not only a foam-lined capsule but also changes to the capsule filling process and the manner with which the inventory is maintained in the capsule. Additionally, changes to target heater power and the temperature drops across target components were required in order to achieve the desired range of shot temperatures. Finally, these changes and the target’s performance during four target shots on NIF are discussed.

42 ENGINEERING↗

Defining upstream enhancing and inhibiting sequence patterns for plant peroxisome targeting signal type 1 using large–scale in silico and in vivo analyses

Peroxisomes are universal eukaryotic organelles essential to plants and animals. Most peroxisomal matrix proteins carry peroxisome targeting signal type 1 (PTS1), a C-terminal tripeptide. Studies from various kingdoms have revealed influences from sequence upstream of the tripeptide on peroxisome targeting, supporting the view that positive charges in the upstream region are the major enhancing elements. However, a systematic approach to better define the upstream elements influencing PTS1 targeting capability is needed. Here, we used protein sequences from 177 plant genomes to perform large-scale and in-depth analysis of the PTS1 domain, which includes the PTS1 tripeptide and upstream sequence elements. We identified and verified 12 low-frequency PTS1 tripeptides and revealed upstream enhancing and inhibiting sequence patterns for peroxisome targeting, which were subsequently validated in vivo. Follow-up analysis revealed that nonpolar and acidic residues have relatively strong enhancing and inhibiting effects, respectively, on peroxisome targeting. However, in contrast to the previous understanding, positive charges alone do not show the anticipated enhancing effect and that both the position and property of the residues within these patterns are important for peroxisome targeting. We further demonstrated that the three residues immediately upstream of the tripeptide are the core influencers, with a ‘basic-nonpolar-basic’ pattern serving as a strong and universal enhancing pattern for peroxisome targeting. These findings have significantly advanced our knowledge of the PTS1 domain in plants and likely other eukaryotic species as well. The principles and strategies employed in the present study may also be applied to deciphering auxiliary targeting signals for other organelles.

59 BASIC BIOLOGICAL SCIENCES↗

Fast ignition when heating the central part of an inertial confinement fusion target by an ion beam

We investigate the ignition and burning of a precompressed laser fusion target when it is rapidly heated by an ion beam with the formation of a temperature peak in the central part of the target. We present the results of our comprehensive numerical simulations of the problem that include the following components: (1) the target compression under the action of a profiled laser pulse, (2) the heating of the compressed target with spatially nonuniform density and temperature distributions by a beam of high-energy ions, and (3) the burning of the target with the initial spatial density distribution formed at the instant of maximum target compression and the initial spatial temperature distribution formed as a result of the compressed-target heating by an ion beam. The dependences of the threshold energies of the igniting ion beam and the thermonuclear gain on the width of the Gaussian beam ion energy spectrum have been established. The peculiarities of fast ignition by an ion beam related to the spatial distribution of parameters for the target precompressed by a laser pulse are discussed.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Cryogenic target system for hydrogen layering

Here, a cryogenic target positioning system was designed and installed on the National Ignition Facility (NIF) target chamber. This instrument incorporates the ability to fill, form, and characterize the NIF targets with hydrogen isotopes needed for ignition experiments inside the NIF target bay then transport and position them in the target chamber. This effort brought to fruition years of research in growing and metrologizing high-quality hydrogen fuel layers and landed it in an especially demanding operations environment in the NIF facility. D-T (deuterium-tritium) layers for NIF ignition experiments have extremely tight specifications and must be grown in a very highly constrained environment: a NIF ignition target inside a cryogenic target positioner inside the NIF target bay. Exquisite control of temperature, pressure, contaminant level, and thermal uniformity are necessary throughout seed formation and layer growth to create an essentially-groove-free single crystal layer.

42 ENGINEERING↗

Fast ignition of an inertial fusion target with a solid noncryogenic fuel by an ion beam

The burning efficiency of a preliminarily compressed inertial confinement fusion (ICF) target with a solid noncryogenic fuel (deuterium-tritium beryllium hydride) upon fast central ignition by a fast ion beam is studied. The main aim of the study was to determine the extent to which the spatial temperature distribution formed under the heating of an ICF target by ion beams with different particle energy spectra affects the thermonuclear gain. The study is based on a complex numerical modeling including computer simulations of (i) the heating of a compressed target with a spatially nonuniform density and temperature distributions by a fast ion beam and (ii) the burning of the target with the initial spatial density distribution formed at the instant of maximum compression of the target and the initial spatial temperature distribution formed as a result of heating of the compressed target by the ion beam. The threshold energy of the igniting ion beam and the dependence of the thermonuclear gain on the energy deposited in the target are determined.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides

Antisense oligonucleotides (ASOs) can suppress the expression of a target gene by cleaving pre-mRNA and/or mature mRNA via RNase H1. Following the initial endonucleolytic cleavage by RNase H1, the target RNAs are degraded by a mechanism that is poorly understood. To better understand this degradation pathway, we depleted the expression of two major 5′ to 3′ exoribonucleases (XRNs), named XRN1 and XRN2, and analyzed the levels of 3′ fragments of the target RNAs in vitro. We found that the 3′ fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5′ ends by nuclear XRN2 after RNase H1-mediated cleavage, whereas the 3′ fragments of mature mRNA were partially degraded by XRN2. In contrast to ASO, small interference RNA (siRNA) could reduce the expression level of only mature mRNA, and the 3′ fragment was degraded by cytoplasmic XRN1. Our findings indicate that the RNAs targeted by RNase H1-dependent ASO are rapidly degraded in the nucleus, contrary to the cytoplasmic degradation pathway mediated by siRNA. - Highlights: • We compared the degradation mechanism of the transcript targeted by ASO and siRNA. • We focused on two 5′ to 3′ exoribonucleases, cytoplasmic XRN1, and nuclear XRN2. • The 3′ fragment of target pre-mRNA generated by ASO was degraded by XRN2. • The 3′ fragment of target mRNA generated by ASO was partially degraded by XRN2. • XRN1 depletion promoted accumulation of the 3′ fragment of mRNA generated by siRNA.

60 APPLIED LIFE SCIENCES↗

Adaptive Radiation Therapy for Postprostatectomy Patients Using Real-Time Electromagnetic Target Motion Tracking During External Beam Radiation Therapy

Purpose: Using real-time electromagnetic (EM) transponder tracking data recorded by the Calypso 4D Localization System, we report inter- and intrafractional target motion of the prostate bed, describe a strategy to evaluate treatment adequacy in postprostatectomy patients receiving intensity modulated radiation therapy (IMRT), and propose an adaptive workflow. Methods and Materials: Tracking data recorded by Calypso EM transponders was analyzed for postprostatectomy patients that underwent step-and-shoot IMRT. Rigid target motion parameters during beam delivery were calculated from recorded transponder positions in 16 patients with rigid transponder geometry. The delivered doses to the clinical target volume (CTV) were estimated from the planned dose matrix and the target motion for the first 3, 5, 10, and all fractions. Treatment adequacy was determined by comparing the delivered minimum dose (D{sub min}) with the planned D{sub min} to the CTV. Treatments were considered adequate if the delivered CTV D{sub min} is at least 95% of the planned CTV D{sub min}. Results: Translational target motion was minimal for all 16 patients (mean: 0.02 cm; range: −0.12 cm to 0.07 cm). Rotational motion was patient-specific, and maximum pitch, yaw, and roll were 12.2, 4.1, and 10.5°, respectively. We observed inadequate treatments in 5 patients. In these treatments, we observed greater target rotations along with large distances between the CTV centroid and transponder centroid. The treatment adequacy from the initial 10 fractions successfully predicted the overall adequacy in 4 of 5 inadequate treatments and 10 of 11 adequate treatments. Conclusion: Target rotational motion could cause underdosage to partial volume of the postprostatectomy targets. Our adaptive treatment strategy is applicable to post-prostatectomy patients receiving IMRT to evaluate and improve radiation therapy delivery.

62 RADIOLOGY AND NUCLEAR MEDICINE↗