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At least 397 records · Page 22

Looking into Ocular Risks of Spaceflight through the Mouse Retina

Ocular alterations have been observed at anatomical levels in astronauts on long duration spaceflight missions, such as what would be required for missions to Mars. These alterations cause an array of signs which together constitute the Spaceflight-Associated Neuro-ocular Syndrome (SANS), one of the top risk priorities of the NASA Human Research Program. Not much is known about SANS at the cellular and molecular level, but studies in mice and rats have recently begun to yield observations on how the spaceflight environment might affect the eye’s biology. Preliminary data from shuttle mouse experiments, and more recently experiments on ISS, have shown changes in retinal physiology via histology and gene expression analysis. This study utilizes samples from the CASIS sponsored Rodent Research 8 Experiment (RRRM-1) tissue sharing opportunity, delivered to the ISS by SpaceX CRS-16 on 12/08/2018. Female BALB/cAnNTac mice were on the ISS for 45 days, while ground controls consisted ofa standard vivarium group and spaceflight habitat group. Here we investigate the molecular response of the mouse retina to identify genes and pathways affected by spaceflight conditions using histology and transcriptomic RNAseq data. This Differentially Expressed Gene (DEG) data was used for pathway analysis with Galaxy (Genelab) and Ingenuity Pathway Analysis (IPA). We identified pathways related to neuronal differentiation, cellular transport/movement, and wound healing. Some of the top DEGs have known relation to ophthalmic diseases. Though there were DEGs throughout the comparisons we tested, there was no clear effect of spaceflight. This could be due to sample processing, which required mice to be returned to Earth about a day before they were sacrificed, possibly allowing for readaptation affecting the retinal transcriptome. However, there was a clear effect of age, between the young (10-12 weeks) and old (32 weeks) groups, and between the baseline and end of experiment, about 46 days.

SANS↗

An Oculometric Standard to Assess the Performance of the Ocular System for Long Duration Spaceflight

Changes in the human brain, due to spaceflight, have been a challenge to the space program since its inception; a challenge that is becoming more acute as extended International Space Station (ISS) missions become routine, a return to crewed lunar exploration is about to begin, and a multi-year crewed trip to Mars is being planned. Determining the extent to which neurophysiological adaptations may adversely impact performance in operational tasks, assessing the full-time course of these changes, and identifying/mitigating any potential long-term health consequences are crucial steps required to enable safe crew-autonomous, long-duration, deep-space missions. Vision is the predominant perceptual sense used to guide cognition and motor control in humans. Thus, it is critical for the success of any future, long-duration mission to understand how long-term exposure to microgravity and to other stressors of spaceflight and their interactions, impact visual function. This is an especially challenging task given the small and disparate samples from which we have been and will be able to collect human performance data. NASA has recently been carefully tracking spaceflight-induced ophthalmic changes, driven in large part by the fluid shifts related to microgravity. In particular, a recent study of Optical Coherence Tomography (OCT) postflight measures revealed that more than two-thirds of US crew members experience significant increases in retinal thickness after 6month or longer ISS missions. Space Associated Neuro-ocular Syndrome (SANS) also includes visual acuity decrements and other ocular structural changes that could adversely impact in-flight performance as missions become longer. However, the impact of spaceflight on the visual system is not limited to the retina. Recent comparisons of pre-and post-flight brain images have revealed structural changes throughout the brain that implicate visual, visuomotor, and visual-cognitive pathways, consistent with observed functional impacts (e.g., decreased speed/accuracy/timing of fine goal-oriented movements). Current limitations on inflight testing make it very difficult to determine when and under what conditions SANS and other disruptions of human neurological subsystems arise. Currently, one cannot anticipate the time course and extent of impairment and recovery. This study addresses this knowledge gap by creating an integrated framework of the relevant existing literature on visual and oculomotor function during spaceflight with an eye towards complementing current structural measures of visuomotor impairment with new oculometric standard measures. Using eye-movement based visual function assessment and diagnostics would provide a valuable enhancement of crew health and performance monitoring in support of deepspace exploration.

Vision↗

A review of application studies on Indian lands using NASA aerospace imagery

Three remote sensing projects are being conducted on three different Indian reservations in eastern Arizona. On the Fort Apache Reservation, a multiband thermal and false color sensing of an Englemann spruce beetle infestation is being investigated on Mount Baldy, adjacent to a U.S. Forest Service proposed wilderness area. On the San Carlos Reservation, there is a joint USGS, EROS, and San Carlos tribe project to examine intensively a circular topographic feature noted on the Apollo 9 imagery. On the Papago Reservation, an EROS-funded contract will provide the Papago tribe with a report showing potential mineral areas, by comparing and correlating space imagery with high resolution imagery and aeromagnetic data.

Woll, A. M.↗

Feasibility study of an aerospace museum in the western United States. Volume 2: Documentation

Papers supporting the study on establishing an aerospace museum in the western United States are presented. These cover the following areas of investigation: (1) The potential locations in the west were analyzed, and the most logical locations for museum development are Los Angeles, San Francisco, San Diego, Seattle, and Phoenix/Tucson. (2) The 26 museums and other organizations with significant public displays of aeronautics, astronautics, or astronomy are listed. (3) The activities and functions of museums, and their obligations to the user-visitor are discussed. (4) The sources for construction and improvements, operations, and acquisitions are described. (5) General curatorial responsibilites in preserving and exhibiting aerospace specimens and artifacts are also discussed.

Source record↗

Subsurface discontinuity detection by microwave radiometry.

Brief description of a joint program undertaken near Austin and San Antonio, Tex., to detect the presence of subsurface voids such as caverns and tunnels by microwave radiometry. Mi crowave radiometric temperature measurements using both vertical and horizontal polarization were taken with fixed-view angle traverses across three sites at two locations. No unambiguous correlation between the microwave temperature contours and the subsurface voids was observed at either location, but a correlation between microwave temperature and moisture patterns was observed at both locations. The large microwave temperature anomalies observed at all three sites indicated a sensitivity to near-surface structure and moisture distribution. A close correlation was noted between low soil-bearing strength values and the tunnel location at the San Antonio site.

Hruby, R. J.↗

Earthquake epicenters and fault intersections in central and southern California

The author has identifed the following significant results. ERTS-1 imagery provided evidence for the existence of short transverse fault segments lodged between faults of the San Andreas system in the Coast Ranges, California. They indicate that an early episode of transverse shear has affected the Coast Ranges prior to the establishment of the present San Andreas fault. The fault has been offset by transverse faults of the Transverse Ranges. It appears feasible to identify from ERTS-1 imagery geomorphic criteria of recent fault movements. Plots of historic earthquakes in the Coast Ranges and western Transverse Ranges show clusters in areas where structures are complicated by interaction of tow active fault systems. A fault lineament apparently not previously mapped was identified in the Uinta Mountains, Utah. Part of the lineament show evidence of recent faulting which corresponds to a moderate earthquake cluster.

Abdel-Gawad, M.↗

Census cities experiment in urban change detection

The author has identified the following significant results. Computer compatible tapes for an early ERTS-1 multispectral scanner image over the San Francisco Bay area are being used to classify and analyze land use in this metropolitan region. NASA aircraft underflight data and land use maps from the Census Cities ERTS-1 experiment are providing training samples. The tape record has been reformatted for use with the LARSYSSA pattern recognition and classification algorithms developed at the Purdue University Laboratory for Applications of Remote Sensing. Trial land use classification systems are being compared with color infrared photography and ground truth data for San Jose and vicinity.

Wray, J. R.↗

Coastal Zone and River Delta Studies

Remote sensing techniques are proposed for the development of a California coastal land use classification system which depicts and reflects essential parameters of environmental conditions and quality. Included in the earth resources survey is the Sacramento - San Joaquin River Delta and its complex hydrologic system which links saline waters of the San Francisco Bay with the Central Valley watershed.

Source record↗

Airborne measurements of air pollution chemistry and transport. 1: Initial survey of major air basins in California

An instrumented aircraft has been used to study photochemical air pollution in the State of California. Simultaneous measurements of the most important chemical constituents (ozone, total oxidant, hydrocarbons, and nitrogen oxides, as well as several meteorological variables) were made. State-of-the-art measurement techniques and sampling procedures are discussed. Data from flights over the South Coast Air Basin, the San Francisco Bay Area, the San Joaquin Valley, the Santa Clara and Salinas Valleys, and the Pacific Ocean within 200 miles of the California coast are presented. Pollutants were found to be concentrated in distant layers up to at least 18,000 feet. In many of these layers, the pollutant concentrations were much higher than at ground level. These findings bring into serious question the validity of the present practice of depending solely on data from ground-based monitoring stations for predictive models.

Gloria, H. R.↗

Remote sensing in the detection of regional change.

Investigation of the impact of the California State Water Project on the west side of the San Joaquin Valley, using aerial photo mosaics and high-altitude photography for 1957 and 1971. Particular attention is paid to a determination of gross land use change and to the detection of specific patterns of development emerging from this change. Information derived from the mapping and tabulating of data acquired in this study indicates a definite trend toward the development of an agricultural landscape and increasing intensification of land use on the west side of the San Joaquin Valley. The introduction of water into this arid region is resulting in large acreages of land being brought under cultivation. Consequently, cropland is assuming a more dominant position with respect to areal extent.

Estes, J. E.↗

Census Cities experiment in urban change detection

The author has identified the following significant results. Mapping of 1970 and 1972 land use from high-flight photography has been completed for all test sites: San Francisco, Washington, Phoenix, Tucson, Boston, New Haven, Cedar Rapids, and Pontiac. Area analysis of 1970 and 1972 land use has been completed for each of the mandatory urban areas. All 44 sections of the 1970 land use maps of the San Francisco test site have been officially released through USGS Open File at 1:62,500. Five thousand copies of the Washington one-sheet color 1970 land use map, census tract map, and point line identification map are being printed by USGS Publication Division. ERTS-1 imagery for each of the eight test sites is being received and analyzed. Color infrared photo enlargements at 1:100,000 of ERTS-1 MSS images of Phoenix taken on October 16, 1972 and May 2, 1973 are being analyzed to determine to what level land use and land use changes can be identified and to what extent the ERTS-1 imagery can be used in updating the 1970 aircraft photo-derived land use data base. Work is proceeding on the analysis of ERTS-1 imagery by computer manipulation of ERTS-1 MSS data in digital format. ERTS-1 CCT maps at 1:24,000 are being analyzed for two dates over Washington and Phoenix. Anniversary tape sets have been received at Purdue LARS for some additional urban test sites.

Wray, J. R.↗

Workmanship vibration test of the SAS-B spacecraft

The occurrence of a technical problem made it necessary to remove the transmitter from the SAS-B spacecraft. The transmitter was repaired and reinstalled in the spacecraft. After this operation it was necessary to test the mechanical properties of the reassembled spacecraft in a vibration test to be conducted near the spacecraft launching place on the San Marco Range in the Indian Ocean. A vibration system was, therefore, sent to San Marco. The design of the vibration system is discussed, giving attention also to alternative solutions for conducting the required tests.

Demas, L. J.↗

Faults on Skylab imagery of the Salton Trough area, Southern California

The author has identified the following significant results. Large segments of the major high angle faults in the Salton Trough area are readily identifiable in Skylab images. Along active faults, distinctive topographic features such as scarps and offset drainage, and vegetation differences due to ground water blockage in alluvium are visible. Other fault-controlled features along inactive as well as active faults visible in Skylab photography include straight mountain fronts, linear valleys, and lithologic differences producing contrasting tone, color or texture. A northwestern extension of a fault in the San Andreas set, is postulated by the regional alignment of possible fault-controlled features. The suspected fault is covered by Holocene deposits, principally windblown sand. A northwest trending tonal change in cultivated fields across Mexicali Valley is visible on Skylab photos. Surface evidence for faulting was not observed; however, the linear may be caused by differences in soil conditions along an extension of a segment of the San Jacinto fault zone. No evidence of faulting could be found along linears which appear as possible extensions of the Substation and Victory Pass faults, demonstrating that the interpretation of linears as faults in small scale photography must be corroborated by field investigations.

Merifield, P. M.↗

Strain buildup and release, earthquake prediction and selection of VLB sites for the margins of the North Pacific

Microearthquake studies of the southern section of the San Andreas fault system were conducted in order to elucidate the role of known but little studied complications in the fault system which could affect the SAFE measurement. Data reduction from microearthquake studies in Baja California, Mexico, was completed. In addition, styles of deformation on the Alpine fault in New Zealand and on the San Andreas fault were compared. Sections of these faults with comparable physical characteristics seem to deform in a similar manner, indicating that deformation style is controlled by certain fundamental relations and will continue in the future. The geology of eastern New Guinea is also discussed. Deformation in the area is proposed to be related to collision of a series of island arcs with central New Guinea, which is part of the Australian continent. Among other unusual properties, eastern New Guinea contains the highest anomaly of the gravimetrically determined geoid based on GEM 6 and surface gravity data.

Scholz, C. H.↗

The Shaw chondrite. I - The case of the missing metal

The mineralogy as well as the elemental and isotopic composition of the Shaw meteorite indicate that it is a highly metamorphosed L-group chondrite which has lost a portion of its metal and sulfide. The metal which remains has an unusual composition relative to that in other L-group chondrites. It is enriched in Ga, Ge, Ir, Mo, Os, Pt, Re, and Ru but depleted in As, Au, Cu, and Sb. A comparison of the relative enrichments and depletions in Shaw with those observed in San Cristobal, the extreme end-member of group IAB iron meteorites, shows that the metal phases in these two meteorites have complementary compositions. This implies that the metal in Shaw represents the residual solid of a partial melting process while the missing metal, which drained away, may have gone to form an iron meteorite, like San Cristobal.

Rambaldi, E. R.↗

Determination of aerosol content in the atmosphere from LANDSAT data

The author has identified the following significant results. A large set of LANDSAT 2 data, obtained at San Diego, showed excellent linear relationships, particularly for MSS 5 and MSS 6, between the radiance over the ocean and the atmospheric aerosol content. Two other data points obtained at Adrigole, Ireland, representing a different ocean and a different ground truth instrument, showed very good agreement with the San Diego data. It appeared that the technique could be used for global monitoring of the atmospheric aerosol content over the oceans. Results obtained at several inland bodies of water showed that MSS 4, MSS 5, and MSS 6 cannot be used due to the effect of water pollution generally present. However, the LANDSAT 1 results suggested that MSS 7, which operates at longer wavelengths, was not very sensitive to water pollution, and might be useful for inland measurements of aerosol content. Use of the longer wavelength would also minimize the effects of adjacent high albedo land, since atmospheric scattering was reduced at longer wavelengths.

Griggs, M.↗

Experimental evidence of interhemispheric transport from airborne carbon monoxide measurements

During the period 28-30 October 1977, a Pan American 747-SP aircraft flew around the world with an automated instrument package that included measurements of atmospheric CO made every 4 sec. The flight path extended from San Francisco, over the North Pole to London, south to Capetown, over the South Pole to Auckland, and back to San Francisco. The data collected show large changes with longitude, which are interpreted as direct evidence of interhemispheric mixing. Possible sources for CO are discussed.

Newell, R. E.↗

Relative toxicity of pyrolysis gases from materials - Effects of chemical composition and test conditions

Relative toxicity test data on 270 materials are presented, based on test procedures developed at the University of San Francisco. The effects of chemical composition, using data on 13 types of synthetic polymers and eight types of fabrics, are discussed. Selected materials were evaluated using nine test conditions with the USF method, and using methods developed at the FAA Civil Aeromedical Institute, Douglas Aircraft Company and San Jose State University.

Hilado, C. J.↗