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Results for “receptors”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Structures of activin ligand traps using natural sets of type I and type II TGF[beta] receptors
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Structures of synthetic nanobody–SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction
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T cell receptors employ diverse strategies to target a p53 cancer neoantigen
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A novel strigolactone receptor antagonist provides insights into the structural inhibition, conditio
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Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recogniti
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Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction
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The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroi
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Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases
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Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4
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Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer’s disease: A putative biomarker of amyloid-induced vascular damage
We have identified FLT1 as a protein that changes during Alzheimer's disease (AD) whereby higher brain protein levels are associated with more amyloid, more tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis and immune activation, we hypothesized that FLT1 is upregulated in response to amyloid pathology, driving a vascular-immune cascade resulting in neurodegeneration and cognitive decline. We sought to determine (1) if in vivo FLT1 levels (CSF and plasma) associate with biomarkers of AD neuropathology or differ between diagnostic staging in an aged cohort enriched for early disease, and (2) whether FLT1 expression interacts with amyloid on downstream outcomes, such as phosphorylated tau levels and cognitive performance. Additionally, we sought to replicate FLT1 interactions in the brain. The results showed that higher levels of FLT1 in CSF and post-mortem brain tissue related to increased tau, particularly among amyloid positive individuals. These analyses help clarify the potential utility of FLT1 as a biomarker among individuals with evidence of brain amyloidosis.
A putative binding model of nitazene derivatives at the μ-opioid receptor
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