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At least 397 records · Page 22

Effects of water immersion on renal hemodynamics in normal man

The present study was undertaken to delineate the effects of water immersion to the neck (NI) on renal plasma flow and glomerular filtration rate as assessed by the clearance of p-aminohippuric acid (PAH) and inulin, respectively. Nine normal male subjects were studied on two occasions, control and NI. The conditions of seated posture and time of day were identical. Immersion did not alter either clearance at a time when sodium excretion was increasing markedly. The constancy of PAH clearance during NI suggests that renal blood flow is unaltered and that the natriuresis of NI is mediated independently of alterations in overall renal perfusion. The sluggish decline of a natriuresis during recovery is consistent with the presence of a humoral factor contributing to the encountered natriuresis.

Epstein, M.↗

Accretion torques in X-ray pulsars

An analysis of the accretion process in an X-ray pulsar, whereby angular momentum is transferred to the star and its rotation period is changed, is presented, and an expression for the fractional rate of change of the pulse period in terms of X-ray luminosity and other star parameters is derived. It is shown that observed characteristic spin-up time scales for seven X-ray pulsars strongly support the view that in every source (1) the pulse period reflects the rotation period of a compact object, (2) the accretion is mediated by a disk surrounding the compact object and rotating in the same sense, and (3) the compact object is a neutron star rather than a white dwarf.

Rappaport, S.↗

Left ventricular function during lower body negative pressure

The response of the human left ventricle to lower body negative pressure (LBNP) and the relation between left ventricular function and hemodynamic response were investigated. Ventricular function curves relating stroke volume to end-diastolic volume were obtained in 12 normal men. Volume data were derived from echocardiographic measurements of left ventricular end-systolic and end-diastolic diameters at rest and during lower body negative pressure (LBNP) at minus 40 mm Hg. End-diastolic volume decreased by 19% and stroke volume by 22%. There were no significant changes in heart rate, arterial blood pressure, or end-systolic volume. Thus, moderate levels of LBNP significantly reduce preload and stroke volume without affecting contractile state. The absence of significant changes in heart rate and arterial blood pressure in the presence of a significant reduction in stroke volume is consistent with an increase in systemic peripheral resistance mediated by low-pressure baroreceptors.

Ahmad, M.↗

Effects of Fe2O3 addition on the nitridation of silicon powder

The reaction of silicon powder and nitrogen was studied in the range of 1300-1400 C. When an addition of Fe2O3 was more than 0.8wt%, the reaction was linear and compared to samples with no Fe2O3, the reaction velocity increased 5 to 10 times. The reactions were mediated by the process of peeling and cracking in a thin layer of Si2N4 formed on the silicon particles or on the surface of the Fe-Si melts. As the addition of Fe2O3 increased, the reaction activation energy for highly pure samples decreased. Fe2O3 which exceeded the Si3N4 solubility limits was finally converted to d-Fe.

Hasegawa, Y.↗

Influence of central venous pressure upon sinus node responses to arterial baroreflex stimulation in man

Measurements were made of sinus node responses to arterial baroreceptor stimulation with phenylephrine injection or neck suction, before and during changes of central venous pressure provoked by lower body negative pressure or leg and lower truck elevation. Variations of central venous pressure between 1.1 and 9.0 mm Hg did not influence arterial baroreflex mediated bradycardia. Baroreflex sinus node responses were augmented by intravenous propranolol, but the level of responses after propranolol was comparable during the control state, lower body negative pressure, and leg and trunk elevation. Sinus node responses to very brief baroreceptor stimuli applied during the transitions of central venous pressure also were comparable in the three states. The authors conclude that physiological variations of central venous pressure do not influence sinus node responses to arterial baroreceptor stimulation in man.

Mark, A. L.↗

A theory of local and global processes which affect solar wind electrons. 1: The origin of typical 1 AU velocity distribution functions: Steady state theory

A detailed first principle kinetic theory for electrons which is neither a classical fluid treatment nor an exospheric calculation is presented. This theory illustrates the global and local properties of the solar wind expansion that shape the observed features of the electron distribution function, such as its bifurcation, its skewness and the differential temperatures of the thermal and suprathermal subpopulations. Coulomb collisions are substantial mediators of the interplanetary electron velocity distribution function and they place a zone for a bifurcation of the electron distribution function deep in the corona. The local cause and effect precept which permeates the physics of denser media is modified for electrons in the solar wind. The local form of transport laws and equations of state which apply to collision dominated plasmas are replaced with global relations that explicitly depend on the relative position of the observer to the boundaries of the system.

Scudder, J. D.↗

Survival and reversion of a stable L form in soil

The stable L form of Agromyces ramosus reverted to a bacterial form when incubated in sterilized soil. The cellular and colonial morphology of this bacterial form resembled that of the original parent bacterial form. The two forms differed, however, in that the revertant maintained its bacterial form when transferred onto a low-salt (NaCl) medium but was virtually completely induced into the L-form state on a high-salt medium. The original parent bacterial form was not sensitive to salt. The possibility is discussed that an L-form - bacterial-form cycle for this bacterium might occur naturally in soil. This cycle would be mediated by fluctuations in local salt concentrations in the soil.

Horwitz, A. H.↗

Directional errors of movements and their correction in a discrete tracking task

Subjects can correct their own errors of movement more quickly than they can react to external stimuli by using three general categories of feedback: (1) knowledge of results, primarily visually mediated; (2) proprioceptive or kinaesthetic such as from muscle spindles and joint receptors, and (3) corollary discharge or efference copy within the central nervous system. The effects of these feedbacks on simple reaction time, choice reaction time, and error correction time were studied in four normal human subjects. The movement used was plantarflexion and dorsiflexion of the ankle joint. The feedback loops were modified, by changing the sign of the visual display to alter the subject's perception of results, and by applying vibration at 100 Hz simultaneously to both the agonist and antagonist muscles of the ankle joint. The central processing was interfered with when the subjects were given moderate doses of alcohol (blood alcohol concentration levels of up to 0.07%). Vibration and alcohol increase both the simple and choice reaction times but not the error correction time.

Jaeger, R. J.↗

A study of the mechanism of thigmomorphogenesis in plants, with special reference to the role of ethylene and its significance to research with plants in space

Because of the paucity of data concerning thigmomorphogenesis, all aspects of the phenomenon were under study, although the role of ethylene mediation was central to the approach. Although this report must necessarily point to a specific time in ongoing research, several aspects of the study reached at least temporary stopping points and were therefore written and submitted for publication. These are identified. Other papers which are currently in preparation, but not yet submitted, are also identified. The phenomenon of thigmomorphogenesis is divided into the sensory function, transduction step(s) and the response function.

Jaffe, M. J.↗

Low tryptophan diet decreases brain serotonin and alters response to apomorphine

The role of the serotoninergic system in the regulation of apomorphine-induced behavior, a behavior primarily controlled by dopaminergic neurotransmission, was investigated in rats fed on a low tryptophan diet since weaning. It was found that reductions in brain seritonin (5-HT) produced by diet result in decreased stereotypy after apomorphine administration. This indicates that although stereotyped behavior is primarily mediated by dopaminergic mechanisms, it can also be modulated by other neurotransmitter including 5-HT. It was also shown that changes in brain seritonin levels can affect psychomotor stimulant-induced hypothermia.

Sahakian, B. J.↗

The significance of ACTH for the process of formation of complex heparin compounds in the blood during immobilization stress

Adrenocorticotropin (ACTH) was administered to rats at different times following adrenalectomy. Adrenocorticotropin caused a significant increase in the formation of heparin complexes even in the absence of stress factor. When ACTH secretion is blocked, immobilization stress is not accompanied by an increase in the process of complex formation. The effect of ACTH on the formation of heparin complexes was mediated through its stimulation of the adrenal cortex.

Kudryashov, B. A.↗

An assessment of inductive coupling roadway powered vehicles

The technical concept underlying the roadway powered vehicle system is the combination of an electrical power source embedded in the roadway and a vehicle-mounted power pickup that is inductively coupled to the roadway power source. The feasibility of such a system, implemented on a large scale was investigated. Factors considered included current and potential transportation modes and requirements, economics, energy, technology, social and institutional issues. These factors interrelate in highly complex ways, and a firm understanding of each of them does not yet exist. The study therefore was structured to manipulate known data in equally complex ways to produce a schema of options and useful questions that can form a basis for further, harder research. A dialectical inquiry technique was used in which two adversary teams, mediated by a third-party team, debated each factor and its interrelationship with the whole of the known information on the topic.

Leschly, K. O.↗

Hydrogen production by photoelectrolytic decomposition of H2O using solar energy

Photoelectrochemical systems for the efficient decomposition of water are discussed. Semiconducting d band oxides which would yield the combination of stability, low electron affinity, and moderate band gap essential for an efficient photoanode are sought. The materials PdO and Fe-xRhxO3 appear most likely. Oxygen evolution yields may also be improved by mediation of high energy oxidizing agents, such as CO3(-). Examination of several p type semiconductors as photocathodes revealed remarkable stability for p-GaAs, and also indicated p-CdTe as a stable H2 photoelectrode. Several potentially economical schemes for photoelectrochemical decomposition of water were examined, including photoelectrochemical diodes and two stage, four photon processes.

Rauh, R. D.↗

Clays in prebiological chemistry

The ways in which clays have been utilized in studies of prebiological chemistry are reviewed, and an assessment is given of the possible role of clays in prebiological systems. The adsorption of organic molecules on clays has been demonstrated, as has the synthesis of bioorganic monomers in the presence of clays. For instance, amino acids, purines and pyrimidines have been obtained from carbon monoxide and nitric acid in the presence of clays at relatively high temperatures (250-325 C). The oligomerization of biochemical monomers, mediated by clays, has also been shown to result in the formation of polymer molecules basic to life. Clays have also been found to affect the condensation of mononucleotides to oligonucleotides.

Rao, M.↗

Nonbonded interactions in membrane active cyclic biopolymers. IV - Cation dependence

Interactions of valinomycin and form of its analogs in several conformations with the central ions Li(+), Na(+), K(+), Rb(+) and Cs(+) are investigated as part of a study of the specific preference of valinomycin for potassium and the mechanisms of carrier-mediated ion transport across membranes. Ion binding energies and conformational potential energies are calculated taking into account polarization energy formulas and repulsive energy between the central ion and the ligand atoms for conformations representing various stages in ion capture and release for each of the two ring chiralities of valinomycin and its analogs. Results allow the prediction of the chirality and conformation most likely to be observed for a given analog, and may be used to synthesize analogs with a desired rigidity or flexibility. The binding energies with the alkali metal cations are found to decrease with increasing ion size, and to be smaller than the corresponding ion hydration energies. It is pointed out that the observed potassium preference may be explainable in terms of differences between binding and hydration energies. Binding energies are also noted to depend on ligand conformation.

Radhakrishnan, R.↗

Vestibular experiments

Spacelab experiments designed to investigate space motion sickness, any associated changes in otolith-mediated responses occurring during weightlessness, and the carryover of any such changes to postflight conditions are described. The experiments aimed at assessing otolithic responses in space are intended to clarify presumed alterations in vestibular function during weightlessness. Vestibular function will be investigated at several levels: vestibulo-ocular reflexes, vestibulo-spinal pathways, cortical functions involving perception of motion and spatial orientation, visual vestibular interaction, and motion sickness susceptibility. A second major objective relates to space motion sickness and man's well-being and productivity in space.

Young, L. R.↗

Intracellular mechanism of the action of inhibin on the secretion of follicular stimulating hormone and of luteinizing hormone induced by LH-RH in vitro

The FSH secretion-inhibiting action of inhibin in vitro under basal conditions and also in the presence of LH-RH is suppressed by the addition of MIX, a phosphodiesterase inhibitor. In the presence of LH-RH, inhibin reduces significantly the intracellular level of cAMP in isolated pituitary cells. In contrast, the simultaneous addition of MIX and inhibin raises the cAMP level, and this stimulation is comparable to the increase observed when MIX is added alone. These observations suggest that one mode of action of inhibin could be mediated by a reduction in cAMP within the pituitary gonadotropic cell.

Lecomte-Yerna, M. J.↗

Comparative evaluation of workload estimation techniques in piloting tasks

Techniques to measure operator workload in a wide range of situations and tasks were examined. The sensitivity and intrusion of a wide variety of workload assessment techniques in simulated piloting tasks were investigated. Four different piloting tasks, psychomotor, perceptual, mediational, and communication aspects of piloting behavior were selected. Techniques to determine relative sensitivity and intrusion were applied. Sensitivity is the relative ability of a workload estimation technique to discriminate statistically significant differences in operator loading. High sensitivity requires discriminable changes in score means as a function of load level and low variation of the scores about the means. Intrusion is an undesirable change in the task for which workload is measured, resulting from the introduction of the workload estimation technique or apparatus.

Wierwille, W. W.↗