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At least 397 records · Page 22

SU-F-T-684: Analysis of Cherenkov Excitation in Tissue and the Feasibility of Cherenkov Excited Photodynamic Therapy

Purpose: The irradiation of photodynamic agents with radiotherapy beams has been demonstrated to enhance tumor killing in various studies, and one proposed mechanism is the optical fluence of Cherenkov emission activating the photosensitizer. This mechanism is explored in Monte Carlo simulations of fluence as well as laboratory measurements of fluence and radical oxygen species. Methods: Simulations were completed using GAMOS/GEANT4 with a 6 MV photon beam in tissue. The effects of blood vessel diameter, blood oxygen saturation, and beam size were examined, recording spectral fluence. Experiments were carried out in solutions of photosensitizer and phantoms. Results: Cherenkov produced by a 100×100um{sup 2} 6 MV beam resulted in fluence of less than 1 nJ/cm{sup 2}/Gy per 1 nm wavelength. At this microscopic level, differences in absorption of blood and water in the tissue affected the fluence spectrum, but variation in blood oxygenation had little effect. Light in tissue resulting from larger (10mm ×10mm) 6 MV beams had greater fluence due to light transport and elastic scattering of optical photons, but this transport process also resulted in higher absorption shifts. Therefore, the spectrum produced by a microscopic beam was weighted more heavily in UV/blue wavelengths than the spectrum at the macroscopic level. At the macroscopic level, the total fluence available for absorption by Verteporfin (BPD) in tissue approached uJ/cm{sup 2} for a high radiation dose, indicating that photodynamic activation seems unlikely. Tissue phantom confirmation of these light levels supported this observation, and photosensitization measurements with a radical oxygen species reporter are ongoing. Conclusion: Simulations demonstrated that fluence produced by Cherenkov in tissue by 6 MV photon beams at typical radiotherapy doses appears insufficient to activate photosensitizers to the level required for threshold effects, yet this disagrees with published biological experiments. Experimental validation in tissue phantoms and cell studies are ongoing to clarify this discrepancy. Funding from NIH grant R01CA109558.

60 APPLIED LIFE SCIENCES↗

Optical Properties of Copper-Doped Lithium Niobate Crystals

We have studied the optical properties of copper-doped lithium niobate crystals using semiconductor light-emitting diodes and lasers emitting in the visible and ultraviolet spectral regions as excitation sources. The results demonstrate that, at an excitation frequency approaching the frequency of electronic absorption in copper ions, there is discrete resonance Raman scattering in the form of a frequency comb. The observed Raman satellites of discrete light scattering are due to polar longitudinal A{sub 1} optical modes of the lithium niobate single crystal. Under excitation by a light-emitting diode with a wavelength of 520 nm, we observe a sharp increase in discrete light scattering intensity in comparison with the photoluminescence excited by shorter wavelength excitation sources.

36 MATERIALS SCIENCE↗

Quasi-Elastic Light Scattering in Congruent Lithium Niobate Crystals

Raman scattering spectra in the frequency range of 5–75 cm{sup –1} in lithium niobate samples with various structural imperfections were obtained. It is shown that the intensity of quasi-elastic light scattering on the wing of the Rayleigh line demonstrates an exponential dependence on the concentration of large-scale defects in the samples. Calibration curves for the intensity of quasi-elastic scattering dependence at low frequencies on the acoustic quality factor are constructed.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Radial scanning diagnostics of bremsstrahlung and line emission in T-10 plasma

The paper describes the scanning spectroscopic diagnostics designed for measurement of line integrated plasma radiation in two visible spectral ranges. This diagnostic system is aimed at measuring the bremsstrahlung absolute values and profile with high spatial resolution. The bremsstrahlung absolute values are used to determine the value and radial distribution of effective plasma ion charge Z{sub eff}(r) in T-10 discharges. The importance of Z{sub eff} measurement is due to its strong influence on plasma heating, confinement, and stability. The spatial distribution of emission for one of the chosen spectral lines is measured simultaneously with bremsstrahlung. The spatial resolution of measurements is ~1 cm, and the temporal resolution is up to 10 ms. The spectral equipment and methods for its calibration are described. Examples of line integrated brightness distribution in a “continuum window” of 5236 ± 6 Å and brightness of the lines C{sup 5+} (5291 Å), He{sup 1+} (4686 Å), and D{sub β} (4861 Å) are given. Flattening of the bremsstrahlung brightness profile in the central region of the plasma column in some discharges with sawtooth oscillations in the T-10 is observed. The measured effective ion charge profiles in ohmic discharges with high plasma density and low discharge currents demonstrate accumulation of light impurities at the column axis; as a consequence, quenching of sawtooth oscillations in some discharges is observed. The developed diagnostics provides necessary data for investigation of heat, particle, and current transport in the plasma of the T-10. Successful application of the obtained data on Z{sub eff}(r) for investigation of geodesic acoustic modes of plasma oscillations in the T-10 should be specially noted.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Imaging of spatial distributions of the millimeter wave intensity by using visible continuum radiation from a discharge in a Cs–Xe mixture. Part I: Review of the method and its fundamentals

The first part of the review is presented which is dedicated to the time-resolved method of imaging and measuring the spatial distribution of the intensity of millimeter waves by using visible continuum (VC) emitted by the positive column (PC) of a dc discharge in a mixture of cesium vapor with xenon. The review focuses on the operating principles, fundamentals, and applications of this new technique. The design of the discharge tube and experimental setup used to create a wide homogeneous plasma slab with the help of the Cs–Xe discharge at a gas pressure of 45 Torr are described. The millimeter-wave effects on the plasma slab are studied experimentally. The mechanism of microwave-induced variations in the VC brightness and the causes of violation of the local relation between the VC brightness and the intensity of millimeter waves are discussed. Experiments on the imaging of the field patterns of horn antennas and quasi-optical beams demonstrate that this technique can be used for good-quality imaging of millimeter-wave beams in the entire millimeter-wavelength band. The method has a microsecond temporal resolution and a spatial resolution of about 2 mm. Energy sensitivities of about 10 μJ/cm{sup 2} in the Ka-band and about 200 μJ/cm{sup 2} in the D-band have been demonstrated.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Red Single-Photon Emission from InAs/AlGaAs Quantum Dots

We report on single-photon emission of InAs/AlGaAs self-assembled quantum dots (QDs) grown by molecular beam epitaxy. By varying the growth conditions the QDs luminescence could be tuned over a wide wavelength range from 0.64 to 1 μm, including red part of the visible spectrum. Emission properties of individual QDs are investigated by micro-photoluminescence (μ-PL) spectroscopy using 500-nm-size etched mesa structures. Autocorrelation functions of photons from single QDs, measured in the wide spectral range demonstrate antibunching effect at zero delay time with a value of g{sup (2)}(0) ~ 0.17 that is a clear evidence of non-classical light.

36 MATERIALS SCIENCE↗

Luminescent Silicon Nanocrystals Prepared by Laser-Assisted Synthesis in Liquid for Imaging and Photovoltaic Applications

Silicon nanocrystals (SiNCs) with photoluminescence in the visible spectral range were synthesized by laser irradiation of silicon wafers in solutions. Laser irradiation leads to the formation of well-dispersed Si–NCs with an average diameter of about 5 nm, which upon excitation with 300−450 nm light exhibited room temperature luminescence tunable in the range from 410 to 650 nm. The results showed that photoluminescence (PL) is affected by both sizes and surface states of the Si–NCs. The results obtained allow to conclude that the synthesized nanoparticles (NPs) can be suitable materials for applications in fluorescence imaging along with photovoltaics.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

Silicon Nanopillar Microarrays: Formation and Resonance Reflection of Light

Abstract—The results of investigating the spectral characteristics of reflection from silicon nanopillar (Si NP) microarrays in the wavelength region from 400 to 1100 nm are presented. The Si nanopillars are formed by electron lithography on a negative resist with subsequent reactive ion etching. The Si nanopillars are etched through a resist mask and SiO{sub 2} 100 nm thick. In the spectra of reflection from nanopillar microarrays, minima are observed, the position of which depends strongly on the Si nanopillar diameter.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Structure and Properties of Gallium-Oxide Films Produced by High-Frequency Magnetron-Assisted Deposition

The properties of gallium-oxide films produced by the radio-frequency magnetron-assisted sputtering of a β-Ga{sub 2}O{sub 3} target with deposition onto sapphire substrates are studied. The as-deposited gallium-oxide films are polycrystalline and contain crystallites of the α and β phases. Exposure to oxygen plasma does not bring about the appearance of new crystallites but makes crystallites several times larger in average dimensions in the substrate plane. After annealing at 900°C, the crystallite size becomes twice as large as that in the unannealed film. The films not subjected to thermal annealing exhibit a high resistance at 20°C. In the range of 50–500°C, the conductivity of the samples (G) only slightly depends on temperature (T) and, as T is elevated further, exponentially increases with the activation energy 0.7–1.0 eV. After annealing of the films in argon at 900°C (30 min), the conductivity G starts to sharply increase at T ≈ 350°C. In the dependence of lnG on T {sup –1}, a maximum in the range of 470–520°C and a portion of decreasing conductivity at higher temperatures are observed. The unusual temperature dependence of the conductivity after annealing is attributed to a change in the structure and phase composition of polycrystalline gallium-oxide films and, possibly, to some effects at the surface. The structures produced on insulating substrates are solar blind in the visible wavelength region and sensitive to radiation in the ultraviolet region (222 nm).

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Black Silicon: a New Manufacturing Method and Optical Properties

A new method for manufacturing nanostructured black silicon (b-Si) by growing cone-shaped (pointed) filamentous nanocrystals (nanowires, FNWs) on the surface of single-crystal Si-plates has been proposed. b-Si samples with reflectivity less than 0.1% have been obtained. It has been shown that the b-Si reflection coefficient depends on the sizes of the FNWs in the visible region of the spectrum: its minimum value (less than 0.1%) has been achieved at diameters at the base of the FNWs of 650–750 nm and a length of 1.5–2 μm.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Technical Scope of Work: Proton Induced Radiation Damage in Crystal Scintillators

This is a technical scope of work (TSW) between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of California Institute of Technology who have committed to participate in beam tests to be carried out during the 2014 Fermilab Test Beam Facility program. The goal of this investigation is to understand the proton-induced radiation damage in candidate fast crystal scintillators for future HEP experiments. Degradations of the optical and scintillation properties, including emission and transmittance spectra, light output, decay time and light response uniformity, will be measured before and after each step of proton irradiation at Fermilab with a defined fluence. The irradiation will start with a fluence of 10 10 /cm 2 and going up in four steps to 10 13 /cm 2 .

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Morphology and Current Transport in a Thin-Film Polycrystalline Au–Zn{sub x}Cd{sub 1–x}S–Mo Structure with Wide Photosensitivity Range in the Ultraviolet and Visible Radiation Spectral Region

Studies are carried out on the morphology of the surface and photovoltaic characteristics of a thinfilm Au–Zn{sub x}Cd{sub 1–x}S–Mo structural injection photodetector with a wide photosensitivity range in the ultraviolet and visible radiation spectral regions. The composition of Zn{sub x}Cd{sub 1–x}S film in the Au–Zn{sub x}Cd{sub 1–x}S–Mo structure with a wide photosensitivity spectrum in the ultraviolet and visible spectrum, where x on the surface varies from 0.22 to 0.24, is studied. The mechanism of current transport is investigated, and the main electrophysical parameters of the semiconducting materials are determined. The use of Zn{sub x}Cd{sub 1–x}S film with a variable band gap in the thin-film heterojunction solar cells, where they are used as the buffer layer, will provide an opportunity to increase the photosensitivity of the structure in the short-wave region of the radiation spectrum, increase the value of the built-in potential, short-circuit current and value of the open-circuit voltage of the structure.

14 SOLAR ENERGY↗

Triple Layer Tungsten Trioxide, Graphene, and Polyaniline Composite Films for Combined Energy Storage and Electrochromic Applications

Different polyaniline (PANI)-based hybrid films were successfully prepared by electro-polymerizing aniline monomers onto pre-spin-coated indium tin oxide (ITO) glass slides with WO 3 , graphene, or WO 3 /graphene films. Comparing with pristine PANI, the shifts of the characteristic peaks of PANI-based nanocomposites in UV-visible absorption spectra (UV-vis) and Fourier transform infrared spectroscopy (FT-IR) indicate the chemical interaction between the PANI matrix and the nanofillers, which is also confirmed by the scanning electron microscope (SEM) images. Corresponding coloration efficiencies were obtained for the WO 3 /PANI (40.42 cm 2 C -1 ), graphene/PANI (78.64 cm 2 C -1 ), and WO 3 /graphene/PANI (67.47 cm 2 C -1 ) films, higher than that of the pristine PANI film (29.4 cm 2 C -1 ), suggesting positive effects of the introduced nanofillers on the electrochromic performance. The areal capacitances of the films were observed to increase following the order as bare WO 3 < WO 3 /graphene < pristine PANI < WO 3 /PANI < graphene/PANI < WO 3 /graphene/PANI films from both the cyclic voltammogram (CV) and galvanostatic charge-discharge (GCD) results. The enhanced energy storage and electrochromic performances of the PANI-based nanocomposite films can be attributed to the capacitance contributions of the introduced nanofillers, increased PANI amount, and the rougher morphology due to the embedment of the nanofillers into the PANI matrix. This extraordinary energy storage and electrochromic performances of the WO 3 /graphene/PANI film make it a promising candidate for combined electrochromic and energy storage applications.

36 MATERIALS SCIENCE↗

ULTRAVIOLET SPECTROSCOPY OF BL Hyi AND EF Eri IN HIGH AND INTERMEDIATE STATES

We present the first phase-resolved ultraviolet spectroscopy of two polar systems, BL Hyi and EF Eri, in high and intermediate states from the International Ultraviolet Explorer ( IUE ) during the periods between 1982–1995 and 1979–1991, respectively. The flux curves for the C iv and He ii emission lines for both systems showing variations in their fluxes at different orbital phases are presented. The emission lines are produced in the accretion stream. The reddening for the two polars is found to be 0.00. Our results show that there are variations of the line fluxes with time, similar to the light curves found for both BL Hyi and EF Eri in the optical, infrared, ultraviolet, and X-ray bands. IUE observations support a radiative shock model of BL Hyi with the heating of matter by radiation from the accretion shock and cooling by the electrons scattering off ultraviolet photons from the surface of the white dwarf. EF Eri observations support a two-temperature white dwarf model producing sufficient ultraviolet flux for orbital modulations.

79 ASTRONOMY AND ASTROPHYSICS↗

GW LIBRAE: STILL HOT EIGHT YEARS POST-OUTBURST

We report continued Hubble Space Telescope ( HST ) ultraviolet spectra and ground-based optical photometry and spectroscopy of GW Librae eight years after its largest known dwarf nova outburst in 2007. This represents the longest cooling timescale measured for any dwarf nova. The spectra reveal that the white dwarf still remains about 3000 K hotter than its quiescent value. Both ultraviolet and optical light curves show a short period of 364–373 s, similar to one of the non-radial pulsation periods present for years prior to the outburst, and with a similar large UV/optical amplitude ratio. A large modulation at a period of 2 hr (also similar to that observed prior to outburst) is present in the optical data preceding and during the HST observations, but the satellite observation intervals did not cover the peaks of the optical modulation, and so it is not possible to determine its corresponding UV amplitude. The similarity of the short and long periods to quiescent values implies that the pulsating, fast spinning white dwarf in GW Lib may finally be nearing its quiescent configuration.

79 ASTRONOMY AND ASTROPHYSICS↗

Jet signatures in the spectra of accreting black holes

Jets are observed as radio emission in active galactic nuclei and during the low/hard state in X-ray binaries (XRBs), but their contribution at higher frequencies has been uncertain. We study the dynamics of jets in XRBs using the general-relativistic magnetohydrodynamic code HARM. We calculate the high-energy spectra and variability properties using a general-relativistic radiative transport code based on grmonty. We find the following signatures of jet emission: (i) a significant γ-ray peak above ∼10{sup 22} Hz, (ii) a break in the optical/UV spectrum, with a change from νL{sub ν}∼ν{sup 0} to νL{sub ν}∼ν, followed by another break at higher frequencies where the spectrum roughly returns to νL{sub ν}∼ν{sup 0}, and (iii) a pronounced synchrotron peak near or below ∼10{sup 14} Hz indicates that a significant fraction of any observed X-ray emission originates in the jet. We investigate the variability during a large-scale magnetic field inversion in which the Blandford–Znajek (BZ) jet is quenched and a new transient hot reconnecting plasmoid is launched by the reconnecting field. The ratio of the γ-rays to X-rays changes from L{sub γ}/L{sub X}>1 in the BZ jet to L{sub γ}/L{sub X}<1 during the launching of the transient plasmoid.

79 ASTRONOMY AND ASTROPHYSICS↗

A COMBINED SPECTROSCOPIC AND PHOTOMETRIC STELLAR ACTIVITY STUDY OF EPSILON ERIDANI

We present simultaneous ground-based radial velocity (RV) measurements and space-based photometric measurements of the young and active K dwarf Epsilon Eridani. These measurements provide a data set for exploring methods of identifying and ultimately distinguishing stellar photospheric velocities from Keplerian motion. We compare three methods we have used in exploring this data set: Dalmatian, an MCMC spot modeling code that fits photometric and RV measurements simultaneously; the FF′ method, which uses photometric measurements to predict the stellar activity signal in simultaneous RV measurements; and H α analysis. We show that our H α measurements are strongly correlated with the Microvariability and Oscillations of STars telescope ( MOST ) photometry, which led to a promising new method based solely on the spectroscopic observations. This new method, which we refer to as the HH′ method, uses H α measurements as input into the FF′ model. While the Dalmatian spot modeling analysis and the FF′ method with MOST space-based photometry are currently more robust, the HH′ method only makes use of one of the thousands of stellar lines in the visible spectrum. By leveraging additional spectral activity indicators, we believe the HH′ method may prove quite useful in disentangling stellar signals.

79 ASTRONOMY AND ASTROPHYSICS↗

RADIAL VELOCITY MONITORING OF KEPLER HEARTBEAT STARS

Heartbeat stars (HB stars) are a class of eccentric binary stars with close periastron passages. The characteristic photometric HB signal evident in their light curves is produced by a combination of tidal distortion, heating, and Doppler boosting near orbital periastron. Many HB stars continue to oscillate after periastron and along the entire orbit, indicative of the tidal excitation of oscillation modes within one or both stars. These systems are among the most eccentric binaries known, and they constitute astrophysical laboratories for the study of tidal effects. We have undertaken a radial velocity (RV) monitoring campaign of Kepler HB stars in order to measure their orbits. We present our first results here, including a sample of 22 Kepler HB systems, where for 19 of them we obtained the Keplerian orbit and for 3 other systems we did not detect a statistically significant RV variability. Results presented here are based on 218 spectra obtained with the Keck/HIRES spectrograph during the 2015 Kepler observing season, and they have allowed us to obtain the largest sample of HB stars with orbits measured using a single instrument, which roughly doubles the number of HB stars with an RV measured orbit. The 19 systems measured here have orbital periods from 7 to 90 days and eccentricities from 0.2 to 0.9. We show that HB stars draw the upper envelope of the eccentricity–period distribution. Therefore, HB stars likely represent a population of stars currently undergoing high eccentricity migration via tidal orbital circularization, and they will allow for new tests of high eccentricity migration theories.

79 ASTRONOMY AND ASTROPHYSICS↗