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At least 397 records · Page 22

Simulations of the churning mode: Toroidally symmetric plasma convection and turbulence around the X-points in a snowflake divertor

Using a reduced MHD model, extended to include field-aligned thermal conduction, we present numerical simulations of the churning mode (CM): a toroidally symmetric, non-linear plasma vortex in the vicinity of the null points in a snowflake (SF) divertor [D. D. Ryutov et al., Phys. Scr. 89, 088002 (2014)]. Simulations are carried out across a range of inter-null separations, d xx ⁠, and inter-null orientations, θ⁠, primarily in conditions relevant to the MAST-U tokamak. We find that, when d xx is small, the CM induces additional transport across the X-points when β pm ≳8%, where β pm is the ratio of the plasma pressure in the null region to poloidal magnetic pressure at the midplane. This transport also increases approximately linearly as d xx is reduced. A diffusive model of this transport is shown to predict the total transport across the null points, where diffusion coefficients of up to ∼ 10 2 m 2 s −1 centered on a small region around the X-points are used. However, the CM also results in significant changes to the flux surfaces in the null region, which is not captured by this diffusive model. The changes in magnetic geometry mean the fractional exhaust power delivered to each divertor leg is highly sensitive to β pm ⁠, d xx ⁠, and θ⁠. For small values of θ⁠, the CM can induce a change in topology, redirecting exhaust power from a secondary divertor leg on the high field side to one on the low field side. Similar behavior is found in the fraction of exhaust power going to the inner and outer divertor. Such changes in the flux surfaces may not be captured by Grad–Shafranov solvers and so may be a source of error in the magnetic reconstruction of SF experiments. We consistently find that the fractional exhaust power going to a secondary divertor leg on the high field side is small, consistent with SF experiments.

Computer simulation↗

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the development of hematopoietic stem cells, germ cells, and other cells. A variety of human cancers, such as acute myeloid leukemia, gastrointestinal stromal tumor, and mast cell leukemia, are driven by somatic gain-of-function KIT mutations. Here, we report cryo electron microscopy (cryo-EM) structural analyses of full-length wild-type and two oncogenic KIT mutants, which show that the overall symmetric arrangement of the extracellular domain of ligand-occupied KIT dimers contains asymmetric D5 homotypic contacts juxtaposing the plasma membrane. Mutational analysis of KIT reveals in D5 region an “Achilles heel” for therapeutic intervention. A ligand-sensitized oncogenic KIT mutant exhibits a more comprehensive and stable D5 asymmetric conformation. A constitutively active ligand-independent oncogenic KIT mutant adopts a V-shaped conformation solely held by D5-mediated contacts. Binding of SCF to this mutant fully restores the conformation of wild-type KIT dimers, including the formation of salt bridges responsible for D4 homotypic contacts and other hallmarks of SCF-induced KIT dimerization. These experiments reveal an unexpected structural plasticity of oncogenic KIT mutants and a therapeutic target in D5.

60 APPLIED LIFE SCIENCES↗

Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2

Bla g 2 is a major indoor cockroach allergen associated with the development of asthma. Antigenic determinants on Bla g 2 were analyzed by mutagenesis based on the structure of the allergen alone and in complex with monoclonal antibodies that interfere with IgE antibody binding. The structural analysis revealed mechanisms of allergen-antibody recognition through cation-π interactions. Single and multiple Bla g 2 mutants were expressed in Pichia pastoris and purified. The triple mutant K132A/K251A/F162Y showed an ~100-fold reduced capacity to bind IgE, while preserving the native molecular fold, as proven by x-ray crystallography. This mutant was still able to induce mast cell release. T-cell responses were assessed by analyzing Th1/Th2 cytokine production and the CD4+ T-cell phenotype in peripheral blood mononuclear cell cultures. Although T-cell activating capacity was similar for the KKF mutant and Bla g 2 based on CD25 expression, the KKF mutant was a weaker inducer of the Th2 cytokine IL-13. Furthermore, this mutant induced IL-10 from a non-T-cell source at higher levels that those induced by Bla g 2. Lastly, our findings demonstrate that a rational design of site-directed mutagenesis was effective in producing a mutant with only 3 amino acid substitutions that maintained the same fold as wild type Bla g 2. These residues, which were involved in IgE antibody binding, endowed Bla g 2 with a T-cell modulatory capacity. The antigenic analysis of Bla g 2 will be useful for the subsequent development of recombinant allergen vaccines.

59 BASIC BIOLOGICAL SCIENCES↗

Analysis of Repeatability and Reproducibility Studies With Ordinal Measurements

A Bayesian inferential approach with a noninformative prior is introduced to analyze ordinal repeatability and reproducibility (R&R) data using the De Mast–Van Wieringen model. This approach is extended with a weakly informative prior and random effects to allow for the consideration of a population of raters and prediction of a new rater. This random-effects approach is also shown to result in partial pooling of estimates across raters. In addition, match-probability-based measures to decompose ordinal R&R study data into contributions due to repeatability and due to reproducibility are defined. All extensions involving Bayesian inference (for fixed or random effects) and measures are illustrated on real and simulated ordinal R&R study data and are applicable in business and industry settings. This methodology can be implemented using the supplemental R package ordinalRR available from CRAN. Additional supplementary material for this article is available online.

97 MATHEMATICS AND COMPUTING↗

Selection and characterization of FcεRI phospho-ITAM specific antibodies

Post-translational modifications, such as the phosphorylation of tyrosines, are often the initiation step for intracellular signaling cascades. Pan-reactive antibodies against modified amino acids (e.g., anti-phosphotyrosine), which are often used to assay these changes, require isolation of the specific protein prior to analysis and do not identify the specific residue that has been modified (in the case that multiple amino acids have been modified). Phosphorylation state-specific antibodies (PSSAs) developed to recognize post-translational modifications within a specific amino acid sequence can be used to study the timeline of modifications during a signal cascade. We utilized the FcεRI receptor as a model system to develop and characterize high-affinity PSSAs using phage and yeast display technologies. We determined three β-subunit antibodies that recognized: 1) phosphorylation of tyrosines Y 218 or Y 224 ; 2) phosphorylation of the Y 228 tyrosine; and 3) phosphorylation of all three tyrosines. We used these antibodies to study the receptor activation timeline of FcεR1 in rat basophilic leukemia cells (RBL-2H3) upon stimulation with DNP 24 -BSA. We also selected an antibody recognizing the N-terminal phosphorylation site of the γ-subunit (Y 65 ) of the receptor and applied this antibody to evaluate receptor activation. Recognition patterns of these antibodies show different timelines for phosphorylation of tyrosines in both β and γ subunits. Our methodology provides a strategy to select antibodies specific to post-translational modifications and provides new reagents to study mast cell activation by the high-affinity IgE receptor, FcεRI.

59 BASIC BIOLOGICAL SCIENCES↗

Fusion nuclear science facilities and pilot plants based on the spherical tokamak

Here, a fusion nuclear science facility (FNSF) could play an important role in the development of fusion energy by providing the nuclear environment needed to develop fusion materials and components. The spherical torus/tokamak (ST) is a leading candidate for an FNSF due to its potentially high neutron wall loading and modular configuration. A key consideration for the choice of FNSF configuration is the range of achievable missions as a function of device size. Possible missions include: providing high neutron wall loading and fluence, demonstrating tritium self-sufficiency, and demonstrating electrical self-sufficiency. All of these missions must also be compatible with a viable divertor, first-wall, and blanket solution. ST-FNSF configurations have been developed simultaneously incorporating for the first time: (1) a blanket system capable of tritium breeding ratio TBR ≈ 1, (2) a poloidal field coil set supporting high elongation and triangularity for a range of internal inductance and normalized beta values consistent with NSTX/NSTX-U previous/planned operation, (3) a long-legged divertor analogous to the MAST-U divertor which substantially reduces projected peak divertor heat-flux and has all outboard poloidal field coils outside the vacuum chamber and superconducting to reduce power consumption, and (4) a vertical maintenance scheme in which blanket structures and the centerstack can be removed independently. Progress in these ST-FNSF missions versus configuration studies including dependence on plasma major radius R 0 for a range 1 m–2.2 m are described. In particular, it is found the threshold major radius for TBR = 1 is ${{R}_{0}}\geqslant 1.7$ m, and a smaller R 0 = 1 m ST device has TBR ≈ 0.9 which is below unity but substantially reduces T consumption relative to not breeding. Calculations of neutral beam heating and current drive for non-inductive ramp-up and sustainment are described. An A = 2, R = 3 m device incorporating high-temperature superconductor toroidal field coil magnets capable of high neutron fluence and both tritium and electrical self-sufficiency is also presented following systematic aspect ratio studies.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Influence of up-down asymmetry in plasma shape on RMP response

Shaping effect on the plasma response to the externally applied resonant magnetic perturbation field is investigated for both DIII-D and MAST experiments, utilizing toroidal modeling. The plasma boundary shape is systematically varied ranging from single-null (SN) to double-null (DN) configurations, while other equilibrium quantities are kept largely unchanged. The relative amplitude of the computed plasma surface displacement, between the top/bottom of the torus and the outboard mid-plane, is identified as the most reliable indicator that distinguishes the plasma response between the SN and DN configurations. Here, the underlying physics is the weakening of the edge-peeling component in the plasma response with increasing up-down symmetry of the plasma boundary shape.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Investigation of the role of hydrogen molecules in 1D simulation of divertor detachment

The role of neutral and charged hydrogenic molecules in detached regimes of tokamak plasmas is investigated using a simplified 1D numerical model. Using MAST Upgrade like conditions, simulations are implemented to study the rollover of target flux Γ in upstream density scan. It is found that if H 2 and H 2 + are considered in simulations a lower target temperature and a larger upstream density will be required to trigger divertor detachment under the same input power and particle flux, and the critical detachment threshold (the critical ratio of upstream static pressure to the power entering the recycling region) is found to be $^{ρ_{up}}_{ρ_{recl}}$ ~ 8.1 NMW -1 at rollover. Molecule–plasma interactions are found to be as crucial as atom–plasma interactions during divertor detachment, both of which account for the majority of plasma momentum loss in the cases studied here. Further analysis of the momentum loss decomposition shows molecule-plasma elastic collisions dominate molecule-plasma interactions, while molecular charge exchange cannot effectively reduce plasma momentum. In terms of H alpha emission, a strong rise of H alpha signal is found to be due to molecular excitation channels when the upstream density further increases after rollover.

SD1D↗

New linear stability parameter to describe low-β electromagnetic microinstabilities driven by passing electrons in axisymmetric toroidal geometry

In magnetic confinement fusion devices, the ratio of the plasma pressure to the magnetic field energy, β, can become sufficiently large that electromagnetic microinstabilities become unstable, driving turbulence that distorts or reconnects the equilibrium magnetic field. In this paper, a theory is proposed for electromagnetic, electron-driven linear instabilities that have current layers localised to mode-rational surfaces and binormal wavelengths comparable to the ion gyroradius. The model retains axisymmetric toroidal geometry with arbitrary shaping, and consists of orbit-averaged equations for the mode-rational surface layer, with a ballooning space kinetic matching condition for passing electrons. The matching condition connects the current layer to the large scale electromagnetic fluctuations, and is derived in the limit that β is comparable to the square root of the electron-to-ion-mass ratio. Electromagnetic fluctuations only enter through the matching condition, allowing for the identification of an effective β that includes the effects of equilibrium flux surface shaping. The scaling predictions made by the asymptotic theory are tested with comparisons to results from linear simulations of micro-tearing and electrostatic microinstabilities in MAST discharge #6252, showing excellent agreement. In particular, it is demonstrated that the effective β can explain the dependence of the local micro-tearing mode (MTM) growth rate on the ballooning parameter θ 0 – possibly providing a route to optimise local flux surfaces for reduced MTM-driven transport.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Effects of equilibrium pressure on plasma response to RMPs in a spherical tokamak

This study presents a comprehensive analysis of the equilibrium pressure on the plasma response to resonant magnetic perturbations (RMPs) in the spherical tokamak (ST) MAST-U, employing both single-fluid and MHD-kinetic hybrid models (implemented via the MARS-F/K codes). As a key finding, the study identifies two different pressure-driven eigenmodes, exhibiting Sturmian property, that affect the Troyon no-wall limits for the onset of the n = 1 and n = 2 ( n is the toroidal mode number) ideal external kink instabilities as well as the corresponding plasma response to the applied RMP. With increasing equilibrium pressure, the plasma response to RMPs is significantly enhanced in the ST plasma, particularly in the high-pressure regime where kinetic effects strongly stabilize the external kink instability. The Troyon no-wall limit divides the plasma response into two regions: well below the limit, the response amplitudes and trends (versus pressure) are similar between the fluid and kinetic models; as the equilibrium pressure approaches the Troyon limit, the kinetic model predicts significant amplification of the RMP field, up to 30 times for cases considered. A relatively weak dependence of the optimal coil phasing on the equilibrium pressure is computed in this ST plasma, similar to the trend obtained for the conventional aspect ratio devices. These findings underscore the importance of incorporating kinetic effects in accurate prediction of the plasma response to RMPs in high-pressure ST tokamak plasmas and provide a theoretical basis for optimizing RMP-based control of the edge-localized modes in future ST devices.

RMP↗

Real-time observation of toroidal current redistributions induced by three-dimensional MHD phenomena triggering vertical displacement events in tokamak plasmas

Three-dimensional MHD instabilities, including edge-localized modes (ELMs) and internal reconnection events (IREs), have been observed to precipitate loss of vertical stability in tokamak plasmas, resulting in vertical displacement events (VDEs). This vertical destabilization can occur due to toroidal current redistributions and/or shape changes resulting from these phenomena. Using a recently introduced method for rapidly reconstructing the two-dimensional toroidal plasma current density profile in real-time, results are presented that demonstrate the specific current distribution changes that occur during ELMs (on KSTAR) and IREs (on MAST-U) that lead to loss of vertical control. The method most efficiently reconstructs the toroidal current density profile by doing so on a basis of principal components of historical profiles. These principal components isolate dominant current profile dynamics, improving interpretability, increasing speed, and reducing dimensionality of the profile computation. On KSTAR, this computation is executed in the real-time plasma control system at a rate of 10 kHz (limited by available CPU cycle times), allowing the current profile evolution to be assessed at several times over the course of each ELM event. Further, by incorporating the reconstructions into a novel vertical stability metric, the contribution of specific current profile dynamics to the loss of vertical stability can be assessed in real-time for VDE avoidance and improved understanding of the causal relationship between three-dimensional MHD phenomena and VDEs. The success of this method in approximating toroidal current density profiles from kinetic equilibrium reconstructions is also presented ($R^2=0.990$), along with its capability to produce other equilibrium quantities of interest in real-time at high time resolution.

edge-localized modes↗

Physics-guided machine learning approaches to predict the ideal stability properties of fusion plasmas

One of the biggest challenges to achieve the goal of producing fusion energy in tokamak devices is the necessity of avoiding disruptions of the plasma current due to instabilities. The disruption event characterization and forecasting (DECAF) framework has been developed in this purpose, integrating physics models of many causal events that can lead to a disruption. Two different machine learning approaches are proposed to improve the ideal magnetohydrodynamic (MHD) no-wall limit component of the kinetic stability model included in DECAF. First, a random forest regressor (RFR), was adopted to reproduce the DCON computed change in plasma potential energy without wall effects for a large database of equilibria from the national spherical torus experiment (NSTX). This tree-based method provides an analysis of the importance of each input feature, giving an insight into the underlying physics phenomena. Secondly, a fully-connected neural network has been trained on sets of calculations with the DCON code, to get an improved closed form equation of the no-wall β limit as a function of the relevant plasma parameters indicated by the RFR. The neural network has been guided by physics theory of ideal MHD in its extension outside the domain of the NSTX experimental data. The estimated value has been incorporated into the DECAF kinetic stability model and tested against a set of experimentally stable and unstable discharges. Moreover, the neural network results were used to simulate a real-time stability assessment using only quantities available in real-time. Finally, the portability of the model was investigated, showing encouraging results by testing the NSTX-trained algorithm on the mega ampere spherical tokamak (MAST).

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Application of simulations and theory of sub-cyclotron frequency modes to DIII-D

Theoretical and numerical study of Alfvén eigenmodes (AEs) in the sub-cyclotron frequency range explains the observed frequency scaling with beam parameters in experiments across different devices. Global Alfvén (GAEs) and compressional Alfvén eigenmodes (CAEs) are frequently excited during neutral beam injection (NBI) in the National Spherical Torus Experiment (NSTX/NSTX-U), as well as other beam-heated devices such as MAST and DIII-D. These modes are driven unstable through the Doppler shifted cyclotron resonance with the NBI ions and can be excited in ITER due to super-Alfvénic velocities and anisotropy of the fast ion distribution. Numerical models and theory for sub-cyclotron frequency modes, previously developed and used to study the excitation of GAEs/CAEs in the NSTX(-U), have been successfully applied to explain the DIII-D observations. Simulations for DIII-D demonstrate that the modes with ω/ω ci ≈ 0.6, previously mis-identified as compressional Alfvén eigenmodes, have shear polarization and should be identified as the GAEs. Simulation results match the observed frequencies and estimated toroidal mode numbers in DIII-D experiments. Good agreement is found between scaling of the experimentally observed GAE frequencies with NBI parameters for NSTX, NSTX-U and DIII-D and scaling predicted by the theory and simulations. Here, the DIII-D simulation results also demonstrate that GAEs can be excited for larger aspect-ratio devices and smaller (sub- Alfvénic) beam injection velocities, therefore they can be unstable in ITER.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Modeling electron temperature profiles in the pedestal with simple formulas for ETG transport

Abstract This paper reports on the refinement (building on (Hatch D.R. et al 2022 Phys. Plasmas 29 062501)) and application of simple formulas for electron heat transport from electron temperature gradient (ETG) driven turbulence in the pedestal. The formulas are improved by (1) improving the parameterization for certain key parameters and (2) carefully accounting for the impact of geometry and shaping in the underlying gyrokinetic simulation database. Comparisons with nonlinear gyrokinetic simulations of ETG transport in the MAST pedestal demonstrate the model’s applicability to spherical tokamaks in addition to standard aspect ratio tokamaks. We identify bounds for model applicability: the model is accurate in the steep gradient region, where the ETG turbulence is largely slab-like, but accuracy decreases as the temperature gradient becomes weaker in the pedestal top. We use the formula to model the electron temperature profile in the pedestal for four experimental scenarios while extensively varying input parameters to represent uncertainties. In all cases, the predicted electron temperature profile exhibits extreme sensitivity to separatrix temperature and density, which has implications for core-edge integration. The model reproduces the electron temperature profile for high η e = L n e / L T e scenarios but not for low η e scenarios in which microtearing modes (MTMs) have been identified. We develop a proof-of-concept model for MTM transport and explore the relative roles of ETG and MTM in setting the electron temperature profile.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DECAF Cross-device characterization of tokamak disruptions indicated by abnormalities in plasma vertical position and current

Abnormal (deviating from target) variations in the plasma vertical position Z and current I p (such as vertical displacements, transient I p 'spikes' and quenches) constitute common elements of a disruption, a phenomenon that is to be mitigated, or ultimately avoided in future reactor-relevant tokamaks. While those abnormalities are generally recognized cross-shot and cross-device, details in terms of appearance (or not) and order of those abnormalities in disruption event chains is bound with the plasma state at the time of the chain initiation. Detection of those abnormalities is thus indicative not only of the onset of the plasma collapse itself, but also of the disruption driving cause that is promoted at the particular plasma state. Here, occurrence of disruptions, explored via detection of a Ip quench, and analysis of disruption event chains constituted by Ip and Z abnormalities, is reported for in total 7 full years of operation of 3 devices (KSTAR, MAST-U and NSTX-U) using the DECAFTM code expanded tools and capabilities. It is shown that the disruption occurrence depends not only on details of the plasma state, but also on (device-dependent) technical elements of the shot exit scenario. A year-to-year change in main disruption causes and a reduction of the disruptivity rate, bound with device and operation upgrades, are reported. Particular trigger instances of disruption event chains (and the full chains, when applicable) are shown to occupy different parts of the operation space diagrams, in accordance with prior expectation. Plasma elongation is identified as an important factor influencing details of the chains and its role will be further explored.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Density pedestal prediction model for tokamak plasmas

Abstract A model for the pedestal density prediction based on neutral penetration combined with pedestal transport is presented. The model is tested against a pedestal database of JET-ILW Type I ELMy H-modes showing good agreement over a wide range of parameters both in standalone modelling (using the experimental temperature profile) and in full Europed modelling that predicts both density and temperature pedestals simultaneously. The model is further tested for ASDEX Upgrade and MAST-U Type I ELMy H-modes and both are found to agree with the same model parameters as for JET-ILW. The JET-ILW experiment where the isotope of the main ion is varied in a D/T scan at constant gas rate and constant β N is successfully modelled as long as the separatrix density ( n e,sep ) and pedestal transport coefficient ratio ( D / χ ) are varied in accordance with the experimentally observed variation of n e,sep and the isotope dependence of D / χ found in gyrokinetic simulations. The predictions are found to be sensitive to n e,sep which is why the model is combined with an n e,sep model to predict the pedestal for the STEP fusion reactor.

Physics↗

Feedforward equilibrium trajectory optimization with GSPulse

One of the common tasks required for designing new plasma scenarios or evaluating capabilities of a tokamak is to design the desired equilibria using a Grad-Shafranov (GS) equilibrium solver. However, most standard equilibrium solvers are time-independent and do not include dynamic effects such as plasma current flux consumption, induced vessel currents, or voltage constraints. Another class of tools, plasma equilibrium evolution simulators, do include time-dependent effects. These are generally structured to solve the forward problem of evolving the plasma equilibrium given feedback-controlled voltages. In this work, we introduce GSPulse, a novel algorithm for equilibrium trajectory optimization, that is more akin to a pulse planner than a pulse simulator. GSPulse includes time-dependent effects and solves the inverse problem: given a user-specified set of target equilibrium shapes, as well as limits on the coil currents and voltages, the optimizer returns trajectories of the voltages, currents, and achievable equilibria. This task is useful for scoping performance of a tokamak and exploring the space of achievable pulses. The computed equilibria satisfy both Grad-Shafranov force balance and axisymmetric circuit dynamics. The optimization is performed by restructuring the free-boundary equilibrium evolution equations into a form where it is computationally efficient to optimize the entire dynamic sequence. GSPulse can solve for hundreds of equilibria simultaneously within a few minutes. GSPulse has been validated against NSTX-U and MAST-U experiments and against SPARC feedback control simulations, and is being used to perform scenario design for SPARC. The computed trajectories can be used as feedforward inputs that are connected to the feedback controller to inform and improve feedback performance. The code for GSPulse is available open-source at github.com/jwai-cfs/GSPulse_public.

equilibrium↗

HIPED: Machine learning framework for spherical tokamak pedestal prediction and optimization

We introduce a Machine Learning framework, HIPED (HeIght and width Predictor for Edge Dynamics), for predicting and optimizing pedestal and core performance in spherical tokamak plasmas. Trained on pedestal and core datasets from the third MAST-U campaign, HIPED provides accurate estimates of pedestal height and width. The results reveal notable differences compared with conventional aspect-ratio studies; for instance, a simple power-law relation between pedestal width and height has very low accuracy. Instead, additional parameters such as normalized plasma pressure, elongation, and Greenwald fraction significantly improve accuracy. HIPED can also be trained only on `control room parameters' to inform experimentalists of which controllable parameters to adjust for improving core-integrated performance. The framework further includes a multi-objective optimization scheme that helps guide experimental planning and optimization. We find Pareto-optimal discharges with respect to various features, including distance from edge-localized modes and normalized plasma pressure, track their parameter trajectories over time, and identify the control room parameters required for these Pareto-optimal discharges. This provides a framework for systematically optimizing core and edge performance according to different experimental priorities.

Parisi, Jason F. [Princeton Plasma Physics Laborat↗