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At least 379 records · Page 21
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

SU-F-T-399: Migration of Treatment Planning Systems Without Beam Data Measurement

Purpose: Data acquisition for commissioning is steered by Treatment Planning System (TPS) requirements which can be cumbersome and time consuming involving significant clinic downtime. The purpose of this abstract is to answer if we could circumvent this by extracting data from existing TPS and speed up the process. Methods: Commissioning beam data was obtained from a clinically commissioned TPS (Pinnacle™) using Matlab™ generated Pinnacle™ executable scripts to commission a secondary 3D dose verification TPS (Eclipse™). Profiles and output factors for commissioning as required by Eclipse™ were computed on a 50 cm{sup 3} water phantom at a dose grid resolution of 2mm3. Verification doses were computed and compared to clinical TPS dose profiles as per TG-106 guidelines. Standard patient plans from Pinnacle™ including IMRT and VMAT plans were re-computed keeping the same monitor units (in order to perform true comparison) using Eclipse™. Computed dose was exported back to Pinnacle for comparison to original plans. This methodology enables us to alleviate all ambiguities that arise in such studies. Results: Profile analysis using in-house software for 6x, showed that for all field sizes including small MLC generated fields, 100% of infield and penumbra data points of Eclipse™ match Pinnacle™ generated and measured profiles with 2%/2 mm gamma criteria. Excellent agreement was observed in the penumbra regions, with all data points passing DTA criteria for complex C-shaped and S-shaped profiles. Patient plan dose volume histograms (DVHs) and isodose lines agreed well to within a 1.5% for target coverage. Conclusion: Secondary 3D dose checking is of utmost importance with advanced techniques such as IMRT and VMAT. Migration of TPS is possible without compromising accuracy or enduring the cumbersome measurement of commissioning data. Economizing time for commissioning such a verification system or for migration of TPS can add great QA value and minimize downtime.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1989

The ultraviolet variability of HD 45166 (qWR + B8 V) - Evidence for stellar wind radiative instabilities

High-resolution IUE spectroscopy of the low-mass qWR star HD 45166, obtained at several epochs during 1980-1988, reveals a complex pattern of variability in its stellar wind emission lines, P Cygni profiles, and highly ionized photospheric absorption spectrum. The most intensive observations, obtained during a 36 hr continuous run in February 1988, show the presence of discrete absorption components (DACs) in the C IV 1550 resonance doublet. These DACs can blend to give the appearance of a well-developed P Cygni absorption profile seen at some other times, roughly doubling the column density of the ground state C(3+) ions in the wind. In the 1988 spectra, two principal features are seen, at about -950 km/s and -750 km/s, with column densities of about 14.0 and 14.7 dex/sq cm, respectively. Both features migrate in velocity with accelerations of about 140 cm/sq sec, implying a recurrence time scale of about 1.6 days and a lifetime of about 3 days for the DACs. A striking characteristic of the acceleration is its slowness. The pattern of DAC variability in HD 45166 is similar to that found for O-type stars and provides further evidence that the DACs are not mass-conserving features but rather that a given feature is formed by different material at different times. It is concluded that the C IV DAC variability observed in HD 45166 results from structural changes in the wind arising from radiative instabilities.

Willis, Allan J.↗
NASA NTRS2003

Numerical Simulations of the Evolution of the CO2 Atmosphere of Mars: 4.53 Ga to the Present

In this paper we approach four key questions that are central to our understanding of the nature of climate change on Mars: 1. By what mechanism has the evolution of the CO2 atmosphere, dominated at early times by violent process, been guided to the moderate quantities present today? 2.How do obliquity cycles affect the migration of CO2 between the various reservoirs of CO2, and what effect does this have on the bulk atmosphere of the planet in time? 3. Is the geophysical evidence that the last few Myr experienced periods that are substantially wetter than the present attributable to a substantially more massive greenhouse atmosphere? 4. Is the current atmospheric pressure determined primarily by the partial pressure of CO2 in cold (approx. 148 K) ice caps, or is it because disequilibrium water, and hence weathering, ceases at pressures below the triple point of water?

C V Manning↗
DOE OSTI2019

Time-Resolved Electrical Scanning Probe Microscopy of Layered Perovskites Reveals Spatial Variations in Photoinduced Ionic and Electronic Carrier Motion

We study light-induced dynamics in thin films comprising Ruddlesden–Popper phases of the layered 2D perovskite (C 4 H 9 NH 3 ) 2 PbI 4 . We probe ionic and electronic carrier dynamics using two complementary scanning probe methods, time-resolved G-mode Kelvin probe force microscopy and fast free time-resolved electrostatic force microscopy, as a function of position, time, and illumination. Here, we show that the average surface photovoltage sign is dominated by the band bending at the buried perovskite–substrate interface. However, the film exhibits substantial variations in the spatial and temporal response of the photovoltage. Under illumination, the photovoltage equilibrates over hundreds of microseconds, a time scale associated with ionic motion and trapped electronic carriers. Surprisingly, we observe that the surface photovoltage of the 2D grain centers evolves more rapidly in time than at the grain boundaries. We propose that the slower evolution at grain boundaries is due to a combination of ion migration occurring between PbI 4 planes, as well as electronic carriers traversing grain boundary traps, thereby changing the time-dependent band unbending at grain boundaries. These results provide a model for the photoinduced dynamics in 2D perovskites and are a useful basis for interpreting photovoltage dynamics on hybrid 2D/3D structures.

14 SOLAR ENERGY↗
DOE OSTI2019

Design and performance of a TDC ASIC for the upgrade of the ATLAS Monitored Drift Tube detector

We present the prototype of a time-to-digital (TDC) ASIC for the upgrade of the ATLAS Monitored Drift Tube (MDT) detector for high-luminosity LHC operation. This ASIC is based on a previously submitted demonstrator ASIC designed for timing performance evaluation, and includes all features necessary for the various operation modes, as well as the migration to the TSMC 130 nm CMOS technology. Here, we present the TDC design with the emphasis on added features and performance optimization. Tests of the timing performance demonstrate that this ASIC meets the design specifications. The TDC has a bin size of about 780 ps, and a timing bin variations within ±40 ps for all 24 channels with leading and trailing edge digitization, while the power consumption has been limited to 250 mW, corresponding to a consumption of about 5.2 mW per edge measurement.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2014

HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation

Highlights: • Simvastatin blocked CCL17-induced and CCR4-dependent RhoA activation in HT29 cells. • CCL17/CCR4-mediated migration of colon cancer cells was antagonised by simvastatin. • Cell migration recovered by adding Mevalonate and geranylgeranyl pyrophosphate. • Targeting HMG-CoA reductase might be useful to inhibit colon cancer metastasis. - Abstract: Background: Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. Aim: The aim of this study was to examine the effect of simvastatin on colon cancer cell migration. Methods: Migration assays were performed to evaluate CCL17-induced colon cancer cell (HT-29) chemotaxis. In vitro tumor growth and apoptosis were assessed using a proliferation assay and annexin V assay, respectively. Active RhoA protein levels in CCL17-stimulated colon cancer cells were quantified using a G-LISA assay. Results: We found that simvastatin dose-dependently decreased CCL17-induced colon cancer cell migration. Simvastatin had no effect on colon cancer cell proliferation or apoptosis. Inhibition of beta chemokine receptor 4, CCR4, reduced CCL17-evoked activation of RhoA in colon cancer cells. Moreover, administration of mevalonate reversed the inhibitory effect of simvastatin on CCL17-induced colon cancer cell migration. Interestingly, co-incubation with geranylgeranyl pyrophosphate (GGPP) antagonized the inhibitory impact of simvastatin on colon cancer cell migration triggered by CCL17. Moreover, we observed that simvastatin decreased CCL17-induced activation of RhoA in colon cancer cells. Administration of mevalonate and GGPP reversed the inhibitory effect of simvastatin on CCL17-provoked RhoA activation in colon cancer cells. Conclusions: Taken together, our findings show for the first time that HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via inhibition of geranylgeranylation and RhoA activation. Thus, statins, such as simvastatin, might be effective tools to antagonize CCL17-dependent migration and metastasis of colon cancer cells.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1977

CCD architecture for spacecraft SAR image processing

A real-time synthetic aperture radar (SAR) image processing architecture amenable to future on-board spacecraft applications is currently under development. Using state-of-the-art charge-coupled device (CCD) technology, low cost and power are inherent features. Other characteristics include the ability to reprogram correlation reference functions, correct for range migration, and compensate for antenna beam pointing errors on the spacecraft in real time. The first spaceborne demonstration is scheduled to be flown as an experiment on a 1982 Shuttle imaging radar mission (SIR-B). This paper describes the architecture and implementation characteristics of this initial spaceborne CCD SAR image processor.

Arens, W. E.↗
DOE OSTI2014

Influence of carbon content on the copper-telluride phase formation and on the resistive switching behavior of carbon alloyed Cu-Te conductive bridge random access memory cells

In this paper, we investigate the influence of the carbon content on the Cu-Te phase formation and on the resistive switching behavior in carbon alloyed Cu{sub 0.6}Te{sub 0.4} based conductive bridge random access memory (CBRAM) cells. Carbon alloying of copper-tellurium inhibits the crystallization, while attractive switching behavior is preserved when using the material as Cu-supply layer in CBRAM cells. The phase formation is first investigated in a combinatorial way. With increasing carbon content, an enlargement of the temperature window in which the material stays amorphous was observed. Moreover, if crystalline phases are formed, subsequent phase transformations are inhibited. The electrical switching behavior of memory cells with different carbon contents is then investigated by implementing them in 580 μm diameter dot TiN/Cu{sub 0.6}Te{sub 0.4}-C/Al{sub 2}O{sub 3}/Si memory cells. Reliable switching behavior is observed for carbon contents up to 40 at. %, with a resistive window of more than 2 orders of magnitude, whereas for 50 at. % carbon, a higher current in the off state and only a small resistive window are present after repeated cycling. This degradation can be ascribed to the higher thermal and lower drift contribution to the reset operation due to a lower Cu affinity towards the supply layer, leading cycle-after-cycle to an increasing amount of Cu in the switching layer, which contributes to the current. The thermal diffusion of Cu into Al{sub 2}O{sub 3} under annealing also gives an indication of the Cu affinity of the source layer. Time of flight secondary ion mass spectroscopy was used to investigate this migration depth in Al{sub 2}O{sub 3} before and after annealing, showing a higher Cu, Te, and C migration for high carbon contents.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2019

The Effect of the Formation of Silicides on the Resistivity of Silicon

The effect of the formation of thin films of nickel silicides on the migration of intrinsic p-type impurities in silicon was studied for the first time. It was found that bulk resistance ρ{sub v} of a single Si crystal increases by a factor of 3–4 if a NiSi{sub 2} film with thickness θ ≥ 50–100 Å forms on its surface. This is attributable to the migration of boron atoms toward the silicide film. The Si layer thickness enabling measurable boron migration was estimated at 800–1000 Å.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2020

Linking Small-Scale Flight Manoeuvers and Density Profiles to the Vertical Movement of Insects in the Nocturnal Stable Boundary Layer

Huge numbers of insects migrate over considerable distances in the stably-stratified night-time atmosphere with great consequences for ecological processes, biodiversity, ecosystem services and pest management. We used a combination of meteorological radar and lidar instrumentation at a site in Oklahoma, USA, to take a new look at the general assistance migrants receive from both vertical and horizontal airstreams during their long-distance flights. Movement in the nocturnal boundary layer (NBL) presents very different challenges for migrants compared to those prevailing in the daytime convective boundary layer, but we found that Lagrangian stochastic modelling is effective at predicting flight manoeuvers in both cases. A key feature for insect transport in the NBL is the frequent formation of a thin layer of fast-moving air – the low-level jet. Modelling suggests that insects can react rapidly to counteract vertical air movements and this mechanism explains how migrants are retained in the jet for long periods (e.g. overnight, and perhaps for several hours early in the morning). This results in movements over much longer distances than are likely in convective conditions, and is particularly significant for the reintroduction of pests to northern regions where they are seasonally absent due to low winter temperatures.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS2004

Migration of the Cratering Flow-Field Center with Implications for Scaling Oblique Impacts

Crater-scaling relationships are used to predict many cratering phenomena such as final crater diameter and ejection speeds. Such nondimensional relationships are commonly determined from experimental impact and explosion data. Almost without exception, these crater-scaling relationships have used data from vertical impacts (90 deg. to the horizontal). The majority of impact craters, however, form by impacts at angles near 45 deg. to the horizontal. While even low impact angles result in relatively circular craters in sand targets, the effects of impact angle have been shown to extend well into the excavation stage of crater growth. Thus, the scaling of oblique impacts needs to be investigated more thoroughly in order to quantify fully how impact angle affects ejection speed and angle. In this study, ejection parameters from vertical (90 deg.) and 30 deg. oblique impacts are measured using three-dimensional particle image velocimetry (3D PIV) at the NASA Ames Vertical Gun Range (AVGR). The primary goal is to determine the horizontal migration of the cratering flow-field center (FFC). The location of the FFC at the time of ejection controls the scaling of oblique impacts. For vertical impacts the FFC coincides with the impact point (IP) and the crater center (CC). Oblique impacts reflect a more complex, horizontally migrating flow-field. A single, stationary point-source model cannot be used accurately to describe the evolution of the ejection angles from oblique impacts. The ejection speeds for oblique impacts also do not follow standard scaling relationships. The migration of the FFC needs to be understood and incorporated into any revised scaling relationships.

Anderson, J. L. B.↗
DOE OSTI2023

Data-assimilated time-lapse visco-acoustic full-waveform inversion: Theory and application for injected CO 2 plume monitoring

Continuous seismic monitoring for quantifying CO 2 plume migration and detection of any potential leakages in the subsurface is essential for the security of long-term anthropogenic carbon dioxide geologic storage. Traditional time-lapse full-waveform inversion (TLFWI) methods aim to map the CO 2 distribution by estimating seismic velocity changes, but recent studies find that CO 2 -induced attenuation is an important complement to seismic velocity for tracking the CO 2 plumes and even quantifying the CO 2 saturation. We have developed a novel data-assimilated TLFWI method to construct high-resolution time-lapse velocity and attenuation changes from dense time-lapse monitoring data. This method consists of two theoretical developments: visco-acoustic full-waveform inversion (QFWI) and multiparameter hierarchical matrix-powered extended Kalman filter (mHiEKF). The method is capable of (1) posing temporal constraints to retrieve time-lapse information from dense monitoring data by using mHiEKF, (2) accurately recovering high-spatial-resolution velocity and attenuation perturbations using first-order equation system-based QFWI, and (3) providing the model uncertainty by estimating their model standard deviation. With numerical examples, we first find the effectiveness of the new QFWI on estimating accurate velocity and attenuation models simultaneously. Then, a CO 2 leakage case and a realistic Frio-II CO 2 monitoring case are presented to find the advantages and applicability of our data-assimilated QFWI method for estimating time-lapse changes using dense time-lapse monitoring surveys. Here, by assimilating time-lapse seismic monitoring data over time, our data-assimilated QFWI method can improve the resolution of velocity and attenuation changes and decrease their model uncertainties.

58 GEOSCIENCES↗
NASA NTRS1994

Providing hydrogen maser timing stability to orbiting VLBI radio telescope observations by post-measurement compensation of linked frequency standard imperfections

Orbiting VLBI (OVLBI) astronomical observations are based upon measurements acquired simultaneously from ground-based and earth-orbiting radio telescopes. By the mid-1990s, two orbiting VLBI observatories, Russia's Radioastron and Japan's VSOP, will augment the worldwide VLBI network, providing baselines to earth radio telescopes as large as 80,000 km. The challenge for OVLBI is to effectuate space to ground radio telescope data cross-correlation (the observation) to a level of integrity currently achieved between ground radio telescopes. VLBI radio telescopes require ultrastable frequency and timing references in order that long term observations may be made without serious cross-correlation loss due to frequency source drift and phase noise. For this reason, such instruments make use of hydrogen maser frequency standards. Unfortunately, space-qualified hydrogen maser oscillators are currently not available for use on OVLBI satellites. Thus, the necessary long-term stability needed by the orbiting radio telescope may only be obtained by microwave uplinking a ground-based hydrogen maser derived frequency to the satellite. Although the idea of uplinking the frequency standard intrinsically seems simple, there are many 'contaminations' which degrade both the long and short term stability of the transmitted reference. Factors which corrupt frequency and timing accuracy include additive radio and electronic circuit thermal noise, slow or systematic phase migration due to changes of electronic circuit temporal operating conditions (especially temperature), ionosphere and troposphere induced scintillations, residual Doppler-incited components, and microwave signal multipath propagation. What is important, though, is to realize that ultimate stability does not have to be achieved in real-time. Instead, information needed to produce a high degree of coherence in the subsequent cross-correlation operation may be derived from a two-way coherent radio link, recorded and later introduced as compensations adjunct to the VLBI correlation process. Accordingly, this paper examines the technique for stable frequency/time transfer within the OVLBI system, together with a critique of the types of link degradation components which must be compensated, and the figures of merit known as coherence factors.

Springett, James C.↗
DOE OSTI2017

Age and Method of Release Affect Migratory Performance of Hatchery Steelhead

Abstract Hatchery programs that are designed to aid recovery of natural populations of anadromous salmonids, including steelhead Oncorhynchus mykiss, require locally derived, natural-origin broodstock. In such programs, achieving smoltification size thresholds may require extending hatchery rearing beyond age 1. We compared out-migration survival and travel rates of 142,990 PIT-tagged steelhead smolts released at age 1 (S1 rearing strategy) or age 2 (S2 rearing strategy) over five release years at Winthrop National Fish Hatchery (WNFH, Okanogan County, Washington). An S2 rearing cycle produced larger smolts with more uniform size distributions, resulting in higher survival during the first portion of their out-migration than for S1 smolts in three of the five release years. The S2 smolts migrated more rapidly to the ocean than S1 smolts in all years except 2011 and arrived in the Columbia River estuary 5.4 d earlier on average than the S1 smolts. The S1 steelhead that did not leave during the volitional release were subsequently forced from the hatchery to measure their survival. Nonvolitional S1 migrants were smaller and had survival rates that were 2.3–66.3 times lower than those of S1 steelhead that left WNFH on their own. The same was true for S2 steelhead, but the magnitude of the survival difference between volitional migrants and fish forced from the raceways was less variable and ranged from 2.5- to 4.6-fold. We conclude that S2 rearing can be a successful strategy for producing smolts from local natural-origin broodstock, with out-migration survival and travel times that are equivalent to or better than those of S1 smolts produced from nonlocal broodstock. Received July 25, 2016; accepted March 31, 2017 Published online May 31, 2017

Tatara, Christopher P.↗
DOE OSTI2023

The complexity of { 11 2 ¯ 1 } twin interface structure and energetics in HCP materials

Here, the quest for a deeper understanding of the mechanical properties of HCP alloys has been an ongoing effort. Due to the lack of a sufficient number of slip systems, twin nucleation and migration originate as a substantial plastic deformation mechanism in HCP metals. The paper uncovers the energetics and atomistic mechanism of the {$11\overline{2}1$} < $11\overline{2}6$ > which is one of the most prominent twin modes in HCP materials that has not been fully understood. In view of corrugated {$11\overline{2}1$} interfaces, the positioning of lattice/motif atoms needs to be clarified. First, we establish the initial twin boundary (TB) structure unambiguously via the lattice offsets resulting in volume invariancy and correct relative positioning of the twin variants. Secondly, the TB migration mechanism is determined from a crystallographic (zero net shuffle, $Σ\vec{s}$ = 0) and energetic standpoints (minimum energy path). The Generalized Planar Fault Energy (GPFE) curves are calculated for Ti, Hf, Mg, and Zr. Such GPFE curves for this twin mode are calculated for the first time, and point to unusually high unstable energies (300-850 mJ/m 2 ), and low migration barriers (<60 mJ/m 2 ) for twinning accompanied with large shuffle magnitudes, |$\vec{s}$|, comparable to the Burger’s vector (|$\vec{s}$| ≅ $b_e$ > 0.44Å)

36 MATERIALS SCIENCE↗
NASA NTRS1991

Nonmigrating diurnal tides in the equatorial middle atmosphere

Data from the Nimbus-7 Limb Infrared Monitor of the Stratosphere (LIMS) are used to extend the analysis of diurnal tides in the middle atmosphere to include the zonally symmetric and eastward propagating components. These modes show vertical and meridional structures that are generally consistent with the predictions of linear tidal theory. The zonal and meridional wind fields are calculated from the tidal temperatures. Diurnal perturbations in LIMS temperature and derived winds agree well with equinoctial model calculations. Comparisons with day-night differences of radiosonde temperature and rocket winds show qualitative agreement in vertical structure and amplitude. The zonally symmetric and eastward migrating tidal components show a higher degree of temporal variability than the sun-synchronous component. These modes at times contribute substantially to the diurnal signal in wind and temperature, with combined amplitudes equal to or in excess of the amplitude of the main migrating diurnal tide. The observed vertical phase variations suggest that their forcing may originate below the stratosphere.

Lieberman, Ruth S.↗
DOE OSTI2015

XL413, a cell division cycle 7 kinase inhibitor enhanced the anti-fibrotic effect of pirfenidone on TGF-β1-stimulated C3H10T1/2 cells via Smad2/4

Pirfenidone is an orally bioavailable synthetic compound with therapeutic potential for idiopathic pulmonary fibrosis. It is thought to act through antioxidant and anti-fibrotic pathways. Pirfenidone inhibits proliferation and/or myofibroblast differentiation of a wide range of cell types, however, little studies have analyzed the effect of pirfenidone on the mesenchymal stem cells, which play an important role on the origin of myofibroblasts. We recently found that pirfenidone had anti-proliferative activity via G1 phase arrest and cell division cycle 7 (Cdc7) kinase expression decrease in transforming growth factor-β1 (TGF-β1)-stimulated murine mesenchymal stem C3H10T1/2 cells. Pirfenidone also had inhibiting effect on the migration and α-SMA expression. Moreover, in this study we showed for the first time that Cdc7 inhibitor XL413 enhanced the anti-fibrotic activity of pirfenidone via depressed the expression of Smad2/4 proteins, and also prevented the nuclear accumulation and translocation of Smad2 protein. In conclusion, we demonstrated that pirfenidone inhibited proliferation, migration and differentiation of TGF-β1-stimulated C3H10T1/2 cells, which could be enhanced by Cdc7 inhibitor XL413, via Smad2/4. Combination with pirfenidone and XL413 might provide a potential candidate for the treatment of TGF-β1 associated fibrosis. It needs in vivo studies to further validate its therapeutic function and safety in the future. - Highlights: • Pirfenidone had anti-proliferative and anti-fibrotic effect on C3H10T1/2 cells. • XL413 enhanced the anti-fibrotic activity of pirfenidone. • The mechanism might be depressing the expression of Smad2/4 proteins.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1993

Inward electrostatic precipitation of interplanetary particles

An inward precipitator collects particles initially dispersed in a gas throughout either a cylindrical or spherical chamber onto a small central planchet. The instrument is effective for particle diameters greater than about 1 micron. One use is the collection of interplanetary dust particles (IDPs) which are stopped in a noble gas (xenon) by drag and ablation after perforating the wall of a thin-walled spacecraft-mounted chamber. First, the particles are positively charged for several seconds by the corona production of positive xenon ions from inward facing needles placed on the chamber wall. Then an electric field causes the particles to migrate toward the center of the instrument and onto the planchet. The collection time (on the order of hours for a 1 m radius spherical chamber) is greatly reduced by the use of optimally located screens which reapportion the electric field. Some of the electric field lines terminate on the wires of the screens so a fraction of the total number of particles in the chamber is lost. The operation of the instrument is demonstrated by experiments which show the migration of carbon soot particles with radius of approximately 1 micron in a 5 cm diameter cylindrical chamber with a single field enhancing screen toward a 3.2 mm central collection rod.

Rulison, Aaron J.↗