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At least 379 records · Page 21

Determining the amount of physical activity needed for long-term weight control

OBJECTIVE: To evaluate prospectively the influence of habitual physical activity on body weight of men and women and to develop a model that defines the role of physical activity on longitudinal weight change. DESIGN AND SETTING: Occupational cohort study conducted for a mean of 5.5 y. SUBJECTS: A total of 496 (341 male and 155 female) NASA/Johnson Space Center employees who completed the 3 month education component of the employee health-related fitness program and remained involved for a minimum of 2 y. MEASUREMENTS: Body weights were measured at baseline (T1) and follow-up (T2), and habitual physical activity was obtained from the mean of multiple ratings of the 11-point (0-10) NASA Activity Scale (NAS) recorded quarterly between T1 and T2. Other measures included age, gender, VO(2 max) obtained from maximal treadmill testing, body mass index (BMI), and body fat percentage. RESULTS: Multiple regression demonstrated that mean NAS, T1 weight, aging and gender all influence long-term T2 weight. T1 age was significant for the men only. Independently, each increase in mean NAS significantly (P<0.01) reduced T2 weight in men (b=-0.91 kg; 95% CI:-1.4 to-0.42 kg) and women (b=-2.14 kg; 95% CI:-2.93 to-1.35 kg). Mean NAS had a greater effect on T2 weight as T1 weight increased, and the relationship was dose-dependent. CONCLUSIONS: Habitual physical activity is a significant source of long-term weight change. The use of self-reported activity level is helpful in predicting long-term weight changes and may be used by health care professionals when counseling patients about the value of physical activity for weight control.

Exercise↗

Systemic clearance of p16 INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration

RATIONALE:Age-related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically secrete numerous inflammatory molecules and proteases, has been reported to cause decline in the health and function of multiple tissues with age. Although senescent cells have been reported to increase in intervertebral degeneration (IDD), it is not known whether they are causative in age-related IDD. OBJECTIVE:The study aimed to elucidate whether a causal relationship exists between cellular senescence and age-related IDD. METHODS AND RESULTS:To examine the impact of senescent cells on age-associated IDD, we used p16-3MR transgenic mice, which enables the selective removal of p16 INK4a -positive senescent cells by the drug ganciclovir. Disc cellularity, aggrecan content and fragmentation alongside expression of inflammatory cytokine (IL-6) and matrix proteases (ADAMTS4 and MMP13) in discs of p16-3MR mice treated with GCV and untreated controls were assessed. In aged mice, reducing the per cent of senescent cells decreased disc aggrecan proteolytic degradation and increased overall proteoglycan matrix content along with improved histological disc features. Additionally, reduction of senescent cells lowered the levels of MMP13, which is purported to promote disc degenerative changes during aging. CONCLUSIONS:The findings of this study suggest that systemic reduction in the number of senescent cells ameliorates multiple age-associated changes within the disc tissue. Cellular senescence could therefore serve as a therapeutic target to restore the health of disc tissue that deteriorates with age.

60 APPLIED LIFE SCIENCES↗

Multi-amplifier Sensing Charge-coupled Devices for Next Generation Spectroscopy

We present characterization results and performance of a prototype Multiple-Amplifier Sensing (MAS) silicon charge-coupled device (CCD) sensor with 16 channels potentially suitable for faint object astronomical spectroscopy and low-signal, photon-limited imaging. The MAS CCD is designed to reach sub-electron readout noise by repeatedly measuring charge through a line of amplifiers during the serial transfer shifts. Using synchronized readout electronics based on the Dark Energy Spectroscopic Instrument CCD controller, we report a read noise of 1.03 e$^{−}$ rms pix$^{−1}$ at a speed of 26 μs pix$^{−1}$ with a single-sample readout scheme where charge in a pixel is measured only once for each output stage. At these operating parameters, we find the amplifier-to-amplifier charge transfer efficiency (ACTE) to be >0.9995 at low counts for all amplifiers but one for which the ACTE is 0.997. This charge transfer efficiency falls above 50,000 electrons for the read-noise optimized voltage configuration we chose for the serial clocks and gates. The amplifier linearity across a broad dynamic range from ∼300 to 35,000 e$^{−}$ was also measured to be ±2.5%. We describe key operating parameters to optimize on these characteristics and describe the specific applications for which the MAS CCD may be a suitable detector candidate.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Preliminary structural control results from the Middeck Active Control Experiment (MACE)

Results are presented of on-going closed-loop ground experiments on the MACE test article, the objective of which is to investigate the extent to which closed-loop behavior of flexible spacecraft in zero gravity can be predicted, as well as to examine orbit system identification and control reconfiguration. The MACE hardware consists of three torque wheels, a two-axis gimballing payload, inertial sensors, and a flexible support structure. With the acquisition of a second payload, this is to represent a multiple payload platform with significant structural flexibility. When linear quadratic Gaussian control is used, payload pointing accuracy is improved by an order of magnitude when disturbed by a broadband torque disturbance. The successes and failures of the design and implementation process are discussed.

Miller, David W.↗

Adaptive Flight Control Research at NASA

A broad overview of current adaptive flight control research efforts at NASA is presented, as well as some more detailed discussion of selected specific approaches. The stated objective of the Integrated Resilient Aircraft Control Project, one of NASA s Aviation Safety programs, is to advance the state-of-the-art of adaptive controls as a design option to provide enhanced stability and maneuverability margins for safe landing in the presence of adverse conditions such as actuator or sensor failures. Under this project, a number of adaptive control approaches are being pursued, including neural networks and multiple models. Validation of all the adaptive control approaches will use not only traditional methods such as simulation, wind tunnel testing and manned flight tests, but will be augmented with recently developed capabilities in unmanned flight testing.

Motter, Mark A.↗

Multi-Evaporator Miniature Loop Heat Pipe for Small Spacecraft Thermal Control: New Technologies and Validation Approach - Part 1

Under NASA s New Millennium Program Space Technology 8 (ST 8) Project, four experiments Thermal Loop, Dependable Microprocessor, SAILMAST, and UltraFlex - were conducted to advance the maturity of individual technologies from proof of concept to prototype demonstration in a relevant environment , i.e. from a technology readiness level (TRL) of 3 to a level of 6. This paper presents the new technologies and validation approach of the Thermal Loop experiment. The Thermal Loop is an advanced thermal control system consisting of a miniature loop heat pipe (MLHP) with multiple evaporators and multiple condensers designed for future small system applications requiring low mass, low power, and compactness. The MLHP retains all features of state-of-the-art loop heat pipes (LHPs) and offers additional advantages to enhance the functionality, performance, versatility, and reliability of the system. Details of the thermal loop concept, technical advances, benefits, objectives, level 1 requirements, and performance characteristics are described. Also included in the paper are descriptions of the test articles and mathematical modeling used for the technology validation. An MLHP breadboard was built and tested in the laboratory and thermal vacuum environments for TRL 4 and TRL 5 validations, and an MLHP proto-flight unit was built and tested in a thermal vacuum chamber for the TRL 6 validation. In addition, an analytical model was developed to simulate the steady state and transient behaviors of the MLHP during various validation tests. Capabilities and limitations of the analytical model are also addressed.

Ku, Jentung↗

Distinguishing Research Reactor Fuels Using Neutron Multiplicity - 25615

Neutron measurements are one of the reliable means of interrogation of fissile material. Neutron measurements are used for total counting (pure metal fissile samples) or counting coincidence/multiplicity (for impure fissile samples). Various flavors of neutron measurement are used routinely by the IAEA to determine the fissile mass of an unknown sample. The objective of this work is to design an experiment to distinguish the two different fuel types using neutron multiplicity method. The design of experiment is performed using Monte Carlo N- Particle (MCNP) transport code. General Electric (GE) designed 1-MWt pool-type research reactor at UMass Lowell (UMLRR) uses Materials Testing Reactor (MTR) plate-type fuel consisting of 19 full and 2 partial fuel assemblies, controlled by four boron control blades and one regulating control rod. Two different fuel types are available at the UMLRR facility. In 2008, UMass Lowell obtained slightly burnt fuel assemblies from the decommissioned WPI research reactor. The simulation results discussed in this paper show that within the limits of statistical error, the single and double moments for the WPI and UMLRR fuels can be measured. The two fuels have very similar composition and enrichments resulting in very similar neutron multiplicity moments. This implies that neutron multiplicity measurements alone would not be sufficient to distinguish between the two fuel types at low burnups. The change in the observed single-double ratio between each fuel type is less than 6 % which falls below the uncertainty in the efficiency of the JCC71 slab detectors. The neutron signature from low burnup and low enriched uranium fuel are not strong, however, these can be measured under low background and long measurement times. This would be an important consideration in designing the experiments and parallel gamma measurements will also be planned. (authors)

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

A Multi-Objective Bayesian Optimized Human Assessed Multi-Target Generated Spectral Recommender System for Rapid Pareto Discoveries of Material Properties

Optimization for different tasks like material characterization, synthesis, and functional properties for desired applications over multi-dimensional control parameter and function spaces need a rapid strategic search through active learning. However, in all cases prior to optimization, the target material properties are assumed known and fixed, which mostly deviates from real-world scenarios in material synthesis. This can be critical for running expensive experiments on new materials, when the experimental results are fuzzy for any scientific outcomes due to improper target setting, ultimately wasting time and cost. The failure rate and cost are even higher over exploring on multi-target space, where we want to learn the pareto among multiple properties, to jointly optimize during material synthesis for desired applications. To address the challenge, here we introduce the human-operator attempt flexibility in the active learning based automated experiment framework, with generating multiple human assessed targets through a voting-based recommender system during real-time microscope measurements over the large material image space, sequentially learn/update multiple desired targets through a weighting system, and adaptively search in multiple material properties functional space for non-dominated pareto discoveries to maximize the custom structural similarity based acquisition function. We term this a multi-objective Bayesian optimized human assessed multi-target generated spectral recommender systems (MOBO-HAM-SRS). The approach has been demonstrated to peizoresponse force spectroscopy of a ferroelectric thin film, exploring with different kernels and acquisition functions. This work shows an advancement towards human-AI collaborated automated experiments, steering optimization trajectories through human overpowering AI at the early stage when uncertainty is high and AI overpowering human at the later stage with rapid exploration towards optimal goal, following human-assessed multiple targets properties.

Biswas, Arpan↗

Wireless Frequency‐Multiplexed Acoustic Array‐Based Acoustofluidics

Abstract Acoustofluidics has shown great potential in enabling on‐chip technologies for driving liquid flows and manipulating particles and cells for engineering, chemical, and biomedical applications. To introduce on‐demand liquid sample processing and micro/nano‐object manipulation functions to wearable and embeddable electronics, wireless acoustofluidic chips are highly desired. This paper presents wireless acoustofluidic chips to generate acoustic waves carrying sufficient energy and achieve key acoustofluidic functions, including arranging particles and cells, generating fluid streaming, and enriching in‐droplet particles. To enable these functions, the wireless acoustofluidic chips leverage mechanisms, including inductive coupling‐based wireless power transfer (WPT), frequency multiplexing‐based control of multiple acoustic waves, and the resultant acoustic radiation and drag forces. For validation, the wirelessly generated acoustic waves are measured using laser vibrometry when different materials (e.g., bone, tissue, and hand) are inserted between the WPT transmitter and receiver. Moreover, the wireless acoustofluidic chips successfully arrange nanoparticles into different patterns, align cells into parallel pearl chains, generate streaming, and enrich in‐droplet microparticles. This research is anticipated to facilitate the development of embeddable wireless on‐chip flow generators, wearable sensors with liquid sample processing functions, and implantable devices with flow generation and acoustic stimulation abilities for engineering, veterinary, and biomedical applications.

Li, Jiali↗

Humanoid Robotics: Real-Time Object Oriented Programming

Programming of robots in today's world is often done in a procedural oriented fashion, where object oriented programming is not incorporated. In order to keep a robust architecture allowing for easy expansion of capabilities and a truly modular design, object oriented programming is required. However, concepts in object oriented programming are not typically applied to a real time environment. The Fujitsu HOAP-2 is the test bed for the development of a humanoid robot framework abstracting control of the robot into simple logical commands in a real time robotic system while allowing full access to all sensory data. In addition to interfacing between the motor and sensory systems, this paper discusses the software which operates multiple independently developed control systems simultaneously and the safety measures which keep the humanoid from damaging itself and its environment while running these systems. The use of this software decreases development time and costs and allows changes to be made while keeping results safe and predictable.

Newton, Jason E.↗

Toward a subhourly net zero energy district design through integrated building and distribution system modeling

A modeling framework integrating both building energy modeling and power system modeling is introduced for the design of net zero energy (NZE) districts for the simultaneous selection of both demand-side efficiency measures and supply-side generation technologies. A novel district control scheme is proposed for pursuing NZE on a subhourly basis while mitigating potential grid impacts such as power backfeeding and voltage violations. As a case study, Pena Station NEXT, a new 100-building, mixed-use district on a 1200-node distribution feeder in Denver, Colorado, is modeled in the integrated framework. An exhaustive scenario analysis is conducted for sizing the district's distributed energy resources, considering multiple objectives such as capital cost, net energy import, and equipment violations. Here, when trying to achieve annual NZE, the district incurs frequent operating violations, and achieving NZE on a 15-min basis is also limited by seasonal fluctuations in photovoltaic output, illustrating the need for diverse generation or seasonal storage. As a practical compromise, both annual and 15-min district import can be reduced by ~78% without significant violations.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Quantitative analysis of cost savings and occupants’ preferences in grid-interactive smart home operation

Many utility companies in the United States have introduced time-of-use (TOU) rates for homeowners with the goal of regulating electricity consumption during peak hours. The electrical appliances in homes include various thermostatically controlled devices, such as air conditioners (AC) for thermal comfort, and nonthermostatically controlled devices such as clothes washers. As a result, homeowners face the complicated challenge of economically operating multiple electrical appliances in their homes while maintaining comfort and convenience. This is usually due to the lack of an explicit understanding of the correlation between cost saving and the users’ comfort. To understand the correlation, this article is designed to construct a framework by integrating three major components: a multi-objective optimization method accommodating multiple competing goals with different weights, a learning-based system modeling approach describing the dynamics and thermal coupling effects of appliances, and a novel comfort index method differentiating preferred and acceptable thermal comfort. Our proposed framework can allow the indoor air temperature to fall into the "preferred" range with a marginal cost increase. Furthermore, the simulation result shows that an additional 8 h for the preferred thermal comfort can be achieved with a cost increase of only 1.77%.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Reconciling Basin-Scale Top-Down and Bottom-Up Methane Emission Measurements for Onshore Oil and Gas Development: Cooperative Research and Development Final Report, CRADA Number CRD-14-572

The overall objective of the Research Partnership to Secure Energy for America (RPSEA)-funded research project is to develop independent estimates of methane emissions using top-down and bottom-up measurement approaches and then to compare the estimates, including consideration of uncertainty. Such approaches will be applied at two scales: basin and facility. At facility scale, multiple methods will be used to measure methane emissions of the whole facility (controlled dual tracer and single tracer releases, aircraft-based mass balance and Gaussian back-trajectory), which are considered top-down approaches. The bottom-up approach will sum emissions from identified point sources measured using appropriate source-level measurement techniques (e.g., high-flow meters). At basin scale, the top-down estimate will come from boundary layer airborne measurements upwind and downwind of the basin, using a regional mass balance model plus approaches to separate atmospheric methane emissions attributed to the oil and gas sector. The bottom-up estimate will result from statistical modeling (also known as scaling up) of measurements made at selected facilities, with gaps filled through measurements and other estimates based on other studies. The relative comparison of the bottom-up and top-down estimates made at both scales will help improve understanding of the accuracy of the tested measurement and modeling approaches. The subject of this CRADA is NREL's contribution to the overall project. This project resulted from winning a competitive solicitation no. RPSEA RFP2012UN001, proposal no. 12122-95, which is the basis for the overall project. This Joint Work Statement (JWS) details the contributions of NREL and Colorado School of Mines (CSM) in performance of the CRADA effort.

54 ENVIRONMENTAL SCIENCES↗

Technical Requirements for Application of Operator Support Technology across Multiple Plant Systems

Argonne National Laboratory (ANL) and Idaho National Laboratory (INL) are jointly developing and evaluating operator aids to: (i) facilitate more timely response to plant faults and grid disturbances; (ii) achieve better management of plant upsets and improved operator performance; and (iii) ultimately improve nuclear plant safety, production, and cost management. The overall objective of the collaborative effort in this third and final year of the project was to conduct human performance tests using nuclear plant operators in the Human Systems Simulation Laboratory (HSSL) control room at INL to assess the value of a computerized operator support system (COSS) as an aid to the operator. This report describes the work performed by ANL. A companion report describes the work performed by INL and the results of the human performance tests.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Simulation of Mission Phases

This position with the Simulation and Graphics Branch (ER7) at Johnson Space Center (JSC) provided an introduction to vehicle hardware, mission planning, and simulation design. ER7 supports engineering analysis and flight crew training by providing high-fidelity, real-time graphical simulations in the Systems Engineering Simulator (SES) lab. The primary project assigned by NASA mentor and SES lab manager, Meghan Daley, was to develop a graphical simulation of the rendezvous, proximity operations, and docking (RPOD) phases of flight. The simulation is to include a generic crew/cargo transportation vehicle and a target object in low-Earth orbit (LEO). Various capsule, winged, and lifting body vehicles as well as historical RPOD methods were evaluated during the project analysis phase. JSC core mission to support the International Space Station (ISS), Commercial Crew Program (CCP), and Human Space Flight (HSF) influenced the project specifications. The simulation is characterized as a 30 meter +V Bar and/or -R Bar approach to the target object's docking station. The ISS was selected as the target object and the international Low Impact Docking System (iLIDS) was selected as the docking mechanism. The location of the target object's docking station corresponds with the RPOD methods identified. The simulation design focuses on Guidance, Navigation, and Control (GNC) system architecture models with station keeping and telemetry data processing capabilities. The optical and inertial sensors, reaction control system thrusters, and the docking mechanism selected were based on CCP vehicle manufacturer's current and proposed technologies. A significant amount of independent study and tutorial completion was required for this project. Multiple primary source materials were accessed using the NASA Technical Report Server (NTRS) and reference textbooks were borrowed from the JSC Main Library and International Space Station Library. The Trick Simulation Environment and User Training Materials version 2013.0 release was used to complete the Trick tutorial. Multiple network privilege and repository permission requests were required in order to access previous simulation models. The project was also an introduction to computer programming and the Linux operating system. Basic C++ and Python syntax was used during the completion of the Trick tutorial. Trick's engineering analysis and Monte Carlo simulation capabilities were observed and basic space mission planning procedures were applied in the conceptual design phase. Multiple professional development opportunities were completed in addition to project duties during this internship through the System for Administration, Training, and Education Resources for NASA (SATERN). Topics include: JSC Risk Management Workshop, CCP Risk Management, Basic Radiation Safety Training, X-Ray Radiation Safety, Basic Laser Safety, JSC Export Control, ISS RISE Ambassador, Basic SharePoint 2013, Space Nutrition and Biochemistry, and JSC Personal Protective Equipment. Additionally, this internship afforded the opportunity for formal project presentation and public speaking practice. This was my first experience at a NASA center. After completing this internship I have a much clearer understanding of certain aspects of the agency's processes and procedures, as well as a deeper appreciation from spaceflight simulation design and testing. I will continue to improve my technical skills so that I may have another opportunity to return to NASA and Johnson Space Center.

Carlstrom, Nicholas Mercury↗

Predicting Arrival and Departure Runway Assignments with Machine Learning

Runway assignments at major airports are made by air traffic controllers subject to various constraints, and to achieve various objectives. In this research, we describe our efforts training machine learning (ML) models to predict both departure and arrival runway assignments using an entirely data-driven approach. This approach is compared to existing rule-based approaches developed in previous research using input from Subject Matter Experts. The models have features derived from various FAA data feeds, and leverage multiple machine learning algorithms. Results for models trained for nine major U.S. airports are described and compared to one another across various important dimensions. Particular attention was paid to developing a repeatable framework for training these models so the approach could be scaled to other airports, and to developing models that are useful in a real-time environment. In addition, the models were designed to be functional in a real-time environment to support NASA’s ATD-2 project, as part of an ML-powered shadow system to compare against the performance of the fielded system.

machine learning↗

Predicting Arrival and Departure Runway Assignments with Machine Learning

Runway assignments at major airports are made by air traffic controllers subject to various constraints, and to achieve various objectives. In this research, we describe our efforts training machine learning (ML) models to predict both departure and arrival runway assignments using an entirely data-driven approach. This approach is compared to existing rule-based approaches developed in previous research using input from Subject Matter Experts. The models have features derived from various FAA data feeds, and leverage multiple machine learning algorithms. Results for models trained for nine major U.S. airports are described and compared to one another across various important dimensions. Particular attention was paid to developing a repeatable framework for training these models so the approach could be scaled to other airports, and to developing models that are useful in a real-time environment. In addition, the models were designed to be functional in a real-time environment to support NASA’s ATD-2 project, as part of an ML-powered shadow system to compare against the performance of the fielded system.

machine learning↗

A Thermodynamically-Based Mesh Objective Work Potential Theory for Predicting Intralaminar Progressive Damage and Failure in Fiber-Reinforced Laminates

A thermodynamically-based work potential theory for modeling progressive damage and failure in fiber-reinforced laminates is presented. The current, multiple-internal state variable (ISV) formulation, enhanced Schapery theory (EST), utilizes separate ISVs for modeling the effects of damage and failure. Damage is considered to be the effect of any structural changes in a material that manifest as pre-peak non-linearity in the stress versus strain response. Conversely, failure is taken to be the effect of the evolution of any mechanisms that results in post-peak strain softening. It is assumed that matrix microdamage is the dominant damage mechanism in continuous fiber-reinforced polymer matrix laminates, and its evolution is controlled with a single ISV. Three additional ISVs are introduced to account for failure due to mode I transverse cracking, mode II transverse cracking, and mode I axial failure. Typically, failure evolution (i.e., post-peak strain softening) results in pathologically mesh dependent solutions within a finite element method (FEM) setting. Therefore, consistent character element lengths are introduced into the formulation of the evolution of the three failure ISVs. Using the stationarity of the total work potential with respect to each ISV, a set of thermodynamically consistent evolution equations for the ISVs is derived. The theory is implemented into commercial FEM software. Objectivity of total energy dissipated during the failure process, with regards to refinements in the FEM mesh, is demonstrated. The model is also verified against experimental results from two laminated, T800/3900-2 panels containing a central notch and different fiber-orientation stacking sequences. Global load versus displacement, global load versus local strain gage data, and macroscopic failure paths obtained from the models are compared to the experiments.

Pineda, Evan J.↗