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At least 379 records · Page 21

Care 3 phase 2 report, maintenance manual

CARE 3 (Computer-Aided Reliability Estimation, version three) is a computer program designed to help estimate the reliability of complex, redundant systems. Although the program can model a wide variety of redundant structures, it was developed specifically for fault-tolerant avionics systems--systems distinguished by the need for extremely reliable performance since a system failure could well result in the loss of human life. It substantially generalizes the class of redundant configurations that could be accommodated, and includes a coverage model to determine the various coverage probabilities as a function of the applicable fault recovery mechanisms (detection delay, diagnostic scheduling interval, isolation and recovery delay, etc.). CARE 3 further generalizes the class of system structures that can be modeled and greatly expands the coverage model to take into account such effects as intermittent and transient faults, latent faults, error propagation, etc.

Bryant, L. A.↗

The CARE 3 Phase 3 Report: Test and Evaluation

CARE 3 (Computer-Aided Reliability Estimation, version three) is a computer program designed to help estimate the reliability of complex, redundant systems; although the program can model a wide variety of redundant structures, it was developed specifically for fault-tolerant avionics systems, systems distinguished by the need for extremely reliable performance since a system failure could well result in the loss of human life. CARE 3 further generalizes the class of system structures that can be modeled and greatly expands the coverage model to take into account such effects as intermittent and transient faults, latent faults, error propagation, etc. The initial test and evaluation of CARE 3 are reported.

Stiffler, J. J.↗

Macromolecular Crystal Growth by Means of Microfluidics

We have performed a feasibility study in which we show that chip-based, microfluidic (LabChip(TM)) technology is suitable for protein crystal growth. This technology allows for accurate and reliable dispensing and mixing of very small volumes while minimizing bubble formation in the crystallization mixture. The amount of (protein) solution remaining after completion of an experiment is minimal, which makes this technique efficient and attractive for use with proteins, which are difficult or expensive to obtain. The nature of LabChip(TM) technology renders it highly amenable to automation. Protein crystals obtained in our initial feasibility studies were of excellent quality as determined by X-ray diffraction. Subsequent to the feasibility study, we designed and produced the first LabChip(TM) device specifically for protein crystallization in batch mode. It can reliably dispense and mix from a range of solution constituents into two independent growth wells. We are currently testing this design to prove its efficacy for protein crystallization optimization experiments. In the near future we will expand our design to incorporate up to 10 growth wells per LabChip(TM) device. Upon completion, additional crystallization techniques such as vapor diffusion and liquid-liquid diffusion will be accommodated. Macromolecular crystallization using microfluidic technology is envisioned as a fully automated system, which will use the 'tele-science' concept of remote operation and will be developed into a research facility for the International Space Station as well as on the ground.

vanderWoerd, Mark↗

Hybrid redundancy system for improving reliability - A concept

System combines two concepts - triple modular redundancy (TMR) and spares (replacement system) redundancy. System has triplicated active unit core with associated bank of specifically arranged standby spare units. Curves plotted from characteristic equation show hybrid system is more reliable than conventional TMR systems.

Mathur, F. P.↗

Assessing the Resource Adequacy and Community Impacts of an Evolving Grid: Considerations for State Regulators

As U.S. power systems continue to decarbonize, state regulators must be able to broadly assess the cost and reliability implications of proposed fossil retirements and the corresponding resources that are coming online to replace them. Specifically, regulators must evaluate whether proposed infrastructure investments are sufficient to ensure the long-term reliability of the system, while also protecting rate payers by ensuring that such investments are necessary and not excessive. Broadly speaking, this objective is typically framed in terms of maintaining long-term resource adequacy at the lowest cost, while also ensuring that other social and/or environmental objectives are satisfied. System planners currently have a host of sophisticated analytical tools at their disposal to evaluate the cost-benefit trade-offs of different approaches to ensuring resource adequacy. However, most of these tools and associated metrics were designed with traditional power systems in mind. Over the past decade, it has become increasingly clear that the metrics and models that have reliably assessed resource adequacy in systems dominated by large thermal and hydropower resources will be insufficient for systems with significant contributions from emerging technologies such as wind, solar and storage. Therefore, in recent years many new metrics and modeling approaches have been developed, and are increasingly being implemented, to meet the needs of the clean energy transition.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Intra-Specific Variability in Plant Hydraulic Parameters Inferred From Model Inversion of Sap Flux Data

Understanding plant hydraulic regulation is critical for predicting plant and ecosystem responses to projected increases in drought stress. Plant hydraulic regulation is controlled by observable, diverse plant hydraulic traits that can vary as much across individuals of the same species as they do across different species. Direct measurements of plant hydraulic traits from a range of ecosystems remain limited in comparison to other, more readily measured traits (e.g., specific leaf area). Furthermore, plant hydraulic trait measurements, often made at leaf or branch levels, are not easily scaled to whole-plant values that are typically used to predict plant and ecosystem fluxes. In this study, multiple whole-plant hydraulic parameters are inferred from observations of plant water use (i.e., sap flow), soil properties, and meteorological data. We use a Markov Chain Monte Carlo model inversion approach to obtain the best estimates and uncertainty of plant hydraulic parameters that capture whole-plant effective embolism resistance and stomatal sensitivity to decreasing plant water potential. We then use the inferred values in the model to estimate whole-tree water use and isohydricity. This approach reliably infers whole-plant parameter values with enough specificity to resolve inter- and intra-specific differences, and thus supplements time- and labor-intensive direct measurements of traits.

54 ENVIRONMENTAL SCIENCES↗

Automatic Certification of Kalman Filters for Reliable Code Generation

AUTOFILTER is a tool for automatically deriving Kalman filter code from high-level declarative specifications of state estimation problems. It can generate code with a range of algorithmic characteristics and for several target platforms. The tool has been designed with reliability of the generated code in mind and is able to automatically certify that the code it generates is free from various error classes. Since documentation is an important part of software assurance, AUTOFILTER can also automatically generate various human-readable documents, containing both design and safety related information. We discuss how these features address software assurance standards such as DO-178B.

Denney, Ewen↗

Feedback on the Electric Emergency Incident and Disturbance Report, OE-417

The US Department of Energy (DOE) Office of Electricity (OE) mandates requirements for reporting electric emergencies and disruptions in the United States. Specific electric power industry organizations (such as balancing authorities, reliability coordinators, some generating entities, and electric utilities) report this information through the OE-417 Electric Emergency Incident and Disturbance Report via Form OE-417. Entities are required to submit Form OE-417 when at least one of the qualifying 26 criteria is met pursuant to Section 13(b) of the Federal Energy Administration Act of 1974 (Public Law 93-275). Entities are required to report, within 6 hours of the incident, loss of electric service to 50,000 customers or more for 1 hour or longer. The deadline for submitting Form OE-417 depends on the nature of the incident. An updated Form OE-417 Schedule 1 and all of Schedule 2 are both due within 72 hours of the incident to provide complete disruption information. Additionally, a Final Report must be filed within 72 hours of the incident, unless an interim update has been provided. If the incident meets specific criteria, the form must be filed within one hour, six hours, or by the later of 24 hours after the recognition of the incident or by the end of the next business day.1 The ability of DOE to respond quickly to energy emergencies that could affect the nation’s infrastructure and help alleviate or prevent further disruptions depends on the industry’s prompt and complete submission of information. This report summarizes current issues with Form OE-417 and the reporting process and presents recommendations for improvements.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Challenges Regarding IP Core Functional Reliability

For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

IP cores↗

Damage Mechanisms and Controlled Crack Propagation in a Hot Pressed Silicon Nitride Ceramic

The subcritical growth of cracks from pre-existing flaws in ceramics can severely affect the structural reliability of a material. The ability to directly observe subcritical crack growth and rigorously analyze its influence on fracture behavior is important for an accurate assessment of material performance. A Mode I fracture specimen and loading method has been developed which permits the observation of stable, subcritical crack extension in monolithic and toughened ceramics. The test specimen and procedure has demonstrated its ability to generate and stably propagate sharp, through-thickness cracks in brittle high modulus materials. Crack growth for an aluminum oxide ceramic was observed to be continuously stable throughout testing. Conversely, the fracture behavior of a silicon nitride ceramic exhibited crack growth as a series of subcritical extensions which are interrupted by dynamic propagation. Dynamic initiation and arrest fracture resistance measurements for the silicon nitride averaged 67 and 48 J/sq m, respectively. The dynamic initiation event was observed to be sudden and explosive. Increments of subcritical crack growth contributed to a 40 percent increase in fracture resistance before dynamic initiation. Subcritical crack growth visibly marked the fracture surface with an increase in surface roughness. Increments of subcritical crack growth loosen ceramic material near the fracture surface and the fracture debris is easily removed by a replication technique. Fracture debris is viewed as evidence that both crack bridging and subsurface microcracking may be some of the mechanisms contributing to the increase in fracture resistance. A Statistical Fracture Mechanics model specifically developed to address subcritical crack growth and fracture reliability is used together with a damaged zone of material at the crack tip to model experimental results. A Monte Carlo simulation of the actual experiments was used to establish a set of modeling input parameters. It was demonstrated that a single critical parameter does not characterize the conditions required for dynamic initiation. Experimental measurements for critical crack lengths, and the energy release rates exhibit significant scatter. The resulting output of the model produces good agreement with both the average values and scatter of experimental measurements.

Calomino, Anthony Martin↗

In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines

Autophagy drives drug resistance and drug-induced cancer cell cytotoxicity. Targeting the autophagy process could greatly improve chemotherapy outcomes. The discovery of specific inhibitors or activators has been hindered by challenges with reliably measuring autophagy levels in a clinical setting. We investigated drug-induced autophagy in breast cancer cell lines with differing ER/PR/Her2 receptor status by exposing them to known but divergent autophagy inducers each with a unique molecular target, tamoxifen, trastuzumab, bortezomib or rapamycin. Differential gene expression analysis from total RNA extracted during the earliest sign of autophagy flux showed both cell- and drug-specific changes. We analyzed the list of differentially expressed genes to find a common, cell- and drug-agnostic autophagy signature. Twelve mRNAs were significantly modulated by all the drugs and 11 were orthogonally verified with Q-RT-PCR (Klhl24, Hbp1, Crebrf, Ypel2, Fbxo32, Gdf15, Cdc25a, Ddit4, Psat1, Cd22, Ypel3). The drug agnostic mRNA signature was similarly induced by a mitochondrially targeted agent, MitoQ. In-silico analysis on the KM-plotter cancer database showed that the levels of these mRNAs are detectable in human samples and associated with breast cancer prognosis outcomes of Relapse-Free Survival in all patients (RSF), Overall Survival in all patients (OS), and Relapse-Free Survival in ER + Patients (RSF ER + ). High levels of Klhl24, Hbp1, Crebrf, Ypel2, CD22 and Ypel3 were correlated with better outcomes, whereas lower levels of Gdf15, Cdc25a, Ddit4 and Psat1 were associated with better prognosis in breast cancer patients. This gene signature uncovers candidate autophagy biomarkers that could be tested during preclinical and clinical studies to monitor the autophagy process.

60 APPLIED LIFE SCIENCES↗

COTS Ceramic Chip Capacitors: An Evaluation of the Parts and Assurance Methodologies

Commercial-Off-The-Shelf (COTS) multilayer ceramic chip capacitors (MLCCs) are continually evolving to reduce physical size and increase volumetric efficiency. Designers of high reliability aerospace and military systems are attracted to these attributes of COTS MLCCs and would like to take advantage of them while maintaining the high standards for long-term reliable operation they are accustomed io when selecting military qualified established reliability (MIL-ER) MLCCs. However, MIL-ER MLCCs are not available in the full range of small chip sizes with high capacitance as found in today's COTS MLCCs. The objectives for this evaluation were to assess the long-term performance of small case size COTS MLCCs and to identify effective, lower-cost product assurance methodologies. Fifteen (15) lots of COTS X7R dielectric MLCCs from four (4) different manufacturers and two (2) MIL-ER BX dielectric MLCCs from two (2) of the same manufacturers were evaluated. Both 0805 and 0402 chip sizes were included. Several voltage ratings were tested ranging from a high of 50 volts to a low of 6.3 volts. The evaluation consisted of a comprehensive screening and qualification test program based upon MIL-PRF-55681 (i.e., voltage conditioning, thermal shock, moisture resistance, 2000-hour life test, etc.). In addition, several lot characterization tests were performed including Destructive Physical Analysis (DPA), Highly Accelerated Life Test (HALT) and Dielectric Voltage Breakdown Strength. The data analysis included a comparison of the 2000-hour life test results (used as a metric for long-term performance) relative to the screening and characterization test results. Results of this analysis indicate that the long-term life performance of COTS MLCCs is variable -- some lots perform well, some lots perform poorly. DPA and HALT were found to be promising lot characterization tests to identify substandard COTS MLCC lots prior to conducting more expensive screening and qualification tests. The results indicate that lot- specific screening and qualification are still recommended for high reliability applications. One significant and concerning observation is that MIL- type voltage conditioning (100 hours at twice rated voltage, 125 C) was not an effective screen in removing infant mortality parts for the particular lots of COTS MLCCs evaluated.

Brusse, Jay A.↗

Using Facility Condition Assessments to Identify Actions Related to Infrastructure

To support cost effective, quality research it is essential that laboratory and testing facilities are maintained in a continuous and reliable state of availability at all times. NASA Langley Research Center (LaRC) and its maintenance contractor, Jacobs Technology, Inc. Research Operations, Maintenance, and Engineering (ROME) group, are in the process of implementing a combined Facility Condition Assessment (FCA) and Reliability Centered Maintenance (RCM) program to improve asset management and overall reliability of testing equipment in facilities such as wind tunnels. Specific areas are being identified for improvement, the deferred maintenance cost is being estimated, and priority is being assigned against facilities where conditions have been allowed to deteriorate. This assessment serves to assist in determining where to commit available funds on the Center. RCM methodologies are being reviewed and enhanced to assure that appropriate preventive, predictive, and facilities/equipment acceptance techniques are incorporated to prolong lifecycle availability and assure reliability at minimum cost. The results from the program have been favorable, better enabling LaRC to manage assets prudently.

Rubert, Kennedy F.↗

Operational Experience and Development of a Reliability Model for the ATR Demineralizer System (Slides)

The Advanced Test Reactor (ATR) is a light water reactor with aluminum clad driver fuel. Strict limits are implemented on pH, conductivity, and filterable solids to assure the performance of the driver fuel limit corrosion of the primary coolant system (PCS) pressure boundary components. A bypass demineralizer system is used to maintain PCS coolant within allowable bands for each of the aforementioned variables. Unlike many other reactors, the ATR does not have a filtration system. As such, failure of ion exchange resin in the bypass demineralizer can defeat the purpose of the system and result in high filterable solids in the PCS. Power operations with high filterable solids is prohibited by a technical safety requirement. This paper discusses recent failures of the ATR bypass demineralizer system. The testing and analysis done to deduce the cause of the failures is covered, as well as short term mitigative steps that were taken. To prevent the likelihood of future issues, historical data from the ATR and industry is used to develop a reliability model of the ATR bypass demineralizer system. Evidence of radiolytic decomposition of ion exchange resin was found in the cause investigation. As such, special attention is given to ion exchange resin failure due to high radiation environments. The reliability model is used to develop the ATR testing and maintenance program. Specifically, limits on resin service life are discussed.

21 - SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLAN↗

Digital Infrastructure Migration Framework Report

This document presents a full-scope Digital Infrastructure implementation and associated lifecycle support recommendations that enable a plant life of 80+ years. Specific technologies and software applications are researched, developed, selected, implemented, and then integrated by utilities to enhance safety, reliability, and economic performance such that the result provides much more than the sum of its parts. Specific selection of these technologies is driven by business case analyses which are utility, station, and unit specific.

42 ENGINEERING↗