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At least 379 records · Page 21

Promethazine affects autonomic cardiovascular mechanisms minimally

Promethazine hydrochloride, Phenergan, is a phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. These properties have made promethazine a candidate for use in environments such as microgravity, which provoke emesis and motion sickness. Recently, we evaluated carotid baroreceptor-cardiac reflex responses during two Space Shuttle missions 18 to 20 hr after the 50 mg intramuscular administration of promethazine. Because the effects of promethazine on autonomic cardiovascular mechanisms in general and baroreflex function in particular were not known, we were unable to exclude a possible influence of promethazine on our results. Our purpose was to determine the ground-based effects of promethazine on autonomic cardiovascular control. Because of promethazine's antihistaminic and anticholinergic properties, we expected that a 50-mg intramuscular injection of promethazine would affect sympathetically and vagally mediated cardiovascular mechanisms. Eight healthy young subjects, five men and three women, were studied at rest in recumbency. All reported drowsiness as a result of the promethazine injection; most also reported nervous excitation, dry mouth, and fatigue. Three subjects had significant reactions: two reported excessive anxiety and one reported dizziness. Measurements were performed immediately prior to injection and 3.1 +/- 0.1 and 19.5 +/- 0.4 hr postinjection. We found no significant effect of promethazine on resting mean R-R interval, arterial pressure, R-R interval power spectra, carotid baroreflex function, and venous plasma catecholamine levels.

Clinical Trial↗

Lymphocyte Functions in Microgravity

To understand the mechanism of immunity impairment in space it is important to analyze the direct effects of space-related conditions on different lymphocytes functions. Since 1992, we are investigating the effect of modeled and true microgravity (MG) on numerous lymphocyte functions. We had shown that modeled (MMG) and true microgravity inhibit lymphocyte locomotion through type I collagen. Modeled microgravity also suppresses polyclonal and antigen-specific lymphocyte activation. Polyclonal activation of lymphocytes prior to exposure to MMG abrogates the MG-induced inhibition of lymphocyte locomotion. The relationship between activation deficits and the loss of locomotion in MG was investigated using PKC activation by phorbol ester (PMA) and calcium ionophore (ionomycin). Direct activation of PKC by PMA substantially restored the MMG-inhibited lymphocyte locomotion and PHA-induced lymphocyte activation lonomycin by itself did not restore either locomotion or activation of the lymphocytes, indicating that these changes are not related to the impairment in the calcium flux in MMG. Treatment of lymphocytes with PMA before exposure to MMG prevented the loss of locomotion. It was observed that DNA synthesis is not necessary for restoration of locomotion since mitomicin C treated and untreated cells recovered their locomotion to the same level after PKC activation. Our recent data indicate that microgravity may selectively effect the expression of novel Ca2+ independent isoforms of PKC, in particularly PKC sigma and delta. This provides a new insight in understanding of the mechanisms of MG-sensitive cellular functions.

Pellis, Neal R.↗

The performance of NASA research hydrogen masers

Field operable hydrogen masers based on prior maser designs are presented. These units incorporate improvements in magnetic shielding, lower noise electronics, better thermal control, and have a microprocessor for operation, monitoring, and diagnostic functions. They are ruggedly built for transportability and ease of service anywhere in the world.

Reinhardt, V. S.↗

Strain rate, temperature, and humidity on strength and moduli of a graphite/epoxy composite

Results of an experimental study of the influence of strain rate, temperature and humidity on the mechanical behavior of a graphite/epoxy fiber composite are presented. Three principal strengths (longitudinal, transverse and shear) and four basic moduli (E1, E2, G12 and U12) of a unidirectional graphite/epoxy composite were followed as a function of strain rate, temperature and humidity. Each test was performed at a constant tensile strain rate in an environmental chamber providing simultaneous temperature and humidity control. Prior to testing, specimens were given a moisture preconditioning treatment at 60 C. Values for the matrix dominated moduli and strength were significantly influenced by both environmental and rate parameters, whereas the fiber dominated moduli were not. However, the longitudinal strength was significantly influenced by temperature and moisture content. A qualitative explanation for these observations is presented.

Lifshitz, J. M.↗

Field-aligned ion streams in the earth's midnight region

Plasma measurements from the University of California at San Diego auroral particles experiment on the geosynchronous Applied Technology Satellite 6 in the midnight region show that the low-energy ion fluxes (1-100 eV) are field aligned and are well characterized as thermal populations (1-10 eV) with a streaming velocity of 30-100 km/s along the magnetic field line. The lowest energies are found prior to injections, on quiet days, with an increase of the streaming velocity evident when an injection occurs near the satellite. Multiple peaks in the ion distribution functions are attributed to the presence of different ions species (H/+/, He/+/, O/+/, O/2+/) streaming at similar velocities, both during quiet times and as the plasma velocity increases in response to an injection.

Olsen, R. C.↗

Droplet combustion experiment drop tower tests using models of the space flight apparatus

The Droplet Combustion Experiment (DCE) is an experiment that is being developed to ultimately operate in the shuttle environment (middeck or Spacelab). The current experiment implementation is for use in the 2.2 or 5 sec drop towers at NASA Lewis Research Center. Initial results were reported in the 1986 symposium of this meeting. Since then significant progress was made in drop tower instrumentation. The 2.2 sec drop tower apparatus, a conceptual level model, was improved to give more reproducible performance as well as operate over a wider range of test conditions. Some very low velocity deployments of ignited droplets were observed. An engineering model was built at TRW. This model will be used in the 5 sec drop tower operation to obtain science data. In addition, it was built using the flight design except for changes to accommodate the drop tower requirements. The mechanical and electrical assemblies have the same level of complexity as they will have in flight. The model was tested for functional operation and then delivered to NASA Lewis. The model was then integrated into the 5 sec drop tower. The model is currently undergoing initial operational tests prior to starting the science tests.

Haggard, J. B.↗

Pressure Control System Design for a Closed Crop Growth Chamber

The Controlled Ecological Life Support System (CELSS) is an area of active research at NASA. CELSS is a plant-based bioregenerative life support system for long term manned space flights where resupply is costly or impractical. The plants in a CELSS will function to convert the carbon dioxide (exhaled by the crew) into oxygen, purify non-potable water into potable quality water, and provide food for the crew. Prior to implementing a CELSS life support system, one must have knowledge on growing plants in a closed chamber under low gravity. This information will come from research to be conducted on the CELSS Test Facility that will operate on the Space Station Freedom. Currently a ground-based CELSS Test Facility is being built at NASA Ames Research Center. It is called the EDU (Engineering Development Unit). This system will allow researchers to identify issues that may cause difficulties in the development of the CELSS Test Facility and aid in the development of new needed technologies. The EDU consists of a 1 m2 crop growth chamber that is surrounded by a containment enclosure. The containment enclosure isolates the system so there is very little mass and thermal exchange with the ambient. The leakage rate is on the order of 1 % of the enclosure's volume per day (with 0.2S psi pressure difference). The thermal leakage is less than 0.5% of the electrical power supplied to the system per degree Celsius difference from the surrounding. The pressure in the containment enclosure is regulated at 62.5 Pa below the ambient by an active controller. The goal is to maintain this set point for a variety of conditions, such as a range of operating temperatures, heat load variations that occur when the lights are turned on and off, and fluctuations in ambient pressure. In addition certain transition tracking performance is required. This paper illustrates the application of some advanced systems control methods to the task of synthesizing the EDU's pressure control system.

Tsai, K.↗

A Bayesian Approach to Estimating Coupling Between Neural Components: Evaluation of the Multiple Component, Event-Related Potential (mcERP) Algorithm

Accurate measurement of single-trial responses is key to a definitive use of complex electromagnetic and hemodynamic measurements in the investigation of brain dynamics. We developed the multiple component, Event-Related Potential (mcERP) approach to single-trial response estimation. To improve our resolution of dynamic interactions between neuronal ensembles located in different layers within a cortical region and/or in different cortical regions. The mcERP model assets that multiple components defined as stereotypic waveforms comprise the stimulus-evoked response and that these components may vary in amplitude and latency from trial to trial. Maximum a posteriori (MAP) solutions for the model are obtained by iterating a set of equations derived from the posterior probability. Our first goal was to use the ANTWERP algorithm to analyze interactions (specifically latency and amplitude correlation) between responses in different layers within a cortical region. Thus, we evaluated the model by applying the algorithm to synthetic data containing two correlated local components and one independent far-field component. Three cases were considered: the local components were correlated by an interaction in their single-trial amplitudes, by an interaction in their single-trial latencies, or by an interaction in both amplitude and latency. We then analyzed the accuracy with which the algorithm estimated the component waveshapes and the single-trial parameters as a function of the linearity of each of these relationships. Extensions of these analyses to real data are discussed as well as ongoing work to incorporate more detailed prior information.

Shah, Ankoor S.↗

Image Compression Algorithm Altered to Improve Stereo Ranging

A report discusses a modification of the ICER image-data-compression algorithm to increase the accuracy of ranging computations performed on compressed stereoscopic image pairs captured by cameras aboard the Mars Exploration Rovers. (ICER and variants thereof were discussed in several prior NASA Tech Briefs articles.) Like many image compressors, ICER was designed to minimize a mean-square-error measure of distortion in reconstructed images as a function of the compressed data volume. The present modification of ICER was preceded by formulation of an alternative error measure, an image-quality metric that focuses on stereoscopic-ranging quality and takes account of image-processing steps in the stereoscopic-ranging process. This metric was used in empirical evaluation of bit planes of wavelet-transform subbands that are generated in ICER. The present modification, which is a change in a bit-plane prioritization rule in ICER, was adopted on the basis of this evaluation. This modification changes the order in which image data are encoded, such that when ICER is used for lossy compression, better stereoscopic-ranging results are obtained as a function of the compressed data volume.

Kiely, Aaron↗

NASA Schedule Management Handbook

The purpose of schedule management is to provide the framework for time-phasing, resource planning, coordination, and communicating the necessary tasks within a work effort. The intent is to improve schedule management by providing recommended concepts, processes, and techniques used within the Agency and private industry. The intended function of this handbook is two-fold: first, to provide guidance for meeting the scheduling requirements contained in NPR 7120.5, NASA Space Flight Program and Project Management Requirements, NPR 7120.7, NASA Information Technology and Institutional Infrastructure Program and Project Requirements, NPR 7120.8, NASA Research and Technology Program and Project Management Requirements, and NPD 1000.5, Policy for NASA Acquisition. The second function is to describe the schedule management approach and the recommended best practices for carrying out this project control function. With regards to the above project management requirements documents, it should be noted that those space flight projects previously established and approved under the guidance of prior versions of NPR 7120.5 will continue to comply with those requirements until project completion has been achieved. This handbook will be updated as needed, to enhance efficient and effective schedule management across the Agency. It is acknowledged that most, if not all, external organizations participating in NASA programs/projects will have their own internal schedule management documents. Issues that arise from conflicting schedule guidance will be resolved on a case by case basis as contracts and partnering relationships are established. It is also acknowledged and understood that all projects are not the same and may require different levels of schedule visibility, scrutiny and control. Project type, value, and complexity are factors that typically dictate which schedule management practices should be employed.

Source record↗

Improved Solar-Radiation-Pressure Models for GPS Satellites

A report describes a series of computational models conceived as an improvement over prior models for determining effects of solar-radiation pressure on orbits of Global Positioning System (GPS) satellites. These models are based on fitting coefficients of Fourier functions of Sun-spacecraft- Earth angles to observed spacecraft orbital motions.

Bar-Sever, Yoaz↗

Silicon-Based Optical Modulator with Ferroelectric Layer

According to a proposal, a silicon dioxide layer in a high-speed, low-power, silicon- based electro-optical modulator would be replaced by a layer of lead zirconate titanate or other ferroelectric oxide material. The purpose of this modification is to enhance the power performance and functionality of the modulator. In its unmodified form, the particular silicon- based electro-optical modulator is of an advanced design that overcomes the speed limitation of prior silicon-based electro- optical modulators. Whereas modulation frequencies of such devices had been limited to about 20 MHz, this modulator can operate at modulation frequencies as high as 1 GHz. This modulator can be characterized as a silicon-waveguide-based metal oxide/semiconductor (MOS) capacitor phase shifter in which modulation of the index of refraction in silicon is obtained by exploiting the free-charge-carrier-plasma dispersion effect. As shown in the figure, the modulator includes an n-doped crystalline silicon slab (the silicon layer of a silicon- on-insulator wafer) and a p-doped polycrystalline silicon rib with a gate oxide layer (the aforementioned silicon dioxide layer) sandwiched between them. Under accumulation conditions, the majority charge carriers in the silicon waveguide modify the index of refraction so that a phase shift is induced in the optical mode propagating in the waveguide. The advantage of using an MOS capacitor phase shifter is that it is possible to achieve high modulation speed because there are no slow carrier-generation or -recombination processes involved in the accumulation operation. The main advantage of the proposed substitution of a ferroelectric oxide layer for the silicon dioxide layer would arise from the spontaneous polarization effect of the ferroelectric layer: This spontaneous polarization would maintain accumulation conditions in the absence of applied voltage. Consequently, once the device had been switched to a given optical state, it would remain in that state, even in the absence of applied voltage (in other words, even with power turned off). A secondary advantage is that because the ferroelectric layer would have an index of refraction larger than that of silicon dioxide, there could be some reduction of optical losses attributable to fabrication of the modulator

Sheldon, Douglas↗

Cytoskeletal and functional changes in bioreactor assembled thyroid tissue organoids exposed to gamma radiation

Fischer rat thyroid cells were grown under low-shear stress in a bioreactor to a stage of organization composed of integrated follicles resembling small thyroid glands prior to exposure to 3 Gray-gamma radiation. Bioreactor tissues and controls (both irradiated and non-irradiated) were harvested at 24, 48, 96 and 144 hours post-exposure. Tissue samples were fixed and fluorescently labeled for actin and microtubules. Tissues were assessed for changes in cytoskeletal components induced by radiation and quantified by laser scanning cytometry. ELISA's were used to quantify transforming growth factor-beta and thyroxin released from cells to the culture supernatant. Tissue architecture was disrupted by exposure to radiation with the structural organization of actin and loss of follicular content the most obviously affected. With time post-irradiation the actin appeared disordered and the levels of fluorescence associated with filamentous-actin and microtubules cycled in the tissue analogs, but not in the flask-grown cultures. Active transforming growth factor-beta was higher in supernatants from the irradiated bioreactor tissue. Thyroxin release paralleled cell survival in the bioreactors and control cultures. Thus, the engineered tissue responses to radiation differed from those of conventional tissue culture making it a potentially better mimic of the in vivo situation.

Non-NASA Center↗

Ultralightweight Fresnel Lens Solar Concentrators for Space Power

The first phase of this project was completed in March 2000, and included the successful technology demonstration of a new ultralightweight photovoltaic concentrator array at the fully functional panel level. The new array is called the Stretched Lens Aurora (SLA) array, and uses deployable, flexible, thin-film silicone rubber Fresnel lenses to focus sunlight onto high efficiency multijunction solar cells, which are mounted to a composite radiator surface for waste heat dissipation. A prototype panel was delivered to NASA Marshall in March 2000, and comprised four side-by-side lenses focussing sunlight onto four side-by-side photovoltaic receivers. This prototype panel was tested by NASA Glenn prior to delivery to NASA Marshall. The best of the four lens/receiver modules achieved 27.4% efficiency at room temperature in the NASA Glenn solar simulator tests. This performance equates to 375 W/sq.m. areal power and 378 W/kg specific power at the fully functional panel level. We believe this to be the first space solar array of any kind to simulataneously meet the two long-standing NASA goals of 300 W/sq.m. and 300 W/kg at the functional panel level. Key results for the first phase of the program have been documented by ENTECH in a Draft Final Technical Report, which is presently being reviewed by NASA, and which should be published in the near future.

ONeill, M. J.↗

NASA NR hydrogen maser

The Johns Hopkins University, Applied Physics Laboratory, under contract to NASA/Goddard Space Flight Center, is engineering a new generation of field operable hydrogen masers (NR) based on prior NASA NP and NX designs. These units incorporate improvements in magnetic shielding, lower noise electronics, better thermal control and have a microprocessor for operation, monitoring and diagnostic functions. They are ruggedly built for transportability and ease of service anywhere in the world.

Rueger, L. J.↗

Role of energetic particles in charging/discharging of spacecraft dielectrics

The role that energetic particles in the substorm plasma have on the charging and discharging of typical dielectric layers used on spacecraft was investigated using spectra and pitch angle distributions measured in situ on the SCATHA spacecraft prior to and during a few kilovolt differential charging event in eclipse conditions. The particle spectra was input to deposition codes that determine the dose rate as a function of depth in Kapton and Teflon layers used in an experiment on SCATHA. The calculated ambient dose rates of a few rads/sec throughout the bulk of the samples are sufficiently high that radiation damage levels are reached on the time scale of 1 year. Surface dose is a factor of 100 higher. Bulk conductivity profiles were obtained from the dose rates using empirical relationships. The radiation induced bulk conductivities calculated at the peak charging time are found to be smaller than the intrinsic dark conductivity range of solar conditioned Kapton but higher than the corresponding value for Teflon.

Reagan, J. B.↗

Partially coherent scattering in stellar chromospheres. II - The first-order escape probability method. III - A second-order escape probability method

Approximate analytic expressions are derived for resonance-line wing diagnostics, accounting for frequency redistribution effects, for homogeneous slabs, and slabs with a constant Planck function gradient. Resonance-line emission profiles from a simplified conceptual standpoint are described in order to elucidate the basic physical parameters of the line-forming layers prior to the performance of detailed numerical calculations. An approximate analytic expression is derived for the dependence on stellar surface gravity of the location of the Ca II and Mg II resonance-line profile peaks. An approximate radiative transfer equation using generalized second-order escape probabilities, applicable even in the presence of nearly coherent scattering in the damping wings of resonance lines, is derived. Approximate analytic solutions that can be applied in special regimes and achieve good agreement with accurate numerical results are found.

Gayley, K. G.↗

Far Ultraviolet Imaging from the Image Spacecraft: System Design - 1

Direct imaging of the magnetosphere by the IMAGE spacecraft A,ill be supplemented by observation of the global aurora, the footprint of magnetospheric regions. To assure the simultaneity of these observations and tile measurement of the magnetospheric back-round neutral gas density, the IMAGE satellite instrument complement includes three Far Ultraviolet (FUV) instruments. In tile wavelength region 120-1 90 nm. a downward-viewing aurora imager is only minimally contaminated sunlight, scattered from clouds and ground, and radiance of the aurora observed in a nadir viewing geometry can be observed in the presence of the high-latitude day-low. Tile Wideband Imaging Camera (WIC) will provide broadband ultraviolet images of the aurora for maximum spatial and temporal resolution by imaging the LBH N2 bands of the aurora. The Spectrographic Imager (SI), a monochromatic imager, will image different types of aurora, filtered by wavelength. By measuring the Doppler-shifted Lyman-alpha, the proton-induced component of the aurora will be imaged separately. Finally, the GEO instrument will observe the distribution of the geocoronal emission, which is a measure of the neutral background density source of the charge exchange in the magnetosphere. The FUV instrument complement looks radially outward from the rotating IMAGE satellite and, therefore, it spends only a short time observing tile aurora and the Earth during, each spin. Detailed descriptions of the WIC, Si, GEO, and their individual performance validations are discussed in companion papers. This paper summarizes the system requirements and system design approach taken to satisfy the science requirements. One primary requirement is to maximize photon collection efficiency and use efficiently tile short time available foe exposures. The FUV auroral imagers WIC and SI both have wide fields of view and take data continuously as the auroral region proceeds through the field of view. To minimize data volume, multiple images are taken and electronically co-added by suitably shifting each image to compensate for the spacecraft rotation. In order to minimize resolution loss, the images have to be distortion-corrected in real time foe both WIC and Si prior to co-adding. The distortion correction is accomplished using high-speed look Lip tables that are pre-generated by least square fitting to polynomial functions by the on-orbit processor. The instruments were calibrated individually while on stationary platforms, mostly in vacuum chambers as described in the companion papers. Extensive -round-based testing was performed with visible and near UV simulators mounted oil a rotating platform to estimate their on-orbit performance. The predicted instrument system performance is summarized and some of the preliminary data formats are shown.

Mende, S. B.↗