Electrical impedance plethysmography - A critical analysis.
Calibration of electrical impedance plethysmograph for blood flow monitoring
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Calibration of electrical impedance plethysmograph for blood flow monitoring
Circuitry for blood flow and pressure probes
Transient method for measuring thermal properties of biological materials, concerning thermal conductivity, inertia and blood flow rate
Circadian variations in human temperature regulation, measuring peripheral and rectal temperatures and peripheral heat and arterial blood flows in clothed resting males
Arterial wall nonlinear distensibility effects on blood flow velocity profiles, considering various mathematical and physical artery models
Eating and digestion effects on arterial pressure and mesenteric and aortic blood flows in intact unanesthetized dogs
Pressure sensors, blood flow transducers, pH electrodes, and photographic recording of biological data for use in aerospace medicine
Living human tissue thermal behavior analytical modeling including internal heat generation and blood flow effects
Dynamic respiratory and circulatory responses to hypoxia in anesthetized dogs, recording oxygen partial pressures, heart rate, blood pressure, blood flows, respiratory rate, etc
Research and experimental effort was carried out on high-density photo-optical recorder design, implantable pH electrodes and the mangetic/doppler blood-flow sensor.
Results of a study in which six supine resting subjects, wearing water-perfused suits, had body skin temperature controlled at 35 C for 30 min (control period), then rapidly increased to 40.5 C for 43 to 50 min (heating period) in a two-part experiment. In the first part of the experiment arterial mean pressure (MP) in three men was increased back to, or above control levels at the 30 to 35th min of heating by total occlusion of both legs for 8 to 10 min. Splanchnic blood flow (SBF), which had fallen from 1.4 to 0.9 L/min at occlusion, rose only 0.05 L/min during occlusion. Splanchnic vascular resistance (SVR) rose throughout heating and occlusion. In the second part of the experiment (three men) SBF fell despite a spontaneous rise in MP and aortic pulse pressure prior to leg occlusion. Cardiac output (CO) was measured just before, during and after occlusion. Occlusion raised MP 10 to 15 mm Hg and reduced CO only slightly. It is concluded that falling MP or aortic pulse pressure are not major causes of the splanchnic vasoconstriction in response to heating man.
An analytical model of transient heat transfer in living biological tissue is considered. The model includes storage, generation, conduction, and convective transport of heat in the tissue. Solutions for rectangular and cylindrical coordinates are presented and discussed. Transient times for reaching the ?locally fully developed' temperature profile were found to be of the order of 5 to 25 min. These transients are dominated by a geometrical parameters and, to a lesser extent, by a parameter representing the ratio of heat supplied by blood flow to heat conducted in the tissue.
An attempt is made to develop a model describing the overall responses of humans to exercise and environmental stresses for prediction of exhaustion vs an individual's physical characteristics. The principal components of the model are a steady state description of circulation and a dynamic description of thermal regulation. The circulatory portion of the system accepts changes in work load and oxygen pressure, while the thermal portion is influenced by external factors of ambient temperature, humidity and air movement, affecting skin blood flow. The operation of the model is discussed and its structural details are given.
NASA is in the process of conducting a broad program of research and development of technology to qualify, support, and permit the successful use of man in long-term space flight. The technological tasks include human engineering, extravehicular engineering, life support, and human research to assess the effect of space stresses on human physiology and psychology. Various testing techniques that are being used may have future relevance to world health. These include a biocybernetic approach to the study of cardiovascular stresses, measurement of blood flow by means of the Doppler effect, and a device for simulating radiation dosages similar to those produced in solar flares. The planned program includes a study of both humans and animals.
The effects upon range of accommodation and color vision of reduced atmospheric pressure, at partial and complete elimination of nitrogen, of hypoxia, and of exposure for varying periods of time to restricted visual environment, have been studied alone or in various combinations. Measurements were made on the electroretinogram, the electrooculogram, and the diameter of the retinal vessels as an indicator of blood flow to the retina at the time of total elimination of nitrogen. An objective method was used to test range of accommodation. In the color vision test the flicker colors of a Benham's top were matched with a colorimeter.
A miniature biotelemeter has been developed for sensing and transmitting multiple channels of wideband biomedical data over a radio link. Its small size and weight make it capable of being carried by free-moving laboratory animals as small as rats. Ten data channels each of 5-kHz data bandwidth are provided to permit monitoring of a wide variety of physiological signals. Multichannel telemetry of electroencephalograms, electrocardiograms, electromyograms, state functions, and dynamic processes such as blood flow and body chemistry are possible applications. Utilization of newly available monolithic chip components, low-power COS/MOS MSI digital logic, and state-of-the-art hybrid mounting techniques makes this novel device useful for both research and clinical bioinstrumentation.
A transcutaneous system for real-time imaging of arteries is described. A transducer probe containing three linear arrays of elements scans tissues within the element Fresnel zones. Each element is multiplexed in turn to a pulsed Doppler processor to permit real-time visualizations of moving targets. Applications of the motion-indicating B-scans are discussed, with special attention to problems in transcutaneous measurement of blood flow.
The resolution of the technique considered is sufficient to describe smooth distributions containing blood flow to unventilated regions (shunt), ventilation to unperfused regions (dead space), and up to three additional modes over the range of finite ventilation-perfusion ratios. In particular, areas whose ventilation-perfusion ratios are low can be separated from unventilated regions and those whose ventilation-perfusion ratios are high can similarly be distinguished from unperfused areas.