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At least 361 records · Page 20

Optimization of current waveform tailoring for magnetically driven isentropic compression experiments

The Thor pulsed power generator is being developed at Sandia National Laboratories. The design consists of up to 288 decoupled and transit time isolated capacitor-switch units, called “bricks,” that can be individually triggered to achieve a high degree of pulse tailoring for magnetically driven isentropic compression experiments (ICE) [D. B. Reisman et al., Phys. Rev. Spec. Top.–Accel. Beams 18, 090401 (2015)]. The connecting transmission lines are impedance matched to the bricks, allowing the capacitor energy to be efficiently delivered to an ICE strip-line load with peak pressures of over 100 GPa. Thor will drive experiments to explore equation of state, material strength, and phase transition properties of a wide variety of materials. We present an optimization process for producing tailored current pulses, a requirement for many material studies, on the Thor generator. This technique, which is unique to the novel “current-adder” architecture used by Thor, entirely avoids the iterative use of complex circuit models to converge to the desired electrical pulse. We begin with magnetohydrodynamic simulations for a given material to determine its time dependent pressure and thus the desired strip-line load current and voltage. Because the bricks are connected to a central power flow section through transit-time isolated coaxial cables of constant impedance, the brick forward-going pulses are independent of each other. We observe that the desired equivalent forward-going current driving the pulse must be equal to the sum of the individual brick forward-going currents. We find a set of optimal brick delay times by requiring that the L{sub 2} norm of the difference between the brick-sum current and the desired forward-going current be a minimum. We describe the optimization procedure for the Thor design and show results for various materials of interest.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Computer-assisted knowledge acquisition for hypermedia systems

The usage of procedural and declarative knowledge to set up the structure or 'web' of a hypermedia environment is described. An automated knowledge acquisition tool was developed that helps a knowledge engineer elicit and represent an expert's knowledge involved in performing procedural tasks. The tool represents both procedural and prerequisite, declarative knowledge that supports each activity performed by the expert. This knowledge is output and subsequently read by a hypertext scripting language to generate the link between blank, but labeled cards. Each step of the expert's activity and each piece of supporting declarative knowledge is set up as an empty node. An instructional developer can then enter detailed instructional material concerning each step and declarative knowledge into these empty nodes. Other research is also described that facilitates the translation of knowledge from one form into a form more readily useable by computerized systems.

Steuck, Kurt↗

Single-Centre Experience with Percutaneous Cryoablation of Breast Cancer in 23 Consecutive Non-surgical Patients

AimTo present our single-centre prospective experience on the use of cryoablation (CA) applied to treat primary breast cancer (BC) in a cohort of patients unsuitable for surgical treatment.Materials and MethodsTwenty-three consecutive post-menopausal female patients (median age 85 years; range 56–96) underwent percutaneous CA of unifocal, biopsy-proven BC, under ultrasound/computed tomography (US/CT) guidance. Clinical and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) follow-ups were systematically scheduled at 3, 12, 18 and 24 months. Local tumour control was assessed by comparing baseline and follow-up DCE-MRI.ResultsTwenty-three BC (median size 14 mm) were treated under local anaesthesia (78.3 %) or local anaesthesia and conscious sedation (21.7 %). Median number of cryo-probes applied per session was 2.0. A “dual-freezing” protocol was applied for the first ten patients and a more aggressive “triple-freezing” protocol for the remaining 13. Median follow-up was 14.6 months. Five patients recurred during follow-up and two were successfully re-treated with CA. Five patients presented immediate CA-related complications: four hematomas evolved uneventfully at 3-month follow-up and one skin burn resulted in skin inflammation and skin retraction at 3 and 12 months, respectively.ConclusionsPercutaneous CA is safe and well tolerated for non-resected elderly BC patients. Procedures can be proposed under local anaesthesia only. Given the insulation properties of the breast gland, aggressive CA protocols are required. Prospective studies are needed to better understand the potential role of CA in the local treatment of early BC.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Percutaneous Thermal Ablation with Ultrasound Guidance. Fusion Imaging Guidance to Improve Conspicuity of Liver Metastasis

PurposeTo assess whether fusion imaging-guided percutaneous microwave ablation (MWA) can improve visibility and targeting of liver metastasis that were deemed inconspicuous on ultrasound (US).Materials and MethodsMWA of liver metastasis not judged conspicuous enough on US was performed under CT/US fusion imaging guidance. The conspicuity before and after the fusion imaging was graded on a five-point scale, and significance was assessed by Wilcoxon test. Technical success, procedure time, and procedure-related complications were evaluated.ResultsA total of 35 patients with 40 liver metastases (mean size 1.3 ± 0.4 cm) were enrolled. Image fusion improved conspicuity sufficiently to allow fusion-targeted MWA in 33 patients. The time required for image fusion processing and tumors’ identification averaged 10 ± 2.1 min (range 5–14). Initial conspicuity on US by inclusion criteria was 1.2 ± 0.4 (range 0–2), while conspicuity after localization on fusion imaging was 3.5 ± 1 (range 1–5, p < 0.001). Technical success rate was 83% (33/40) in intention-to-treat analysis and 100% in analysis of treated tumors. There were no major procedure-related complications.ConclusionsFusion imaging broadens the scope of US-guided MWA to metastasis lacking adequate conspicuity on conventional US. Fusion imaging is an effective tool to increase the conspicuity of liver metastases that were initially deemed non visualizable on conventional US imaging.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Ablation Volume Measurement After Percutaneous Cryoablation Using a Two-cryo-probe Technique for Small Hepatocellular Carcinomas

Purpose: To calculate the ablation volume of percutaneous cryoablation (PCA) with a two-cryo-probe technique for small hepatocellular carcinomas (HCCs) and to assess risk factors for local tumor recurrence (LTR). Materials and Methods: Between January 2013 and June 2017, 96 patients (mean age, 60.7 years; range, 37–83 years) with 106 small HCCs were retrospectively analyzed. The ablation volume, technical success, LTR rates, and complications were evaluated. Ablation volume was measured after the first freezing and immediately after completing PCA twice via computed tomography imaging. Prognostic factors associated with LTR were analyzed. Results: Technical success was achieved in all patients. The mean final ablation volume was 19.1 ± 4.8 cm{sup 3}, which was significantly higher than the first freezing ablation volume (14.7 ± 4.3 cm{sup 3}, p < 0.001). During the median follow-up period of 16.7 months (range, 5–52 months), LTR-free survival rates based on Kaplan–Meier analyses at 6 months, 1 year, and 2 years were 87.7%, 84.0%, and 80.2%, respectively. Only one major complication of post-procedural arterial bleeding occurred. A final ablation volume/tumor volume < 10 was a significant risk factor for LTR (p = 0.044). Conclusions: A ratio of final ablation volume to tumor volume < 10 was a significant prognostic factor for LTR. Therefore, the measurement and prediction of the final ablation volume are important to reduce LTR.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Girsanov's transformation based variance reduced Monte Carlo simulation schemes for reliability estimation in nonlinear stochastic dynamics

The study considers the problem of simulation based time variant reliability analysis of nonlinear randomly excited dynamical systems. Attention is focused on importance sampling strategies based on the application of Girsanov's transformation method. Controls which minimize the distance function, as in the first order reliability method (FORM), are shown to minimize a bound on the sampling variance of the estimator for the probability of failure. Two schemes based on the application of calculus of variations for selecting control signals are proposed: the first obtains the control force as the solution of a two-point nonlinear boundary value problem, and, the second explores the application of the Volterra series in characterizing the controls. The relative merits of these schemes, vis-à-vis the method based on ideas from the FORM, are discussed. Illustrative examples, involving archetypal single degree of freedom (dof) nonlinear oscillators, and a multi-degree of freedom nonlinear dynamical system, are presented. The credentials of the proposed procedures are established by comparing the solutions with pertinent results from direct Monte Carlo simulations. - Highlights: • The distance minimizing control forces minimize a bound on the sampling variance. • Establishing Girsanov controls via solution of a two-point boundary value problem. • Girsanov controls via Volterra's series representation for the transfer functions.

97 MATHEMATICS AND COMPUTING↗

Analytical method for predicting the pressure distribution about a nacelle at transonic speeds

The formulation and development of a computer analysis for the calculation of streamlines and pressure distributions around two-dimensional (planar and axisymmetric) isolated nacelles at transonic speeds are described. The computerized flow field analysis is designed to predict the transonic flow around long and short high-bypass-ratio fan duct nacelles with inlet flows and with exhaust flows having appropriate aerothermodynamic properties. The flow field boundaries are located as far upstream and downstream as necessary to obtain minimum disturbances at the boundary. The far-field lateral flow field boundary is analytically defined to exactly represent free-flight conditions or solid wind tunnel wall effects. The inviscid solution technique is based on a Streamtube Curvature Analysis. The computer program utilizes an automatic grid refinement procedure and solves the flow field equations with a matrix relaxation technique. The boundary layer displacement effects and the onset of turbulent separation are included, based on the compressible turbulent boundary layer solution method of Stratford and Beavers and on the turbulent separation prediction method of Stratford.

Keith, J. S.↗

GRAPhEME: a setup to measure (n, xn γ) reaction cross sections

Most of nuclear reactor developments are using evaluated data base for numerical simulations. However, the considered databases present still large uncertainties and disagreements. To improve their level of precision, new measurements are needed, in particular for (n, xn) reactions, which are of great importance as they modify the neutron spectrum, the neutron population, and produce radioactive species. The IPHC group started an experimental program to measure (n, xn gamma) reaction cross sections using prompt gamma spectroscopy and neutron energy determination by time of flight. Measurements of (n, xn gamma) cross section have been performed for {sup 235,238}U, {sup 232}Th, {sup nat,182,183,184,186}W, {sup nat}Zr. The experimental setup is installed at the neutron beam at GELINA (Geel, Belgium). The setup has recently been upgraded with the addition of a highly segmented 36 pixels planar HPGe detector. Significant efforts have been made to reduce radiation background and electromagnetic perturbations. The setup is equipped with a high rate digital acquisition system. The analysis of the segmented detector data requires a specific procedure to account for cross signals between pixels. An overall attention is paid to the precision of the measurement. The setup characteristic and the analysis procedure will be presented along with the acquisition and analysis challenges. Examples of results and their impact on models will be discussed. (authors)

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

SU-F-J-167: Use of MR for Permanent Prostate Implant Preplanning

Purpose: To study the feasibility using MR imaging to improve target definition on ultrasound during permanent prostate implants and aid in source strength determination for treatment planning in the OR. Methods: Patients who receive permanent prostate implants undergo MR and CT imaging prior to the implant procedure to determine the volume of the prostate, bony restriction to the procedure, bladder extension, external sphincter length and neurovascular bundle. The volume of the prostate is generally used to order seeds for the procedure. In 10 patients, the MR was used as the preplanning study with the PTV defined as a 2 mm expansion of the MR prostate in all directions except the posterior. Various dose volume parameters for the MR prostate and the PTV were compared to the actual preplan developed and executed in the OR. In addition, there parameters were compared to the post implant dosimetry performed 3 weeks after the implant procedure. Results: The results show that the number of seeds used using MR and US (ultrasound) planning was generally with 2 seeds and the maximum difference was 7 seeds. There is no significant difference between any of the dose index parameters of V100, V150, V200, D99 and D90 parameters between MR planning, US planning and postimplant evaluation There was a significant difference between planned D99 (avg of 105%) and achieved D99 (avg 91%). Conclusion: MR imaging is an invaluable tool to improve target definition for permanent prostate implants. Use of MR images for preplanning improves the confidence with which source can be ordered for the procedure that is OR planned. Ordering a maximum of 10 seeds more than planned would be sufficient to deliver a plan in the OR using US. Moving ahead to non-rigid registration between MR ad US images could further increase the confidence level of MR planning.

60 APPLIED LIFE SCIENCES↗

Long-term Spot Stability in the Post-common-envelope Binary QS Vir

We observed the post-common-envelope eclipsing binary with a white dwarf component, QS Vir, using the 1.88 m telescope of Kotammia Observatory in Egypt. The new observations were analyzed together with all multicolor light curves available online (sampling a period of 25 yr), using a full-feature binary system modeling software based on Roche geometry. This is the first time complete photometric modeling was done with most of these data. QS Vir is a detached system, with the red dwarf component underfilling its Roche lobe by a small margin. All light curves feature out-of-eclipse variability that is associated with ellipsoidal variation, mutual irradiation and irregularities in surface brightness of the tidally distorted and magnetically active red dwarf. We tested models with one, two, and three dark spots and found that one spot is sufficient to account for the light curve asymmetry in all data sets, although this does not rule out the presence of multiple spots. We also found that a single spotted model cannot fit light curves observed simultaneously in different filters. Instead, each filter requires a different spot configuration. To thoroughly explore the parameter space of spot locations, we devised a grid-search procedure and used it to find consistent solutions. Based on this, we conclude that the dark spot responsible for light curve distortions has been stable for the past 15 yr, after a major migration that happened between 1993 and 2002, possibly due to a flip-flop event.

79 ASTRONOMY AND ASTROPHYSICS↗

Endovascular Management of Iatrogenic Native Renal Arterial Pseudoaneurysms

Purpose: Our purpose was to evaluate iatrogenic renal pseudoaneurysms, endovascular treatment, and outcomes. Methods: This retrospective study (2003-2011) reported the technical and clinical outcomes of endovascular therapy for renal pseudoaneurysms in eight patients (mean age, 46 (range 24-68) years). Renal parenchymal loss evaluation was based on digital subtraction angiography and computed tomography. Results: We identified eight iatrogenic renal pseudoaneurysm patients with symptoms of hematuria, pain, and hematoma after renal biopsy (n = 3), surgery (n = 3), percutaneous nephrolithotomy (n = 1), and endoscopic shock-wave lithotripsy (n = 1). In six patients, the pseudoaneurysms were small-sized (<20 mm) and peripherally located and were treated solely with coil embolization (n = 5). In one patient, coil embolization was preceded by embolization with 500-700 micron embospheres to control active bleeding. The remaining two patients had large-sized ({>=}50 mm), centrally located renal pseudoaneurysms treated with thrombin {+-} coils. Technical success with immediate bleeding cessation was achieved in all patients. There were no procedure-related deaths or complications (mean follow-up, 23.5 (range, 1-67) months). Conclusions: Treatment of renal pseudoaneurysms using endovascular approach is a relatively safe and viable option regardless of location (central or peripheral) and size of the lesions with minimal renal parenchymal sacrifice.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Radiation Exposure of Interventional Radiologists During Computed Tomography Fluoroscopy-Guided Renal Cryoablation and Lung Radiofrequency Ablation: Direct Measurement in a Clinical Setting

IntroductionComputed tomography (CT) fluoroscopy-guided renal cryoablation and lung radiofrequency ablation (RFA) have received increasing attention as promising cancer therapies. Although radiation exposure of interventional radiologists during these procedures is an important concern, data on operator exposure are lacking.Materials and MethodsRadiation dose to interventional radiologists during CT fluoroscopy-guided renal cryoablation (n = 20) and lung RFA (n = 20) was measured prospectively in a clinical setting. Effective dose to the operator was calculated from the 1-cm dose equivalent measured on the neck outside the lead apron, and on the left chest inside the lead apron, using electronic dosimeters. Equivalent dose to the operator’s finger skin was measured using thermoluminescent dosimeter rings.ResultsThe mean (median) effective dose to the operator per procedure was 6.05 (4.52) μSv during renal cryoablation and 0.74 (0.55) μSv during lung RFA. The mean (median) equivalent dose to the operator’s finger skin per procedure was 2.1 (2.1) mSv during renal cryoablation, and 0.3 (0.3) mSv during lung RFA.ConclusionRadiation dose to interventional radiologists during renal cryoablation and lung RFA were at an acceptable level, and in line with recommended dose limits for occupational radiation exposure.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Unidirectional wireless power transfer using near-field plates

One of the obstacles preventing wireless power transfer from becoming ubiquitous is their leakage of power: high-amplitude electromagnetic fields that can interfere with other electronic devices, increase health concerns, or hinder power metering. In this paper, we present near-field plates (NFPs) as a novel method to tailor the electromagnetic fields generated by a wireless power transfer system while maintaining high efficiency. NFPs are modulated arrays or surfaces designed to form prescribed near-field patterns. The NFP proposed in this paper consists of an array of loaded loops that are designed to confine the electromagnetic fields of a resonant transmitting loop to the desired direction (receiving loop) while suppressing fields in other directions. The step-by-step design procedure for this device is outlined. Two NFPs are designed and examined in full-wave simulation. Their performance is shown to be in close agreement with the design predictions, thereby verifying the proposed design and operation. A NFP is also fabricated and experimentally shown to form a unidirectional wireless power transfer link with high efficiency.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Analysis of biological tissues in infant chest for the development of an equivalent radiographic phantom

Purpose: The main purpose of the present study was to determine the amounts of different tissues in the chest of the newborn patient (age {<=}1 year), with the aim of developing a homogeneous phantom chest equivalent. This type of phantom is indispensable in the development of optimization procedures for radiographic techniques, including dosimetric control, which is a crucial aspect of pediatric radiology. The authors present a systematic set of procedures, including a computational algorithm, to estimate the amounts of tissues and thicknesses of the corresponding simulator material plates used to construct the phantom. Methods: The Gaussian fit of computed tomographic (CT) analysis was applied to classify and quantify different biological tissues. The methodology is summarized with a computational algorithm, which was used to quantify tissues through automated CT analysis. The thicknesses of the equivalent homogeneous simulator material plates were determined to construct the phantom. Results: A total of 180 retrospective CT examinations with anterior-posterior diameter values ranging 8.5-13.0 cm were examined. The amounts of different tissues were evaluated. The results provided elements to construct a phantom to simulate the infant chest in the posterior-anterior or anterior-posterior (PA/AP) view. Conclusions: To our knowledge, this report represents the first demonstration of an infant chest phantom dedicated to the radiology of children younger than one year. This phantom is a key element in the development of clinical charts for optimizing radiographic technique in pediatric patients. Optimization procedures for nonstandard patients were reported previously [Pina et al., Phys. Med. Biol. 49, N215-N226 (2004) and Pina et al., Appl. Radiat. Isot. 67, 61-69 (2009)]. The constructed phantom represents a starting point to obtain radiologic protocols for the infant patient.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

SU-E-J-216: A Sequence Independent Approach for Quantification of MR Image Deformations From Brachytherapy Applicators

Purpose: MRI is increasingly used as a single imaging modality for brachytherapy treatment planning. The presence of a brachytherapy applicator may cause distortions in the images, especially at higher field strengths. Our aim is to develop a procedure to quantify these distortions theoretically for any MR-sequence and to verify the estimated deformations for clinical sequences. Methods: Image distortions due to perturbation of the B0-field are proportional to the ratio of the induced frequency shift and the read-out bandwidth of the applied sequence. By reconstructing a frequency-shift map from the phase data from a multi-echo sequence, distortions can be calculated for any MR-sequence. Verification of this method for estimating distortions was performed by acquiring images with opposing read-out directions and consequently opposing distortions. The applicator shift can be determined by rigidly matching these images. Clinically, T2W-TSE-images are used for this purpose. For pre-clinical tests, EPI-sequences with narrow read-out bandwidth (19.5–47.5Hz), consequently large distortions, were added to the set of clinical MRsequences. To quantify deformations of the Utrecht Interstitial CT/MR applicator (Elekta Brachytherapy) on a Philips Ingenia 3T MRI, pre-clinical tests were performed in a phantom with the applicator in water, followed by clinical validation. Results: Deformations observed in the narrow bandwidth EPI-images were well predicted using the frequency-shift, the latter giving an overestimation up to 30%/up to 1 voxel. For clinically applied MR-sequences distortions were well below the voxel size. In patient setup distortions determined from the frequency-shift map were at sub-voxel level (<0.7mm). Using T2W-images larger distortions were found (1–2mm). This discrepancy was caused by patient movement between/during acquisition of the T2W-images with opposing read-out directions. Conclusion: Phantom experiments demonstrated the feasibility of a clinical procedure for quantification of MR-image distortions for any MR-sequence. In a clinical set-up the distortions from a Utrecht interstitial CT/MR applicator are sub-voxel level. This work was partially funded by Elekta Brachytherpy.

60 APPLIED LIFE SCIENCES↗

Modeling quasi-lattice with octagonal symmetry

We prove the possibility to use the method of modeling of a quasi-lattice with octagonal symmetry similar to that proposed earlier for the decagonal quasicrystal. The method is based on the multiplication of the groups of basis sites according to specified rules. This model is shown to be equivalent to the method of the periodic lattice projection, but is simpler because it considers merely two-dimensional site groups. The application of the proposed modeling procedure to the reciprocal lattice of octagonal quasicrystals shows a fairly good matching with the electron diffraction pattern. Similarly to the decagonal quasicrystals, the possibility of three-index labeling of the diffraction reflections is exhibited in this case. Moreover, the ascertained ratio of indices provides information on the intensity of diffraction reflections.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Development of Treatment Process for Radioactive Wastewater Generated from Molybdenum-99 Study - 16415

Molybdenum-99 (Mo-99) high acidic waste solution was securely stored at INER for numerous years. Until 2004, the procedures of waste solution draw-out and pressure-release were accompanied, along with construction of treatment facilities. In 2009, after simulated solution and small volume Mo-99 waste solution tests, the treatment procedure was determined. Then batch-scale treatment facilities were set up. The waste solution was preserved using the instrument, along with modification of some facilities simultaneously. Ultimately all of 12 tanks of Mo-99 inorganic waste solution stored in Building 014 were finished on July, 2012. And residential 5 tanks of those solution served in Building 015B were also completed on September, 2014. A practicable process has been developed for treating radioactive waste generated from Mo-99 study, and it can effectively remove radionuclides from a nitric acid solution. At first, after the waste was sucked from the bucket, the pH value was adjusted to about 10.0 through acid-alkali neutralization. Then, an adsorbent of natural zeolite powder was added to adsorb nuclides, and two adsorption columns filled with Cs-treat and Sr-treat adsorbents were used for removing nuclear species of Cs-137 and Sr-90. In this step, the nuclear species of Cs-137 and Sr-90 contained in the liquid waste are significantly reduced to a degree for manual operation allowable. Then, nitrate ion and mercury ion were removed through another procedure. As a result, the operations were safer and more efficient than other conventional methods. Additionally, the hazard of accidental leakage caused by corrosion of the bucket after long period of storage can be effectively prevented and potential pollution threats are also eliminated. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Development of a core coolant flow distribution calculation code for HTGRs - 18484

In order to ensure the thermal integrity of fuel in high temperature gas-cooled reactors (HTGRs), it is necessary that the maximum fuel temperature in the normal operation is to be lower than the thermal design target. In the core thermal-hydraulic design of block-type HTGRs, the maximum fuel temperature should be evaluated considering data such as thermal power, core geometry, power and neutron fluence distributions, and core coolant flow distribution. The core coolant flow distribution calculation code used in the design stage of High Temperature engineering Test Reactor (HTTR) presupposes to run on UNIX systems, and its operation and execution procedure are complicated and not user-friendly. Therefore, a new core coolant flow distribution calculation code with a user-friendly system such as simple and easy operations and execution procedures has been developed. In this paper, the outline of the new code is described and the simulation result of an out-of-pile test with one fuel column are shown as the first step of the code validation. The simulation results provide good agreement with the test one. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗