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At least 361 records · Page 20

Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification

Abstract Aim Lipoprotein(a) [Lp(a)] is a potential causal factor in the pathogenesis of aortic valve disease. However, the relationship of Lp(a) with new onset and progression of aortic valve calcium (AVC) has not been studied. The purpose of the study was to assess whether high serum levels of Lp(a) are associated with AVC incidence and progression. Methods and results A total of 922 individuals from the population-based Rotterdam Study (mean age 66.0±4.2 years, 47.7% men), whose Lp(a) measurements were available, underwent non-enhanced cardiac computed tomography imaging at baseline and after a median follow-up of 14.0 [interquartile range (IQR) 13.9–14.2] years. New-onset AVC was defined as an AVC score >0 on the follow-up scan in the absence of AVC on the first scan. Progression was defined as the absolute difference in AVC score between the baseline and follow-up scan. Logistic and linear regression analyses were performed to evaluate the relationship of Lp(a) with baseline, new onset, and progression of AVC. All analyses were corrected for age, sex, body mass index, smoking, hypertension, dyslipidaemia, and creatinine. AVC progression was analysed conditional on baseline AVC score expressed as restricted cubic splines. Of the 702 individuals without AVC at baseline, 415 (59.1%) developed new-onset AVC on the follow-up scan. In those with baseline AVC, median annual progression was 13.5 (IQR = 5.2–37.8) Agatston units (AU). Lipoprotein(a) concentration was independently associated with baseline AVC [odds ratio (OR) 1.43 for each 50 mg/dL higher Lp(a); 95% confidence interval (CI) 1.15–1.79] and new-onset AVC (OR 1.30 for each 50 mg/dL higher Lp(a); 95% CI 1.02–1.65), but not with AVC progression (β: −71 AU for each 50 mg/dL higher Lp(a); 95% CI −117; 35). Only baseline AVC score was significantly associated with AVC progression (P < 0.001). Conclusion In the population-based Rotterdam Study, Lp(a) is robustly associated with baseline and new-onset AVC but not with AVC progression, suggesting that Lp(a)-lowering interventions may be most effective in pre-calcific stages of aortic valve disease.

Kaiser, Yannick (ORCID:0000000168690042)↗

Incorporating Valve Switching Losses Into a Static Optimal Control Algorithm for the Hybrid Hydraulic-Electric Architecture (HHEA)

The Hybrid Hydraulic-Electric Architecture (HHEA) has, in recent years, been proposed as an energy efficient alternative to conventional load-sensing architectures in mobile machines such as excavators and wheel-loaders. HHEA leverages the advantages of hydraulic power and electric power to eliminate throttling valves while also improving the energy and control performance of the system. The architecture utilizes a set of common pressure rails to provide a majority of power and and a small electric motor driven pump to modulate this power to meet the exact demand. Previous work has developed a computationally efficient Lagrange Multiplier approach for determining the optimal pressure rail selections that minimizes the energy losses in the system. The static model used considers only the energy use for each pressure rail selection but not the losses associated with the valves during the transition. This paper presents an approach to include the switching losses in the model and in the optimization procedure. To capture the switching losses, switching events between different rails and at various input and output flow rates were simulated with consideration of valve spool dynamics. A parameterized model that summarizes the losses is then obtained, allowing switching losses to be added to the previous energy analysis. The performance of the switching loss model was compared with reference data obtained from a high-fidelity simulation model. To incorporate the switching losses into optimal control algorithm, an efficient dynamic programming approach that prevents frequent switching is adopted in place of the Lagrange multiplier approach. The overall effect of switching losses on the energy consumption and optimal control decisions is presented. In general, switching losses contribute to about 9–10% of input energy.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Impact of Effective Compression Ratio on Gasoline-Diesel Dual-Fuel Combustion in a Heavy-Duty Engine Using Variable Valve Actuation

Dual-fuel combustion using port-injected gasoline with a direct diesel injection has been shown to achieve low-temperature combustion with moderate peak pressure rise rates, low engine-out soot and NOx emissions, and high indicated thermal efficiency. A key requirement for extending high-load operation is moderating the reactivity of the premixed charge prior to the diesel injection. Reducing compression ratio, in conjunction with a higher expansion ratio using alternative valve timings, decreases compressed charge reactivity while maintain a high expansion ratio for maximum work extraction. Experimental testing was conducted on a 13L multi-cylinder heavy-duty diesel engine modified to operate dual-fuel combustion with port gasoline injection to supplement the direct diesel injection. The engine employs intake variable valve actuation (VVA) for early (EIVC) or late (LIVC) intake valve closing to yield reduced effective compression ratio. Testing was conducted at a mid-load operating condition using a gasoline-diesel dual-fuel operating strategy. The impact on dual-fuel engine performance and emissions with respect to varying effective compression ratio is quantified within this study. As effective compression ratio is reduced, overall massflow through the engine decreases, yielding both higher gas exchange efficiencies and increased heat transfer losses. With constant combustion phasing gasoline/diesel fueling fraction, and NOx emissions held constant, overall brake thermal efficiency remains relatively constant across effective compression ratios.

Ickes, Andrew↗

Improved fluid control valve extends diaphragm life

Wear resistance of flexible diaphragms in fluid control valves is increased by incorporating a soft rubber washer at the bottom of the piston, a flexible buffer between the diaphragm and the valve seat, and a fluid feedback arrangement. The stress and wear of components at the valve seat are minimized.

Mac Glashan, W. F.↗

One-shot valve may be remotely actuated

One-shot valve, with spring-loaded plunger and sealing diaphragm, incorporates an emergency release actuated by a remote sensor. The plunger is released by the electrical melting of a fuse link and pierces the valve seal. The valve lowers fluid pressure in a container without losing the contained fluid.

Kami, S.↗

In-tank shutoff valve is provided with maximum blast protection

In-tank shutoff valve is installed with the valve poppet and actuator inside the tank to provide maximum blast protection during rocket engine test operation. This valve design is applicable wherever explosive fuels are used and is currently being used in lox and liquid hydrogen tanks at a rocket engine test site.

Holden, C. F.↗

Fuel and oxidizer valve assembly employs single solenoid actuator

Valve assembly simultaneously starts or stops the flow of oxidizer and fuel from separate inlet channels to reaction control motors. The assembly combines an oxidizer shutoff valve and a fuel shutoff valve which are mechanically linked and operated by a single high-speed solenoid actuator.

Source record↗

Actuator device schedules rate of valve closure

Prevalve actuator schedules the closure rate of a valve. The actuator is spring loaded to produce a normally open valve and pneumatically powered to close the valve. The closure rate is controlled by means of pneumatic snubber and booster circuitry.

Source record↗

Aspirator increases relief valve poppet stroke

Addition of an aspirator to a relief valve increases the valve poppet stroke under dynamic flow conditions. The aspirator allows poppet inlet dynamic forces to overcome relief valve spring force. It reduces the fluid pressure in the skirt cavity by providing a low pressure sense probe.

Biddle, M. E.↗

Remotely operated high pressure valve protects test personnel

High pressure valve used in testing certain spacecraft systems is safely opened and closed by a remotely stationed operator. The valve is self-regulating in that if the incoming pressure drops below a desired value the valve will automatically close, warning the operator that the testing pressure has dropped to an undesired level.

Howland, B. T.↗

Solenoid valve performance characteristics studied

Current and voltage waveforms of a solenoid coil are recorded as the valve opens and closes. Analysis of the waveforms with respect to time and the phase of the valve cycle accurately describes valve performance.

Abe, J. T.↗

Pilot-booster control valve

Two-stage, pressure-sensing control valve is designed for servocontrol of 10-inch main tank valve regulating pressure of liquid oxygen in tank and serving to vent tank during filling. Valve uses a negative-rate Belleville spring to cancel positive spring rates of bellows and coil springs.

Marley, D.↗

Low-noise flow valve for air ducts

Valve assembly controls air flow from feeder into main duct, with minimum of turbulence, friction, pressure differential, and noise. Valve consists of damper, deflector, and spring. Streamlining of damper and deflector merges flow smoothly, while spring keeps damper and deflector in contact and eliminates valve chatter and damping vibrations.

Gallo, E. A.↗

Chatter-free check valve - A concept

Valve head moves in spiral motion away from seat. Motion is controlled by travel of pin along spiral groove in valve guide. Clearances between pin and groove permit free motion of valve, but effectively dampen vibration and chattering.

Dunbar, J. E.↗

Ultrathin gate valve for high vacuum operation

Thin, compact, high-vacuum gate valve used to join two vacuum systems together demonstrates multiple operation reliability. Valve measurements and non-protruding handle make valve usable in confined areas.

Ugiansky, R. J.↗