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At least 361 records · Page 20

TU-F-CAMPUS-J-01: A Formulation of 4D Treatment Planning for Tumour Tracking Volumetric Modulated Arc Therapy for Lung Cancer

Purpose: To develop a formulation for 4D treatment planning for a tumour tracking volumetric modulated arc therapy treatment (VMAT) plan for lung cancer. Methods: A VMAT plan was optimized based on a reference phase of the 4DCT of a lung cancer patient. The PTV was generated from the GTV of the reference phase. The collimator angle was set to 90 degrees such that the MLC travels along superior-inferior direction which is the main component of movement of a lung tumour. Then, each control point of the VMAT plan was assigned to a particular phase of the 4DCT in chronological order. The MLC positions of each control point were shifted according to the position of the tumour centroid of its assigned phase to form a tumour tracking VMAT plan. The control points of the same phase were grouped to form a pseudo VMAT plan for that particular phase. Dose calculation was performed for each pseudo VMAT plan on the corresponding phase of the 4DCT. The CTs of all phases were registered to the reference phase CT according to the displacement of the tumour centroid. The individual dose distributions of the pseudo VMAT plans were summed up and displayed on the reference phase of the 4DCT. A control VMAT plan was optimized based on a PTV generated from the ITV of all phases and compared with the tumour tracking VMAT plan. Results: Both plans achieved >95% volume coverage at the prescription dose level (96% for the tumour tracking plan and 97% for the control plan). But the normal lung volume irradiated at the prescription dose level was 39% less for the tumour tracking plan than the control plan. Conclusion: A formulation of 4D treatment planning for tumour tracking VMAT plans for lung cancer was developed.

60 APPLIED LIFE SCIENCES↗

SU-G-BRA-02: Development of a Learning Based Block Matching Algorithm for Ultrasound Tracking in Radiotherapy

Purpose: To develop an ultrasound learning-based tracking algorithm with the potential to provide real-time motion traces of anatomy-based fiducials that may aid in the effective delivery of external beam radiation. Methods: The algorithm was developed in Matlab R2015a and consists of two main stages: reference frame selection, and localized block matching. Immediately following frame acquisition, a normalized cross-correlation (NCC) similarity metric is used to determine a reference frame most similar to the current frame from a series of training set images that were acquired during a pretreatment scan. Segmented features in the reference frame provide the basis for the localized block matching to determine the feature locations in the current frame. The boundary points of the reference frame segmentation are used as the initial locations for the block matching and NCC is used to find the most similar block in the current frame. The best matched block locations in the current frame comprise the updated feature boundary. The algorithm was tested using five features from two sets of ultrasound patient data obtained from MICCAI 2014 CLUST. Due to the lack of a training set associated with the image sequences, the first 200 frames of the image sets were considered a valid training set for preliminary testing, and tracking was performed over the remaining frames. Results: Tracking of the five vessel features resulted in an average tracking error of 1.21 mm relative to predefined annotations. The average analysis rate was 15.7 FPS with analysis for one of the two patients reaching real-time speeds. Computations were performed on an i5-3230M at 2.60 GHz. Conclusion: Preliminary tests show tracking errors comparable with similar algorithms at close to real-time speeds. Extension of the work onto a GPU platform has the potential to achieve real-time performance, making tracking for therapy applications a feasible option. This work is partially funded by NIH grant R01CA190298.

60 APPLIED LIFE SCIENCES↗

SU-G-BRA-16: Target Dose Comparison for Dynamic MLC Tracking and Mid- Ventilation Planning in Lung Radiotherapy Subject to Intrafractional Baseline Drifts

Purpose: Lung tumor motion during radiotherapy can be accounted for by expanded treatment margins, for example using a mid-ventilation planning approach, or by localizing the tumor in real-time and adapting the treatment beam with multileaf collimator (MLC) tracking. This study evaluates the effect of intrafractional changes in the average tumor position (baseline drifts) on these two treatment techniques. Methods: Lung stereotactic treatment plans (9-beam IMRT, 54Gy/3 fractions, mean treatment time: 9.63min) were generated for three patients: either for delivery with MLC tracking (isotropic GTV-to-PTV margin: 2.6mm) or planned with a mid-ventilation approach and delivered without online motion compensation (GTV-to-PTV margin: 4.4-6.3mm). Delivery to a breathing patient was simulated using DynaTrack, our in-house tracking and delivery software. Baseline drifts in cranial and posterior direction were simulated at a rate of 0.5, 1.0 or 1.5mm/min. For dose reconstruction, the corresponding 4DCT phase was selected for each time point of the delivery. Baseline drifts were accounted for by rigidly shifting the CT to ensure correct relative beam-to-target positioning. Afterwards, the doses delivered to each 4DCT phase were accumulated deformably on the mid-ventilation phase using research RayStation v4.6 and dose coverage of the GTV was evaluated. Results: When using the mid-ventilation planning approach, dose coverage of the tumor deteriorated substantially in the presence of baseline drifts. The reduction in D98% coverage of the GTV in a single fraction ranged from 0.4-1.2, 0.6-3.3 and 4.5-6.2Gy, respectively, for the different drift rates. With MLC tracking the GTV D98% coverage remained unchanged (+/− 0.1Gy) regardless of drift. Conclusion: Intrafractional baseline drifts reduce the tumor dose in treatments based on mid-ventilation planning. In rare, large target baseline drifts tumor dose coverage may drop below the prescription, potentially affecting clinical outcome in hypofractionated treatment protocols. Dynamic MLC tracking preserves tumor dose coverage even in the presence of extreme baseline drifts. We acknowledge financial and technical support of the MLC tracking research from Elekta AB. Research at ICR is supported by CRUK under Programme C33589/A19727 and NHS funding to the NIHR Biomedical Research Centre at RMH and ICR. MFF is supported by CRUK under Programme C33589/A19908.

60 APPLIED LIFE SCIENCES↗

SU-G-JeP1-09: Evaluation of Transperineal Ultrasound Imaging as a Potential Solution for Target Tracking During Ablative Body Radiotherapy for Prostate Cancer

Purpose: Prostate SABR is emerging as a clinically viable, potentially cost effective alternative to prostate IMRT but its adoption is contingent on providing solutions for accurate tracking during beam delivery. Our goal is to evaluate the performance of the Clarity Autoscan ultrasound monitoring system for inter-fractional prostate motion tracking in both phantoms and in-vivo. Methods: In-vivo evaluation was performed under IRB protocol to allow data collection in prostate patients treated with VMAT whereby prostate was imaged through the acoustic window of the perineum. The probe was placed before KV imaging and real-time tracking was started and continued until the end of treatment. Initial absolute 3D positions of fiducials were estimated from KV images. Fiducial positions in MV images subsequently acquired during beam delivery were compared with predicted positions based on Clarity estimated motion. Results: Phantom studies with motion amplitudes of ±1.5, ±3, ±6 mm in lateral direction and ±2 mm in longitudinal direction resulted in tracking errors of −0.03 ± 0.3, −0.04 ± 0.6, −0.2 ± 0.9 mm, respectively, in lateral direction and −0.05 ± 0.30 mm in longitudinal direction. In phantom, measured and predicted fiducial positions in MV images were within 0.1 ± 0.6 mm. Four patients consented to participate in the study and data was acquired over a total of 140 fractions. MV imaging tracking was possible in about 75% of the time (due to occlusion of fiducials) compared to 100% with Clarity. Overall range of estimated motion by Clarity was 0 to 4.0 mm. In-vivo fiducial localization error was 1.2 ± 1.0 mm compared to 1.8 ± 1.9 mm if not taking Clarity estimated motion into account. Conclusion: Real-time transperineal ultrasound tracking reduces uncertainty in prostate position due to intrafractional motion. Research was supported by Elekta.

60 APPLIED LIFE SCIENCES↗

Performance of a geometric deep learning pipeline for HL-LHC particle tracking

The Exa.TrkX project has applied geometric learning concepts such as metric learning and graph neural networks to HEP particle tracking. Exa.TrkX’s tracking pipeline groups detector measurements to form track candidates and filters them. The pipeline, originally developed using the TrackML dataset (a simulation of an LHC-inspired tracking detector), has been demonstrated on other detectors, including DUNE Liquid Argon TPC and CMS High-Granularity Calorimeter. This paper documents new developments needed to study the physics and computing performance of the Exa.TrkX pipeline on the full TrackML dataset, a first step towards validating the pipeline using ATLAS and CMS data. The pipeline achieves tracking efficiency and purity similar to production tracking algorithms. Crucially for future HEP applications, the pipeline benefits significantly from GPU acceleration, and its computational requirements scale close to linearly with the number of particles in the event.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Performance of the reconstruction of large impact parameter tracks in the inner detector of ATLAS

Searches for long-lived particles (LLPs) are among the most promising avenues for discovering physics beyond the Standard Model at the Large Hadron Collider (LHC). However, displaced signatures are notoriously difficult to identify due to their ability to evade standard object reconstruction strategies. In particular, the ATLAS track reconstruction applies strict pointing requirements which limit sensitivity to charged particles originating far from the primary interaction point. To recover efficiency for LLPs decaying within the tracking detector volume, the ATLAS Collaboration employs a dedicated large-radius tracking (LRT) pass with loosened pointing requirements. During Run 2 of the LHC, the LRT implementation produced many incorrectly reconstructed tracks and was therefore only deployed in small subsets of events. In preparation for LHC Run 3, ATLAS has significantly improved both standard and large-radius track reconstruction performance, allowing for LRT to run in all events. This development greatly expands the potential phase-space of LLP searches and streamlines LLP analysis workflows. This paper will highlight the above achievement and report on the readiness of the ATLAS detector for track-based LLP searches in Run 3.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Patterns of Precipitation Change and Climatological Uncertainty among CMIP5 Models, with a Focus on the Midlatitude Pacific Storm Track

Projections of modeled precipitation ( P ) change in global warming scenarios demonstrate marked intermodel disagreement at regional scales. Empirical orthogonal functions (EOFs) and maximum covariance analysis (MCA) are used to diagnose spatial patterns of disagreement in the simulated climatology and end-of-century P changes in phase 5 of the Coupled Model Intercomparison Project (CMIP5) archive. The term principal uncertainty pattern (PUP) is used for any robust mode calculated when applying these techniques to a multimodel ensemble. For selected domains in the tropics, leading PUPs highlight features at the margins of convection zones and in the Pacific cold tongue. The midlatitude Pacific storm track is emphasized given its relevance to wintertime P projections over western North America. The first storm-track PUP identifies a sensitive region of disagreement in P increases over the eastern midlatitude Pacific where the storm track terminates, related to uncertainty in an eastward extension of the climatological jet. The second PUP portrays uncertainty in a zonally asymmetric meridional shift of storm-track P , related to uncertainty in the extent of a poleward jet shift in the western Pacific. Both of these modes appear to arise primarily from intermodel differences in the response to radiative forcing, distinct from sampling of internal variability. The leading storm-track PUPs for P and zonal wind change exhibit similarities to the leading uncertainty patterns for the historical climatology, indicating important and parallel sensitivities in the eastern Pacific storm-track terminus region. However, expansion coefficients for climatological uncertainties tend to be weakly correlated with those for end-of-century change.

54 ENVIRONMENTAL SCIENCES↗

High Bacterial Diversity of Biological Soil Crusts in Water Tracks over Permafrost in the High Arctic Polar Desert

In this paper we report the bacterial diversity of biological soil crusts (biocrusts) inhabiting polar desert soils at the northern land limit of the Arctic polar region (83° 05 N). Employing pyrosequencing of bacterial 16S rRNA genes this study demonstrated that these biocrusts harbor diverse bacterial communities, often as diverse as temperate latitude communities. The effect of wetting pulses on the composition of communities was also determined by collecting samples from soils outside and inside of permafrost water tracks, hill slope flow paths that drain permafrost-affected soils. The intermittent flow regime in the water tracks was correlated with altered relative abundance of phylum level taxonomic bins in the bacterial communities, but the alterations varied between individual sampling sites. Bacteria related to the Cyanobacteria and Acidobacteria demonstrated shifts in relative abundance based on their location either inside or outside of the water tracks. Among cyanobacterial sequences, the proportion of sequences belonging to the family Oscillatoriales consistently increased in relative abundance in the samples from inside the water tracks compared to those outside. Acidobacteria showed responses to wetting pulses in the water tracks, increasing in abundance at one site and decreasing at the other two sites. Subdivision 4 acidobacterial sequences tended to follow the trends in the total Acidobacteria relative abundance, suggesting these organisms were largely responsible for the changes observed in the Acidobacteria. Finally, taken together, these data suggest that the bacterial communities of these high latitude polar biocrusts are diverse but do not show a consensus response to intermittent flow in water tracks over high Arctic permafrost.

59 BASIC BIOLOGICAL SCIENCES↗

Tracking Provenance in ORNL's Flexible Research Platforms

Provenance is dened as information about the origin of objects, a concept that applies to both physical and digital objects and often overlaps both. The use of provenance in systems designed for research is an important but forgotten feature. Provenance allows for proper and exact tracking of information, its use, its lineage, its derivations and other metadata that are important for correctly adhering to the scien- tic method. In our project's prescribed use of provenance, researchers can determine detailed information about the use of sensor data in their experiments on ORNL's Flexible Research Platforms (FRPs). Our project's provenance system, Provenance Data Management System (ProvDMS), tracks information starting with the creation of information by an FRP sensor. The system determines station information, sensor information, and sensor channel information. The system allows researchers to derive generations of experiments from the sensor data and tracks their hierarchical flow. Key points can be seen in the history of the information as part of the information's workflow. The concept of provenance and its usage in science is relatively new and while used in other cases around the world, our project's provenance diers in a key area. To keep track of provenance, most systems must be designed or redesigned around the new provenance system. Our system is designed as a cohesive but sepa- rate entity and allows for researchers to continue using their own methods of analysis without being constrained in their ways in order to track the provenance. We have designed ProvDMS using a lightweight provenance library, Core Provenance Library (CPL) v.6 In addition to keeping track of sensor data experiments and its provenance, ProvDMS also provides a web-enabled visualization of the inheritance.

provenance↗

Alignment of the straw tracking detectors for the Fermilab Muon $g − 2$ experiment and systematic studies for a muon electric dipole moment measurement

The Fermilab Muon $g-2$ experiment is currently preparing for its fourth data-taking period (Run-4). The experiment-wide effort on the analysis of Run-1 data is nearing completion, with the announcement of the first result expected in the coming months. The final goal of the experiment is to determine the muon magnetic anomaly to a precision of 140 ppb. This level of precision will provide indirect evidence of new physics, if the central value agrees with the previously-measured value of the magnetic anomaly. Essential in reducing the systematic uncertainty, through measurements of the muon beam profile, are the in-vacuum straw tracking detectors. A crucial prerequisite in obtaining accurate distributions of the beam profile is the internal alignment of the tracking detectors, which is described in this thesis. As a result of this position calibration, the tracking efficiency has increased by 3%, while the track quality increased by 4%. This thesis also discusses an additional measurement that will be made using the tracking detectors: a search for an electric dipole moment (EDM) of the muon, through the direct detection of an oscillation in the average vertical angle of the electron from the muon decay. An observation of a muon EDM would be evidencemore » of new physics and would provide a new source of CP violation in the charged lepton sector. Essential in measuring the EDM are accurate and precise estimations of potential non-zero radial and longitudinal magnetic fields, which were estimated using the Run-1 data. In addition, a preliminary analysis using the Run-1 data was undertaken to estimate the available precision for the magnetic anomaly measurement using the tracking detectors.« less

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

A Novel Spatio-Temporal Regime Tracking Method for Impact Simulations

In this proposal, we present a novel method of tracking the rheological regimes activated during impact cratering events that will allow researchers to gain new insights into cratering mechanics. Rheology describes the stress-strain response of rocks to different conditions. Planetary impact cratering events often occur on too large of a scale to be feasibly captured in controlled experiments. Instead, these dynamic events are primarily studied using multi-physics codes equipped with complex material models that enable calculations of the impact event at scale. However, determining which physical processes are required for the problem of interest is challenging. Because the dominant rheological regimes change with space and time during crater formation, it is difficult to link numerical simulations with observable features of craters at the end of the event. The basis of this work is the implementation of numerical flags that track the activation of each rheological regime throughout impact simulations. We demonstrate this with the ‘Rock Model’ implemented in the CTH shock-physics code. We will use this rheology tracking method to ’zoom in’ on a specific region within an event and track the conditions the rock experiences over time. This work will develop community benchmarks to validate and distribute our implemented rheological models. We will focus on improving the melt models used by the planetary impact modeling community by developing an EOS-aware rheological transition from solid to melt. Through analysis of cell and tracer-particle based tracking data, we will study the effects of different rheologies on modeled outcomes, particularly on the volume and distributions of impacts melts. We will also use this method to link observable features with the rheological mechanisms responsible for them. The deliverables (peer-reviewed papers) from the proposed work are (i) tests of the implemented rheologic processes and demonstrations of the tracking flags; (ii) the first calculations of the spatio-temporal evolution of the dominant rheologies during impact cratering events; and (iii) application to delivery of impactor iron during basin-scale impacts.

58 GEOSCIENCES↗

NMF-Based Anomaly Detection in CMS 2D Tracking Occupancy Histograms

The CMS experiment relies on Data Quality Monitoring (DQM) to ensure that recorded collision data are suitable for physics analysis. During LHC Run 3, each run contains many lumisections and tracking monitoring elements, making offline inspection challenging, especially for localized detector effects that may appear only for short periods of time. This poster presents an unsupervised machine-learning approach to identify anomalous lumisections in CMS tracking occupancy histograms using Non-Negative Matrix Factorization (NMF). The workflow uses offline CMS DQMIO tracking histograms retrieved with the CMS DIALS API and organized as two-dimensional occupancy maps for each lumisection. After selecting stable lumisections, the occupancy maps are normalized and arranged into a non-negative data matrix. The NMF model learns a compact set of basis patterns describing normal tracking occupancy. Each lumisection is then reconstructed from these learned components, and the reconstruction error is used as an anomaly score. Large residuals indicate occupancy patterns that deviate from normal detector behavior and are flagged for further inspection. This NMF-based approach provides a fast and interpretable way to flag lumisections whose tracking occupancy patterns differ from normal detector behavior. Preliminary studies show sensitivity to known tracking anomalies, and ongoing work is focused on validating the method across additional Run 3 Pixel and Strip detector issues.

Rodríguez Ramos, Iliomar [Puerto Rico U., Mayaguez↗

Design, Selection, and Evaluation of Reinforcement Learning Single Agents for Ground Target Tracking

Previous approaches for small fixed-wing unmanned air systems that carry strapdown rather than gimbaled cameras achieved satisfactory ground target tracking performance using both standard and deep reinforcement learning algorithms. However, these approaches have significant restrictions and abstractions to the dynamics of the vehicle, such as constant airspeed and constant altitude, because the number of states and actions was necessarily limited. Thus, extensive tuning was required to obtain good tracking performance. The expansion from 4 state–action degrees of freedom to 15 enabled the agent to exploit previous reward functions that produced novel yet undesirable emergent behavior. This paper investigates the causes of and various potential solutions to undesirable emergent behavior in the ground target tracking problem. A combination of changes to the environment, reward structure, action space simplification, command rate, and controller implementation provides insight into obtaining stable tracking results. Consideration is given to reward structure selection and refinement to mitigate undesirable emergent behavior. Results presented in the paper for a simulated environment of a single unmanned air system tracking a randomly moving single ground target show that a soft actor–critic algorithm can produce feasible tracking trajectories without limiting the state space and action space, provided that the environment is properly posed.

Engineering↗

Congruent and spurious motion in the learning and performance of a compensatory tracking task.

Examination of the importance of congruent and spurious yaw motion in compensatory tracking by eight airline pilots. The pilots, seated erect in the Ames man-carrying rotation device(MCRD), tracked with k/s+1 and k/s(s+1) vehicle dynamics in fixed- and moving-base simulation. Following the learning phase of the experiment, five levels of spurious angular acceleration were superimposed on the motion of the MCRD. Learning of the tracking task was found to be a function of both vehicle dynamics and mode of simulation. The presence of congruent motion information reduced learningtime in k/s(s+1) vehicle dynamics and resulted in lower tracking error in both vehicle dynamics. The spurious angular accelerations resulted in an increase in pilot tracking error; however, the relationship between the magnitude of the acceleration and its effect was highly complex. The data suggest that the minimal disturbance level for spurious angular accelerations during tracking is below 0.4 degec.

Guercio, J. G.↗

On the nature of the radial and cross track errors for artificial earth satellites

The analysis of the radial and cross track errors of artificial earth satellites is discussed in terms of the interference of two one-dimensional celestial mechanical wave trains. Resulting equations for these tracking errors describe the behavior of the uncertainties in the orbital parameters as oscillatory in nature, with a rapidly oscillating term, which is a function of the sum of the observed and computed orbital frequencies, modulated in amplitude by a slowly varying oscillation. This latter term is itself a function of either the difference between these orbital frequencies or between the values of the computed and observed right ascensions, depending upon whether it is the radial or cross track case under consideration. These results indicate that the cross track calculation describes the behavior of uncertainties in the right ascension of the ascending node and the inclination, while the radial calculation gives information on uncertainties in the semi-major axis, the eccentricity, and the argument of perigee. In addition, expressions for the radial and cross track oscillatory frequencies are obtained in terms of the orbital frequencies of the satellites. Data show that the time average of the radial and cross track errors in any case, will both approach zero.

Bonavito, N. L.↗

GEOS-3 Doppler difference tracking

The Doppler difference method as applied to track the GEOS 3 spacecraft is discussed. In this method a pair of 2 GHz ground tracking stations simultaneously track a spacecraft beacon to generate an observable signal in which bias and instability of the carrier frequency cancel. The baselines are formed by the tracking sites at Bermuda, Rosman, and Merritt Island. Measurements were made to evaluate the effectiveness of the Doppler differencing procedure in tracking a beacon target with the high dynamic rate of the GEOS 3 orbit. Results indicate the precision of the differenced data to be at a level comparable to the conventional precise two way Doppler tracking.

Rosenbaum, B.↗

The fission track record of Apennine Front KREEP basalts

Whitlockite grains in two Apennine Front KREEP soil fragments contain extremely high densities of fission tracks. A new method is described in which particle tracks are examined in an actinide-poor phase bordering an actinide-rich whitlockite phase. This method clearly distinguishes the fission track contributions from other track sources; e.g., Fe-group cosmic rays, spallation recoils, and dislocations. Observed track excesses, when corrected for U- and Th-related fission sources, are 4-20 times greater than the contribution from spontaneous fission of U-238 (based on an age of 4 b.y.), and probably represent a large and variable contribution from the fission of Pu-244. These fragments may have pre-Imbrium ages, underscoring the importance of KREEP as a constituent of the pre-mare lunar crust. Track excesses are not correlated with the U or Th contents of the whitlockite grains. This behavior suggests that Pu fractionates differently from U and Th in lunar igneous KREEP.

Haines, E. L.↗

Capturing and tracking performance of the horizontal guidance and control systems of the terminal configured vehicle

A twin-jet commercial transport equipped with digital navigation, guidance, and control systems and advanced electronic display system was used for airborne operational research. The results of flight tests which evaluated a second-order horizontal-path guidance control law and the autopilot and airplane response are presented. This evaluation was accomplished through analysis of recorded flight data and through pilot opinion of the airplane maneuvers during automatic path-capture scenarios and path tracking. Four different path captures were flown at a ground speed of approximately 160 knots and repeated at approximately 300 knots. Path tracking tracking error was measured in terms of cross track error along two paths: one pat at cruise speeds and one at airport-terminal-area speeds. The path tracking accuracy and the smoothness of the airplane maneuvers were judged satisfactory for high speeds; however, at lower speeds the control law design should be improved so that tracking will be more accurate for operations in the airport terminal area.

Knox, C. E.↗