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At least 361 records · Page 20

SU-E-T-259: Development of a Primary Standard for LDR Brachytherapy

Purpose: The National Research Council initiated a program in 2012 to develop a primary standard to calibrate I-125 and Pd-103 sources used for LDR brachytherapy and disseminate this through calibration services to Canadian users. This will simplify procedures as Canadian cancer centres currently have to ship instruments to the US. Methods: The standard is based on a commercial version of the wide-angle free air chamber (WAFAC) pioneered by NIST. Significant enhancements were implemented to improve signal-to-noise and measurement reproducibility and eliminate electric field effects. Validation of this ionization chamber was then carried out in a low-energy X -ray beam (∼ 31 keV) where the dose rate had been previously established using the existing NRC primary standard free-air chamber. As a final component of this initial testing, measurements were made with a set of I-125 seeds (with air kerma strength traceable to NIST). Results: Excellent agreement of the two NRC free-air chambers was obtained within the combined standard uncertainty of 0.5 %. However, it was found that the WAFAC response is very sensitive to the beam geometry (distance from the source, diameter of the beam-defining aperture, etc) and Monte Carlo calculations, carried out to evaluate these geometry corrections, have confirmed the experimental results. The results for the seed measurements indicated a precision of better than 1 % is achievable for a reasonable acquisition time and the air kerma strength agreed with the manufacturer (NIST-traceable) value within 2 %. Conclusion: The prototype primary standard for LDR brachytherapy has met accuracy target of 3 % for the determination of air kerma strength. Work is ongoing to refine operation of the device and develop the calibration protocol for clinical users, with an anticipated launch of a calibration service in late 2015.

60 APPLIED LIFE SCIENCES↗

Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments

In the search for effective immunologic interventions to prevent and treat HIV-1 infection, standardized reference reagents are a cost-effective way to maintain robustness and reproducibility among immunological assays. To support planned and ongoing studies where clade C predominates, here we describe three virus panels, chosen from 200 well-characterized clade C envelope (Env)-pseudotyped viruses from early infection. All 200 Envs were expressed as a single round of replication pseudoviruses and were tested to quantify neutralization titers by 16 broadly neutralizing antibodies (bnAbs) and sera from 30 subjects with chronic clade C infections. We selected large panels of 50 and 100 Envs either to characterize cross-reactive breadth for sera identified as having potent neutralization activity based on initial screening or to evaluate neutralization magnitude-breadth distributions of newly isolated antibodies. We identified these panels by downselection after hierarchical clustering of bnAb neutralization titers. The resulting panels represent the diversity of neutralization profiles throughout the range of virus sensitivities identified in the original panel of 200 viruses. A small 12-Env panel was chosen to screen sera from vaccine trials or natural-infection studies for neutralization responses. We considered panels selected by previously described methods but favored a computationally informed method that enabled selection of viruses representing diverse neutralization sensitivity patterns, given that we do not a priori know what the neutralization-response profile of vaccine sera will be relative to that of sera from infected individuals. The resulting 12-Env panel complements existing panels. Use of standardized panels enables direct comparisons of data from different trials and study sites testing HIV-1 clade C-specific products. HIV-1 group M includes nine clades and many recombinants. Clade C is the most common lineage, responsible for roughly half of current HIV-1 infections, and is a focus for vaccine design and testing. Standard reference reagents, particularly virus panels to study neutralization by antibodies, are crucial for developing cost-effective and yet rigorous and reproducible assays against diverse examples of this variable virus. We developed clade C-specific panels for use as standardized reagents to monitor complex polyclonal sera for neutralization activity and to characterize the potency and breadth of cross-reactive neutralization by monoclonal antibodies, whether engineered or isolated from infected individuals. We chose from 200 southern African, clade C envelope-pseudotyped viruses with neutralization titers against 16 broadly neutralizing antibodies and 30 sera from chronic clade C infections. We selected panels to represent the diversity of bnAb neutralization profiles and Env neutralization sensitivities. Finally, use of standard virus panels can facilitate comparison of results across studies and sites.

59 BASIC BIOLOGICAL SCIENCES↗

The Standard Model from String Theory: What Have We Learned?

Amid all candidates of physics beyond the Standard Model, string theory provides a unique proposal for incorporating gauge and gravitational interactions. In string theory, a four-dimensional theory that unifies quantum mechanics and gravity is obtained automatically if one posits that the additional dimensions predicted by the theory are small and curled up—a concept known as compactification. The gauge sector of the theory is specified by the topology and geometry of the extra dimensions, and the challenge is to reproduce all of the features of the Standard Model of particle physics from them. We review the state of the art in reproducing the Standard Model from string compactifications and summarize the lessons drawn from this fascinating quest. We describe novel scenarios and mechanisms that string theory provides to address some of the Standard Model puzzles as well as the most frequent signatures of new physics that could be detected in future experiments. We then comment on recent developments that connect, in a rather unexpected way, the Standard Model with quantum gravity and that may change our field theory notion of naturalness.

Physics↗

Internal Standards for Quantitative Analysis of Chemical Warfare Agents by the GC/MS Method: Nerve Agents

General conditions and requirements for an internal standard useful in the determination of chemical warfare agents (CWAs) by the method of gas chromatography coupled with mass detection (GC/MS) were defined. The determination is based on a GC/MS analysis of a mixture of a CWA with an internal standard, conversion of the TIC chromatogram to a chromatogram extracted at a particular m / z ratio, and calculation of the CWA concentration from the internal standard concentration, response factor, and chromatographic peak areas. Available internal standards were identified, and they were verified for seven organophosphorus nerve-paralysing agents. Corresponding response factors were determined as a ratio of gradients of the linear functions of the peak area and compound concentration. Linearity, repeatability, and accuracy of the measurements were evaluated. The determination can be performed on all GC/MS systems of the Fire Rescue Service of the Czech Republic (FRS), where no CWA standards are available.

Capoun, Tomas↗

BSDF Data generation for daylight applications: A call for international standardization

Standardized methods for generating angle-dependent, bidirectional, solar-optical properties for complex fenestration systems do not exist, which means that energy and daylight evaluations in building performance simulations often suffer from major inaccuracies. This position paper provides an overview of state-of-the-art data-driven methods for characterizing light scattering properties of fenestration materials and blind systems (e.g. fabrics, metal slats, patterned glazing), validation via laboratory, simulation and field tests, and salient issues in support of standardization of such methods via the International Standardization Organization (ISO). The ISO standard is intended to provide the fundamental underpinnings for recently mandated daylight standards that rely on bidirectional scattering distribution function data for climate-based daylight modelling and building performance simulations.

Geisler-Moroder, D.↗

Review of footnotes and annotations to the 1949–2013 tables of standard atomic weights and tables of isotopic compositions of the elements (IUPAC Technical Report)

Abstract The Commission on Isotopic Abundances and Atomic Weights uses annotations given in footnotes that are an integral part of the Tables of Standard Atomic Weights to alert users to the possibilities of quite extraordinary occurrences, as well as sources with abnormal atomic-weight values outside an otherwise acceptable range. The basic need for footnotes to the Standard Atomic Weights Table and equivalent annotations to the Table of Isotopic Compositions of the Elements arises from the necessity to provide users with information that is relevant to one or more elements, but that cannot be provided using numerical data in columns. Any desire to increase additional information conveyed by annotations to these Tables is tempered by the need to preserve a compact format and a style that can alert users, who would not be inclined to consult either the last full element-by-element review or the full text of a current Standard Atomic Weights of the Elements report. Since 1989, the footnotes of the Tables of Standard Atomic Weights and the annotations in column 5 of the Table of Isotopic Compositions of the Elements have been harmonized by use of three lowercase footnotes, “g”, “m”, and “r”, that signify geologically exceptionally specimens (“g”), modified isotopic compositions in material subjected to undisclosed or inadvertent isotopic fractionation (“m”), and the range in isotopic composition of normal terrestrial material prevents more precise atomic-weight value being given (“r”). As some elements are assigned intervals for their standard atomic-weight values (applies to 12 elements since 2009), footnotes “g” and “r” are no longer needed for these elements.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Standard atomic weights of the elements 2021 (IUPAC Technical Report)

Following the reviews of atomic-weight determinations and other cognate data in 2015, 2017, 2019 and 2021, the IUPAC (International Union of Pure and Applied Chemistry) Commission on Isotopic Abundances and Atomic Weights (CIAAW) reports changes of standard atomic weights. The symbol A r°(E) was selected for standard atomic weight of an element to distinguish it from the atomic weight of an element E in a specific substance P, designated A r(E, P). The CIAAW has changed the values of the standard atomic weights of five elements based on recent determinations of terrestrial isotopic abundances. The standard atomic weight of argon and lead have changed to an interval to reflect that the natural variation in isotopic composition exceeds the measurement uncertainty of A r(Ar) and A r(Pb) in a specific substance. The standard atomic weights and/or the uncertainties of fourteen elements have been changed based on the Atomic Mass Evaluations 2016 and 2020 accomplished under the auspices of the International Union of Pure and Applied Physics (IUPAP). A r° of Ho, Tb, Tm and Y were changed in 2017 and again updated in 2021.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Controlling for Survey Effort Is Worth the Effort: Comparing Bottlenose Dolphin ( Tursiops truncatus ) Habitat Use Between Standardized and Opportunistic Photographic-Identification Surveys

Although opportunistic data collected from wildlife ecotours can provide useful information on marine mammal distribution and behavior, concerns exist about whether resultant analyses have diminished accuracy due to spatial bias. To address these concerns, this study compared common bottlenose dolphin ( Tursiops truncatus ) habitat use results derived from standardized boat-based photographic-identification surveys and opportunistic photographic-identification surveys conducted during wildlife ecotours in Roanoke Sound, North Carolina. The main objectives of this study were to (1) identify areas of importance to dolphins, (2) identify activities (feed, mill, social, and travel) most often observed in these areas, and (3) determine the consistency of habitat use results between standardized and opportunistic surveys. Standardized survey hot spots for feeding and travel were located in southern Roanoke Sound according to the hot spot (Getis-Ord Gi*) spatial statistic. Conversely, opportunistic survey hot spots for feeding and travel were detected in central Roanoke Sound near the wildlife ecotour launch site. Opportunistic survey effort was concentrated around the ecotour launch site which introduced spatial bias by overestimating dolphin density in this area. These hot spot location differences between survey methods indicate that opportunistic survey results are affected by spatial bias which can lead to inaccurate conclusions about dolphin habitat use. Hot spot results of standardized data without survey effort supported the conclusion that spatial bias affected opportunistic habitat use results. Furthermore this study provides a direct comparison of standardized and opportunistic datasets and demonstrates the importance of controlling for survey effort when examining marine mammal distribution and habitat use.

59 BASIC BIOLOGICAL SCIENCES↗

Developing Performance Cost Index Targets for ASHRAE Standard 90.1 Appendix G – Performance Rating Method

Appendix G, the Performance Rating Method in ASHRAE Standard 90.1 has been updated to make two significant changes for the 2016 edition, to be published in October of 2016. First, it allows Appendix G to be used as a third path for compliance with the standard in addition to rating beyond code building performance. This prevents modelers from having to develop separate building models for code compliance and beyond code programs. Using this new version of Appendix G to show compliance with the 2016 edition of the standard, the proposed building design needs to have a performance cost index (PCI) less than targets shown in a new table based on building type and climate zone. The second change is that the baseline design is now fixed at a stable level of performance set approximately equal to the 2004 code. Rather than changing the stringency of the baseline with each subsequent edition of the standard, compliance with new editions will simply require a reduced PCI (a PCI of zero is a net-zero building). Using this approach, buildings of any era can be rated using the same method. The intent is that any building energy code or beyond code program can use this methodology and merely set the appropriate PCI target for their needs. This report discusses the process used to set performance criteria for compliance with ASHRAE Standard 90.1-2016 and suggests a method for demonstrating compliance with other codes and beyond code programs.

99 GENERAL AND MISCELLANEOUS↗

Developing Performance Cost Index Targets for ASHRAE Standard 90.1 Appendix G – Performance Rating Method - Rev.1

Appendix G, the Performance Rating Method in ASHRAE Standard 90.1 has been updated to make two significant changes for the 2016 edition, to be published in October of 2016. First, it allows Appendix G to be used as a third path for compliance with the standard in addition to rating beyond code building performance. This prevents modelers from having to develop separate building models for code compliance and beyond code programs. Using this new version of Appendix G to show compliance with the 2016 edition of the standard, the proposed building design needs to have a performance cost index (PCI) less than targets shown in a new table based on building type and climate zone. The second change is that the baseline design is now fixed at a stable level of performance set approximately equal to the 2004 code. Rather than changing the stringency of the baseline with each subsequent edition of the standard, compliance with new editions will simply require a reduced PCI (a PCI of zero is a net-zero building). Using this approach, buildings of any era can be rated using the same method. The intent is that any building energy code or beyond code program can use this methodology and merely set the appropriate PCI target for their needs. This report discusses the process used to set performance criteria for compliance with ASHRAE Standard 90.1-2016 and suggests a method for demonstrating compliance with other codes and beyond code programs.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Prospective Evaluation of the Energy and CO 2 Emissions Impact of China’s 2010 – 2013 Efficiency Standards for Products

Since China introduced its first mandatory minimum energy performance standards (MEPS) for eight major household products in 1989, its MEPS program has expanded significantly to cover nearly 60 residential, industrial and commercial products. In June of 2012, the pace of standards development for new and revised standards was further accelerated with the launch of the national “100 Energy Efficiency Standards.” Initiatives. An unprecedented 21 MEPS were adopted by China from 2012 to 2013, compared to only 7 MEPS adopted from 2010 to 2011. The Chinese MEPS program now covers 15 products in the residential sector, 15 types of commercial and office equipment, 14 types of industrial equipment and 13 lighting products, making it one of the most comprehensive MEPS program in the world. This study provides an updated prospective evaluation of the potential energy and CO 2 impact of 23 of the 28 MEPS adopted by China from 2010 to 2013. This study updates a previous analysis (Zhou et al. 2011) by quantifying the additional potential energy and CO 2 reductions from the newest standards that have been adopted since 2010. The most recent actual and projected sales, usage, and efficiency data were collected for 14 product categories covered under 23 MEPS adopted between 2010 and 2013. Three scenarios are then used to quantify the energy and CO 2 reduction potential of the one-time implementation of these 23 MEPS, including a baseline counterfactual scenario, the actual MEPS scenario and a best available technologies efficiency scenario. The setting of the baseline efficiency is crucial to determining the savings potential of the new and revised MEPS and international best available technology efficiency levels, as it reflects the market average in the absence of MEPS. For this study, the average baseline is based on either the reported 2010 market-average efficiency if sales-weighted efficiency data is available for new product MEPS and selected products with revised MEPS, or the minimum efficiency requirement of the previous MEPS for products with revised MEPS from 2010 to 2013 that do not have sales-weighted efficiency data. Using sales-weighted efficiency data for the baseline help capture market transformation that has already occurred prior to the implementation of the MEPS, and can better differentiate the savings that are attributable to MEPS. The efficiency levels of best available technologies are taken from recent reviews of international commercially available best available technologies.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

ANSI/ASHRAE/IES Standard 90.1-2016 Performance Rating Method Reference Manual

This document is intended to be a reference manual for the Appendix G Performance Rating Method (PRM) of ANSI/ASHRAE/IES Standard 90.1-2016 (Standard 90.1-2016). The PRM can be used to demonstrate compliance with the standard and to rate the energy efficiency of commercial and high-rise residential buildings with designs that exceed the requirements of Standard 90.1. Use of the PRM for demonstrating compliance with Standard 90.1 is a new feature of the 2016 edition. The procedures and processes described in this manual are designed to provide consistency and accuracy by filling in gaps and providing additional details needed by users of the PRM.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Lattice Gauge Theories Within and Beyond the Standard Model

The Standard Model of particle physics has been very successful in describing fundamental interactions up to the highest energies currently probed in particle accelerator experiments. However, the Standard Model is incomplete and currently exhibits tension with experimental data for interactions involving $B$~mesons. Consequently, $B$-meson physics is of great interest to both experimentalists and theorists. Experimentalists worldwide are studying the decay and mixing processes of $B$~mesons in particle accelerators. Theorists are working to understand the data by employing lattice gauge theories within and beyond the Standard Model. This work addresses the theoretical effort and is divided into two main parts. In the first part, I present a lattice-QCD calculation of form factors for exclusive semileptonic decays of $B$~mesons that are mediated by both charged currents ($B \to \pi \ell \nu$, $B_s \to K \ell \nu$) and neutral currents ($B \to \pi \ell^+ \ell^-$, $B \to K \ell ^+ \ell^-$). The results are important for constraining or revealing physics beyond the Standard Model. This work uses MILC's (2+1+1)-flavor ensembles, with the HISQ action for the up, down, strange, and charm sea and valence quarks, and the clover action in the Fermilab interpretation for the $b$~quark. Simulations are carried out on five ensembles at three lattice spacings down to $\approx 0.088$~fm, with both physical and unphysical sea-quark masses. I present results for correlation-function fits and describe the chiral-continuum extrapolation and $z$~expansion of the form factors. In the second part, I present the status of an ongoing lattice calculation of $SU(3)$ gauge theory with eight and 12 fundamental fermions, in which I search for the endpoint of the line of first-order phase transitions in the mass--coupling plane. The results are important for understanding the phase diagram of these models, with possible applications to physics beyond the Standard Model. This work uses the staggered action and the nHYP-improved stagge! red action for the fermions, as well as the Wilson action in the fundamental and fundamental--adjoint representations for the gauge bosons. With the unimproved actions, I present results for a small lattice and describe the ongoing effort on larger lattices. I also discuss the shift symmetry on lattices with and without improved actions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Assessment of Applicability of Standards Endorsed by Regulatory Guides to Sodium Fast Reactors

The benefits of the use of voluntary consensus standards and industry standards is evident in the design and licensing of the current generation of nuclear power plants. The use of voluntary consensus standards and industry standards would be helpful in the design and licensing of advanced reactors to improve the effectiveness and efficiency of the licensing and regulation of non-LWR technologies. Most of the regulations, guidance, and standards applicable to nuclear power plants were developed for water-cooled plants, so they may not adequately address the coolants, materials, temperatures, operations, testing, maintenance, etc., proposed for advanced reactors.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Update of ASHRAE Standard 140 Section 5.2 and Related Sections (BESTEST Building Thermal Fabric Test Cases)

This report documents new work intended to update the current building thermal fabric software-to-software comparative test specifications and example results of ANSI/ASHRAE Standard 140-2017, Sections 5.2.1, 5.2.2, 5.2.3, and related supporting sections. The Building Energy Simulation Test and Diagnostic Method (BESTEST) test specification and example results that provide the basis for these Standard 140 sections were originally published in 1995. The state of the art in building energy simulation modeling has advanced since then. Additionally, comments on the test specification over the years highlighted ambiguities, further necessitating the update to the original work. This new work was conducted for the U.S. Department of Energy (DOE) by Argonne National Laboratory (Argonne) and National Renewable Energy Laboratory (NREL), in collaboration with a working group of international experts associated with the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) Standing Standard Project Committee (SSPC) 140. SSPC 140 is responsible for ANSI/ASHRAE Standard 140. The new work, presented in this report, defined the test cases and specifications such that building energy simulation programs with time steps of one hour or less can perform the tests. Revisions to the test specification and update of example results follow the vetting process of iterative field trials established for previous BESTEST work that has been adapted for ASHRAE Standard 140.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Development of an international security standard for devices containing high-activity radioactive sources

Radioisotopes such as Cs-137 and Co-60 are utilized in various medical, industrial, and research applications. This radiological material can be a theft or sabotage target, which necessitates a certain level of security to adequately protect it. The presented work will explore the necessity of an international security standard for devices used in clinical settings that contain high activity radiological material and the facilities that contain these devices. This standard intends to complement existing safety standards; however, it serves a very different purpose: to reduce the threat of radiological theft and sabotage while taking into full consideration the effect on the patient, user safety, and patient workflow with the aim to minimize the unwanted effects of the security measures. The proposed standard will complement existing International Atomic Energy Agency (IAEA) guidance, published in the IAEA Nuclear Security Series. While those documents primarily focus on the state, competent authorities, and regulatory agencies, the proposed industry standard will involve device manufacturers, source producers, and medical staff.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

PMK 1000 cone-socket ventilator fittings force testing to ISO 5356-1:2015 Standard

This memo summarizes the results of verification tests on a cone-socket fitting to the ISO 5356-1:2015 standard, annexes B and F. The components were found to meet requirements holding 50N tensile force and more than 35 N-cm of torque for 10 seconds without separating at 35°C with a fresh socket. Humidity control was unavailable; consequently, humidity was significantly lower than the values in the ISO standard. Several repeat tests of the fitting with force, torque, and time excursions give us confidence that the fittings perform suitably to the ISO standard. Force overload tests suggest that the samples will disengage under tension at around 69 N, while torque overload tests under a force of 50 N will fail at 79 N-cm of torque. If repeated tests are performed on the same component, the socket can deform and lead to the connection failing the standard requirements. However, such failures only occur with repeated testing, and the gripping of such units can be modified so that they pass the standard. This observation demonstrates that socket gripping is responsible for those failures and would not be a problem in application.

42 ENGINEERING↗

Distributed Energy Resource Cybersecurity Standards Development [Final Report]

Currently, the solar industry is operating with little application-specific guidance on how to protect and defend their systems from cyberattacks. This 3-year Department of Energy (DOE) Solar Energy Technologies Office-funded project helped advance the distributed energy resource (DER) cybersecurity state-of-the-art by (a) bolstering industry awareness of cybersecurity concepts, risks, and solutions through a webinar series and (b) developing recommendations for DER cybersecurity standards to improve the security performance of DER products and networks. Drafting DER standards is a lengthy, consensus-based process requiring effective leadership and stakeholder participation. This project was designed to reduce standard and guide writing times by creating well-researched recommendations that could act as a starting place for national and international standards development organizations. Working within the SunSpec/Sandia DER Cybersecurity Workgroup, the team produced guidance for DER cybersecurity certification, communication protocol standards, network architecture s, access control, and patching. The team also led subgroups within the IEEE P 1547.3 Guide for Cybersecurity of Distributed Energy Resources Interconnected with Electric Power Systems committee and pushed a draft to ballot in October 2021.

14 SOLAR ENERGY↗