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At least 361 records · Page 20

Medical Updates Number 5 to the International Space Station Probability Risk Assessment (PRA) Model Using the Integrated Medical Model

The Integrated Medical Model (IMM) Project has been developing a probabilistic risk assessment tool, the IMM, to help evaluate in-flight crew health needs and impacts to the mission due to medical events. This package is a follow-up to a data package provided in June 2009. The IMM currently represents 83 medical conditions and associated ISS resources required to mitigate medical events. IMM end state forecasts relevant to the ISS PRA model include evacuation (EVAC) and loss of crew life (LOCL). The current version of the IMM provides the basis for the operational version of IMM expected in the January 2011 timeframe. The objectives of this data package are: 1. To provide a preliminary understanding of medical risk data used to update the ISS PRA Model. The IMM has had limited validation and an initial characterization of maturity has been completed using NASA STD 7009 Standard for Models and Simulation. The IMM has been internally validated by IMM personnel but has not been validated by an independent body external to the IMM Project. 2. To support a continued dialogue between the ISS PRA and IMM teams. To ensure accurate data interpretation, and that IMM output format and content meets the needs of the ISS Risk Management Office and ISS PRA Model, periodic discussions are anticipated between the risk teams. 3. To help assess the differences between the current ISS PRA and IMM medical risk forecasts of EVAC and LOCL. Follow-on activities are anticipated based on the differences between the current ISS PRA medical risk data and the latest medical risk data produced by IMM.

Butler, Doug↗

International Space Station Lithium-Ion Battery

The International Space Station (ISS) primary Electric Power System (EPS) currently uses Nickel-Hydrogen (Ni-H2) batteries to store electrical energy. The electricity for the space station is generated by its solar arrays, which charge batteries during insolation for subsequent discharge during eclipse. The Ni-H2 batteries are designed to operate at a 35 depth of discharge (DOD) maximum during normal operation in a Low Earth Orbit. Since the oldest of the 48 Ni-H2 battery Orbital Replacement Units (ORUs) has been cycling since September 2006, these batteries are now approaching their end of useful life. In 2010, the ISS Program began the development of Lithium-Ion (Li-Ion) batteries to replace the Ni-H2 batteries and concurrently funded a Li-Ion ORU and cell life testing project. When deployed, they will be the largest Li-Ion batteries ever utilized for a human-rated spacecraft. This paper will include an overview of the ISS Li-Ion battery system architecture, the Li-Ion battery design and development, controls to limit potential hazards from the batteries, and the status of the Li-Ion cell and ORU life cycle testing.

battery↗

Microbial Characteristics of ISS Environmental Surfaces

The microbiome of environmental surfaces from the International Space Station were characterized in order to examine the relationship to crew and hardware maintenance. The Microbial Observatory (ISS-MO) experiment generated a microbial census of ISS environments using advanced molecular microbial community analyses along with traditional culture-based methods. Since the “omics” methodologies generated an extensive microbial census, significant insights into spaceflight-induced changes in the populations of beneficial and/or potentially harmful microbes were gained. Surface samples were collected from several ISS surface locations from three flight opportunities, and were returned to Earth via the Soyuz TMA-14M or the Space X Dragon capsule. In addition to cultivation methods, viable microbial burden, iTag-based sequencing, and metagenome analyses were carried out. The cultivable microbial bioburden differed by location and sampling event. Exploring the ISS environmental microbiome revealed presence of opportunistic pathogens and antibiotic resistant microbes. Genes involved in ATP binding cassette transporters, two component systems, and beta-lactam resistance were among a diverse set of metabolic and genetic information processing pathways. Whole genome sequencing (WGS) of 50 ISS strains exhibiting resistance to various antibiotics was carried out. The antibiotic resistant genes deduced from the WGS were compared with the resistomes generated directly from the gene pool of the environmental samples. Two unique Aspergillus fumigatus strains isolated from the ISS were characterized and compared to the experimentally established clinical isolates Af293 and CEA10. A virulence assessment in a neutrophil-deficient larval zebrafish model of invasive aspergillosis indicated that both ISSFT-021 and IF1SW-F4 were significantly more lethal compared to Af293 and CEA10. The findings from this Environmental “Omics” project should be exploited to enhance human health and well-being of a closed system. In other words, the ISS-MO research aims to "translate" findings in fundamental research into medical practice (pathogen detection) and meaningful health outcomes (countermeasure development).

Perry, Jay↗

Large-Scale Spacecraft Fire Safety Tests

An international collaborative program is underway to address open issues in spacecraft fire safety. Because of limited access to long-term low-gravity conditions and the small volume generally allotted for these experiments, there have been relatively few experiments that directly study spacecraft fire safety under low-gravity conditions. Furthermore, none of these experiments have studied sample sizes and environment conditions typical of those expected in a spacecraft fire. The major constraint has been the size of the sample, with prior experiments limited to samples of the order of 10 cm in length and width or smaller. This lack of experimental data forces spacecraft designers to base their designs and safety precautions on 1-g understanding of flame spread, fire detection, and suppression. However, low-gravity combustion research has demonstrated substantial differences in flame behavior in low-gravity. This, combined with the differences caused by the confined spacecraft environment, necessitates practical scale spacecraft fire safety research to mitigate risks for future space missions. To address this issue, a large-scale spacecraft fire experiment is under development by NASA and an international team of investigators. This poster presents the objectives, status, and concept of this collaborative international project (Saffire). The project plan is to conduct fire safety experiments on three sequential flights of an unmanned ISS re-supply spacecraft (the Orbital Cygnus vehicle) after they have completed their delivery of cargo to the ISS and have begun their return journeys to earth. On two flights (Saffire-1 and Saffire-3), the experiment will consist of a flame spread test involving a meter-scale sample ignited in the pressurized volume of the spacecraft and allowed to burn to completion while measurements are made. On one of the flights (Saffire-2), 9 smaller (5 x 30 cm) samples will be tested to evaluate NASAs material flammability screening tests. The first flight (Saffire-1) is scheduled for July 2015 with the other two following at six-month intervals. A computer modeling effort will complement the experimental effort. Although the experiment will need to meet rigorous safety requirements to ensure the carrier vehicle does not sustain damage, the absence of a crew removes the need for strict containment of combustion products. This will facilitate the first examination of fire behavior on a scale that is relevant to spacecraft fire safety and will provide unique data for fire model validation.

Combustion↗

Demonstrating Autonomous Mission Operations Onboard the International Space Station

The NASA Autonomous Mission Operations (AMO) project conducted an experiment to turn over operation and management of selected International Space Station (ISS) sys- tems to the on-board crew. ISS crews managed two different spacecraft systems: the Total Organic Carbon Analyzer (TOCA), a water quality analyzer, and Station Support Com- puters (SSC) laptops, which are non-critical crew computer systems. These systems were selected because they are representative of systems a future crew may need to operate au- tonomously during a deep space mission. The crew autonomously operated these systems, taking on mission operations functions traditionally performed by support teams on the ground, using new software tools that provide decision support algorithms for planning, monitoring and fault management, hardware schematics, system briefs, and data displays that are normally unavailable to the crew. The experiment lasted seven months, during which ISS crews managed TOCA and SSCs on 22 occasions. The AMO software processed data from TOCA and SSCs continuously during this seven month period. The combined performance of the software and crew achieved a 88 success rate on managing TOCA activity, the system for which ground-truth was available.

Autonomous Mission Operations↗

ECLSS Evolution

Environmental Control and Life Support Systems (ECLSS) Evolution is comprised of a large portfolio of projects funded by the Mars Campaign Office (MCO) and is focused on the following: - Utilize ISS as a testbed to determine and refine ECLSS gaps - Develop technologies to close ECLSS gaps - Improve performance and reliability of ECLS systems - Prove out integrated system in relevant environment for long duration - Test representative system on ground to increase overall data set

ECLSS↗

Content and Representation of Information Needed to Support Time-Constrained Problem Solving

NASA’s current mission-operations paradigm originated with Project Mercury and endured with minimum evolution through the Apollo Program, Space Shuttle Program, and ISS missions. At its foundation is a near-complete real-time dependence on a ground team to manage the combined state of the mission, vehicle, and crew. Utilizing many engineers and operators with broad and deep expertise; large, distributed datasets including extensive telemetry; and expansive analytical and computing power, this ground team has served as the safety net for crewed spaceflight missions over the past 60 years. This approach must change to address challenges associated with missions beyond low Earth orbit (BLEO), including infrequent resupply, reduced ability to evacuate, and delayed communications that prohibit real-time operational support. We anticipate that a necessary part of this change will be increased independence for the crew, as roles and responsibilities traditionally performed by ground teams move on board the vehicle. While many risks are associated with Earth-independent operations, one particular concern is ensuring that the crew will have adequate onboard support to perform urgent problem solving when communication with the ground is delayed or intermittent. A key resource that enables the ground team to respond to anomalies quickly and effectively is the extraordinary expertise and experience it possesses. It is comprised of 80+ experts on at any given time, with a combined 600+ years of system-specific experience across 22 unique console disciplines. A small crew will face the unprecedented challenge of independently responding to anomalies that have historically been handled by a team 20 times their size. Another important resource upon which the ground heavily relies to support procedure execution and anomaly response is data. The amount of telemetry data that each flight controller monitors is extensive. In addition, as the ground team works to further assess impacts, trouble shoot, identify workarounds, and oversee procedure execution, it accesses and synthesizes engineering and procedure information, as well as system build, test, and configuration documentation. It is not feasible nor useful to put all these data onboard as crews become more Earth independent. Each member of a small Mars mission small crew will have multiple roles beyond monitoring telemetry and data gathering, and multiple roles within anomaly resolution processes, thereby limiting their capacity for copious amounts of information. Moreover, while access is necessary, it alone is insufficient. Information will need to be compiled, refined, and represented appropriately to support the crew’s reduced attention and expertise. This work seeks to understand the content and representation of information needed to support time-constrained problem solving and decision making by the crew without real-time ground support. To build this understanding, we first surveyed the literature, focusing on how expert problem solvers construct and manipulate their mental models. Next, we interviewed expert problem solvers in spaceflight and analogous domains and surveyed industry solutions for data presentation. Finally, we analyzed current spaceflight operations by investigating flight controller anomaly resolution processes during ISS training simulations and real operational events. These methods led to creating a problem-solving framework that details common themes and features of attending to, assessing, analyzing, and acting on problems in complex, time-constrained domains. Using this framework and the results of our analysis, we identified conceptual data representations needed for crew-led problem-solving. Preliminary onboard user interface concepts to meet identified needs will be presented.

anomaly response↗

ISS and Space Shuttle Radiation Measurements at Solar Minimum

A summary of 2008-2011 ISS and Space Shuttle radiation dosimetry results for inside vehicle radiation monitoring in low-Earth orbit will be presented. Results include new data from ISS Expedition 22-25/20A radiation area monitors (RAM) and Shuttle Missions STS127-STS133 passive radiation dosimeters (PRD). ISS 20A radiation measurement locations included three Node 2 crew quarters locations at NOD2S5_CQ, NOD2P5_CQ and CQ-3 (Deck), as well as ESA Columbus, and JAXA Kibo locations. ISS 20A and STS127-STS133 missions were flown at 51.6 inclination with an altitude range of 330-350 km. The passive radiation results will be presented in terms of measured daily dose obtained using luminescence detectors (i.e., Al2O3:C, LiF:Mg,Ti and CaF2:Tm). In addition, preliminary results from the DOSIS 2 Project, in collaboration with the German Space Agency (DLR) will be presented. SRAG s participation to the DOSIS 2 exposure on ISS (11/16/2009-05/26/2010) involved passive radiation measurements at 10 different shielding locations inside the ESA Columbus Module.

Gaza, Ramona↗

Gene and MicroRNA Expression Profile Changes in ISS Crewmembers’ Blood Samples

In space, living organisms are exposed to multiple stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. This study is part of the Functional Immune Project, intended to determine alterations in crewmember immunobiology before, during, and after spaceflight. It emphasizes the study of DNA damage in the ISS crewmembers’ peripheral blood mononuclear cells (PBMCs), expression patterns of damage-response and inflammatory process genes, and changes in latent virus reactivation biomarkers.

Moreno-Villanueva, Maria↗

ASK Talks with Dennis Grounds

Dennis Grounds recently finished a one-year assignment at NASA Headquarters in the Office of Bioastronautics as the Acting Flight Program Manager He has returned to Johnson Space Center (JSC), where he is Director of the International Space Station Bioastronautics Research Program Office with the NASA Life Sciences Projects Division. Under his management, the Human Research Facility (HRF) was developed to support a broad range of scientific investigations pertaining to human adaptation to the spaceflight environment and issues of human space exploration. The HRF rack was developed to international standards in order to be compatible with payloads developed anywhere in the world, thereby streamlining the process of getting payloads on the Space Station. Grounds has worked with NASA for more than 15 years. Prior to joining ISS, he worked with General Electric as a manager of payloads and analysis in support of the NASA Life Science Projects Division at JSC. ASK spoke with Grounds in Washington, D.C., during his Headquarters assignment.

Source record↗

NASA's In Space Manufacturing Initiatives: Conquering the Challenges of In-Space Manufacturing

Current maintenance logistics strategy will not be effective for deep space exploration missions. ISM (In Space Manufacturing) offers the potential to: Significantly reduce maintenance logistics mass requirements; Enable the use of recycled materials and in-situ resources for more dramatic reductions in mass requirements; Enable flexibility, giving systems a broad capability to adapt to unanticipated circumstances; Mitigate risks that are not covered by current approaches to maintainability. Multiple projects are underway currently to develop and validate these capabilities for infusion into ISM exploration systems. ISS is a critical testbed for demonstrating ISM technologies, proving out these capabilities, and performing operational validation of deep space ISM applications. Developing and testing FabLab is a major milestone for springboard to DSG/Cis-lunar Space applications. ISM is a necessary paradigm shift in space operations – design for repair culture must be embraced. ISM team needs to be working with exploration system designers now to identify high-value application areas and influence design.

Clinton, R. G., Jr.↗

Development and Flammability Testing of Magnesium Alloys for Space Applications

This project will be comparing the flammability of select lightweight Mg alloys for use in a simulated ISS environment. It will also be determining the factors that influence flammability of selected alloys in elevated oxygen, including the formation of an oxide layer. The significance of this work is that such alloys can reduce weight saving by up to 30%. This work is adding to knowledge base of lightweight Mg alloys for possible future applications, as no previous flammability testing of Mg alloys have been conducted at elevated oxygen concentrations.

International Space Station↗

Development of the Continuous-Fill Brine Evaporation Bag (BEB) System

The existing water recovery system on the International Space Station (ISS) is limited to 70 percent reclamation; consequently, long duration space missions are currently unfeasible due to the large quantity of water necessary to sustain the crew. The Brine Evaporation Bag (BEB) is a proposed system to supplement the existing water recovery system aboard the ISS and future deep space missions that can increase water recovery to 99 percent. The BEB project previously focused on the development of only the bag portion of the system. This paper focuses on the development of the BEB Evaporator. It will discuss the work to understand, optimize, and improve the entire BEB system while implementing a continuous-fill process. The results of that development and the advantages and limitations of the continuous-fill process will be presented.

Water Recovery↗

Development of the Auto-Fill Brine Evaporation Bag (BEB) System

The existing water recovery system on the International Space Station (ISS) is limited to 70 percent reclamation; consequently, long duration space missions are currently unfeasible due to the large quantity of water necessary to sustain the crew. The Brine Evaporation Bag (BEB) is a proposed system to supplement the existing water recovery system aboard the ISS and future deep space missions that can increase water recovery to 99 percent. The BEB project previously focused on the development of only the bag portion of the system. This paper focuses on the development of the BEB Evaporator. It will discuss the work to understand, optimize, and improve the entire BEB system while implementing a continuous-fill process. The results of that development and the advantages and limitations of the continuous-fill process will be presented.

Delzeit, Lance↗

Comparison of the Integrated Medical Model Predictions to Real World ISS and STS Observations

The Human Research Program funded the development of the integrated medical model (IMM) to quantify the medical component of overall mission risk. The IMM uses Monte Carlo methodology to integrate space flight and ground medical data to assess the probability of mission medical outcomes and resource utilization. To determine the credibility of IMM output the IMM project team completed two validation studies that compare IMM output to observed medical events from a selection of Shuttle Transportation System (STS) and International Space Station (ISS) missions.

validation↗

Development of the Miniature Total Organic Carbon Analyzer

Monitoring the Total Organic Carbon (TOC) in spacecraft potable water will be of major importance in long-duration human space exploration. In-flight analysis of potable water produced from a regenerative water processor provides immediate feedback on the quality of reclaimed water for crew health as well as water processing system health monitoring. This paper updates the progress in development of the next generation Total Organic Carbon Analyzer (TOCA) designed for the unique requirements of an exploration-class mission. The current objective is to design, build, certify, deliver, and operate a TOCA technology demonstration on the International Space Station (ISS). The next generation analyzer system technology was previously developed and selected among a feasibility study of other options. The new system provides primary advantages of reduced mass and volume through reduced system complexity and reduced need for consumables; therefore, the flight project is named MiniTOCA. The project has recently completed design of the tech demo instrument and assembled and tested a flight-like engineering development unit. The engineering unit has undergone performance testing and environmental testing which provides confidence for the project to move forward with flight unit production and certification activities. Test results are summarized in this paper. The flight unit is targeted for delivery to ISS in late 2025.

TOC↗

Development of the Miniature Total Organic Carbon Analyzer

Monitoring the Total Organic Carbon (TOC) in spacecraft potable water will be of major importance in long-duration human space exploration. In-flight analysis of potable water produced from a regenerative water processor provides immediate feedback on the quality of reclaimed water for crew health as well as water processing system health monitoring. This paper updates the progress in development of the next generation Total Organic Carbon Analyzer (TOCA) designed for the unique requirements of an exploration-class mission. The current objective is to design, build, certify, deliver, and operate a TOCA technology demonstration on the International Space Station (ISS). The next generation analyzer system technology was previously developed and selected among a feasibility study of other options. The new system provides primary advantages of reduced mass and volume through reduced system complexity and reduced need for consumables; therefore, the flight project is named MiniTOCA. The project has recently completed design of the tech demo instrument and assembled and tested a flight-like engineering development unit. The engineering unit has undergone performance testing and environmental testing which provides confidence for the project to move forward with flight unit production and certification activities. Test results are summarized in this paper. The flight unit is targeted for delivery to ISS in late 2025.

TOC↗