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At least 361 records · Page 20

Space Environment Effects on Stability of Medications Flown on Space Shuttles and the International Space Station (ISS)

The purpose is to assess physical and chemical degradation of select pharmaceutical formulations from the Shuttle and ISS medical kits. Eleven pharmaceuticals dispensed as different dosage forms were selected based on their physical / chemical characteristics and susceptibility to environmental factors such as, temperature, humidity and light sensitivity. When available, ground-controls of the study medications with matching brand and lot numbers were used for comparison. Samples retrieved from flight were stored along with their matching controls in a temperature and humidity controlled environmental chamber. Temperature, humidity, and radiation data from the Shuttle and ISS were retrieved from onboard HOBO U12 Temp/RH Data Loggers, and from passive dosimeters. Physical and chemical analyses of the pharmaceuticals were conducted using validated United States Pharmacopeia (USP) methods. Results indicated degradation of 6 of the 11 formulations returned from space flights. Four formulations, Amoxicillin / Clavulanate, promethazine, sulfamethoxazole / trimethoprim, and ciprofloxacin tablets depicted discoloration after flight. Chemical content analyses using High or Ultra Performance Liquid Chromatography (HPLC / UPLC) methods revealed that dosage forms of Amoxicillin / Clavulanate, promethazine, sulfamethoxazole / trimethoprim, lidocaine, ciprofloxacin and mupirocin contained less than 95% of manufacturer s labeled claim of active drug compound. Shuttle and ISS environments affect stability and shelf life of certain mediations flown on these missions. Data analysis is in progress to examine the effect of specific space flight environmental factors on pharmaceutical stability. The degradation profiles generated from ground studies in analog environments will be useful in establishing predictive shelf-life profiles for medications intended for use during long-term space exploration missions.

Daniels, Vernie↗

The MISSE 7 Flexural Stress Effects Experiment After 1.5 Years of Wake Space Exposure

Low Earth orbit space environment conditions, including ultraviolet radiation, thermal cycling, and atomic oxygen exposure, can cause degradation of exterior spacecraft materials over time. Radiation and thermal exposure often results in bond- breaking and embrittlement of polymers, reducing mechanical strength and structural integrity. An experiment called the Flexural Stress Effects Experiment (FSEE) was flown with the objective of determining the role of space environmental exposure on the degradation of polymers under flexural stress. The FSEE samples were flown in the wake orientation on the exterior of International Space Station for 1.5 years. Twenty-four samples were flown: 12 bent over a 0.375 in. mandrel and 12 were over a 0.25 in. mandrel. This was designed to simulate flight configurations of insulation blankets on spacecraft. The samples consisted of assorted polyimide and fluorinated polymers with various coatings. Half the samples were designated for bend testing and the other half will be tensile tested. A non-standard bend-test procedure was designed to determine the surface strain at which embrittled polymers crack. All ten samples designated for bend testing have been tested. None of the control samples' polymers cracked, even under surface strains up to 19.7%, although one coating cracked. Of the ten flight samples tested, seven show increased embrittlement through bend-test induced cracking at surface strains from 0.70%to 11.73%. These results show that most of the tested polymers are embrittled due to space exposure, when compared to their control samples. Determination of the extent of space induced embrittlement of polymers is important for designing durable spacecraft.

Snow, Kate E.↗

Impact of Space Radiation with Other Combined Space Environmental Factors on Plant Seeds and Plant Development: from Arabidopsis thaliana to Crops

One of the major concerns for long-term exploration missions beyond Earth’s magnetosphere is radiation risk, primarily from solar particle events (SPE) and galactic cosmic rays (GCR). With the goal of manned Mars exploration, the production of fresh food during long-duration space missions provides critical nutritional supplementation and may also benefit astronauts’ behavioral health. However, the effects of space radiation on plants and plant propagules have not been sufficiently investigated and characterized. To evaluate the effects of space radiation on plant seeds and development, we explored several platforms, including ground-based radiation facilities, the MISSE platform outside the ISS, and other Low Earth Obit (LEO) opportunities. Radiation particle types ranged from neutrons, single charged particles, simulated galactic cosmic rays, simulated solar particle events, the radiation field outside the ISS (total 10 months on the ISS), and the field inside a LEO vehicle (over 3 years). Radiation doses ranged from around 10 cGy to 80 cGy with acute or chronic exposures. In these studies up to 15 types of model plant and crop seeds were evaluated. In addition, tests were conducted to determine whether the combination of radiation exposure and simulated microgravity could have synergetic effects. Exposure to space radiation at the levels tested had no significant impact on the germination rate in Arabidopsis and the seeds from multiple crop plants; however, radiation exposure alone or with other combined factors reduced the viability of some seed types. Overall, the changes within plants grown from irradiated seeds were dose- and ion quality- dependent, with heavier ions causing more severe damage. These changes ranged from cotyledon deformation, shortened root length, smaller seedling size, and other signs of stress, depending on the seed types. Radiation exposure also significantly altered transcriptomic profiles in seedlings grown from irradiated seeds. The impact of space radiation on seeds and plants potentially affects the ability of plants to adapt to other environmental stresses (e.g. microgravity, water stress, and hardware constraints) as well as susceptibility to plant diseases, which need to be furtherly investigated.

Y Zhang↗

Ceramics in severe environments; Proceedings of the Sixth University Conference on Ceramic Science, North Carolina State University, Raleigh, N.C., December 7-9, 1970.

The papers examine new findings and present technologically significant environmental effects and limitations relating to ceramic materials, their properties, and their uses. The effects of thermal and thermochemical factors, thermal shock, concentrated stresses, and severe mechanical environments are considered, as well as stress corrosion, hydrostatic stress, and electromagnetic and nuclear radiation environments. Individual items are abstracted in this issue.

Kriegel, W. W.↗

Applicability of the Remote Mobile Emplacement Package (RMEP) design as a mobility aid for proposed post-84 Mars missions, phase O

The results of study to determine the applicability of the Remote Mobile Emplacement Package (RMEP) design concept as a mobility aid for the proposed post-'84 Mars missions are presented. The RMEP wheel and mobility subsystem parameters: wheel tire size, weight, stowed volume, and environmental effects; obstacle negotiation; reliability and wear; motor and drive train; and electrical power demand were reviewed. Results indicated that: (1) the basic RMEP wheel design would be satisfactory, with additional attention to heating, side loading, tread wear and ultraviolet radiation protection; (2) motor and drive train power requirements on Mars would be less than on Earth; and (3) the mobility electrical power requirements would be small enough to offer the option of operating the Mars mini rover untethered. Payload power required for certain sampling functions would preclude the use of battery power for these missions. Hazard avoidance and reverse direction maneuvers are discussed. Limited examination of vehicle payload integration and thermal design was made, pending establishment of a baseline vehicle/payload design.

Source record↗

STS-53 Space Shuttle mission report

The STS-53 Space Shuttle Program Mission Report provides a summary of the Orbiter, External Tank (ET), Solid Rocket Booster/Redesigned Solid Rocket Motor (SRB/RSRM), and the Space Shuttle Main Engine (SSME) subsystems performance during the fifty-second flight of the Space Shuttle Program, and the fifteenth flight of the Orbiter vehicle Discovery (OV-103). In addition to the Orbiter, the flight vehicle consisted of an ET, which was designated as ET-49/LWT-42; three SSME's, which were serial numbers 2024, 2012, and 2017 in positions 1, 2, and 3, respectively; and two SRB's, which were designated BI-055. The lightweight RSRM's that were installed in each SRB were designated 360L028A for the left SRB, and 360L028B for the right SRB. The primary objective of this flight was to successfully deploy the Department of Defense 1 (DOD-1) payload. The secondary objectives of this flight were to perform the operations required by the Glow Experiment/Cryogenic Heat Pipe Experiment Payload (GCP); the Hand-Held, Earth-Oriented, Real-Time, Cooperative, User-Friendly, Location-Targeting and Environmental System (HERCULES); the Space Tissue Loss (STL); the Battlefield Laser Acquisition Sensor Test (BLAST); the Radiation Monitoring Equipment-III (RME-III); the Microcapsules in Space-1 (MIS-1); the Visual Function Tester-2 (VFT-2); the Cosmic Radiation Effects and Activation Monitor (CREAM); the Clouds Logic to Optimize Use of Defense Systems-1A (CLOUDS-1A); the Fluids Acquisition and Resupply Experiment (FARE); and the Orbital Debris Radar Calibration Spheres (ODERACS). In addition to presenting a summary of subsystem performance, this report also discusses each Orbiter, ET, SSME, SRB, and RSRM in-flight anomaly in the applicable section of the report. Listed in the discussion of each anomaly is the officially assigned tracking number as published by each Project Office in their respective Problem Tracking List. All times given in this report are in Greenwich mean time (G.m.t.) as well as mission elapsed time (MET).

Fricke, Robert W., Jr.↗

Further investigations of experiment A0034 atomic oxygen stimulated outgassing

Thermal control coatings within the recessed compartments of LDEF Experiment A0034 experienced the maximum leading edge fluence of atomic oxygen with considerably less solar UV radiation exposure than top-surface mounted materials of other LDEF experiments on either the leading or the trailing edge. This combination of exposure within A0034 resulted in generally lower levels of darkening attributable to solar UV radiation than for similar materials on other LDEF experiments exposed to greater cumulative solar UV radiation levels. Changes in solar absorptance and infrared thermal emittance of the exposed coatings are thus unique to this exposure. Analytical results for other applications have been found for environmentally induced changes in fluorescence, surface morphology, light scattering, and the effects of coating outgassing products on adjacent mirrors and windows of the A0034 experiment. Some atmospheric bleaching of the thermal control coatings, in addition to that presumably experience during reentry and recovery operations, has been found since initial post-flight observations and measurements.

Linton, Roger C.↗

Inductively-Coupled RF Powered O2 Plasma as a Sterilization Source

Low-temperature or cold plasmas have been shown to be effective for the sterilization of sensitive medical devices and electronic equipment. Low-temperature plasma sterilization procedures possess certain advantages over other protocols such as ethylene oxide, gamma radiation, and heat due to the use of inexpensive reagents, the insignificant environmental impacts and the low energy requirements. In addition, plasmas may also be more efficacious in the removal of robust microorganisms due to their higher chemical reactivity. Together, these attributes render cold plasma sterilization as ideal for the surface decontamination requirements for NASA Planetary Protection. Hence, the work described in this study involves the construction, characterization, and application of an inductively-coupled, RF powered oxygen (O2) plasma.

Sharma, S. P.↗

Aerothermodynamics of a MESUR Martian entry

Computational fluid dynamics models for the thermodynamics and transport properties used in an equilibrium version of the Langley Aerothermodynamics Upwind Relaxation Algorithm (LAURA) for Martian Atmospheric entries are described. In addition, the physical models used in a nonequilibrium version of LAURA for Martian-entry flows are described. Uncertainties exist in defining constants used in the transport properties for the equilibrium model and in many of the physical models for the nonequilibrium version. Solutions from the two codes using the best available constants are examined at the Martian-entry conditions characteristic of the Mars Environmental Survey (MESUR) mission. While the flowfields are near thermal equilibrium, chemical nonequilibrium effects are present in the entry cases examined. Convective heating at the stagnation point for these flows (assuming fully catalytic wall boundary conditions) is approximately 100 W/sq cm. Radiative heating is negligible.

Mitcheltree, R. A.↗

Natural transfer of viable microbes in space

The possibility and probability of natural transfer of viable microbes from Mars to Earth and Earth to Mars traveling in meteoroids during the first 0.5 Ga and the following 4 Ga are investigated, including: --radiation protection against the galactic cosmic ray nuclei and the solar rays, dose rates as a function of the meteorite's radial column mass (radius x density), combined with dose rates generated by natural radioactivity within the meteorite; and survival curves for some bacterial species using NASA's HZETRN transport code --other factors affecting microbe survival: vacuum; central meteorite temperatures at launch, orbiting, and arrival; pressure and acceleration at launch; spontaneous DNA decay; metal ion migration --mean sizes and numbers of unshocked meteorites ejected and percentage falling on Earth, using current semiempirical results --viable flight times for the microbe species Bacillus subtilis and Deinococcus radiodurans R1 --the approximate fraction of microbes (with properties like the two species studied) viably arriving on Earth out of those ejected from Mars during the period 4 Ga BP to the present time, and during the 700 Ma from 4.5 to 3.8 Ga. Similarly, from Earth to Mars. The conclusion is that if microbes existed or exist on Mars, viable transfer to Earth is not only possible but also highly probable, due to microbes' impressive resistance to the dangers of space transfer and to the dense traffic of billions of martian meteorites which have fallen on Earth since the dawn of our planetary system. Earth-to-Mars transfer is also possible but at a much lower frequency.

Non-NASA Center↗

Wear and Tear - Mechanical

The focus of this chapter is on the long term wear and tear, or aging, of the mechanical subsystem of a spacecraft. The mechanical subsystem is herein considered to be the primary support structure (as in a skeleton or exoskeleton) upon which all other spacecraft systems rest, and the associated mechanisms. Mechanisms are devices which have some component that moves at least once, in response to some type of passive or active control system. For the structure, aging may proceed as a gradual degradation of mechanical properties and/or function, possibly leading to complete structural failure over an extended period of time. However, over the 50 years of the Space Age such failures appear to be unusual. In contrast, failures for mechanisms are much more frequent and may have a very serious effect on mission performance. Just as on Earth, all moving devices are subject to normal (and possibly accelerated) degradation from mechanical wear due to loss or breakdown of lubricant, misalignment, temperature cycling effects, improper design/selection of materials, fatigue, and a variety of other effects. In space, such environmental factors as severe temperature swings (possibly 100's of degrees C while going in and out of direct solar exposure), hard vacuum, micrometeoroids, wear from operation in a dusty or contaminated environment, and materials degradation from radiation can be much worse. In addition, there are some ground handling issues such as humidity, long term storage, and ground transport which may be of concern. This chapter addresses the elements of the mechanical subsystem subject to wear, and identifies possible causes. The potential impact of such degradation is addressed, albeit with the recognition that the impact of such wear often depends on when it occurs and on what specific components. Most structural elements of the mechanical system typically are conservatively designed (often to a safety factor of greater than approximately 1.25 on yield for unmanned spacecraft) but do not have backup structure due to the added mass this would impose, and also due to the fact that structural elements can be accurately modeled mathematically and in test. Critical mechanisms or devices may have backups, or alternate work-arounds, since characterization of these systems in a 1g environment is less accurate than structure, and repair in-space is often impossible.

Swanson, Theodore↗

Spacecraft environmental anomalies expert system

A microcomputer-based expert system is being developed at the Aerospace Corporation Space Sciences Laboratory to assist in the diagnosis of satellite anomalies caused by the space environment. The expert system is designed to address anomalies caused by surface charging, bulk charging, single event effects and total radiation dose. These effects depend on the orbit of the satellite, the local environment (which is highly variable), the satellite exposure time and the hardness of the circuits and components of the satellite. The expert system is a rule-based system that uses the Texas Instruments Personal Consultant Plus expert system shell. The completed expert system knowledge base will include 150 to 200 rules, as well as a spacecraft attributes database, an historical spacecraft anomalies database, and a space environment database which is updated in near real-time. Currently, the expert system is undergoing development and testing within the Aerospace Corporation Space Sciences Laboratory.

Koons, H. C.↗

Development of Skylab environmental protection for photographic film

The problems of providing adequate environmental protection for photographic film on three Skylab missions and the technical and management approach to resolving these problems are presented. The radiation, temperature, and humidity environments to which film will be exposed for up to 230 days in space and the effects of these environments on film are discussed. The report concludes with a definition of the design requirements for the Skylab film repository.

Askew, W. C.↗

Aerosol-Water Cycle Interaction: A New Challenge in Monsoon Climate Research

Long recognized as a major environmental hazard, aerosol is now known to have strong impacts on both regional and global climate. It has been estimated that aerosol may reduce by up to 10% of the seasonal mean solar radiation reaching the earth surface, producing a global cooling effect that opposes global warming (Climate Change 2001). This means that the potential perils that humans have committed to global warming may be far greater than what we can detect at the present. As a key component of the Earth climate system, the water cycle is profoundly affected by the presence of aerosols in the atmosphere. Through the so-called direct effect , aerosol scatters and/or absorbs solar radiation, thus cooling the earth surface and changing the horizontal and vertical radiational heating contrast in the atmosphere. The heating contrast drives anomalous atmospheric circulation, resulting in changes in convection, clouds, and rainfall. Another way aerosol can affect the water cycle is through the so-called indirect effects, whereby aerosol increases the number of cloud condensation nuclei, prolongs life time of clouds, and inhibits the growth of cloud drops to raindrops. This leads to more clouds, and increased reflection of solar radiation, and further cooling at the earth surface. In monsoon regions, the response of the water cycle to aerosol forcing is especially complex, not only because of presence of diverse mix of aerosol species with vastly different radiative properties, but also because the monsoon is strongly influenced by ocean and land surface processes, land use, land change, as well as regional and global greenhouse warming effects. Thus, sorting out the impacts of aerosol forcing, and interaction with the monsoon water cycle is a very challenging problem. In this talk, I will offer some insights into how aerosols may impact the Asian monsoon based on preliminary results from satellite observations and climate model experiments. Specifically, I will discuss the elevated heat pump hypothesis, involving atmospheric heating by absorbing aerosols (dust and black carbon) over the southern slopes of the Himalayas, and feedback with the deep convection, in modifying monsoon water cycle over South .and East Asia. The role of aerosol forcing relative to those due to sea surface temperature and land surface processes, as well as observation requirements to verify such a hypothesis will also be discussed.

Lau, William K. M.↗

Aerosol-Water Cycle Interaction: A New Challenge in Monsoon Climate Research

Long recognized as a major environmental hazard, aerosol is now known to have strong impacts on both regional and global climate. It has been estimated that aerosol may reduce by up to 10% of the seasonal mean solar radiation reaching the earth surface, producing a global cooling effect that opposes global warming (Climate Change 2001). This means that the potential perils that humans have committed to global warming may be far greater than what we can detect at the present. As a key component of the Earth climate system, the water cycle is profoundly affected by the presence of aerosols in the atmosphere. Through the so-called "direct effect", aerosol scatters and/or absorbs solar radiation, thus cooling the earth surface and changing the horizontal and vertical radiational heating contrast in the atmosphere. The heating contrast drives anomalous atmospheric circulation, resulting in changes in convection, clouds, and rainfall. Another way aerosol can affect the water cycle is through the so-called "indirect effects", whereby aerosol increases the number of cloud condensation nuclei, prolongs life time of clouds, and inhibits the growth of cloud drops to raindrops. This leads to more clouds, and increased reflection of solar radiation, and further cooling at the earth surface. In monsoon regions, the response of the water cycle to aerosol forcing is especially complex, not only because of presence of diverse mix of aerosol species with vastly different radiative properties, but also because the monsoon is strongly influenced by ocean and land surface processes, land use, land change, as well as regional and global greenhouse warming effects. Thus, sorting out the impacts of aerosol forcing, and interaction with the monsoon water cycle is a very challenging problem. In this talk, I will offer some insights into how aerosols may impact the Asian monsoon based on preliminary results from satellite observations and climate model experiments. Specifically, I will discuss the "elevated heat pump" hypothesis, involving atmospheric heating by absorbing aerosols (dust and black carbon) over the southern slopes of the Himalayas, and feedback with the deep convection, in modifying monsoon water cycle over South and East Asia. The role of aerosol forcing relative to those due to sea surface temperature and land surface processes, as well as observation requirements to verify such a hypothesis will also be discussed.

Lau, William K. M.↗

Assessing impacts of canopy 3D structure on chlorophyll fluorescence radiance and radiative budget of deciduous forest stands using DART

Although remote sensing (RS) of solar-induced chlorophyll fluorescence (SIF) is increasingly used as a valuable source of information about vegetation photosynthetic activity, the RS SIF observations are significantly influenced by canopy-specific structural features (i.e., canopy architecture including leaf area index and presence of woody components), atmospheric conditions during their acquisition (e.g., proportion of direct and diffuse irradiance) and observational geometric configurations (e.g., sun and viewing directions). Radiative transfer (RT) models have the potential to provide a better understanding of the canopy structural effects on the SIF emission and RS signals. Here, we used the DART model to assess the daily influence, from morning to evening, of forest 3D architecture on SIF nadir radiance, emission, escape factor and nadir yield of eight 100 m × 100 m forest study plots established in a temperate deciduous forest of the Smithsonian Environmental Research Center (Edgewater, MD, USA). The 3D architecture of each plot was derived from airborne LiDAR. DART simulations of these 3D forest plots and their 1D (i.e., vertical profile of sun-adapted and shade-adapted leaves) and 0D (i.e., homogeneous layer of sun-adapted leaves above an homogeneous layer of shade-adapted leaves) abstractions were compared to assess the relative errors (ε1D−3D and ε0D−3D) associated with horizontal and vertical structural heterogeneity, respectively. Forest 3D structure, especially horizontal heterogeneity, had a great influence on forest nadir SIF radiance, resulting in ε1D−3D up to 55% at 8:00 and 18:00 (i.e., for oblique sun directions). The key indicators of this impact, in the descending order of importance, were the SIF escape factor (ε1D−3D up to 40%), the attenuation of incident photosynthetically active radiation (ε1D−3D less than 5%), and the SIF emission yield (ε1D−3D less than 2%). The influence of forest architecture on the nadir SIF escape factor and SIF yield (ε1D−3D up to 40%) varied over time, with differences in forest stand structure, and per spectral domain, being always larger between 640 and 700 nm than between 700 and 850 nm. In addition, woody elements demonstrated a large influence on forest SIF radiance due to their “shading” effect (ε up to 17%) and their “blocking” effect (ε ≈ 10%), both of them higher for far-red than for red SIF. These results underline the importance of 3D forest canopy architecture, especially 2D heterogeneity, and inclusion of woody elements in RT modeling used for interpretation of the RS SIF signal, and subsequently for the estimation of gross primary production and detection of vegetation stress.

Omar Regaieg↗

System concepts for a large UV/optical/IR telescope on the moon

To assess the systems and technological requirements for constructing lunar telescopes in conjunction with the buildup of a lunar base for scientific exploration and as a waypoint for travel to Mars, the NASA Marshall Space Flight Center conducted concept studies of a 16-m-aperture large lunar telescope (LLT) and a 4-m-aperture precursor telescope, both operating in the UV/visible/IR spectral region. The feasibility of constructing a large telescope on the lunar surface is assessed, and its systems and subsystems are analyzed. Telescope site selection, environmental effects, and launch and assembly scenarios are also evaluated. It is argued that key technical drivers for the LLT must be tested in situ by precursor telescopes to evaluate such areas as the operations and long-term reliability of active optics, radiation protection of instruments, lunar dust mitigation, and thermal shielding of the telescope systems. For a manned lunar outpost or an LLT to become a reality, a low-cost dependable transportation system must be developed.

Nein, Max E.↗