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Chimeric Mouse Models for Space Radiation Risk Investigations

Assessment of human health risks associated with space radiation exposure is based largely on the knowledge learned from studies in which animals, mostly rodents, are exposed to high-LET radiation on the ground. It has been recognized that translation of animal results to meaningful implications for human disease can be challenging, particularly for certain risk categories such as the high-LET radiation effects in the central nervous system (CNS). Considering limitations in utilizing non-human primates and clinical studies in humans, chimeric animals can potentially bridge the knowledge gap between rodents and humans. In a chimeric animal, a specific organ or a cell type is replaced with respective human cells that are functional. A number of chimeric mouse models have been developed in the medical research community to study human diseases, and some of the models can potentially be used for NASA applications. For instance, mice engrafted with human hepatocytes, which have been used in studies of genotoxicity from carcinogen exposures, can be used for quantification of space radiation damage. A chimeric brain model, which was shown to perform superiorly in memory and cognitive tests, can also be a candidate for studying the CNS effects of radiation. It has also been reported that mice engrafted with human hematopoietic progenitor cells were exposed to X-rays and high-LET Si ions to investigate the radiation effects in the immune system. In a pilot study, we use PXB mice whose livers contain >90% human cells. These mice are exposed to gamma rays for investigations of DNA damage and transcriptomics changes in the humanized livers. Results obtained from PXB mice will be compared non-engrafted control animals from the same background strain that are exposed to identical conditions. The aim of the study is to determine whether chimeric mouse models are suitable for investigations of space radiation risks.

Honglu Wu↗

Freezable Radiator Coupon Testing and Full Scale Radiator Design

Freezable radiators offer an attractive solution to the issue of thermal control system scalability. As thermal environments change, a freezable radiator will effectively scale the total heat rejection it is capable of as a function of the thermal environment and flow rate through the radiator. Scalable thermal control systems are a critical technology for spacecraft that will endure missions with widely varying thermal requirements. These changing requirements are a result of the space craft s surroundings and because of different thermal loads during different mission phases. However, freezing and thawing (recovering) a radiator is a process that has historically proven very difficult to predict through modeling, resulting in highly inaccurate predictions of recovery time. This paper summarizes tests on three test articles that were performed to further empirically quantify the behavior of a simple freezable radiator, and the culmination of those tests into a full scale design. Each test article explored the bounds of freezing and recovery behavior, as well as providing thermo-physical data of the working fluid, a 50-50 mixture of DowFrost HD and water. These results were then used as a tool for developing correlated thermal model in Thermal Desktop which could be used for modeling the behavior of a full scale thermal control system for a lunar mission. The final design of a thermal control system for a lunar mission is also documented in this paper.

Lillibridge, Sean T.↗

Feasibility Study of a Nuclear-Stirling Plant for the Jupiter Icy Moons Orbiter

NASA is undertaking the design of a new spacecraft to explore the planet Jupiter and its three moons Calisto, Ganymede and Europa. This proposed mission, known as Jupiter Icy Moons Orbiter (JIMO) would use a nuclear reactor and an associated electrical generation system (Reactor Power Plant-RPP) to provide power to the spacecraft. The JIMO spacecraft is envisioned to use this power for science and communications as well as Electric Propulsion (EP). Among other potential power-generating concepts, previous studies have considered Thermoelectric and Brayton Power conversion systems, coupled to a liquid metal reactor for the JIMO mission. This paper will explore trades in system mass and radiator area for a nuclear reactor power conversion system, however this study will focus on Stirling power conversion. The Stirling convertor modeled in this study is based upon the Component Test Power Convertor design that was designed and operated successfully under the Civil Space Technology Initiative for use with the SP-100 nuclear reactor i the 1980's and early 1990's. The study design is such that two of the four convertors would operate at any time to generate the 100 kWe while the others are held in reserve. For this study the Stirling convertors hot-side temperature is 1050 K, would operate at a temperature ratio of 2.4 for a minimum mass system and would have a system efficiency of 29%. The Stirling convertor would generate high voltage (400 volt), 100 Hz single phase AC that is supplied to the Power Management and Distribution system. The waste hear is removed from the Stirling convertors by a flowing liquid sodium-potassium eutectic and then rejected by a shared radiator. The radiator consists of two coplanar wings, which would be deployed after the reactor is in space. System trades were performed to vary cycle state point temperatures and convertor design as well as power output. Other redundancy combinations were considered to understand the affects of convertor size and number of spares to the system mass.

Schmitz, Paul C.↗

Space shuttle thermal scale modeling application study

The critical thermal control problems and verification of thermal mathematical model results for the space shuttle concept are discussed. The use of a small scale thermal model of the space shuttle is proposed. It was determined that a one-third scale model of the space shuttle would serve as a useful tool throughout the entire thermal design and verification program. The major considerations in modeling the conduction-radiation-convection fields, the level of detail for modeling various systems, preliminary test requirements, and potential applications of the thermal scale model are summarized.

Marshall, K. N.↗

Synthetic Scene Generation of the Stennis V and V Target Range for the Calibration of Remote Sensing Systems

The verification and validation (V&V) target range developed at Stennis Space Center is a useful test site for the calibration of remote sensing systems. In this paper, we present a simple algorithm for generating synthetic radiance scenes or digital models of this target range. The radiation propagation for the target in the solar reflective and thermal infrared spectral regions is modeled using the atmospheric radiative transfer code MODTRAN 4. The at-sensor, in-band radiance and spectral radiance for a given sensor at a given altitude is predicted. Software is developed to generate scenes with different spatial and spectral resolutions using the simulated at-sensor radiance values. The radiometric accuracy of the simulation is evaluated by comparing simulated with AVIRIS acquired radiance values. The results show that in general there is a good match between AVIRIS sensor measured and MODTRAN predicted radiance values for the target despite the fact that some anomalies exist. Synthetic scenes provide a cost-effective way for in-flight validation of the spatial and radiometric accuracy of the data. Other applications include mission planning, sensor simulation, and trade-off analysis in sensor design.

Cao, Chang-Yong↗

The Goddard Cumulus Ensemble Model (GCE): Improvements and Applications for Studying Precipitation Processes

Convection is the primary transport process in the Earth's atmosphere. About two-thirds of the Earth's rainfall and severe floods derive from convection. In addition, two-thirds of the global rain falls in the tropics, while the associated latent heat release accounts for three-fourths of the total heat energy for the Earth's atmosphere. Cloud-resolving models (CRMs) have been used to improve our understanding of cloud and precipitation processes and phenomena from micro-scale to cloud-scale and mesoscale as well as their interactions with radiation and surface processes. CRMs use sophisticated and realistic representations of cloud microphysical processes and can reasonably well resolve the time evolution, structure, and life cycles of clouds and cloud systems. CRMs also allow for explicit interaction between clouds, outgoing longwave (cooling) and incoming solar (heating) radiation, and ocean and land surface processes. Observations are required to initialize CRMs and to validate their results. The Goddard Cumulus Ensemble model (GCE) has been developed and improved at NASA/Goddard Space Flight Center over the past three decades. It is amulti-dimensional non-hydrostatic CRM that can simulate clouds and cloud systems in different environments. Early improvements and testing were presented in Tao and Simpson (1993) and Tao et al. (2003a). A review on the application of the GCE to the understanding of precipitation processes can be found in Simpson and Tao (1993) and Tao (2003). In this paper, recent model improvements (microphysics, radiation and land surface processes) are described along with their impact and performance on cloud and precipitation events in different geographic locations via comparisons with observations. In addition, recent advanced applications of the GCE are presented that include understanding the physical processes responsible for diurnal variation, examining the impact of aerosols (cloud condensation nuclei or CCN and ice nuclei or IN) on precipitation processes, utilizing a satellite simulator to improve the microphysics, providing better simulations for satellite-derived latent heating retrieval, and coupling with a general circulation model to improve the representation of precipitation processes.

GCE↗

Influence of Dust and Black Carbon on the Snow Albedo in the NASA Goddard Earth Observing System Version 5 Land Surface Model

Present-day land surface models rarely account for the influence of both black carbon and dust in the snow on the snow albedo. Snow impurities increase the absorption of incoming shortwave radiation (particularly in the visible bands), whereby they have major consequences for the evolution of snowmelt and life cycles of snowpack. A new parameterization of these snow impurities was included in the catchment-based land surface model used in the National Aeronautics and Space Administration Goddard Earth Observing System version 5. Validation tests against in situ observed data were performed for the winter of 2003.2004 in Sapporo, Japan, for both the new snow albedo parameterization (which explicitly accounts for snow impurities) and the preexisting baseline albedo parameterization (which does not). Validation tests reveal that daily variations of snow depth and snow surface albedo are more realistically simulated with the new parameterization. Reasonable perturbations in the assigned snow impurity concentrations, as inferred from the observational data, produce significant changes in snowpack depth and radiative flux interactions. These findings illustrate the importance of parameterizing the influence of snow impurities on the snow surface albedo for proper simulation of the life cycle of snow cover.

Yasunari, Teppei J.↗

Overview of the space environmental effects observed on the retrieved Long Duration Exposure Facility (LDEF)

The Long Duration Exposure Facility (LDEF), which encompassed 57 experiments with more than 10,000 test specimens, spent 69 months in Low Earth Orbit (LEO) before it was retrieved by the Space Shuttle in January 1990. Hundreds of LDEF investigators, after studying for over two years these retrieved test specimens and the onboard recorded data and systems hardware, have generated a unique first-hand view of the long-term synergistic effects that the LEO environment can have on spacecraft. These studies have also contributed significantly toward more accurate models of the LEO radiation, meteoroid, manmade debris and atomic oxygen environments. This paper provides an overview of some of the many LDEF observations and the implications these can have on future spacecraft such as Space Station Freedom.

Kinard, W.↗

A cesium plasma TELEC device for conversion of laser radiation to electric power

Tests of the thermoelectronic laser energy converter (TELEC) concept are reported. This device has been devised as a means to convert high-average-power laser radiation into electrical energy, a crucial element in any space laser power transmission scheme using the available high-power/efficiency infrared lasers. Theoretical calculations, based upon inverse bremsstrahlung absorption in a cesium plasma, indicate internal conversion efficiency up to 50% with an overall system efficiency of 42%. The experiments reported were made with a test cell designed to confirm the theoretical model rather than demonstrate efficiency; 10.6-micron laser-beam absorption was limited to about 0.001 of the incident beam by the short absorption region. Nevertheless, confirmatory results were obtained, and the conversion of absorbed radiation to electric power is estimated to be near 10%.

Britt, E. J.↗

Development of a Model for the Small-Particle Orbital Debris Population Based on the STS Impact Record

In preparation for the release of the Orbital Debris Engineering Model (ORDEM) version 3.1, the NASA Orbital Debris Program Office (ODPO) revisited how orbiting debris populations of characteristic sizes smaller than 1 cm were modeled. The primary contributor to the population of sub-centimeter debris particles is the surface deterioration or erosion of spacecraft materials exposed to the outer-space environment. Because small particulates are not directly trackable by remote sensing, the primary means of detection is via historical counts of small impact features on flown radiator and window surfaces of the U.S. Space Transportation System (STS, also known as the Space Shuttle) from 1995-2011. Historic NASA studies of high-velocity impact tests have related impact-feature size to particle mass and velocity for certain STS surfaces, so that a corresponding particle size may be inferred from each small-impact feature observed. Micro-debris populations are then estimated by modeling the path and orientation of an STS mission through a simulated debris environment, and the densities of this simulated environment are rescaled to approximate the number of observed STS impact features. Monte-Carlo methods are further employed to gauge the estimation uncertainty of the rescaled environment. A description of the chosen methodologies for estimating and adjusting the micro-debris population model, and the results, are presented.

Seago, J..↗

Optimized shielding for space radiation protection

Future deep space mission and International Space Station exposures will be dominated by the high-charge and -energy (HZE) ions of the Galactic Cosmic Rays (GCR). A few mammalian systems have been extensively tested over a broad range of ion types and energies. For example, C3H10T1/2 cells, V79 cells, and Harderian gland tumors have been described by various track-structure dependent response models. The attenuation of GCR induced biological effects depends strongly on the biological endpoint, response model used, and material composition. Optimization of space shielding is then driven by the nature of the response model and the transmission characteristics of the given material.

NASA Discipline Radiation Health↗

Shields-1, A SmallSat Radiation Shielding Technology Demonstration

The NASA Langley Research Center Shields CubeSat initiative is to develop a configurable platform that would allow lower cost access to Space for materials durability experiments, and to foster a pathway for both emerging and commercial-off-the-shelf (COTS) radiation shielding technologies to gain spaceflight heritage in a relevant environment. The Shields-1 will be Langleys' first CubeSat platform to carry out this mission. Radiation shielding tests on Shields-1 are planned for the expected severe radiation environment in a geotransfer orbit (GTO), where advertised commercial rideshare opportunities and CubeSat missions exist, such as Exploration Mission 1 (EM-1). To meet this objective, atomic number (Z) graded radiation shields (Zshields) have been developed. The Z-shield properties have been estimated, using the Space Environment Information System (SPENVIS) radiation shielding computational modeling, to have ~30% increased shielding effectiveness of electrons, at half the thickness of a corresponding single layer of aluminum. The Shields-1 research payload will be made with the Z-graded radiation shields of varying thicknesses to create dose-depth curves to be compared with baseline materials. Additionally, Shields-1 demonstrates an engineered Z-grade radiation shielding vault protecting the systems' electronic boards. The radiation shielding materials' performances will be characterized using total ionizing dose sensors. Completion of these experiments is expected to raise the technology readiness levels (TRLs) of the tested atomic number (Z) graded materials. The most significant contribution of the Z-shields for the SmallSat community will be that it enables cost effective shielding for small satellite systems, with significant volume constraints, while increasing the operational lifetime of ionizing radiation sensitive components. These results are anticipated to increase the development of CubeSat hardware design for increased mission lifetimes, and enable out of low earth orbit (LEO) missions by using these tested material concepts as shielding for sensitive components and new spaceflight hardware

Thomsen, D. Laurence, III↗

Advanced Power and Propulsion: Insuring Human Survival and Productivity in Deep Space Missions

Dr. Chang-Diaz gave an intriguing presentation of his research in advanced rocket propulsion and its relevance for planning and executing crewed deep space explorations. Though not necessarily exclusively Martian, his thrust looks critically at future Mars missions. Initially Dr. Chang-Diaz showed the time constraints of Mars missions due to orbital mechanics and our present chemically powered rocket technology. Since essentially all the energy required to place current generation spacecraft into a Martian trajectory must be expended in the early minutes of a flight, most of such a mission is spent in free-fall drift, captive to the gravitational forces among Earth, the Sun, and Mars. The simple physics of such chemically powered missions requires nearly a year in transit for each direction of a Mars mission. And the optimal orientations of Earth and Mars for rendezvous require further time on or around Mars to await return. These extensions of mission duration place any crew under a three-fold jeopardy: (1) physiological deconditioning (which in some aspects is still unknown and unpreventable), (2) psychological stress, and (3) ionizing radiation. This latter risk is due to exposure of crew members for extended time to the highly unpredictable and potentially lethal radiations of open space. Any gains in shortening mission duration would reap equivalent or greater benefits for these crew concerns. Dr. Chang-Diaz has applied his training and expertise (Ph.D. from Massachusetts Institute of Technology in applied plasma physics) toward development of continuous rocket propulsion which would offer great time advantages in travel, and also more launch options than are now available. He clearly explained the enormous gains from a relatively low thrust accelerative force applied essentially continuously versus the high, but short-lived propulsion of present chemical rockets. In fact, such spacecraft could be powered throughout the mission, accelerating to approximately the midpoint and decelerating during the latter half. This would not only provide some level of gravity (acceleration) throughout the mission but also allow very high velocities to be achieved, thus saving many months of travel time. In proposing the design of such a spacecraft propulsion system, Dr. Chang-Diaz was quick to acknowledge the need for a large power source, which undoubtedly must be nuclear fueled at the solar distances involved. He calls his system the Variable Specific Impulse Magnetoplasma Rocket (VASIMR). The other major ingredient is a mass (deuterium, which could also function as a radiation shield for crews) for energizing into the ultra hot, high velocity exhaust plasma. He foresees models now functional in the laboratory soon to be tested in space. In fact, some of these concepts have already been tried there. His optimism and determination would have operational rockets in the next decades.

Chang-Diaz, Franklin R.↗

Experimental Testing and Modeling of a Pneumatic Regolith Delivery System for ISRU

Excavating and transporting planetary regolith are examples of surface activities that may occur during a future space exploration mission to a planetary body. Regolith, whether it is collected on the Moon, Mars or even an asteroid, consists of granular minerals, some of which have been identified to be viable resources that can be mined and processed chemically to extract useful by-products, such as oxygen, water, and various metals and metal alloys. Even the depleted "waste" material from such chemical processes may be utilized later in the construction of landing pads and protective structures at the site of a planetary base. One reason for excavating and conveying planetary regolith is to deliver raw regolith material to in-situ resource utilization (ISRU) systems. The goal of ISRU is to provide expendable supplies and materials at the planetary destination, if possible. An in-situ capability of producing mission-critical substances such as oxygen will help to extend the mission and its success, and will greatly lower the overall cost of a mission by either eliminating, or significantly reducing, the need to transport the same expendable materials from the Earth. In order to support the goals and objectives of present and future ISRU projects, NASA seeks technology advancements in the areas of regolith conveying. Such systems must be effective, efficient and provide reliable performance over long durations while being exposed to the harsh environments found on planetary surfaces. These conditions include contact with very abrasive regolith particulates, exposure to high vacuum or dry (partial) atmospheres, wide variations in temperature, reduced gravity, and exposure to space radiation. Regolith conveying techniques that combine reduced failure modes and low energy consumption with high material transfer rates will provide significant value for future space exploration missions to the surfaces of the moon, Mars and asteroids. Pneumatic regolith conveying has demonstrated itself to be a viable delivery system through testing under terrestrial and reduced gravity conditions in recent years. Modeling and experimental testing have been conducted at NASA Kennedy Space Center to study and advance pneumatic planetary regolith delivery systems in support of NASA's ISRU project. The goal of this work is to use the model to predict solid-gas flow patterns in reduced gravity environments for ISRU inlet gas line allowing the eductor inlet gas flow to vary and depend on the flow pattern developed at the eductor as inferred by the experimental observations.

Santiago-Maldonado, Edgardo↗

Solar Energetic Particle Spectrometer (SEPS)

An outstanding problem of solar and heliospheric physics is the transport of solar energetic particles. The more energetic particles arriving early in the event can be used to probe the transport processes. The arrival direction distribution of these particles carries information about scattering during their propagation to Earth that can be used to test models of interplanetary transport. Also, of considerable importance to crewed space missions is the level of ionizing radiation in the interplanetary medium, and the dose that the crew experiences during an intense solar particle event, as well as the risk to space systems. A recent study concludes that 90% of the absorbed dose results from particles in the energy range 20-550 MeV. We will describe a new compact instrument concept, SEPS, that can cover the energy range from 50-600 MeV with a single compact detector. This energy range has been difficult to cover. There are only limited data, generally available only in broad energy bins, from a few past and present instruments outside Earth s magnetosphere. The SEPS concept can provide improved measurements for this energy range and its simple light-weight design could be easily accommodated on future missions.

Christl, Mark J.↗

A New Handbook for the Development of Space Vehicle Terrestrial Environment Design Requirements.

A new NASA document entitled "Terrestrial Environment (Climatic) Criteria Handbook for Use in Aerospace Vehicle Development (NASA-HDBK-1001A) has been developed. The Handbook provides terrestrial environment information, data bases, models, recommendations, etc. for use in the design, development, trade studies, testing, and mission analyses for space (or launch) .vehicles. This document is organized into fourteen specific natural environment disciplines of which some are winds, atmospheric models, thermal radiation, precipitation-for-icing, cloud cover, atmospheric electricity, geologic hazards, toxic chemical release by propulsion systems, and sea state. Atmospheric phenomena play a significant role in the design and flight of aerospace vehicles and in the integrity of the associated aerospace systems and structures. Environmental design criteria guidelines in this document are based on measurements and observations of atmospheric and climatic phenomena relative to various aerospace development, operational, and vehicle launch locations. The natural environment criteria guidelines data presented in this Handbook were formulated based on discussions with and requests from engineers involved in aerospace vehicle development and operations. Therefore, they represent responses to actual engineering problems and are not just a general compilation of environmental data. The Handbook addresses the basis for the information presented, the interpretations of the terrestrial environment guideline given in the Handbook, and its application to the development of aerospace vehicle design requirements. Specific examples of the Handbook content and associated "lessons lenmed" are given in this paper.

Johnson, Dale L.↗

A New Handbook for the Development of Space Vehicle Terrestrial Environment Design Requirements

A new NASA document entitled "Terrestrial Environment (Climatic) Criteria Handbook for Use in Aerospace Vehicle Development (NASA-HDBK-IOO1A) has been developed. The Handbook provides terrestrial environment information, data bases, models, recommendations, etc. for use in the design, development, trade studies, testing, and mission analyses for space (or launch) vehicles. This document is organized into fourteen specific natural environment disciplines of which some are winds, atmospheric models, thermal radiation, precipitation-for-icing, cloud cover, atmospheric electricity, geologic hazards, toxic chemical release by propulsion systems, and sea state. Atmospheric phenomena play a significant role in the design and flight of aerospace vehicles and in the integrity of the associated aerospace systems and structures. Environmental design criteria guidelines in this document are based on measurements and observations of atmospheric and climatic phenomena relative to various aerospace development, operational, and vehicle launch locations. The natural environment criteria guidelines data presented in this Handbook were formulated based on discussions with and requests from engineers involved in aerospace vehicle development and operations. Therefore, they represent responses to actual engineering problems and are not just a general compilation of environmental data. The Handbook addresses the basis for the information presented, the interpretations of the terrestrial environment guideline given in the Handbook, and its application to the development of aerospace vehicle design requirements. Specific examples of the Handbook content and associated "lessons lenmed" are given in this paper.

Johnson, Dale L.↗

Radiation Hardening by Software Techniques on FPGAs: Flight Experiment Evaluation and Results

We present our work on implementing Radiation Hardening by Software (RHBSW) techniques on the Xilinx Virtex5 FPGAs PowerPC 440 processors on the SpaceCube 2.0 platform. The techniques have been matured and tested through simulation modeling, fault emulation, laser fault injection and now in a flight experiment, as part of the Space Test Program- Houston 4-ISS SpaceCube Experiment 2.0 (STP-H4-ISE 2.0). This work leverages concepts such as heartbeat monitoring, control flow assertions, and checkpointing, commonly used in the High Performance Computing industry, and adapts them for use in remote sensing embedded systems. These techniques are extremely low overhead (typically <1.3%), enabling a 3.3x gain in processing performance as compared to the equivalent traditionally radiation hardened processor. The recently concluded STP-H4 flight experiment was an opportunity to upgrade the RHBSW techniques for the Virtex5 FPGA and demonstrate them on-board the ISS to achieve TRL 7. This work details the implementation of the RHBSW techniques, that were previously developed for the Virtex4-based SpaceCube 1.0 platform, on the Virtex5-based SpaceCube 2.0 flight platform. The evaluation spans the development and integration with flight software, remotely uploading the new experiment to the ISS SpaceCube 2.0 platform, and conducting the experiment continuously for 16 days before the platform was decommissioned. The experiment was conducted on two PowerPCs embedded within the Virtex5 FPGA devices and the experiment collected 19,400 checkpoints, processed 253,482 status messages, and incurred 0 faults. These results are highly encouraging and future work is looking into longer duration testing as part of the STP-H5 flight experiment.

Hybrid Flight Architectures↗