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At least 37 records · Page 2

Techniques Optimized for Reducing Instabilities in Advanced Nickel-Base Superalloys for Turbine Blades

The High-Speed Research (HSR) Airfoil Alloy program developed fourth-generation single-crystal superalloys with up to an 85 F increase in creep rupture capability over current production airfoil alloys. Recent results have been generated at the NASA Glenn Research Center on these fourth-generation alloys, but in coated form, for subsonic turbine blade applications under NASA's Ultra-Efficient Engine Technology (UEET) Program. One goal for UEET is to optimize the airfoil alloy/thermal barrier coating system for 3100 F turbine inlet temperatures. The state-of-the art turbine blade airfoil system consists of a superalloy single crystal that provides the basic mechanical performance of the airfoil. A thermal barrier coating is used to reduce the temperature of the base superalloy, and a bondcoat is deposited between the base material and the thermal barrier coating. The bondcoat improves the oxidation and corrosion resistance of the base superalloy and improves the spallation resistance of the thermal barrier coating. A commercial platinum aluminide bondcoat was applied to the HSR-developed alloys, and a diffusion zone developed as a result of interaction between the bondcoat and the superalloy. Optimized strength is obtained for superalloys when the refractory element content is high and the limits of microstructural stability are approached or exceeded slightly. For fourthgeneration alloys, instability leads to the formation of topologically close packed (TCP) phases, which form internally in the superalloy, and a secondary reaction zone (SRZ), which forms under the diffusion zone. There was a concern that excessive quantities of either TCP or SRZ might decrease the mechanical properties of the superalloy, with SRZ thought to be particularly detrimental and its formation unpredictable. Thus, an SRZreduction effort was initiated in the NASA UEET Program so that methods developed during the HSR project could be optimized further to reduce or eliminate the SRZ. An SRZ is a three-phase constituent composed of TCP and stringers of gamma phase in a matrix of gamma prime. An incoherent grain boundary separates the SRZ from the gammagamma prime microstructure of the superalloy. The SRZ is believed to form as a result of local chemistry changes in the superalloy due to the application of the diffusion aluminide bondcoat. Locally high surface stresses also appear to promote the formation of the SRZ. Thus, techniques that change the local alloy chemistry or reduce surface stresses have been examined for their effectiveness in reducing SRZ. These SRZ-reduction steps are performed on the test specimen or the turbine blade before the bondcoat is applied. Stressrelief heat treatments developed at NASA Glenn have been demonstrated to reduce significantly the amount of SRZ that develops during subsequent high-temperature exposures. Stress-relief heat treatments reduce surface stresses by recrystallizing a thin surface layer of the superalloy. However, in alloys with very high propensities to form SRZ, stress relief heat treatments alone do not eliminate SRZ entirely. Thus, techniques that modify the local chemistry under the bondcoat have been emphasized and optimized successfully at Glenn. One such technique is carburization, which changes the local chemistry by forming submicron carbides near the surface of the superalloy. Detailed characterizations have demonstrated that the depth and uniform distribution of these carbides are enhanced when a stress relief treatment and an appropriate surface preparation are employed in advance of the carburization treatment. Even in alloys that have the propensity to develop a continuous SRZ layer beneath the diffusion zone, the SRZ has been completely eliminated or reduced to low, manageable levels when this combination of techniques is utilized. Now that the techniques to mitigate SRZ have been established at Glenn, TCP phase formation is being emphasized in ongoing work under the UEET Program. The limitsf stability of the fourth-generation alloys with respect to TCP phase formation are currently being defined along with high-temperature creep rupture properties. In addition, a regression model is being developed at Glenn for the prediction of the presence of TCP phase in the microstructure and SRZ under the diffusion zone. The model is based on a design-of-experiments methodology with emphasis on the potential synergistic effects of alloying elements.

MacKay, Rebecca A.↗

Nonlinear Acoustics Used To Reduce Leakage Flow

Leakage and wear are two fundamental problems in all traditional turbine seals that contribute to an engine's inefficiency. The solutions to seal leakage and wear conflict in the conventional design space. Reducing the clearance between the seal and rotating shaft reduces leakage but increases wear because of increased contact incidents. Increasing the clearance to reduce the contact between parts reduces wear but increases parasitic leakage. The goal of this effort is to develop a seal that restricts leakage flow using acoustic pressure while operating in a noncontacting manner, thereby increasing life. In 1996, Dr. Timothy Lucas announced his discovery of a method to produce shock-free high-amplitude pressure waves. For the first time, the formation of large acoustic pressures was possible using dissonant resonators. A pre-prototype acoustic seal developed at the NASA Glenn Research Center exploits this fundamental acoustic discovery: a specially shaped cavity oscillated at the contained fluid's resonant frequency produces high-amplitude acoustic pressure waves of a magnitude approaching those required of today's seals. While the original researchers are continuing their development of acoustic pumps, refrigeration compressors, and electronic thermal management systems using this technology, the goal of researchers at Glenn is to apply these acoustic principles to a revolutionary sealing device. When the acoustic resonator shape is optimized for the sealing device, the flow from a high-pressure cavity to a low-pressure cavity will be restricted by a series of high-amplitude standing pressure waves of higher pressure than the pressure to be sealed. Since the sealing resonator cavity will not touch the adjacent sealing structures, seal wear will be eliminated, improving system life. Under a cooperative agreement between Glenn and the Ohio Aerospace Institute (OAI), an acoustic-based pre-prototype seal was demonstrated for the first time. A pressurized cavity was attached to one end of the resonator while the other end remained open to ambient pressure. Measurements were taken at several values of applied pressure with the assembly stationary, oscillated at an off-resonance frequency, and then oscillated on-resonance. The three cases show that the flow through the conical resonator can be reduced by oscillating the resonator at the resonance frequency of the air contained within the cavity. The results are currently being compared with results obtained from a commercial computational fluid dynamics code. The objective is to improve the design through numerical simulation before fabricating a next-generation prototype sealing device. Future work is aimed at implementing acoustic seal design improvements to further reduce the leakage flow rate through the device and at reducing the device's overall size.

Daniels, Christopher C.↗

Investigation on the Practicality of Developing Reduced Thermal Models

Throughout the spacecraft design and development process, detailed instrument thermal models are created to simulate their on-orbit behavior and to ensure that they do not exceed any thermal limits. These detailed models, while generating highly accurate predictions, can sometimes lead to long simulation run times, especially when integrated with a spacecraft observatory model. Therefore, reduced models containing less detail are typically produced in tandem with the detailed models so that results may be more readily available, albeit less accurate. In the current study, both reduced and detailed instrument models are integrated with their associated spacecraft bus models to examine the impact of instrument model reduction on run time and accuracy. Preexisting instrument bus thermal model pairs from several projects were used to determine trends between detailed and reduced thermal models; namely, the Mirror Optical Bench (MOB) on the Gravity and Extreme Magnetism Small Explorer (GEMS) spacecraft, Advanced Topography Laser Altimeter System (ATLAS) on the Ice, Cloud, and Elevation Satellite 2 (ICESat-2), and the Neutral Mass Spectrometer (NMS) on the Lunar Atmosphere and Dust Environment Explorer (LADEE). Hot and cold cases were run for each model to capture the behavior of the models at both thermal extremes. It was found that, though decreasing the number of nodes from a detailed to reduced model brought about a reduction in the run-time, a large time savings was not observed, nor was it a linear relationship between the percentage of nodes reduced and time saved. However, significant losses in accuracy were observed with greater model reduction. It was found that while reduced models are useful in decreasing run time, there exists a threshold of reduction where, once exceeded, the loss in accuracy outweighs the benefit from reduced model runtime.

0000↗

Reduced El NiñO Variability in the Mid-Pliocene According to the Pliomip2 Ensemble

The mid-Pliocene warm period (3.264–3.025 Ma) is the most recent geological period during which atmospheric CO 2 levels were similar to recent historical values (∼400 ppm). Several proxy reconstructions for the mid-Pliocene show highly reduced zonal sea surface temperature (SST) gradients in the tropical Pacific Ocean, indicating an El Niño-like mean state. However, past modelling studies do not show these highly reduced gradients. Efforts to understand mid-Pliocene climate dynamics have led to the Pliocene Model Intercomparison Project (PlioMIP). Results from the first phase (PlioMIP1) showed clear El Niño variability (albeit significantly reduced) and did not show the greatly reduced time-mean zonal SST gradient suggested by some of the proxies. In this work, we study El Niño–Southern Oscillation (ENSO) variability in the PlioMIP2 ensemble, which consists of additional global coupled climate models and updated boundary conditions compared to PlioMIP1. We quantify ENSO amplitude, period, spatial structure and “flavour”, as well as the tropical Pacific annual mean state in mid-Pliocene and pre-industrial simulations. Results show a reduced ENSO amplitude in the model-ensemble mean (−24 %) with respect to the pre-industrial, with 15 out of 17 individual models showing such a reduction. Furthermore, the spectral power of this variability considerably decreases in the 3–4-year band. The spatial structure of the dominant empirical orthogonal function shows no particular change in the patterns of tropical Pacific variability in the model-ensemble mean, compared to the pre-industrial. Although the time-mean zonal SST gradient in the equatorial Pacific decreases for 14 out of 17 models (0.2 ∘C reduction in the ensemble mean), there does not seem to be a correlation with the decrease in ENSO amplitude. The models showing the most “El Niño-like” mean state changes show a similar ENSO amplitude to that in the pre-industrial reference, while models showing more “La Niña-like” mean state changes generally show a large reduction in ENSO variability. The PlioMIP2 results show a reasonable agreement with both time-mean proxies indicating a reduced zonal SST gradient and reconstructions indicating a reduced, or similar, ENSO variability.

mid-Pliocene warm period↗

Progress on the Reduced Gravity Cryogenic Transfer (RGCT) Project

Reduced gravity transfer of cryogenic propellants is crucial to being able to perform planned extended-duration space exploration missions. However, the transfer of cryogenic propellants under reduced gravity conditions has never been demonstrated in a mass-efficient fashion. Efficient cryogenic fluid transfer methods will reduce the transfer time or amount of propellant consumed for chilldown of transfer lines and tanks and ensure successful engine restart or fill of a customer receiver tank. The purpose of the Reduced Gravity Cryogenic Transfer (RGCT) project is to enhance line chilldown, tank chilldown, and tank fill/transfer in a reduced gravity environment through (1) ground and reduced gravity cryogenic testing and (2) numerical model development and validation, which includes empirical, lumped capacitance, and computational fluid dynamics modeling. Technologies developed, data gathered, and models developed and validated under RGCT have played a critical role in enabling longer duration in-space missions. This presentation will provide a description of the ongoing cryogenic propellant transfer ground and reduced gravity testing, numerical modeling, and technology development to-date.

Boiling↗

Implementation of a Hybrid Edge Node-Centroid Node Approach for the Generation of Reduced Thermal Models

Reduced thermal models are often required for delivery to organizations that manage observatory or launch models at the highest levels of assembly. However, the effort to generate reduced models, and verify against their detailed counterparts, is a challenge that has not yet been conclusively solved. Higher level organizations often place a limit on the number of nodes for delivered models with the assumption that smaller models generally result in less computation time. However, the burden of producing and verifying the accuracy of the reduced models is placed primarily on the lower-level organizations, which in turn consumes resources needed to produce these models. Limiting the total number of allowable nodes may also prevent users from taking full advantage of software capabilities that allow for faster generation of models, such as finite elements, which generally require more nodes than older centroid based models. A methodology using Thermal Desktop was described in 2010 which used: (1) finite elements and edge nodes for a conduction matrix, (2) centroid nodes for capacitance and radiative computations, and (3) the super network feature to produce a conduction matrix based only on the centroid nodes. At that time, the methodology was clear, but the implementation would have had to be done manually; however, with the inclusion of the OpenTD API, this methodology can now be implemented programmatically and for the first time, be a viable approach for the generation of reduced models. The approach was implemented and developed at the NASA Goddard Space Flight Center (GSFC) for the Capture, Containment, and Return System (CCRS) payload on the Earth Return Orbiter (ERO) as part of the Mars Sample Return (MSR) mission, resulting in the TCYEE tool. ERO features a spacecraft bus provided by Airbus through the European Space Agency (ESA) with node limitations on the delivered CCRS model provided by GSFC. TCYEE was used to generate the reduced model for this delivery and the predictions compared favorably to the detailed model currently in use for the thermal performance evaluation. Furthermore, TCYEE is being explored for potential use on the Roman Space Telescope (RST) for the generation of reduced models for delivery to the launch provider, which also has node limit requirements on the RST observatory model for use in launch simulation analyses. This paper describes the methodology, its implementation, and compares the performance of reduced models generated by TCYEE to their detailed counterparts.

Hume L. Peabody↗

AMORE-Isoprene v1.0: A New Reduced Mechanism for Gas-Phase Isoprene Oxidation

Gas-phase oxidation of isoprene by ozone (O 3 ) and the hydroxyl (OH) and nitrate (NO 3 ) radicals significantly impacts tropospheric oxidant levels and secondary organic aerosol formation. The most comprehensive and up-to-date chemical mechanism for isoprene oxidation consists of several hundred species and over 800 reactions. Therefore, the computational expense of including the entire mechanism in large-scale atmospheric chemical transport models is usually prohibitive, and most models employ reduced isoprene mechanisms ranging in size from ∼ 10 to ∼ 200 species. We have developed a new reduced isoprene oxidation mechanism using a directed-graph path-based automated model reduction approach, with minimal manual adjustment of the output mechanism. The approach takes as inputs a full isoprene oxidation mechanism, the environmental parameter space, and a list of priority species which are protected from elimination during the reduction process. Our reduced mechanism, AMORE-Isoprene (where AMORE stands for Automated Model Reduction), consists of 12 species which are unique to the isoprene mechanism as well as 22 reactions. We demonstrate its performance in a box model in comparison with experimental data from the literature and other current isoprene oxidation mechanisms. AMORE-Isoprene's performance with respect to predicting the time evolution of isoprene oxidation products, including isoprene epoxydiols (IEPOX) and formaldehyde, is favorable compared with other similarly sized mechanisms. When AMORE-Isoprene is included in the Community Regional Atmospheric Chemistry Multiphase Mechanism 1.0 (CRACMM1AMORE) in the Community Multiscale Air Quality Model (CMAQ, v5.3.3), O 3 and formaldehyde agreement with Environmental Protection Agency (EPA) Air Quality System observations is improved. O 3 bias is reduced by 3.4 ppb under daytime conditions for O 3 concentrations over 50 ppb. Formaldehyde bias is reduced by 0.26 ppb on average for all formaldehyde measurements compared with the base CRACMM1. There was no significant change in computation time between CRACMM1AMORE and the base CRACMM. AMORE-Isoprene shows a 35 % improvement in agreement between simulated IEPOX concentrations and chamber data over the base CRACMM1 mechanism when compared in the Framework for 0-D Atmospheric Modeling (F0AM) box model framework. This work demonstrates a new highly reduced isoprene mechanism and shows the potential value of automated model reduction for complex reaction systems.

Automated Model Reduction↗

Some design philosophy for reducing the community noise of advanced counter-rotation propellers

Advanced counter-rotation propellers have been indicated as possibly generating an unacceptable amount of noise for the people living near an airport. This report has explored ways to reduce this noise level, which is treated as being caused by the interaction of the upstream propeller wakes and vortices with the downstream propeller. The noise reduction techniques fall into two categories: (1) reducing the strength of the wakes and vortices, and (2) reducing the response of the downstream blades to them. The noise from the wake interaction was indicated as being reduced by increased propeller spacing and decreased blade drag coefficient. The vortex-interaction noise could be eliminated by having the vortex pass over the tips of the downstream blade, and it could be reduced by increased spacing or decreased initial circulation. The downstream blade response could be lessened by increasing the reduced frequency parameter omega or by phasing of the response from different sections to have a mutual cancellation effect. Uneven blade to blade spacing for the downstream blading was indicated as having a possible effect on the annoyance of counter-rotation propeller noise. Although there are undoubtedly additional methods of noise reduction not covered in this report, the inclusion of the design methods discussed would potentially result in a counter-rotation propeller that is acceptably quiet.

Dittmar, J. H.↗

Two-phase reduced gravity experiments for a space reactor design

Future space missions researchers envision using large nuclear reactors with either a single or a two-phase alkali-metal working fluid. The design and analysis of such reactors require state-of-the-art computer codes that can properly treat alkali-metal flow and heat transfer in a reduced-gravity environment. New flow regime maps, models, and correlations are required if the codes are to be successfully applied to reduced-gravity flow and heat transfer. General plans are put forth for the reduced-gravity experiments which will have to be performed, at NASA facilities, with benign fluids. Data from the reduced-gravity experiments with innocuous fluids are to be combined with normal gravity data from two-phase alkali-metal experiments. Because these reduced-gravity experiments will be very basic, and will employ small test loops of simple geometry, a large measure of commonality exists between them and experiments planned by other organizations. It is recommended that a committee be formed to coordinate all ongoing and planned reduced gravity flow experiments.

Antoniak, Zenen I.↗

Development of a reduced area horizontal tail for a wide body jet aircraft

Commercial transport aircraft fuel consumption can be significantly reduced by decreasing the size of the horizontal tail. Work on reducing the horizontal tail area of the L-1011 is discussed. The reduced area horizontal tail program consisted of design, fabrication and wind tunnel testing of horizontal tails with reduced planform areas of 30 to 38 percent relative to the standard L-1011 tail. The total drag of the aircraft in cruise was reduced by approximately 2 percent. However, it was necessary to impose forward center of gravity limitations on the aircraft because the maximum lift goal of the reduced area tail was not achieved and sufficient nose-up control authority was not available. On a new design this problem could have been solved by moving the landing gear aft and enlarging the cut-out in the aft fuselage to allow for larger horizontal stabilizer deflections. However, since this is an existing design, these modifications were unfeasible and resulted in the center of gravity restriction.

Rising, Jerry J.↗

Study of Critical Heat Flux and Two-Phase Pressure Drop Under Reduced Gravity

The design of the two-phase flow systems which are anticipated to be utilized in future spacecraft thermal management systems requires a knowledge of two-phase flow and heat transfer phenomena in reduced gravities. This program was funded by NASA headquarters in response to NRA-91-OSSA-17 and was managed by Lewis Research Center. The main objective of this program was to design and construct a two-phase test loop, and perform a series of normal gravity and aircraft trajectory experiments to study the effect of gravity on the Critical Heat Flux (CHF) and onset of instability. The test loop was packaged on two aircraft racks and was also instrumented to generate data for two-phase pressure drop. The normal gravity tests were performed with vertical up and downflow configurations to bound the effect of gravity on the test parameters. One set of aircraft trajectory tests was performed aboard the NASA DC-9 aircraft. These tests were mainly intended to evaluate the test loop and its operational performance under actual reduced gravity conditions, and to produce preliminary data for the test parameters. The test results were used to demonstrate the applicability of the normal gravity models for prediction of the two-phase friction pressure drop. It was shown that the two-phase friction multipliers for vertical upflow and reduced gravity conditions can be successfully predicted by the appropriate normal gravity models. Limited critical heat flux data showed that the measured CHF under reduced gravities are of the same order of magnitude as the test results with vertical upflow configuration. A simplified correlation was only successful in predicting the measured CHF for low flow rates. Instability tests with vertical upflow showed that flow becomes unstable and critical heat flux occurs at smaller powers when a parallel flow path exists. However, downflow tests and a single reduced gravity instability experiment indicated that the system actually became more stable with a parallel single-phase flow path. Several design modifications have been identified which will improve the system performance for generating reduced gravity data. The modified test loop can provide two-phase flow data for a range of operating conditions and can serve as a test bed for component evaluation.

Abdollahian, Davood↗

Reduced Toxicity Fuel Satellite Propulsion System

A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster, whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

Schneider, Steven J.↗

Reduced Toxicity Fuel Satellite Propulsion System Including Axial Thruster and ACS Thruster Combination

A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster, whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

Steven J Schneider↗

Reduced Toxicity Fuel Satellite Propulsion System Including Fuel Cell Reformer with Alcohols Such as Methanol

A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster, whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

Steven J Schneider↗

Reduced Toxicity Fuel Satellite Propulsion System Including Catalytic Decomposing Element with Hydrogen Peroxide

A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster, whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

Steven J Schneider↗

Reduced Toxicity Fuel Satellite Propulsion System Including Plasmatron

A reduced toxicity fuel satellite propulsion system including a reduced toxicity propellant supply for consumption in an axial class thruster and an ACS class thruster. The system includes suitable valves and conduits for supplying the reduced toxicity propellant to the ACS decomposing element of an ACS thruster. The ACS decomposing element is operative to decompose the reduced toxicity propellant into hot propulsive gases. In addition the system includes suitable valves and conduits for supplying the reduced toxicity propellant to an axial decomposing element of the axial thruster. The axial decomposing element is operative to decompose the reduced toxicity propellant into hot gases. The system further includes suitable valves and conduits for supplying a second propellant to a combustion chamber of the axial thruster. whereby the hot gases and the second propellant auto-ignite and begin the combustion process for producing thrust.

Schneider, Steven J.↗

Respiration rate in maize roots is related to concentration of reduced nitrogen and proliferation of lateral roots

The relationship between specific rate of respiration (respiration rate per unit root dry weight) and concentration of reduced nitrogen was examined for maize (Zea mays L.) roots. Plants with 2 primary nodal root axes were grown for 8 days in a split-root hydroponic system in which NO3- was supplied to both axes at 1.0 mol m-3, to one axis at 1.0 mol m-3 and the other axis at 0.0 mol m-3, or to both axes at 0.0 mol m-3. Respiration rates and root characteristics were measured at 2-day intervals. Specific rate of respiration was positively correlated in a nonlinear relationship with concentration of reduced nitrogen. The lowest specific rates of respiration occurred when neither axis received exogenous NO3- and the concentration of reduced nitrogen in the axes was less than 9 mg g-1. The greatest rates occurred in axes that were actively absorbing NO3- and contained more than 35 mg g-1 of reduced nitrogen. At 23 mg g-1 of reduced nitrogen, below which initiation of lateral branches was decreased by 30-50%, specific rate of respiration was 17% greater for roots actively absorbing NO3- than for roots not absorbing NO3-. Increases in specific rate of respiration associated with concentrations of reduced nitrogen greater than 23 mg g-1 were concluded to be attributable primarily to proliferation of lateral branches.

Non-NASA Center↗

Anterior segment sparing to reduce charged particle radiotherapy complications in uveal melanoma

PURPOSE: The purpose of this investigation is to delineate the risk factors in the development of neovascular glaucoma (NVG) after helium-ion irradiation of uveal melanoma patients and to propose treatment technique that may reduce this risk. METHODS AND MATERIALS: 347 uveal melanoma patients were treated with helium-ions using a single-port treatment technique. Using univariate and multivariate statistics, the NVG complication rate was analyzed according to the percent of anterior chamber in the radiation field, tumor size, tumor location, sex, age, dose, and other risk factors. Several University of California San Francisco-Lawrence Berkeley National Laboratory (LBNL) patients in each size category (medium, large, and extralarge) were retrospectively replanned using two ports instead of a single port. By using appropriate polar and azimuthal gaze angles or by treating patients with two ports, the maximum dose to the anterior segment of the eye can often be reduced. Although a larger volume of anterior chamber may receive a lower dose by using two ports than a single port treatment. We hypothesize that this could reduce the level of complications that result from the irradiation of the anterior chamber of the eye. Dose-volume histograms were calculated for the lens, and compared for the single and two-port techniques. RESULTS: NVG developed in 121 (35%) patients. The risk of NVG peaked between 1 and 2.5 years posttreatment. By univariate and multivariate analysis, the percent of lens in the field was strongly correlated with the development of NVG. Other contributing factors were tumor height, history of diabetes, and vitreous hemorrhage. Dose-volume histogram analysis of single-port vs. two-port techniques demonstrate that for some patients in the medium and large category tumor groups, a significant decrease in dose to the structures in the anterior segment of the eye could have been achieved with the use of two ports. CONCLUSION: The development of NVG after helium-ion irradiation is correlated to the amount of lens, anterior chamber in the treatment field, tumor height, proximity to the fovea, history of diabetes, and the development of vitreous hemorrhage. Although the influence of the higher LET deposition of helium-ions is unclear, this study suggests that by reducing the dose to the anterior segment of the eye may reduce the NVG complications. Based on this retrospective analysis of LBNL patients, we have implemented techniques to reduce the amount of the anterior segment receiving a high dose in our new series of patients treated with protons using the cyclotron at the UC Davis Crocker Nuclear Laboratory (CNL).

NASA Discipline Radiation Health↗