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At least 37 records · Page 2

Temporal dynamics of the multi-omic response to endurance exercise training

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood. Here, the Molecular Transducers of Physical Activity Consortium profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (https://motrpac-data.org/).

59 BASIC BIOLOGICAL SCIENCES↗

Bearing endurance tests in vacuum for sputtered molybdenum disulfide films

Angular-contact, 440C stainless steel, ball bearings with sputtered MoS2 films 0.0000006 x 10-7m (6000 A) thick were evaluated in a vacuum bearing chamber (1750 rpm, 137.9-N- (31-lbf-) thrust load) for endurance. Two types of sputtered films were evaluated: (1) MOS2 sputtered directly onto bearing components, and (2) a thin 0.0000001 x 10-7m (1000 A) underlayer of Cr3Si2 subsequently sputtered with MoS2. Bearing test evaluations in vacuum showed that endurance lives of more than 1000 hours (105,000,000 cycles) were obtained with bearings (cage, races, and balls) directly sputtered with MoS2. The same endurance lives were also obtained when only the races and cage were sputtered with an underlayer of Cr3Si2 and subsequently with MoS2.

Spalvins, T.↗

Handgrip and general muscular strength and endurance during prolonged bedrest with isometric and isotonic leg exercise training

Measurements of maximal grip strength and endurance at 40 percent max strength were obtained for 7 men 19-21 years of age, 1-2 days before and on the first recovery day during three 2-week bedrest (BR) periods, each separated by a 3-week ambulatory recovery period. The subjects performed isometric exercise (IME) for 1 hr/day, isotonic exercise (ITE) for 1 hr/day, and no exercise (NOE) in the three BR periods. It was found that the mean maximal grip strength was unchanged after all three BR periods. Mean grip endurance was found to be unchanged after IME and ITE training, but was significantly reduced after NOE. These results indicate that IME and ITE training during BR do not increase or decrease maximal grip strength, alghough they prevent loss of grip endurance, while the maximal strength of all other major muscle groups decreases in proportion to the length of BR to 70 days. The maximal strength reduction of the large muscle groups was found to be about twice that of the small muscle groups during BR. In addition, it is shown that changes in maximal strength after spaceflight, BR, or water immersion deconditioning cannot be predicted from changes in submaximal or maximal oxygen uptake values.

Greenleaf, J. E.↗

Ion thruster system (8-cm) cyclic endurance test

This report describes the qualification test of an Engineering-Model 5-mN-thrust 8-cm-diameter mercury ion thruster which is representative of the Ion Auxiliary Propulsion System (IAPS) thrusters. Two of these thrusters are scheduled for future flight test. The cyclic endurance test described herein was a ground-based test performed in a vacuum facility with a liquid-nitrogen-cooled cryo-surface and a frozen mercury target. The Power Electronics Unit, Beam Shield, Gimal, and Propellant Tank that were used with the thruster in the endurance test are also similar to those of the IAPS. The IAPS thruster that will undergo the longest beam-on-time during the actual space test will be subjected to 7,055 hours of beam-on-time and 2,557 cycles during the flight test. The endurance test was successfully concluded when the mercury in the IAPS Propellant Tank was consumed. At that time, 8,471 hours of beam-on-time and 599 cycles had been accumulated. Subsequent post-test-evaluation operations were performed (without breaking vacuum) which extended the test values to 652 cycles and 9,489 hours of beam-on-time. The Power Electronic Unit (PEU) and thruster were in the same vacuum chamber throughout the test. The PEU accumulated 10,268 hr of test time with high voltage applied to the operating thruster or dummy load.

Dulgeroff, C. R.↗

Preliminary design of a long-endurance Mars aircraft

The preliminary design requirements of a long endurance aircraft capable of flight within the Martian environment was determined. Both radioisotope/heat engine and PV solar array power production systems were considered. Various cases for each power system were analyzed in order to determine the necessary size, weight and power requirements of the aircraft. The analysis method used was an adaptation of the method developed by Youngblood and Talay of NASA-Langley used to design a high altitude earth based aircraft. The analysis is set up to design an aircraft which, for the given conditions, has a minimum wingspan and maximum endurance parameter. The results showed that, for a first approximation, a long endurance aircraft is feasible within the Martian environment. The size and weight of the most efficient solar aircraft were comparable to the radioisotope powered one.

Colozza, Anthony J.↗

Preliminary design of a long-endurance Mars aircraft

The preliminary design requirements of a long endurance aircraft capable of flight within the Martian environment was determined. Both radioisotope/heat engine and PV solar array power production systems were considered. Various cases for each power system were analyzed in order to determine the necessary size, weight and power requirements of the aircraft. The analysis method used was an adaptation of the method developed by Youngblood and Talay of NASA-Langley used to design a high altitude earth based aircraft. The analysis is set up to design an aircraft which, for the given conditions, has a minimum wingspan and maximum endurance parameter. The results showed that, for a first approximation, a long endurance aircraft is feasible within the Martian environment. The size and weight of the most efficient solar aircraft were comparable to the radioisotope powered one.

Colozza, Anthony J.↗

Charts for estimating the hovering endurance of a helicopter

As a means of comparing the performance capabilities of various helicopter propulsion systems, charts have been presented for estimating the hovering endurance of a helicopter in the form of a hovering-endurance parameter as a function of the ratio of total fuel load to helicopter initial weight for a range of initial thrust coefficients from 0.002 to 0.012 and for values of rotor mean lift coefficient from 0.24 to .072. The charts were presented for a helicopter having rotor blades with ideal twist. However, corrections may be applied to the hovering endurance to account for other combinations of twist and taper. The effects of stall and compressibility have been neglected.

HELICOPTERS↗

Pre-exercise hypervolemia and cycle ergometer endurance in men

Time to exhaustion at 87-91% of peak VO2 was measured in 5 untrained men (age: 31 +/- 8 years, body mass: 74.20 +/- 16.50 kg, body surface area: 1.90 +/- 0.24 m2, peak VO2: 2.87 +/- 0.40 l min-1, plasma volume: 3.21 +/- 0.88 l; means +/-SD) after consuming nothing (N) or two fluid formulations (10 ml kg-1, 743 +/- 161 ml): Performance 1 (P1), a multi-ionic carbohydrate drink, containing 55 mEq l-1 Na+, 4.16 g l-1 citrate, 20.49 g l-1 glucose, and 365 mOsm kg-1 H2O, and AstroAde (AA), a sodium chloride-sodium citrate hyperhydration drink, containing 164 mEq l-1 Na+, 8.54 g l-1 citrate, <5 mg l-1 glucose, and 253 mOsm kg-1 H2O. Mean (+/-SE) endurance for N, P1 and AA was 24.68 +/- 1.50, 24.55 +/- 1.09, and 30.50 +/- 3.44 min respectively. Percent changes in plasma volume (PV) from -105 min of rest to zero min before exercise were -1.5 +/- 3.2% (N), 0.2 +/- 2.2% (P1), and 4.8 +/- 3.0% (AA; P < 0.05). The attenuated endurance for N and P1 could not be attributed to differences in exercise metabolism (VE, RE, VO2) from the carbohydrate or citrate, terminal heart rate, levels of perceived exertion, forehead or thigh skin blood flow velocity, changes or absolute termination levels of rectal temperature. Thus, the higher level of resting PV for AA just before exercise, as well as greater acid buffering and possible increased energy substrate from citrate, may have contributed to the greater endurance.

NASA Center ARC↗

Twins Bed Rest Project: LBNP/Exercise Minimizes Changes in Lean Leg Mass, Strength and Endurance

Decreases in muscle strength and endurance frequently are observed in non-weightbearing conditions such as bed rest (BR), spaceflight or limb immobilization. Purpose: Ow purpose was to determine if supine treadmill exercise against simulated gravity, by application of lower body negative pressure (LBNP), prevents loss of lean leg mass, strength and endurance during 30 d of 6deg head-down bed rest (BR). Methods: Fifteen pairs of monozygous twins (8 male, 7 female pairs; 26+/-4 yrs; 170+/-12 cm; 62.6+/-11.3 kg; mean+/-SD) were subjects in the present study. One sibling of each pair of twins was randomly assigned to either an exercise (EX) or non-exercise (CON) group. The EX twin walked/jogged on a vertical treadmill within LBNP chamber 6 d/wk using a 40-min interval exercise protocol at 40-80% of pre-BR VO(sub 2peak). LBNP was adjusted individually for each subject such that footward force was between 1.0 and 1.2 times body weight (-53+/-5 mmHg LBNP). The CON twin performed no exercise during BR. Subjects performed isokinetic knee (60 and 120deg/s) and ankle (60deg/s) testing to assess strength and endurance (End) before and after BR. They also had their lean leg mass (L(sub mass)) evaluated by DEXA before and after BR. Results: Changes in peak torque (T(sub pk)) were smaller for flexion (flex) than for extension (ext) after BR and did not differ between groups. The CON group had larger decreases (P<0.05) in L(sub mass), knee and ankle ext T(sub pk), and knee ext End.

Amorim, Fabiano T.↗

Effect of Radiation and Endurance on Pulsed Programming of Commercial NAND Flash Memory

Independent and coupled effects of radiation and endurance on commercial NAND Flash memory is studied using pulsed programming enabled by interrupting the programming command at the chip-level. The effects of total ionization dose (TID) and endurance stress increase and decrease, respectively, the number of pulses needed to program an entire page. The coupled effect of endurance stress and TID appear to exhibit linear correlation. A neutral electron/ hole trap model is evaluated and correlates well with our results.

Narasimham, Avyaya Jayanthi↗

Amorphous Indium Oxide Channel FEFETs With Write Voltage of 0.9 V and Endurance >10 12 for Refresh-Free Embedded Memory

This work presents, for the first time, a back-end-of-the-line (BEOL)-compatible W-doped indium oxide (IWO) ferroelectric field-effect transistor (FEFET) with a record-low operating voltage below 0.9 V and a write speed of 20 ns while achieving a transient read current window (CW) ratio ( I LVT /I HVT ) greater than 10 4 . The device also exhibits exceptional reliability characteristics such as: 1) measured bipolar write endurance up to 10 12 cycles; 2) a fast read speed of 50 ns; 3) read endurance surpassing 10 12 cycles; and 4) retention exceeding 10 4 s at 85 ∘ C. Furthermore, a physics-based numerical model has been developed to investigate the nanoscale characteristics of BEOL FEFET devices, leveraging nucleation-limited switching in HfO 2 ferroelectrics and dc characterization to extract material and channel parameters for accurate device simulation. The simulation uncovers the stochastic switching behavior of BEOL amorphous oxide semiconductor (AOS) FEFETs and demonstrates an intrinsic switching time as low as 1 ps, highlighting the potential of BEOL AOS FEFETs for ultrafast memory applications. These results establish AOS FEFETs as a compelling candidate for high-density embedded memory applications for last-level cache (LLC) (L4) in advanced CMOS technology nodes.

1-V ferroelectric field-effect transistor (FEFET)↗

A 5,730-Hr Cyclic Endurance Test of the SPT-100

A cyclic endurance test of the Russian 1.35 kW Stationary Plasma Thruster SPT-100 is described. The endurance test was performed for 6,925 on/off cycles and 5,730.3 hours of operation at an input power to the thruster of 1.35 kW. Each cycle was approximately 50 minutes of thruster on-time and 23 minutes of thruster off-time. Thruster efficiency decreased from 50% to 42% as the thruster aged over the first 1,000 hours. The efficiency increased slowly over the next 1,000 hours and then slowly decreased to 45% by the end of the wear test. The unused cathode ignitor and radiation shields were found to erode at an unexpectedly high rate. A short between the cathode emitter and cathode ignitor occurred at cycle 5,316; the short was cleared without opening the vacuum tank but the short reoccurred at cycle 6,344.

Cyclic↗

Learning From Failure: Boosting Cycling Endurance of Optical Phase Change Materials

Chalcogenide phase change materials (PCMs) are a unique class of compounds whose switchable optical and electronic properties have fueled an explosion of emerging applications in microelectronics and microphotonics. Key to any application is the ability of PCMs to reliably switch between crystalline and amorphous states over a large number of cycles. While this issue has been extensively studied in the case of microelectronic memories, current PCM-based optical devices suffer from much inferior endurance. To understand the failure mechanisms limiting endurance of PCMs specifically in microphotonic devices, we have developed an on-chip resistive micro-heater platform and an automatic multi-modal characterization system to analyze cycling performance of optical PCMs. Reversible switching of large-area PCM devices over 50,000 cycles was demonstrated.

Optical phase change material↗

ILEOS: A Novel Intelligent Observing System Enabled by High Altitude Long Endurance Uncrewed Aerial Systems

Most major global satellite surveyors of climate-relevant trace gases have relatively coarse spatial resolution or temporal sampling. While these data can be supplemented by fine-pointing satellites and aircraft, the spatial and temporal resolutions available from crewed aircraft is not sufficient to observe stochastic, ephemeral events that take place between observations. Emerging High Altitude Long Endurance (HALE) Uncrewed Aerial Systems (UAS) can operate for months at a time and loiter over targets to provide continuous daylight geostationary-like observations, allowing these new platforms to be integrated with existing satellites as part of a New Observing Strategy (NOS).To aid in the planning of future NOS missions, NASA is developing the Intelligent Long Endurance Observing System (ILEOS), a science activity planning system. ILEOS will help scientists build plans to improve spatio-temporal resolution of climate-relevant gases by fusing coarse-grained sensor data from satellites and other sources(e.g., terrain, forecasts), and plan HALE UAS flights to obtain finer-grain (high spatio-temporal) data. ILEOS will also enable observations for longer periods and of environments not accessible through in-situ observations and crewed aircraft field campaigns.

science planning pipeline↗

Oxygen vacancy contributions to the electrical stress response and endurance of ferroelectric hafnium zirconium oxide thin films

Despite its scalability and CMOS process compatibility, the limited endurance and sub-optimal stress response of ferroelectric Zr-substituted hafnia [(Hf,Zr)O 2 ] have been one of the key impediments toward its integration into practical device and technology applications. Here, using electrical measurements complemented by photoluminescence spectroscopy, we investigate the underlying mechanisms behind this behavior in 10 nm thick W/Hf 0.5 Zr 0.5 O 2 /W capacitors. Analyzing the evolution of leakage current with stress cycles and the spectroscopic response of the stress-induced leakage current, we attribute the behavior to defect levels, which lie at 0.6 eV from the conduction band edge of the ferroelectric. Photoluminescence spectroscopy, in turn, further corroborates the defect level's position within the bandgap while enabling its attribution to the presence of oxygen vacancies. Furthermore, this work helps to identify oxygen vacancies as the key factor responsible for the degraded endurance and stress response in (Hf,Zr)O 2 and subsequently motivates the exploration of methods to reduce the oxygen vacancy concentrations without destabilizing the ferroelectric orthorhombic phase.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Endurance testing of a 30-cm Kaufman thruster

Results of a program to demonstrate lifetime capability of a 30-cm Kaufman ion thruster with a 6000 hour endurance test are described. Included in the program are (1) thruster fabrication, (2) design and construction of a test console containing a transistorized high frequency power processor, and control circuits which provide unattended automatic operation of the thruster, and (3) modification of a vacuum facility to incorporate a frozen mercury collector and permit unattended operation. Four tests ranging in duration from 100 to 1100 hours have been completed. These tests and the resulting thruster modifications are described. The status of the endurance test is also presented.

Collett, C. R.↗

A 20000-hour endurance test of a structurally and thermally integrated 5-cm diameter ion thruster main cathode

A 5-cm diameter mercury ion thruster main cathode has completed over 20,000 hours of operation in an ongoing lifetime endurance test. The cathode operating parameters remained at acceptable performance levels throughout the test, the first 9175 hours of which were part of a thruster endurance test. After 20,000 hours, the cathode discharge was easily restarted, the tip orifice indicated negligible erosion and the tip heater showed no degradation. The cathode-isolator- vaporizer assembly, a major thruster subsystem, has thus successfully demonstrated an operational lifetime capability of 20,000 hours, which is the lifetime goal of the 8-cm diameter auxiliary propulsion ion thruster.

Wintucky, E. G.↗

A 20,000-hour endurance test of a structurally and thermally integrated 5-cm diameter ion thruster main cathode

A 5-cm diameter mercury ion thruster main cathode has completed over 20,000 hours of operation in an ongoing lifetime endurance test. The cathode operating parameters remained at acceptable performance levels throughout the test, the first 9175 hours of which were part of a thruster endurance test. After 20,000 hours, the cathode discharge was easily restarted, the tip orifice indicated negligible erosion and the tip heater showed no degradation. The cathode-isolator-vaporizer assembly, a major thruster subsystem, has thus successfully demonstrated an operational lifetime capability of 20,000 hours, which is the lifetime goal of the 8-cm diameter auxiliary propulsion ion thruster.

Wintucky, E. G.↗