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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sources NASA NTRS DOE OSTI

NASA NTRS1934

Pressure-Distribution Measurements on the Hull and Fins of a 1/40-Scale Model of the U. S. Airship "Akron."

This report presents the results of measurements of pressure distribution conducted in the propeller-research wind tunnel of the National Advisory Committee for Aeronautics on a 1/40-scale model of the U. S. Airship "Akron" (ZRS-4). The pressures, which were measured simultaneously at nearly 400 orifices located at 26 stations along one side of the hull, were recorded by two photographic multiple manometers placed inside the model. The hull pressures were measured both with and without the tail surfaces and the control car for eight angles of pitch varying from 0 degree to 20 degrees and at air speeds of approximately 70 and 100 miles per hour. The pressures were also measured at approximately 160 orifices on one horizontal fin for the above speeds and pitch angles and for nine elevator angles.

Freeman, Hugh B↗

DOE OSTI2020

Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants

Establishing causal links between non-coding variants and human phenotypes is an increasing challenge. In this paper, we introduce a high-throughput mouse reporter assay for assessing the pathogenic potential of human enhancer variants in vivo and examine nearly a thousand variants in an enhancer repeatedly linked to polydactyly. We show that 71% of all rare non-coding variants previously proposed as causal lead to reporter gene expression in a pattern consistent with their pathogenic role. Variants observed to alter enhancer activity were further confirmed to cause polydactyly in knockin mice. We also used combinatorial and single-nucleotide mutagenesis to evaluate the in vivo impact of mutations affecting all positions of the enhancer and identified additional functional substitutions, including potentially pathogenic variants hitherto not observed in humans. Our results uncover the functional consequences of hundreds of mutations in a phenotype-associated enhancer and establish a widely applicable strategy for systematic in vivo evaluation of human enhancer variants.

59 BASIC BIOLOGICAL SCIENCES↗