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At least 37 records · Page 2

On the isolation of halophilic microorganisms from salt deposits of great geological age

From salt sediments of Triassic or Permian age from various locations in the world halophilic microorganisms were isolated. Molecular characteristics of several of the isolates suggested they belong to the archaebacteria. One group appears to represent novel strains; several properties of one such isolate, strain BIp, are described here. The existence of viable microorganisms in ancient sediment would have great implications with respect to our notions on evolution, the research for life in extraterrestrial environments, and the longterm survival of functional biological structures. Of crucial importance is thus the question if these microorganisms existed in the salt since the time of deposition or invaded at some later date. Some suggestions to address these issues experimentally are discussed.

Stan-Lotter, Helga↗

On the Isolation of Halophilic Microorganisms from Salt Deposits of Great Geological Age

From salt sediments of Triassic or Permian ace from various locations in the world halophilic microorganisms were isolated. Molecular characteristics of several of the isolates suggested they belong to the archaebacteriae. One group appears to represent novel strains; several properties or one such isolate, strain BIp, are described here. The existence of viable microorganisms in ancient sediments would have great implications with respect to our notions on evolution, the search for life in extraterrestrial environments and the long- term survival of functional biological structures. Of crucial importance is thus the question if these microorganisms existed in the salt since the time of deposition or invaded at some later date. Some suggestions to address these issues experimentally are discussed.

Stan-Lotter, Helga↗

Application of Rotating Wall Vessel (RWV) Cell Culture for Pancreas Islet Cell Transplantation

Type I insulin-dependent diabetes mellitus (IDDM) remains a major cause of morbidity and mortality in both pediatric and adult populations, despite significant advances in medical management. While insulin therapy treats symptoms of acute diabetes, it fails to prevent chronic complications such as microvascular disease, blindness, neuropathy, and chronic renal failure. Strict control of blood glucose concentrations delays but does not prevent the onset and progression of secondary complications. Although, whole pancreas transplantation restores physiological blood glucose levels, a continuous process of allograft rejection causes vascular and exocrine-related complications. Recent advances in methods for isolation and purification of pancreatic islets make transplantation of islet allografts an attractive alternative to whole pancreas transplantation. However, immunosuppressive drugs are necessary to prevent rejection of islet allografts and many of these drugs are known to be toxic to the islets. Since auto-transplants of isolated islets following total pancreatectomy survive and function in vivo, it is apparent that a major obstacle to successful clinical islet transplantation is the immunogenicity of the islet allografts.

Rutzky, Lynne P.↗

Gyro Evaluation for the Mission to Jupiter

As an important component in NASA's New Frontiers Program, the Jupiter Polar Orbiter (Juno) mission is designed to investigate in-depth physical properties of Jupiter. It will include the giant planet's ice-rock core and atmospheric studies as well as exploration of its polar magnetosphere. It will also provide the opportunity to understand the origin of the Jovian magnetic field. Due to severe radiation environment of the Jovian system, this mission inherently presents a significant technical challenge to Attitude Control System (ACS) design since the ACS sensors must survive and function properly to reliably maneuver the spacecraft throughout the mission. Different gyro technologies and their critical performance characteristics are discussed, compared and evaluated to facilitate a choice of appropriate gyro-based inertial measurement unit to operate in a harsh Jovian environment to assure mission success.

physical properties↗

Human Space Flight

The first human space flight, in the early 1960s, was aimed primarily at determining whether humans could indeed survive and function in micro-gravity. Would eating and sleeping be possible? What mental and physical tasks could be performed? Subsequent programs increased the complexity of the tasks the crew performed. Table 1 summarizes the history of U.S. space flight, showing the projects, their dates, crew sizes, and mission durations. With over forty years of experience with human space flight, the emphasis now is on how to design space vehicles, habitats, and missions to produce the greatest returns to human knowledge. What are the roles of the humans in space flight in low earth orbit, on the moon, and in exploring Mars?

Woolford, Barbara↗

Small and Lightweight Laser Retro-Reflector Arrays for Lunar Landers

A set of small and lightweight laser retro-reflector arrays (LRAs) was fabricated and tested for use on lunar landersunder NASA's Commercial Lunar Payload Service program. Each array contains eight 1.27-cm-diameter cornercube retro-reflectors mounted on a dome-shaped aluminum structure. The arrays are 5.0cmin diameter at the base,1.6 cm in height, and 20 g in mass. They can be tracked by an orbiting laser altimeter, such as the Lunar OrbiterLaser Altimeter, froma distance of a few hundred kilometers or by a landing lidar on future lunar landers. TheLRAsdemonstrated a diffraction-limited optical performance. They were designed and tested to survive and function ontheMoon for decades,well after the lander missions are completed.

Sun, Xiaoli↗

Optimization of Debris Shields on the NISAR Mission’s L-Band Radar Instrument

The NASA-ISRO Synthetic Aperture Radar (NISAR) space mission is a collaboration between NASA and the Indian Space Research Organization (ISRO), launching in the 2020s to a polar orbit of 747km altitude. The mission will provide spatial and temporal measurements of land surface changes (e.g. ice sheets, vegetation, earthquakes). Many of the SAR electronics boxes are mounted on the exterior of the structure. Their singlewall box lids efficiently radiate heat for thermal control, but are not very efficient debris shields. The initial design showed an unacceptably high impact risk as estimated with NASA’s ORDEM3 debris model and Bumper impact analysis tool. Each box has a different role in instrument functionality, and this was captured in a reliability model used to optimize the distribution of shield mass among the boxes: total added mass was minimized while maintaining a threshold of functionality and survival probability that was acceptable to the project.

Chinn, James Z.↗

Penetrator Science Objectives for the Moon and Artemis

Some key decadal-scale mission goals at the Moon have been proposed, these include sample return, the establishment of a lunar geophysical network, and exploring extreme environments, such as the permanently shadowed regions at the lunar poles. These environments present accessibility challenges, though contain significant rewards for science return. Small penetrator experiments have great potential for precursor and survey missions for the exploration of these environments, producing early science data and later mission planning. Penetrators have been conceptualized for planetary exploration for several decades but have yet to be operated successfully. Penetrators are designed to be self-contained vehicles with a suite of instruments de-signed to survive and function after achieving certain depth into the regolith using the kinetic energy of impact, or designed to measure mechanical (or compositional) properties as part of a much larger vehicle.

C. J. Ahrens↗

NiCd battery reliability for shuttle serviced spacecraft

Data from life-cycle testing of 22-cell NiCd batteries designed for shuttle-service spacecrafts are analyzed, first by averaging battery cycle lives as a function of temperature and depth of discharge, and then by calculating single cell failure and survival probabilities as a function of temperature, depth of discharge, and number of operating cycles. The single cell data are used to calculate battery survival probabilities. A mathematical failure model which is a function of the quantity of charge through the battery and the temperature is characterized, suggesting a predictive capability for accurate estimation of energy storage subsystem life and performance of accelerated tests. The failure mechanism described is apparently independent of most charge-discharge parameters and common to most cell sizes.

Eliason, J.↗

On reliability modeling and analysis of ultrareliable fault-tolerant digital systems.

The processes of protective redundancy, namely, standby replacement (SR) redundancy and hybrid redundancy (a combination of SR and multiple-line voting redundancy), find application in the architecture of fault-tolerant digital computers and enable them to be ultrareliable and self-repairing. The claims to ultrareliability lead to the challenge of quantitatively evaluating and assigning a value to the probability of survival as a function of the mission durations intended. This note presents various mathematical models, and derives and displays quantitative evaluations of system reliability as a function of various mission parameters of interest to the system designer.

Mathur, F. P.↗

An Experimental and Theoretical Study of Radiative Extinction of Diffusion Flames

In a recent paper on 'Observations of candle flames under various atmospheres in microgravity' by Ross et al., it was found that for the same atmosphere, the burning rate per unit wick surface area and the flame temperature were considerably reduced in microgravity as compared with normal gravity. Also, the flame (spherical in microgravity) was much thicker and further removed from the wick. It thus appears that the flame becomes 'weaker' in microgravity due to the absence of buoyancy generated flow which serves to transport the oxidizer to the combustion zone and remove the hot combustion products from it. The buoyant flow, which may be characterized by the strain rate, assists the diffusion process to execute these essential functions for the survival of the flame. Thus, the diffusion flame is 'weak' at very low strain rates and as the strain rate increases the flame is initially 'strengthened' and eventually it may be 'blown out'. The computed flammability boundaries of T'ien show that such a reversal in material flammability occurs at strain rates around 5 sec. At very low or zero strain rates, flame radiation is expected to considerably affect this 'weak' diffusion flame because: (1) the concentration of combustion products which participate in gas radiation is high in the flame zone; and (2) low strain rates provide sufficient residence time for substantial amounts of soot to form which is usually responsible for a major portion of the radiative heat loss. We anticipate that flame radiation will eventually extinguish this flame. Thus, the objective of this project is to perform an experimental and theoretical investigation of radiation-induced extinction of diffusion flames under microgravity conditions. This is important for spacecraft fire safety.

Atreya, Arvind↗

Neuritogenesis: A model for space radiation effects on the central nervous system

Pivotal to the astronauts' functional integrity and survival during long space flights are the strategies to deal with space radiations. The majority of the cellular studies in this area emphasize simple endpoints such as growth related events which, although useful to understand the nature of primary cell injury, have poor predictive value for extrapolation to more complex tissues such as the central nervous system (CNS). In order to assess the radiation damage on neural cell populations, we developed an in vitro model in which neuronal differentiation, neurite extension, and synaptogenesis occur under controlled conditions. The model exploits chick embryo neural explants to study the effects of radiations on neuritogenesis. In addition, neurobiological problems associated with long-term space flights are discussed.

Vazquez, M. E.↗

Radiant extinction of gaseous diffusion flames

The absence of buoyancy-induced flows in microgravity significantly alters the fundamentals of many combustion processes. Substantial differences between normal-gravity and microgravity flames have been reported during droplet combustion, flame spread over solids, candle flames, and others. These differences are more basic than just in the visible flame shape. Longer residence time and higher concentration of combustion products create a thermochemical environment which changes the flame chemistry. Processes such as flame radiation, that are often ignored under normal gravity, become very important and sometimes even controlling. This is particularly true for conditions at extinction of a microgravity diffusion flame. Under normal-gravity, the buoyant flow, which may be characterized by the strain rate, assists the diffusion process to transport the fuel and oxidizer to the combustion zone and remove the hot combustion products from it. These are essential functions for the survival of the flame which needs fuel and oxidizer. Thus, as the strain rate is increased, the diffusion flame which is 'weak' (reduced burning rate per unit flame area) at low strain rates is initially 'strengthened' and eventually it may be 'blown-out'. Most of the previous research on diffusion flame extinction has been conducted at the high strain rate 'blow-off' limit. The literature substantially lacks information on low strain rate, radiation-induced, extinction of diffusion flames. At the low strain rates encountered in microgravity, flame radiation is enhanced due to: (1) build-up of combustion products in the flame zone which increases the gas radiation, and (2) low strain rates provide sufficient residence time for substantial amounts of soot to form which further increases the flame radiation. It is expected that this radiative heat loss will extinguish the already 'weak' diffusion flame under certain conditions. Identifying these conditions (ambient atmosphere, fuel flow rate, fuel type, etc.) is important for spacecraft fire safety. Thus, the objective is to experimentally and theoretically investigate the radiation-induced extinction of diffusion flames in microgravity and determine the effect of flame radiation on the 'weak' microgravity diffusion flame.

Atreya, Arvind↗

Survivability Versus Time

Develop Survivability vs Time Model as a decision-evaluation tool to assess various emergency egress methods used at Launch Complex 39B (LC 39B) and in the Vehicle Assembly Building (VAB) on NASAs Kennedy Space Center. For each hazard scenario, develop probability distributions to address statistical uncertainty resulting in survivability plots over time and composite survivability plots encompassing multiple hazard scenarios.

Probability Distribution Function↗

Fire Detection Tradeoffs as a Function of Vehicle Parameters

Fire survivability depends on the detection of and response to a fire before it has produced an unacceptable environment in the vehicle. This detection time is the result of interplay between the fire burning and growth rates; the vehicle size; the detection system design; the transport time to the detector (controlled by the level of mixing in the vehicle); and the rate at which the life support system filters the atmosphere, potentially removing the detected species or particles. Given the large differences in critical vehicle parameters (volume, mixing rate and filtration rate) the detection approach that works for a large vehicle (e.g. the ISS) may not be the best choice for a smaller crew capsule. This paper examines the impact of vehicle size and environmental control and life support system parameters on the detectability of fires in comparison to the hazard they present. A lumped element model was developed that considers smoke, heat, and toxic product release rates in comparison to mixing and filtration rates in the vehicle. Recent work has quantified the production rate of smoke and several hazardous species from overheated spacecraft polymers. These results are used as the input data set in the lumped element model in combination with the transport behavior of major toxic products released by overheating spacecraft materials to evaluate the necessary alarm thresholds to enable appropriate response to the fire hazard.

microgravity↗

Fire Detection Tradeoffs as a Function of Vehicle Parameters

Fire survivability depends on the detection of and response to a fire before it has produced an unacceptable environment in the vehicle. This detection time is the result of interplay between the fire burning and growth rates; the vehicle size; the detection system design; the transport time to the detector (controlled by the level of mixing in the vehicle); and the rate at which the life support system filters the atmosphere, potentially removing the detected species or particles. Given the large differences in critical vehicle parameters (volume, mixing rate and filtration rate) the detection approach that works for a large vehicle (e.g. the ISS) may not be the best choice for a smaller crew capsule. This paper examines the impact of vehicle size and environmental control and life support system parameters on the detectability of fires in comparison to the hazard they present. A lumped element model was developed that considers smoke, heat, and toxic product release rates in comparison to mixing and filtration rates in the vehicle. Recent work has quantified the production rate of smoke and several hazardous species from overheated spacecraft polymers. These results are used as the input data set in the lumped element model in combination with the transport behavior of major toxic products released by overheating spacecraft materials to evaluate the necessary alarm thresholds to enable appropriate response to the fire hazard.

microgravity↗

Characterization and recovery of Deep Sub Micron (DSM) technologies behavior under radiation

This paper serves a twofold purpose: characterize the behavior of a reconfigurable chip exposed to radiation; and demonstrate a method for functionality recovery due to Total Ionizing Dose (TID) effects. The experiments are performed using a PL developed reconfigurable device, a Field Programmable Transistor Array (FPTA). The paper initially describes experiments on the characterization of the NMOS transistor behavior for TID values up to 300krad. The behavior of analog and digital circuits downloaded onto the FPTA chip is also assessed for TID effects. This paper also presents a novel approach for circuit functionality recovery due to radiation effects based on Evolvable Hardware. The key idea is to reconfigure a programmable device, in-situ, to compensate, or bypass its degraded or damaged components. Experiments with total radiation dose up to 300kRad show that while the functionality of a variety of circuits, including digital gates, a rectifier and a Digital to Analog Converter implemented on a FPTA-2 chip is degraded/lost at levels before 200kRad, the correct functionality can be recovered through the proposed evolutionary approach and the chips are able to survive higher radiation, for several functions in excess of total radiation dose of 250kRad.

evolvable hardware↗