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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Self-Driving Laboratories for Chemistry and Materials Science

Self-driving laboratories (SDLs) promise an accelerated application of the scientific method. Through the automation of experimental workflows, along with autonomous experimental planning, SDLs hold the potential to greatly accelerate research in chemistry and materials discovery. This review provides an in-depth analysis of the state-of-the-art in SDL technology, its applications across various scientific disciplines, and the potential implications for research and industry. This review additionally provides an overview of the enabling technologies for SDLs, including their hardware, software, and integration with laboratory infrastructure. Most importantly, this review explores the diverse range of scientific domains where SDLs have made significant contributions, from drug discovery and materials science to genomics and chemistry. We provide a comprehensive review of existing real-world examples of SDLs, their different levels of automation, and the challenges and limitations associated with each domain.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS2004

NASA Classroom Bioreactor

Exploration of space provides a compelling need for cell-based research into the basic mechanisms that underlie the profound changes that occur in terrestrial life that is transitioned to low gravity environments. Toward that end, NASA developed a rotating bioreactor in which cells are cultured while continuously suspended in a cylinder in which the culture medium rotates with the cylinder. The randomization of the gravity vector accomplished by the continuous rotation, in a low shear environment, provides an analog of microgravity. Because cultures grown in bioreactors develop structures and functions that are much closer to those exhibited by native tissue than can be achieved with traditional culture methods, bioreactors have contributed substantially to advancing research in the fields of cancer, diabetes, infectious disease modeling for vaccine production, drug efficacy, and tissue engineering. NASA has developed a Classroom Bioreactor (CB) that is built from parts that are easily obtained and assembled, user-friendly and versatile. It can be easily used in simple school settings to examine the effect cultures of seeds or cells. An educational brief provides assembly instructions and lesson plans that describes activities in science, math and technology that explore free fall, microgravity, orbits, bioreactors, structure-function relationships and the scientific method.

Scully, Robert↗
NASA NTRS2001

Instrument technologies for the detection of extraterrestrial intersteller robotic probes.

In the continuing endeavor to detect evidence of ETI (Extraterrestrial Intelligence) in the solar neighborhood, instrument technologies now exist that allow the formation of a scientific method to carry out a search for interstellar robotic probes of possible extraterrestrial origin. The range of currently observable probe features/manifestations will be shown and how they influence search space, instrument selection and deployment. Autonomous instrument platforms (i.e. robotic observatories) to search for anomalous energy signatures can be designed and assembled using Commercial off-the-shelf (COTS) hardware and software. The COTS approach to observatory design provides an economical, flexible and robust path toward collecting reliable data. The present variety of COTS instruments permits the necessary observational sensitivity , bandwidth and embedded processing speed to establish a nearby robotic probe detection envelope. A survey of these instrument technologies will be presented and how they can be applied to the challenge of collecting enough scientific data on anomalous observational phenomena to determine whether or not a robotic probe was detected

Stride, Scot Lloyd↗
NASA NTRS2017

Benefits of International Collaboration on the International Space Station

The International Space Station is a valuable platform for research in space, but the benefits are limited if research is only conducted by individual countries. Through the efforts of the ISS Program Science Forum, international science working groups, and interagency cooperation, international collaboration on the ISS has expanded as ISS utilization has matured. Members of science teams benefit from working with counterparts in other countries. Scientists and institutions bring years of experience and specialized expertise to collaborative investigations, leading to new perspectives and approaches to scientific challenges. Combining new ideas and historical results brings synergy and improved peer-reviewed scientific methods and results. World-class research facilities can be expensive and logistically complicated, jeopardizing their full utilization. Experiments that would be prohibitively expensive for a single country can be achieved through contributions of resources from two or more countries, such as crew time, up- and downmass, and experiment hardware. Cooperation also avoids duplication of experiments and hardware among agencies. Biomedical experiments can be completed earlier if astronauts or cosmonauts from multiple agencies participate. Countries responding to natural disasters benefit from ISS imagery assets, even if the country has no space agency of its own. Students around the world participate in ISS educational opportunities, and work with students in other countries, through open curriculum packages and through international competitions. Even experiments conducted by a single country can benefit scientists around the world, through specimen sharing programs and publicly accessible "open data" repositories. For ISS data, these repositories include GeneLab and the Physical Science Informatics System. Scientists can conduct new research using ISS data without having to launch and execute their own experiments. Multilateral collections of research results publications, maintained by the ISS international partnership and accessible via nasa.gov, make ISS results available worldwide, and encourage new users, ideas and research. The paper explores international collaboration history, its evolution and maturation, change of focus during its different phases, and growth of its effectiveness (in accordance with the especially established criteria) in the light of benefits for the entire ISS community. With the International Space Station extended through at least 2024, more crew time becoming available and new facilities arriving on board the ISS, these benefits of international scientific collaboration on the ISS can only increase.

Hasbrook, Pete↗
NASA NTRS2017

Benefits of International Collaboration on the International Space Station

The International Space Station is a valuable platform for research in space, but the benefits are limited if research is only conducted by individual countries. Through the e orts of the ISS Program Science Forum, international science working groups, and interagency cooperation, international collaboration on the ISS has expanded as ISS utilization has matured. Members of science teams benefit from working with counterparts in other countries. Scientists and institutions bring years of experience and specialized expertise to collaborative investigations, leading to new perspectives and approaches to scientific challenges. Combining new ideas and historical results brings synergy and improved peer-reviewed scientific methods and results. World-class research facilities can be expensive and logistically complicated, jeopardizing their full utilization. Experiments that would be prohibitively expensive for a single country can be achieved through contributions of resources from two or more countries, such as crew time, up- and downmass, and experiment hardware. Cooperation also avoids duplication of experiments and hardware among agencies. Biomedical experiments can be completed earlier if astronauts or cosmonauts from multiple agencies participate. Countries responding to natural disasters benefit from ISS imagery assets, even if the country has no space agency of its own. Students around the world participate in ISS educational opportunities, and work with students in other countries, through open curriculum packages and through international competitions. Even experiments conducted by a single country can benefit scientists around the world, through specimen sharing programs and publicly accessible \open data" repositories. For ISS data, these repositories include GeneLab, the Physical Science Informatics System, and different Earth science data systems. Scientists can conduct new research using ISS data without having to launch and execute their own experiments. Multilateral collections of research results publications, maintained by the ISS international partnership and accessible via nasa.gov, make ISS results available worldwide, and encourage new users, ideas and research. The paper explores effectiveness of international collaboration in the course of the ISS Program execution. The collaboration history, its evolution and maturation, change of focus during its different phases, and growth of its effectiveness (in accordance with the especially established criteria) are also considered in the paper in the light of benefits for the entire ISS community. With the International Space Station extended through at least 2024, more crew time becoming available and new facilities arriving on board the ISS, these benefits of international scientific collaboration on the ISS can only increase.

Robinson, Julie A.↗
DOE OSTI2023

Standards, dissemination, and best practices in systems biology

In this study, the reproducibility of scientific research is crucial to the success of the scientific method. Here, we review the current best practices when publishing mechanistic models in systems biology. We recommend, where possible, to use software engineering strategies such as testing, verification, validation, documentation, versioning, iterative development, and continuous integration. In addition, adhering to the Findable, Accessible, Interoperable, and Reusable modeling principles allows other scientists to collaborate and build off of each other’s work. Existing standards such as Systems Biology Markup Language, CellML, or Simulation Experiment Description Markup Language can greatly improve the likelihood that a published model is reproducible, especially if such models are deposited in well-established model repositories. Where models are published in executable programming languages, the source code and their data should be published as open-source in public code repositories together with any documentation and testing code. For complex models, we recommend container-based solutions where any software dependencies and the run-time context can be easily replicated.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Message in a Bottle—An Update to the Golden Record: 1. Objectives and Key Content of the Message

In the first part of this series, we delve into the foundational aspects of “Message in a Bottle (MIAB)” (henceforth referred to as MIAB). This study builds upon the legacy of the Voyager Golden Records, launched aboard Voyager 1 and 2 in 1977, which aimed to communicate with intelligent species beyond our world. These records not only offer a snapshot of Earth and human civilization but also represent our desire to establish contact with advanced alien civilizations. Given the absence of mutually understood signs, symbols, and semiotic conventions, MIAB, like its predecessor, uses scientific methods to design an innovative means of communication that encapsulates the story of humanity. Our goal is to share our collective knowledge, emotions, innovations, and aspirations in a way that provides a universal, yet contextually relevant, understanding of human society, the evolution of life on Earth, and our hopes and concerns for the future. Through this time and space traveling capsule, we also strive to inspire and unify current and future generations to celebrate and safeguard our shared human experience.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2024

Information and Statistics in Nuclear Experiment and Theory (ISNET)

As with all empirical sciences, nuclear physics operates in the virtuous cycle of the scientific method: observations inspire theoretical models; models lead to new predictions; predictions are tested in experiments; experiments lead to new observations; and so on. Evaluating what we are inferring, and how certain we are of it, is key to this process. These requirements, and a general interest in applying novel statistical, mathematical, and computational techniques, led to the formation of a dedicated research community entitled “Information and Statistics in Nuclear Experiment and Theory (ISNET)” (https://isnet-series.github.io/), which now includes more than 300 members. While the community’s interests lean toward nuclear theory, the unifying theme for this group is the inference of knowledge from data.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2022

PDB‐101: Molecular Explorations through Biology and Medicine

PDB‐101 is an online portal for teachers, students, and the general public to promote exploration of the structural biology of proteins and nucleic acids ( pdb101.rcsb.org ). Learning about the diverse shapes and functions of these biological macromolecules helps to understand all aspects of biomedicine and agriculture, from protein synthesis to health and disease to biological energy. Why PDB‐101? Researchers around the world are studying these molecules at the atomic level. These 3D structures are freely available at the Protein Data Bank (PDB), the central storehouse of biomolecular structures. This website builds introductory materials to help beginners get started in the basics of biomolecular structure and function (“101”, as in an entry level course) as well as resources for extended learning. Since 2011, PDB‐101 has been developed by the RCSB PDB , a global resource for the advancement of research and education in biology and medicine. Along with our Worldwide PDB collaborators, RCSB PDB curates, annotates, and makes publicly available the PDB data deposited by scientists around the globe. The RCSB PDB then provides a window to these data through a rich online resource with powerful searching, reporting, and visualization tools for researchers. This information is then streamlined for students and teachers at PDB‐101. Features include the ongoing Molecule of the Month series, educational materials such as paper models, posters, molecular animations, educational curricula and more. The section “Guide to Understanding PDB Data” is a primer for detailed PDB‐specific information: PDB Data, Visualizing Structures, Reading Coordinate Files, scientific methods for structure determination, and more. PDB‐101 also runs annual Video Challenges for high school students. Participants create short videos that tell molecular stories that connect structural biology and medicine. Previous topics have included HIV/AIDS, diabetes, and antimicrobial resistance. The 2022 challenge will focus on Molecular Mechanisms of Cancer. PDB‐101 activities are evaluated using user surveys, feedback from in‐person activities, and website analytics. In 2020, PDB‐101 hosted >850,000 users and >2.6 million page views.

Zardecki, Christine↗
DOE OSTI2021

Examining Nuisance Aerosol Detections in Light of the Origin of the Screening Process (November 2021)

The evolution of philosophy and computations in the International Data Center (IDC) related to aerosol samples have had profound impacts on the number of recorded detections in the network since routine operations began in 2000. Key decisions from policymakers have been the list of triggering radionuclides, the scheme for categorizing these into interest levels 1-5, and an algorithm for determining when an anthropogenic isotope is seen so often that it is no longer interesting, known as the Exponential Weighted Moving Average (EWMA). These are described in the Operations Manual of the IDC. Key parameters that are controlled by the IDC but for which the IDC receives occasional input from policymakers include the constants in EWMA and the peak significance threshold for individual gamma rays, the latter of which directly leads to determination of the presence or absence of a radionuclide in a sample. There are also changes in computations which the IDC makes and informs policy makers about, such as changes in how background is computed, which could also affect the ease of detecting a peak – real or false. Rather than focus on the quantitative changes due to computation changes, this work records some thinking on how isotopes and peak significance levels were chosen, and the resulting detections seen over 18 years during the buildup of the International Monitoring System (IMS). These detections are considered on a global scale to try to determine the relative impact on monitoring, and in some cases, the nature of their existence. Repeated detections of 131I and 133I are the most troublesome, but they are not so frequent to be a major problem for the Verification Regime. These detections could probably be handled adequately using scientific methods currently under development for xenon backgrounds. It is also somewhat problematic that top-level analysis of aerosol backgrounds has not been reported previous to this. The steep increase in the rate of detections after 2016 are a concern, either in the actual backgrounds or from changes in the calculations methods used to generate the Reviewed Radionuclide Report (RRR.) Final conclusions of the authors are that the computational stability of the RRR is very important. With computational stability, changes can be usefully analyzed as being due to changes in radioactivity in Earth’s atmosphere This report is a distillation into text of a talk given in the Radionuclide Experts Group (RNEG) in Vienna during Working Group B (WGB) in February of 2019. This report does not directly contain any IDC data, only summaries by year, or by isotope, or by location. No specific IDC detection by time, location, or isotope is included.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2024

Extended Application of State LiDAR Datasets in Locating Orphaned Wells in Appalachian Region

Location inaccuracies in historical and state oil and gas well databases present a major challenge in locating these orphaned wells. To address this, modern scientific methods such as Light Detection and Ranging (LiDAR), aerial magnetic remote sensing, and digital GIS products have been employed. LiDAR technology uses light to detect surface area changes, providing detailed surface views. This is a workflow to process LiDAR data for use in locating orphaned wells.

Gorantla, Vijaya [NETL Site Support Contractor, Na↗
DOE OSTI2022

Observing Arctic Sea Ice

Our understanding of Arctic sea ice and its wide-ranging influence is deeply rooted in observation. Advancing technologies have profoundly improved our ability to observe Arctic sea ice, document its processes and properties, and describe atmosphere-ice-ocean interactions with unprecedented detail. Yet, our progress toward better understanding the Arctic sea ice system is mired by the stark disparities between observations that tend to be siloed by method, scientific discipline, and application. This article presents a review and philosophical design for observing sea ice and accelerating our understanding of the Arctic sea ice system. We give a brief history of Arctic sea ice observations and showcase the 2018 melt season within the context of five observational themes: spatial heterogeneity, temporal variability, cross-disciplinary science, scalability, and retrieval uncertainty. We synthesize buoy data, optical imagery, satellite retrievals, and airborne measurements to demonstrate how disparate data sets can be woven together to transcend observational-scale issues. The results show that there are limitations to interpreting any single data set alone. However, many of these limitations can be surmounted by combining observations that cross spatial and temporal scales. We conclude the article with pathways toward coordinating across observational platforms in order to: (1) optimize the scientific, operational, and community return on observational investments, and (2) facilitate a richer understanding of Arctic sea ice and its role in the climate system.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1972

Social impact evaluation : Some implications of the specific decisional context approach for anticipatory project assessment with special reference to available alternatives and to techniques of evaluating the social impacts of the anticipated effects of such alternatives

The implications are explored of the specific decision context approach to anticipatory project assessment. More specifically, it is hypothesized that with respect to any given effect of a proposed project or action (mobility, job opportunities, air pollution, population distribution, etc.) such effect will likely differ in probability and/or magnitude from one decisional context to another; that the social desirability or undesirability of a given effect is a function (will differ with) each specific decisional context; that therefore the social impact of such effect will in all likelihood differ with each specific decisional context; and that the social significance of even the dame social impact of a given effect will vary from one decisional context to another when such social impact interacts with (competes with or reinforces) the social impacts of other effects. It also follows from this analysis that the respective roles of scientific method (demonstrable data) and adversarial system will not only differ with each specific decisional context but with each alternative course of action available to the decisional entity in each specific context.

Mayo, L. H.↗
NASA NTRS1976

The concept verification testing of materials science payloads

The concept Verification Testing (CVT) project at the Marshall Space Flight Center, Alabama, is a developmental activity that supports Shuttle Payload Projects such as Spacelab. It provides an operational 1-g environment for testing NASA and other agency experiment and support systems concepts that may be used in shuttle. A dedicated Materials Science Payload was tested in the General Purpose Laboratory to assess the requirements of a space processing payload on a Spacelab type facility. Physical and functional integration of the experiments into the facility was studied, and the impact of the experiments on the facility (and vice versa) was evaluated. A follow-up test designated CVT Test IVA was also held. The purpose of this test was to repeat Test IV experiments with a crew composed of selected and trained scientists. These personnel were not required to have prior knowledge of the materials science disciplines, but were required to have a basic knowledge of science and the scientific method.

Griner, C. S.↗
NASA NTRS1982

Wind shear and vortex wake research in UK, 1982

A wind shear and vortex wake and their impact on aircraft were investigated. The systems and advice to help pilots, and rational scientific methods to assist in advising certification authorities and those interested in improving flight safety were developed. Wind Shear and Vortex Wakes are related, they are both invisible enemies of aircraft in the form of large disturbances in the atmosphere, both cause major accidents. Problems of building wakes at airports are is considered. Research on wind shear was initiated by the American FAA following the Boston, New York and Denver accidents to civil airliners. This resulted in: useful advice to pilots about wind shear; better attempts by the meteorologists at forecasting wind shear conditions; and useful ideas for wind shear measurement and warning systems. Three major research tasks are outstanding: (1) Worldwide measurements to give reliable estimates of probability and details of the forms of large wind shears; (2) Developments of real time wind shear measuring systems for ground or airborne use; and (3) Establishing relationships between measured wind shear and the potential hazard to an aircraft, or class of aircraft.

Alan A. Woodfield↗
NASA NTRS1991

FAST: A multi-processed environment for visualization of computational fluid

Three dimensional, unsteady, multizoned fluid dynamics simulations over full scale aircraft is typical of problems being computed at NASA-Ames on CRAY2 and CRAY-YMP supercomputers. With multiple processor workstations available in the 10 to 30 Mflop range, it is felt that these new developments in scientific computing warrant a new approach to the design and implementation of analysis tools. These large, more complex problems create a need for new visualization techniques not possible with the existing software or systems available as of this time. These visualization techniques will change as the supercomputing environment, and hence the scientific methods used, evolve ever further. Visualization of computational aerodynamics require flexible, extensible, and adaptable software tools for performing analysis tasks. FAST (Flow Analysis Software Toolkit), an implementation of a software system for fluid mechanics analysis that is based on this approach is discussed.

Bancroft, Gordon V.↗
NASA NTRS1991

FAST: A multi-processed environment for visualization of computational fluid dynamics

Three-dimensional, unsteady, multi-zoned fluid dynamics simulations over full scale aircraft are typical of the problems being investigated at NASA Ames' Numerical Aerodynamic Simulation (NAS) facility on CRAY2 and CRAY-YMP supercomputers. With multiple processor workstations available in the 10-30 Mflop range, we feel that these new developments in scientific computing warrant a new approach to the design and implementation of analysis tools. These larger, more complex problems create a need for new visualization techniques not possible with the existing software or systems available as of this writing. The visualization techniques will change as the supercomputing environment, and hence the scientific methods employed, evolves even further. The Flow Analysis Software Toolkit (FAST), an implementation of a software system for fluid mechanics analysis, is discussed.

Bancroft, Gordon V.↗