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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults

Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex, which may reflect the beginning of Alzheimer's disease (AD). Functional connectivity between the anterolateral EC and the anterior-temporal (AT) memory network appears to drive higher tau deposition in AT than in the posterior-medial (PM) memory network. Here, we investigated whether this differential vulnerability to tau deposition may predict different cognitive consequences of EC, AT, and PM tau. Using 18 F-flortaucipir (FTP) and 11 C-Pittsburgh compound-B (PiB) positron emission tomography (PET) imaging, we measured tau and Aβ in 124 cognitively normal human older adults (74 females, 50 males) followed for an average of 2.8 years for prospective cognition. We found that higher FTP in all three regions was individually related to faster memory decline, and that the effects of AT and PM FTP, but not EC, were driven by Aβ+ individuals. Moreover, when we included all three FTP measures competitively in the same model, only AT FTP significantly predicted memory decline. Our data support a model whereby tau, facilitated by Aβ, transits from EC to cortical regions that are most closely associated with the anterolateral EC, which specifically affects memory in the initial stage of AD. Memory also appears to be affected by EC tau in the absence of Aβ, which may be less clinically consequential. These findings may provide clarification of differences between normal aging and AD, and elucidate the transition between the two stages. SIGNIFICANCE STATEMENT Tau and β-amyloid (Aβ) are hallmarks of Alzheimer's disease (AD) but are also found in cognitively normal people. It is unclear whether, and how, this early deposition of tau and Aβ may affect cognition in normal aging and the asymptomatic stage of AD. We show that tau deposition in the entorhinal cortex (EC), which is common in advanced age, predicts memory decline in older adults independent of Aβ, likely reflecting normal, age-related memory loss. In contrast, tau in anterior-temporal (AT) regions is most predictive of memory decline in Aβ+ individuals. These data support the idea that tau preferentially spreads to specific cortical regions, likely through functional connections, which plays a primary role in memory decline in the early stage of AD.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2018

Disentangling Climate and Disturbance Effects on Regional Vegetation Greening Trends

Productivity of northern latitude forests is an important driver of the terrestrial carbon cycle and is already responding to climate change. Studies ofthe satellite-derived Normalized Difference VegetationIndex (NDVI) for northern latitudes indicate recent changes in plant productivity. These detected greening and browning trends are often attributedto a lengthening of the growing season from warming temperatures. Yet, disturbance-recovery dynamics are strong drivers of productivity and can mask direct effects of climate change. Here, we analyze 1-km resolution NDVI data from 1989to 2014 for the northern latitude forests of the Greater Yellowstone Ecosystem for changes in plant productivity to address the following questions:(1) To what degree has greening taken place in the GYE over the past three decades? and (2) What is the relative importance of disturbance and climate in explaining NDVI trends? We found that the spatial extents of statistically significant productivity trends were limited to local greening and browning areas. Disturbance history, predominately fire disturbance, was a major driver of these detected NDVI trends. After accounting for fire-,insect-, and human-caused disturbances, increasing productivity trends remained. Productivity of northern latitude forests is generally considered temperature-limited; yet, we found that precipitation was a key driver of greening in the GYE.

Disturbance↗
NASA NTRS1979

Effects of regional hemoconcentration during LBNP on plasma volume determinations

Blood samples were obtained from forearm vein or artery with indwelling cannula (1) before, (2) during the last min, and (3) about 2 min after lower body negative pressure (LBNP) in 16 experiments to determine whether plasma volume (PV) estimates were affected by regional hemoconcentration in the lower body. Total hemoglobin (THb) was estimated with the CO method prior to LBNP. Hemoglobin (Hb) and hematocrit (Hct) values from (2) gave only a 3% (87 ml) loss in PV due to LBNP, assuming no change in THb. However, Hb and Hct values from (3) showed an 11% loss in PV (313 ml). This 72% underestimation of PV loss with (2) must have resulted from the sequestration of blood and subsequent hemoconcentration in the lower body during LBNP. The effects of LBNP on PV should be estimated 1-3 min after exposure, after mixing but before extravascular fluid returns to the circulation.

Loeppky, J. A.↗
NASA NTRS1995

Observations of the Global Characteristics and Regional Radiative Effects of Marine Cloud Liquid Water

The large-scale spatial distribution and temporal variability of cloud liquid water path (LWP) over the world's oceans and the relationship of cloud LWP to temperature and the radiation budget are investigated using recent satellite measurements from the Special Sensor Microwave/Imager (SSM/I), the Earth Radiation Budget Experiment (ERBE), and the International Satellite Cloud Climatology Project (ISCCP). Observations of cloud liquid water on a 2.5 deg x 2.5 deg and are used over a 53-month period beginning July 1987 and ending in December 1991. The highest values of cloud liquid water (greater than 0.13 kg/sq m) occur largely along principal routes of northern midlatitude storms and in areas dominated by tropical convection. The zonally averaged structure is distinctly trimodal, where maxima appear in the midlatitudes and near the equator. The average marine cloud LWP over the globe is estimated to be about 0.113 kg/sq m. Its highest seasonal variability is typically between 15% and 25% of the annual mean but in certain locations can exceed 30%. Comparisons of cloud LWP to temperature for low clouds during JJA and DJF of 1990 show significant positive correlations at colder temperatures and negative correlations at warmer temperatures. The correlations also exhibit strong seasonal and regional variation. Coincident and collocated observations of cloud LWP from the SSM/I and albedo measurements from the Earth Radiation Budget Satellite (ERBS) and the NOAA-10 satellite are compared for low clouds in the North Pacific and North Atlantic. The observed albedo-LWP relationships correspond reasonably well with theory, where the average cloud effective radius (r(sub e)) is 11.1 microns and the standard deviation is 5.2 microns. The large variability in the inferred values of r(sub e) suggests that other factors may be important in the albedo-LWP relationships. In terms of the effect of the LWP on the net cloud forcing, the authors find that a 0.05 kg/sq m increase in LWP (for LWP less than 0.2 kg/sq m) results in a -25 W/sq m change in the net cloud forcing at a solar zenith angle of 75 deg.

Greenwald, Thomas J.↗
NASA NTRS2001

The Effect of Regional Climate Variability on Outbreak of Bartonellosis Epidemics in Peru

Bartonellosis is a vector-borne, highly fatal, emerging infectious disease, which has been known in the Peruvian Andes since the early 1600s and has continued to be a problem in many mountain valleys in Peru and other Andean South American countries. The causative bacterium, Bartonella bacilliformis (Bb), is believed to be transmitted to humans by bites of the sand fly Lutzomyia verrucarum. According to available medical records, the transmission of infection often occurs in river valleys of the Andes Mountains at an altitude between 800 and 3500 meters above sea level. It shows a seasonal pattern, which usually begins to rise in December, peaks in February and March, and is at its lowest from July until November. The epidemics of bartonellosis also vary interannually, occurring every four to eight years, and appear to be associated with the El Nino cycle. In response to the National Oceanic and Atmospheric Administration (NOAA) announcement on climate variability and human health, which was constructed to stimulate integrated multidisciplinary research in the area of climate variability and health interactions, we have conducted a study to investigate the relationship between the El Nino induced regional climate variation and the outbreak of bartonellosis epidemics in Peru. Two test sites, Caraz and Cusco, were selected for this study. According to reports, Caraz has a long-standing history of endemic transmission and Cusco, which is located about five degrees poleward of Caraz, had no recorded epidemics until the most recent 1997/1998 El Nino event. The goal of this study is to clarify the relative importance of climatic risk factors for each area that could be predicted in advance, thus allowing implementation of cost-effective control measures, which would reduce disease morbidity and mortality.

Zhou, Jia-Yu↗
NASA NTRS2011

Climatic Effects of Regional Nuclear War

We use a modern climate model and new estimates of smoke generated by fires in contemporary cities to calculate the response of the climate system to a regional nuclear war between emerging third world nuclear powers using 100 Hiroshima-size bombs (less than 0.03% of the explosive yield of the current global nuclear arsenal) on cities in the subtropics. We find significant cooling and reductions of precipitation lasting years, which would impact the global food supply. The climate changes are large and longlasting because the fuel loadings in modern cities are quite high and the subtropical solar insolation heats the resulting smoke cloud and lofts it into the high stratosphere, where removal mechanisms are slow. While the climate changes are less dramatic than found in previous "nuclear winter" simulations of a massive nuclear exchange between the superpowers, because less smoke is emitted, the changes seem to be more persistent because of improvements in representing aerosol processes and microphysical/dynamical interactions, including radiative heating effects, in newer global climate system models. The assumptions and calculations that go into these conclusions will be described.

Oman, Luke D.↗
DOE OSTI2022

Contribution of Tibetan Plateau ecosystems to local and remote precipitation through moisture recycling

The ecosystems of the Tibetan Plateau (TP) provide multiple important ecosystem services that benefit both local populations and those beyond, such as through climate regulation services on precipitation for East Asia and China. However, the precipitation regulation service of the TP ecosystems for supplying moisture and maintaining precipitation is yet to be evaluated. In this study, we used the moisture recycling framework and a moisture tracking model to quantify the precipitation regulation services of TP ecosystems for their contribution to precipitation. We found TP ecosystems contributed substantially to local and downwind precipitation, with a declined contribution from 221 mm/year for the TP and neighboring areas, to <10 mm/year for eastern China and other surrounding countries. Among ecosystem types, grassland contributed most to precipitation, followed by barren and snow lands, forests, and shrublands. In terms of seasonality, precipitation contribution from TP ecosystems was greater in summer months than in non-summer months for western China, while the opposite was true for eastern China – though the magnitude was much smaller. Over the past two decades, the significant evapotranspiration increases in TP translated to a widespread increase in precipitation contribution for TP and downwind beneficiary regions from 2000 to 2020. Our study provides a quantitative way to understand the precipitation regulation services of TP ecosystems through moisture recycling, substantiating their key role to safeguard precipitation and the water cycle for downwind regions– effectively acting as an ecological security shelter that could be perceived by the public.

Li, Yan↗
DOE OSTI2024

Genome-wide Association Study Identifies Candidate Loci with Major Contributions to the Genetic Control of Pod Morphological Traits in Snap Bean

Snap beans are cultivars of common bean (Phaseolus vulgaris) that are cultivated for their fleshy immature pods that exhibit a wide diversity of pod shapes and sizes. The genetic basis of the snap bean pod shape is complex and involves the interaction of multiple genes. This study used a snap bean diversity panel composed of heirloom and improved cultivars used in North America and genome-wide association studies (GWAS) to investigate the genetic basis of pod morphological characteristics, including length, width, height, width/height ratio, and coefficients of variation (CVs). The GWAS detected multiple genomic regions associated with each pod trait, with a total of 20 quantitative trait loci (QTLs) for pod length, 9 for pod width, 14 for pod height, and 10 for pod width/height ratio. Regarding theCVof each pod trait, genome-wide association analyses detected six QTL for lengthCVs, five for widthCVs, 15 for heightCVs, and six for width/height ratioCVs. Thirteen regions in seven chromosomes were associated with two or more pod traits. Eighteen QTLs for pod traits in this study colocated with previously reported QTLs for pod and seed traits. The QTL intervals encompass gene models with homologues in other species that are involved in the control of developmental processes. These results capture the complex nature of the genetic control of snap bean pod traits and confirm the significance of genomic regions harboring overlapping QTLs identified in this and other studies. The phenotypic expression of pod traits in snap bean appears to be under the control of a few genomic regions with a strong effect with additional contributions of multiple small-effect regions. Validation of the function of the candidate genes identified in associated regions will contribute to our understanding of legume pod development.

Agriculture↗
NASA NTRS1980

The effects of regional insolation differences upon advanced solar thermal electric power plant performance and energy costs

The performance and cost of four 10 MWe advanced solar thermal electric power plants sited in various regions of the continental United States was studied. Each region has different insolation characteristics which result in varying collector field areas, plant performance, capital costs and energy costs. The regional variation in solar plant performance was assessed in relation to the expected rise in the future cost of residential and commercial electricity supplied by conventional utility power systems in the same regions. A discussion of the regional insolation data base is presented along with a description of the solar systems performance and costs. A range for the forecast cost of conventional electricity by region and nationally over the next several decades is given.

Latta, A. F.↗
NASA NTRS1979

The effects of regional insolation differences upon advanced solar thermal electric power plant performance and energy costs

This paper presents the performance and cost of four 10-MWe advanced solar thermal electric power plants sited in various regions of the continental United States. Each region has different insolation characteristics which result in varying collector field areas, plant performance, capital costs, and energy costs. The paraboloidal dish, central receiver, cylindrical parabolic trough, and compound parabolic concentrator (CPC) comprise the advanced concepts studied. This paper contains a discussion of the regional insolation data base, a description of the solar systems' performances and costs, and a presentation of a range for the forecast cost of conventional electricity by region and nationally over the next several decades.

Latta, A. F.↗
DOE OSTI2024

Developing expert scientific consensus on the environmental and societal effects of marine artificial structures prior to decommissioning

Thousands of artificial (‘human-made’) structures are present in the marine environment, many at or approaching end-of-life and requiring urgent decisions regarding their decommissioning. No consensus has been reached on which decommissioning option(s) result in optimal environmental and societal outcomes, in part, owing to a paucity of evidence from real-world decommissioning case studies. To address this significant challenge, we asked a worldwide panel of scientists to provide their expert opinion. They were asked to identify and characterise the ecosystem effects of artificial structures in the sea, their causes and consequences, and to identify which, if any, should be retained following decommissioning. Experts considered that most of the pressures driving ecological and societal effects from marine artificial structures (MAS) were of medium severity, occur frequently, and are dependent on spatial scale with local-scale effects of greater magnitude than regional effects. The duration of many effects following decommissioning were considered to be relatively short, in the order of days. Overall, environmental effects of structures were considered marginally undesirable, while societal effects marginally desirable. Experts therefore indicated that any decision to leave MAS in place at end-of-life to be more beneficial to society than the natural environment. However, some individual environmental effects were considered desirable and worthy of retention, especially in certain geographic locations, where structures can support improved trophic linkages, increases in tourism, habitat provision, and population size, and provide stability in population dynamics. The expert analysis consensus that the effects of MAS are both negative and positive for the environment and society, gives no strong support for policy change whether removal or retention is favoured until further empirical evidence is available to justify change to the status quo. The combination of desirable and undesirable effects associated with MAS present a significant challenge for policy- and decision-makers in their justification to implement decommissioning options. Decisions may need to be decided on a case-by-case basis accounting for the trade-off in costs and benefits at a local level.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2025

Self-Assembled Oligomers Facilitate Amino Acid-Driven CO 2 Capture at the Air–Aqueous Interface

Direct air capture of CO 2 using amino acid absorbents, such as glycine or sarcosine, is constrained by the relatively slow mass transfer of CO 2 through the air–aqueous interface. Our recent study showed a marked improvement in CO 2 capture by introducing CO 2 -permeable oligo-dimethylsiloxane (ODMS-MIM + ) oligomers with cationic (imidazolium, MIM + ) headgroups. Here, in this work, we have employed all-atom molecular dynamics simulations in combination with subensemble analysis using network theory to provide a detailed molecular picture of the behavior of CO 2 and the glycinate anions (Gly – ) at the ODMS-MIM + decorated air–aqueous interfaces. We show that the cationic head groups of the surfactants enhance the concentration and lifetime of Gly – in the interfacial region, while ODMS tails promote the physisorption of CO 2 in the interfacial region. Together, these two factors increase the effective region of contact and the probability of interactions between CO 2 and Gly – compared to that of the pure air–aqueous interface. The fundamental insights gained in this work establish essential foundations for developing hybrid systems with oligomer-decorated interfaces to maximize the overall CO 2 capture rates.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2024

Explaining Health Risk Behaviors in the U.S. with Social Deprivation at Local and Regional Levels

Health risk behaviors are precursors to many chronic health outcomes, and hence, they pose a challenge to public health. Social deprivation undoubtedly creates circumstances that limit access to healthy habits. Moreover, broad regional effects (weather patterns, political ideology, social norms), and local characteristics (cultural notions and barriers, urban places) also influence lifestyle choices and must be accounted for to truly understand the impact of social deprivation on risky behaviors. This research fills the knowledge gap in epidemiological modeling of health risk behaviors by leveraging machine learning to find associations between social deprivation and health risk behaviors, when adjusted by regional and local effects. Four health risk behaviors, namely, binge drinking, smoking, lack of sleep, and lack of physical activity from the CDC PLACES project are considered in a single framework to understand and compare the interplay between local/regional characteristics and seven measures of social deprivation. Our results indicate that local and/or regional factors rise to the top for three out of four risk behaviors (binge drinking, smoking and lack of sleep) out-competing social deprivation measures. Un-entangling the geographical effects reveals that poverty, educational attainment and non-employment are the three deprivation measures most significantly associated with all four health risk factors. The research thus indicates that public health policies to promote healthy lifestyle behaviors must seek to remedy social deprivation, but using socially and culturally sensitive interventions.

Gokhale, Swapna↗
NASA NTRS1979

Effects of D region ionization on radio wave propagation

The effects of anomalous D region ionization upon radio wave propagation are described for the main types of disturbances: sudden ionospheric disturbances, relativistic electron events, magnetic storms, auroral disturbances, polar cap events, and stratospheric warmings. Examples of radio wave characteristics for such conditions are given for the frequencies between the extremely low (3-3000 Hz) and high (3-30 MHz) frequency domains. Statistics on the disturbance effects and radio wave data are given in order to contribute towards the evaluation of possibilities for predicting the radio effects.

Larsen, T. R.↗