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A series of virtual workshops was held during June 2020 to seek ways to integrate the efforts of the astrobiology and space biology research communities under a broad umbrella of space life sciences. The overall goal was to help inspire creativity that will guide us towards new synergistic ideas complementing these existing disciplines that are of such importance to NASA. Workshop participants aspired to: (1) Exploit synergies across the biological sciences at NASA, (2) Foster research, enabling technology, and mission concepts that support commonalities in space biology, astrobiology, synthetic biology, planetary protection, and relevant human health, performance, and habitation concerns, (3) Envision the development of an “Arc of Biology in Space” to encompass this multi-faceted joint research community. The focused objective of the workshop series was to explore and demonstrate how the integration of astrobiology and space biology could be achieved, identify strengths and weaknesses in the current state of the art, and recognize where our greatest challenges lay. Specifically, we seek to: (1) Establish a scientific framework for an integrated life sciences effort, (2) Pioneer discovery by creating unique opportunities in the fundamental biological sciences, (3) Explore novel combinations of existing technologies across the relevant disciplines, (4) Invent new technologies and applications in space life sciences, and (5) Creatively increase access to spaceflight, emerging and novel technologies, Earth analogs, and simulated natural and spaceflight environments. The community aims for a broad arc of biological competence in the context of space and planetary science, spaceflight, and habitation. We will present dominant themes and innovative ideas that resulted from this interchange of relevant communities.