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Cardiovascular Disease Risk in NASA Astronauts Across the Lifespan: Historical Cohort Studies

Acute effects of spaceflight on the cardiovascular system have been studied extensively, but the combined chronic effects of spaceflight and aging are not well understood. Preparation for and participation in space flight activities are potentially associated with cardiovascular disease risk factors (e.g., altered dietary and exercise habits, physical and emotional stress, circadian shifts, radiation). Further, astronauts who travel into space multiple times may be at an increased risk across their lifespan. However, comparing the risk of cardiovascular disease in astronauts to other large cohorts is difficult. For example, comparisons between astronauts and large national cohorts, such as the National Health and Nutrition Examination Survey and the National Health Information Survey, are hampered by significant differences in health status between astronauts and the general population, and most of these national studies fail to provide longitudinal data on population health. To address those limitations, NASA's Longitudinal Study of Astronaut Health previously sought to compare the astronauts to a cohort of civil servants employed at the Johnson Space Center. However, differences between the astronauts and civil servants at the beginning of the study, as well as differential follow up, limited the ability to interpret the results. To resolve some of these limitations, two unique cohorts of healthy workers, U.S. Air Force aviators and Cooper Center Longitudinal Study participants, have been identified as potential comparison populations for the astronaut corps. The Air Force cohort was chosen due to similarities in health at selection, screening, and some occupational exposures that Air Force aviators endure, many of which mirror that of the astronaut corps. The Cooper Clinic cohort, a generally healthy prevention cohort, was chosen for the vast array of clinical cardiovascular measures collected in a longitudinal manner complementary to those collected on astronauts, for a large number of subjects since 1971. The purpose of this study is to understand the incidence of cardiovascular disease outcomes and risk factors in the astronaut corps and determine whether the rates of disease are different than these two cohorts. The research questions are: 1. Are there differences in the incidence of CVD outcomes (MI, revascularization, and stroke) between each cohort and the NASA Astronaut cohort? 2. Are there differences in the incidence of CVD risks (hypertension, hyperlipidemia, arrhythmias, and diabetes) between each cohort and the NASA Astronaut cohort? 3. Are there differences between each cohort and the NASA Astronaut cohort in how CVD risk factors (e.g., lipids, behaviors) change across time? Collectively, results from these studies will enhance our understanding of how cardiovascular disease outcomes and risk factors change across time in astronauts compared to other longitudinally-studied healthy cohorts and determine if there are interactions between or additive effects of the occupational health effects of spaceflight exposure and normal aging.

Charvat, Jacqueline M.

A numerical study of longitudinal vortex interaction with a boundary layer

A numerical study of vortex generator aerodynamics has been carried out with a reduced set of Navier-Stokes equations. These are used to model the physical process of longitudinal vortex interaction with a turbulent boundary layer on a flat plate in incompressible flow. Comparison with experimental data is used to validate the approach, and detailed predictions are made. Results show an increase in skin friction and a decrease in integral layer thicknesses where the flow is toward the wall, and the reverse where the flow is away from the wall. The major controlling parameters of vortex strength, spacing and height are each found to have optimum values for which the efficiency of boundary-layer thinning is maximized. Vortex core spreading and secondary vorticity produced in the layer are observed and studied, as well as circulation decay and other features of the flow.

Russell, D. A.

Qualitative Simulator Study of Longitudinal Stick Forces and Displacements Desirable During Tracking

In this study in which an airplane simulator with one degree of freedom (pitch) was used, results were determined for three conditions of airplane dynamics. For an undamped natural frequency of 1/2 cps with a damping ratio of 0.18 and for an undamped natural frequency of 1 cps with a damping ratio of 0.11, moderate longitudinal stick forces and displacements were desired.

CONTROL, LONGITUDINAL

A study of longitudinal dynamic stability in flight

This investigation was carried out by the aerodynamic staff of the National Advisory Committee for Aeronautics for the purpose of studying experimentally the longitudinal dynamic stability of airplanes in flight. The airplanes selected for this purpose were a standard rigged VE-7 advanced-training airplane and a JN4H with special tail surfaces. The airplanes were caused to oscillate by means of the elevator, then the longitudinal control was either locked or kept free while the oscillation died out. The magnitude of the oscillation was recorded either by a kymograph or an airspeed meter. The results show that the engine speed has as much effect on the period and damping as the airspeed, and that, contrary to theory as developed for small oscillations, the damping decreased at the higher airspeeds with closed throttle.

Norton, F H

Complete Study of Longitudinal Oscillation of a VE-7 Airplane

This investigation was carried out by the National Advisory Committee for Aeronautics at Langley Field in order to study as closely as possible the behavior of an airplane when it was making a longitudinal oscillation. The airspeed, the altitude, the angle with the horizon and the angle of attack were all recorded simultaneously and the resulting curves plotted to the same time scale. The results show that all the curves are very close to damped sine curves, with the curves for height and angle of attack in phase, that for angle with the horizon leading them by 18 per cent and that for path angle leading them by 25 per cent.

Norton, F H

Motion simulator study of longitudinal stability requirements for large delta wing transport airplanes during approach and landing with stability augmentation systems failed

A ground-based simulator investigation was conducted in preparation for and correlation with an-flight simulator program. The objective of these studies was to define minimum acceptable levels of static longitudinal stability for landing approach following stability augmentation systems failures. The airworthiness authorities are presently attempting to establish the requirements for civil transports with only the backup flight control system operating. Using a baseline configuration representative of a large delta wing transport, 20 different configurations, many representing negative static margins, were assessed by three research test pilots in 33 hours of piloted operation. Verification of the baseline model to be used in the TIFS experiment was provided by computed and piloted comparisons with a well-validated reference airplane simulation. Pilot comments and ratings are included, as well as preliminary tracking performance and workload data.

Snyder, C. T.

A Study of Longitudinal Control Problems at Low and Negative Damping and Stability with Emphasis on Effects of Motion Cues

As part of a general investigation to determine the effects of simulator motions on pilot opinion and task performance over a wide range of vehicle longitudinal dynamics, a cooperative NASA-AMAL program was conducted on the centrifuge at Johnsville, Pennsylvania. The test parameters and measurements for this program duplicated those of earlier studies made at Ames Research Center with a variable-stability airplane and with a pitch-roll chair flight simulator. Particular emphasis was placed on the minimum basic damping and stability the pilots would accept and on the minimum dynamics they considered controllable in the event of stability-augmentation system failure. Results of the centrifuge-simulator program indicated that small positive damping was required by the pilots over most of the frequency range covered for configurations rated acceptable for emergency conditions only (e.g., failure of a pitch damper). It was shown that the pilot's tolerance for unstable dynamics was dependent primarily on the value of damping. For configurations rated acceptable for emergency operation only, the allowable instability and damping corresponded to a divergence time to double amplitude of about 1 second. Comparisons were made of centrifuge, pitch-chair and fixed-cockpit simulator tests with flight tests. Pilot ratings indicated that the effects of incomplete or spurious motion cues provided by these three modes of simulation were important only for high-frequency, lightly damped dynamics or unstable, moderately damped dynamics. The pitch- chair simulation, which provided accurate angular-acceleration cues to the pilot, compared most favorably with flight. For the centrifuge simulation, which furnished accurate normal accelerations but spurious pitching and longitudinal accelerations, there was a deterioration of pilots' opinion relative to flight results. Results of simulator studies with an analog pilot replacing the human pilot illustrated the adaptive capability of human pilots in coping with the wide range of vehicle dynamics and the control problems covered in this study. It was shown that pilot-response characteristics, deduced by the analog-pilot method, could be related to pilot opinion. Possible application of these results for predicting flight-control problems was illustrated by means of an example control-problem analysis. The results of a brief evaluation of a pencil-type side-arm controller in the centrifuge showed a considerable improvement in the pilots' ability to cope with high-frequency, low-damping dynamics, compared to results obtained with the center stick. This improvement with the pencil controller was attributed primarily to a marked reduction in the adverse effects of large and exaggerated pitching and longitudinal accelerations on pilot control precision.

Sadoff, Melvin

Method for Studying Helicopter Longitudinal Maneuver Stability

A theoretical analysis of helicopter maneuver stability is made and the results are compared with experimental results for both a single and a tandem rotor helicopter. Techniques are described for measuring in flight the significant stability derivatives for use with the theory to aid in design studies of means for achieving marginal maneuver stability for a prototype helicopter.

Amer, Kenneth B

Concepts for NASA longitudinal health studies

Clinical data collected from a 15-year study of the homogenous group of pre-Shuttle astronauts have revealed no significant long-term effects from spaceflight. The current hypothesis suggests that repeated exposures to the space environment in the Shuttle era will similarly have no long-term health effects. However, a much more heterogenous group of astronauts and non-astronaut scientists will fly in Shuttle, and data on this group's adaptation to the space environment and readaptation to earth are currently sparse. In addition, very little information is available concerning the short- and long-term medical consequences of long duration exposure to space and subsequent readaptation to the earth environment. In this paper, retrospective clinical information on astronauts is reviewed and concepts for conducting epidemiological studies examining long-term health effects of spaceflight on humans, including associated occupational risks factors, are presented.

Nicogossian, A. E.

Low-speed wind tunnel study of longitudinal stability and usable-lift improvement of a cranked wing

An exploratory low-speed investigation of a 70 deg/46 deg cranked-wing planform was undertaken to evaluate two vortex-control concepts aimed at alleviating a severe pitch up which limits the usable lift well below the C(sub L,max) of the basic wing. One concept was a strake-like extension introduced across the wing crank, whose vortex helps to stabilize the outer-wing flow and alleviate tip stall. The other was a lower-surface cavity flap employed to trap a vortex just beneath the inboard leading edge, resulting in reduced vortex lift over the inner-wing panel. Each of these concepts was shown to eliminate the high-alpha pitch up, potentially raising the maximum usable lift of the cranked wing practically to its C(sub L,max) value.

Rao, Dhanvada M.

Long-term study of longitudinal dependence in primary particle precipitation in the north Jovian aurora

The wavelength-dependent absorption apparent in IUE spectra of the north Jovian aurora is analyzed to determine the column density of hydrocarbons above the altitude of the FUV auroral emission. Both the magnetotail and torus auroral zone models are considered in estimating zenith angles, with very similar results obtained for both models. It is found that the hydrocarbon column density above the FUV emission displays a consistent dependence on magnetic longitude, with the peak density occurring approximately coincident with the peak in the observed auroral intensity. Two distinct scenarios for the longitude dependence of the column density are discussed. In one, the Jovian upper atmosphere is longitudinally homogeneous, and the variation in optical depth is due to a variation in penetration, and thus energy, of the primary particles. In the other, the energy of the primaries is longitudinally homogeneous, and it is aeronomic properties which change, probably due to auroral heating.

Livengood, T. A.