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NASA NTRS1978

Mechanisms and sites for astrophysical gamma ray line production

The production of gamma ray lines and estimates of line fluxes resulting from nuclear deexcitations, positron annihilation, and electron capture at various astrophysical sites are discussed. Supernova and nova explosions synthesize long-lived radioactive isotopes and eject them into space where they produce observable gamma ray lines by decaying into excited levels of daughter nuclei or by emitting positrons. Energetic charged particles in the interstellar medium, in supernova remants, in solar or stellar flares, and possibly in the vicinity of compact objects, produce gamma-ray lines by inelastic collisions which either excite nuclear levels or produce positrons and neutrons. Energetic particles can result from acceleration in time-varying magnetic fields (solar flares) or from gravitational accretion onto neutron stars and black holes. Electromagnetic processes in the strong magnetic fields of pulsars can produce positron-electron pairs, with line emission resulting from positron annihilation. Deexcitations of quantized states in strong magnetic fields can also produce lines.

Ramaty, R.↗

NASA NTRS1994

Cytokines and immune surveillance in humans

Evidence from both human and rodent studies has indicated that alterations in immunological parameters occur after space flight. Among the parameters shown, by us and others, to be affected is the production of interferons. Interferons are a family of cytokines that are antiviral and play a major role in regulating immune responses that control resistance to infection. Alterations in interferon and other cytokine production and activity could result in changes in immunity and a possible compromise of host defenses against both opportunistic and external infections. The purpose of the present study is to explore further the effects of space flight on cyotokines and cytokine-directed immunological function. Among the tests carried out are interferon-alpha production, interferon-gamma production, interleukin-1 and -2 production, signal transduction in neutrophils, signal transduction in monocytes, and monocyte phagocytic activity. The experiments will be performed using peripheral blood obtained from human subjects. It is our intent to eventually carry out these experiments using astronauts as subjects to determine the effects of space flight on cytokine production and activity. However, these subjects are not currently available. Until they become available, we will carry out these experiments using subjects maintained in the bed-rest model for microgravity.

Sonnenfeld, Gerald↗

NASA NTRS1985

Gamma ray observatory productivity showcase

The Gamma Ray Observatory (GRO) Program has been proclaimed to be the showcase productivity program for NASA and TRW. Among the multiple disciplines of a large-scale program, there is opportunity and need for improved efficiency, effectiveness, and reduction in the cost of doing business. The efforts and tools that will or have been implemented to achieve this end are described. Since the GRO Program is mainly an engineering program with the build of one satellite, the primary emphasis is placed on improving the efficiency and quality of management and engineering.

Davis, R. L.↗

NASA NTRS1970

Production of gamma rays in the crab nebula pulsar

The gamma-ray flux at energies above 50 MeV from NP0532 is evaluated for a pulsar model in which the optical and X-radiation is produced by synchrotron effect. Synchrotron radiation and inverse Compton scattering are considered as production mechanisms of the gamma-rays. The theoretical estimates are compared with the experimental values.

Treves, A.↗

NASA NTRS1992

Neutron and gamma ray production in the 1991 June X-class flares

We present new calculations of pion radiation and neutron emission from solar flares. We fit the recently reported high energy GAMMA-1 observations with pion radiation produced in a solar flare magnetic loop. We calculate the expected neutron emission in such a loop model and make predictions of the neutron fluences expected from the 1991 June X-class flares.

Ramaty, R.↗

NASA NTRS1986

High energy irradiations simulating cosmic-ray-induced planetary gamma ray production. I - Fe target

Two thick Fe targets were bombarded by a series of 6 GeV proton irradiations for the purpose of simulating the cosmic ray bombardment of planetary objects in space. Gamma ray energy spectra were obtained with a germanium solid state detector during the bombardment, and 46 of the gamma ray lines were ascribed to the Fe targets. A comparison between observed and predicted values showed good agreement for Fe lines from neutron inelastic scattering and spallation reactions, and less satisfactory agreement for neutron capture reactions, the latter attributed to the difference in composition between the Fe target and the mean lunar abundance used in the modeling. Through an analysis of the irradiation results together with continuum data obtained in lunar orbit, it was found that 100 hours of measurement with a current instrument should generate a spectrum containing approximately 20 lines due to Fe alone, with a 2-sigma sensitivity for detection of about 0.2 percent.

Metzger, A. E.↗

NASA NTRS1977

The relationship between the galactic matter distribution, cosmic-ray dynamics, and gamma-ray production

The concept that cosmic-ray density is related to the matter to which cosmic rays are dynamically coupled through magnetic fields on the scale of galactic arm segments is considered with specific reference to gamma-ray astronomy. A model of the galactic-matter and cosmic-ray distributions is developed on the basis of 21-cm radio surveys and recent observations of the 2.6-mm CO emission line by assuming that cosmic rays are galactic in origin, their column density is proportional to the total interstellar-gas column density, their scale height is considerably larger than that of the matter, and the Galaxy is a spiral with an arm/interarm density ratio of about 3 to 1. It is found that there is a good correlation between the observed gamma-ray intensity and that predicted on the basis of essentially complete coupling of cosmic rays to the best estimate of atomic and molecular hydrogen in the Galaxy. Individual maxima observed in gamma-radiation from the central region of the Galaxy are shown to be well correlated with those predicted to result from certain spiral-arm tangents if all the matter is assumed to be modulated in a particular spiral-arm segment pattern.

Kniffen, D. A.↗

NASA NTRS1999

Altered Cytokine Production By Specific Human Peripheral Blood Cell Subsets Immediately Following Spaceflight

In this study, we have attempted to combine standard immunological assays with the cellular resolving power of the flow cytometer to positively identify the specific cell types involved in spaceflight-induced immune alterations. We have obtained whole blood samples from 27 astronauts collected at three timepoints (L-10, R+0 and R+3) surrounding four recent space shuttle missions. The duration of these missions ranged from 10 to 18 days. Assays performed included serum/urine cortisol, comprehensive subset phenotyping, assessment of cellular activation markers and intracellular cytokine production following mitogenic stimulation. Absolute levels of peripheral granulocytes were significantly elevated following spaceflight, but the levels of circulating lymphocytes and monocytes were unchanged. Lymphocyte subset analysis demonstrated trends towards a decreased percentage of T cells and an increased percentage of B cells. Nearly all of the astronauts exhibited an increased CD4:CD8 ratio, which was dramatic in some individuals. Assessment of memory (CD45RA+) vs. naive (CD45RO+) CD4+ T cell subsets was more ambiguous, with subjects tending to group more as a flight crew. All subjects from one mission demonstrated an increased CD45RA:CD45RO ratio, while all subjects from another Mission demonstrated a decreased ratio. While no significant trend was seen in the monocyte population as defined by scatter, a decreased percentage of the CD14+ CD16+ monocyte subset was seen following spaceflight in all subjects tested. In general, most of the cellular changes described above which were assessed at R+O and compared to L-10 trended to pre-flight levels by R+3. Although no significant differences were seen in the expression of the cellular activation markers CD69 and CD25 following exposure to microgravity, significant alterations were seen in cytokine production in response to mitogenic activation for specific subsets. T cell (CD3+) production of IL-2 was significantly decreased after at R+O as was IL-2 production by both CD4+ and CD8+ T cell subsets for most subjects. Production of IFN(sub gamma) did not appear to be affected by microgravity exposure in either T cells in general or in the CD8+ T cell subset. There was a spaceflight-induced decrease in IFN(sub gamma) production in the CD4+ T cell subset, however it did not reach statistical significance. Serum and urine stress-hormone analysis indicated significant physiologic stresses in astronauts following spaceflight. In summary, these results demonstrate alterations in the peripheral immune system of astronauts immediately after spaceflight of 10 to 18 days duration and support continued research regarding microgravity and immunology (including in-flight sampling) prior to routine long-term spaceflight for astronauts.

Crucian, Brian E.↗

NASA NTRS2000

Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight

In this study, flow cytometry was used to positively identify the specific lymphocyte subsets exhibiting space flight-induced alterations in cytokine production. Whole blood samples were collected from 27 astronauts at three points (one preflight, two postflight) surrounding four space shuttle missions. Assays performed included serum/urine stress hormones, white blood cell (WBC) phenotyping, and intracellular cytokine production following mitogenic stimulation. Absolute levels of peripheral granulocytes were significantly elevated following space flight, but the levels of circulating lymphocytes and monocytes were unchanged. Lymphocyte subset analysis demonstrated a decreased percentage of T cells, whereas percentages of B cells and natural killer (NK) cells remained unchanged after flight. Nearly all the astronauts exhibited an increased CD4/CD8 T cell ratio. Assessment of naive (CD45RA+) vs. memory (CD45RO+) CD4+ T cell subsets was ambiguous, and subjects tended to group within specific missions. Although no significant trend was seen in absolute monocyte levels, a significant decrease in the percentage of the CD14+ CD16+ monocytes was seen following space flight in all subjects tested. T cell (CD3+) production of interleukin-2 (IL-2) was significantly decreased after space flight, as was IL-2 production by both CD4+ and CD8+ T cell subsets. Production of interferon-gamma (IFN-gamma) was not altered by space flight for the CD8+ cell subset, but there was a significant decrease in IFN-gamma production for the CD4+ T cell subset. Serum and urine stress hormone analysis indicated significant physiologic stresses in astronauts following space flight. Altered peripheral leukocyte subsets, altered serum and urine stress hormone levels, and altered T cell cytokine secretion profiles were all observed postflight. In addition, there appeared to be differential susceptibility to space flight regarding cytokine secretion by T cell subsets. These alterations may be the result of either microgravity exposure or the physiologic stresses of landing and readaptation to unit gravity. Future studies, including in-flight analysis or sampling, will be necessary to determine the cause of these alterations.

NASA Discipline Cell Biology↗

NASA NTRS1989

Thermonuclear breakup reactions of light nuclei. II - Gamma-ray line production and other applications

The main consequence of nuclear breakup reactions in high-temperature plasmas is shown to be to reduce the production of the gamma-ray lines, due to the breakup of these species at high temperature. Results of the emissivities of all the relevant gamma-ray lines are discussed. It is shown that the magnitude of the breakup effect on the line emissivities depends strongly on temperature, but more importantly on the plasma density and on the available time for the ion processes. Other effects considered include the production of neutrons (from the breakup of helium) and its consequences (such as the production of gamma rays from n-capture reactions and dynamical effects in accretion disk plasmas).

Guessoum, Nidhal↗

NASA NTRS2010

Particular Characterisation of an In-Vitro-DTH Test to Monitor Cellular Immunity - Applications for Patient Care and Space Flight

Goal:i) Characterization of the role of the main immune reactive cell types contributing to the cellular immune response in the in-vitro DTH and ii) Validation of the in-vitro DTH under different clinical and field conditions. Methods:As positive control whole blood was incubated in the in-vitro DTH, supernatants were gathered after 12, 24 and 48h. Readout parameters of this test are cytokines in the assay's supernatant. To determine the role of T-cells, monocytes and natural killer (NK), these cell populations were depleted using magnetic beads prior to in-vitro-DTH incubation. Validation of the test has occurred under clinical (HIV-patients, ICU) and field-conditions (parabolic/space-flights, confinement). Results:T-cell depletion abandoned almost any IL-2 production and reduced IFN-gamma production irrespective of the type of antigen, whereas CD56 depleted cultures tended to lower IL-2 secretion and IFN-gamma and to parallel a IL-10-increase after viral challenge. This IL-10-increase was seen also in CD14-depleted setups. DTH read-out was significantly different under acute stress (parabolic flight) or chronic stress (ISS), respectively. Preliminary data of HIV infected patients demonstrate that this test can display the contemporary immune status during an antiviral therapy. Conclusion:The in-vitro DTH mirrors adaptive and innate immune activation and may serve as tool also for longitudinal follow up of Th1/Th2 weighed immune response under adverse life conditions on earth and in space. It is planned to implement the assay in the on the ISS (MoCISS).

Feurecker, M.↗

NASA NTRS1981

Production spectrum of gamma rays in interstellar space through neutral pion decay

A simple representation is obtained of the observed invariant cross section for the production of neutral pions in proton-proton collisions. Using this representation, the differential and integral production spectra of gamma rays in the galaxy are calculated from interactions of cosmic ray nuclei with interstellar gas. It is shown that the uncertainties in deducing interstellar proton spectrum by demodulating the observed spectrum have only a limited effect on the gamma ray spectrum. Also determined is the gamma ray production spectrum through bremsstrahlung process for a typical interstellar electron spectrum derived from the radio spectrum in the galaxy.

Stephens, S. A.↗

NASA NTRS1988

Inhibited interferon production after space flight

Several studies have been performed in our laboratories indicating that interferon production may be impaired in rodents after space flight. Using an antiorthostatic suspension model that simulates some of the effects of microgravity seen during space flight, we have shown that interferon-alpha/beta production was inhibited. The inhibition was not due solely to the stress of suspension. The inhibited interferon production was transient, as suspended animals returned to normal caging recovered the ability to produce interferon. Antiorthostatic suspension of mice also resulted in a loss of resistance to infection with the diabetogenic strain of encephalomyocarditis virus, which correlated with the drop in interferon production. In rats flown in US Space Shuttle mission SL-3, interferon-gamma production was inhibited severely when spleen cells were challenged with concanavalin-A upon return to earth. In contrast, interleukin-3 production by these cells was normal. These results suggest that immune responses may be altered after antiorthostatic modeling or space flight, and the resistance to viral infections may be especially affected.

Flight Experiment↗

NASA NTRS1985

Gamma ray line production from cosmic ray spallation reactions

The gamma ray line intensities due to cosmic ray spallation reactions in clouds, the galactic disk and accreting binary pulsars are calculated. With the most favorable plausible assumptions, only a few lines may be detectable to the level of 0.0000001 per sq. cm per sec. The intensities are compared with those generated in nuclear excitation reactions.

Silberberg, R.↗

NASA NTRS1974

Neutron propagation and 2.2 MeV gamma-ray line production in the solar atmosphere

The 2.2 MeV gamma ray line intensity from the sun was calculated using a Monte Carlo method for neutron propagation in the solar atmosphere. Detailed results are provided on the total gamma ray yield per neutron and on the time profile of the 2.2 MeV line from an instantaneous and monoenergetic neutron source. The parameters which have the most significant effects on the line intensity are the energies of the neutrons, the position of the neutron source on the sun, and the abundance of He-3 in the photosphere. For an isotropic neutron source which is not too close to the limb of the sun, the gamma ray yield is between about 0.02 to 0.2 photons per neutron, provided that the neutron energies are in the range 1 to 100 MeV and the ratio He-3/H is less than about .00005.

Wang, H. T.↗

NASA NTRS1970

The effects of nuclear power generators upon electronic instrumentation

Radiation sensitivity of electronic instruments susceptible to neutron and gamma radiation is evaluated by means of a radioisotope thermoelectric generator /RTG/. The gamma field of the RTG affects instrument operation and requires shielding, the neutron field does not affect operation via secondary capture-gamma production.

Miller, C. G.↗

NASA NTRS1971

Nonelastic nuclear reactions and accompanying gamma radiation

Several aspects of nonelastic nuclear reactions which proceed through the formation of a compound nucleus are dealt with. The full statistical model and the partial statistical model are described and computer programs based on these models are presented along with operating instructions and input and output for sample problems. A theoretical development of the expression for the reaction cross section for the hybrid case which involves a combination of the continuum aspects of the full statistical model with the discrete level aspects of the partial statistical model is presented. Cross sections for level excitation and gamma production by neutron inelastic scattering from the nuclei Al-27, Fe-56, Si-28, and Pb-208 are calculated and compared with avaliable experimental data.

Snow, R.↗

NASA NTRS1983

Hot accretion disks in the centers of quasars

Hot accretion disks around massive, rotating black holes could exist in the centers of quasars. These hot accretion disks produce copious amounts of e(+)e(-) pairs, gamma-rays and X-rays. Most of the disk models that produce significant amounts of gamma-rays, say 10 percent of the total luminosity, and have an energy flux spectral index at X-rays of order unity, are optically thick to gamma-gamma pair production. Gamma-rays, therefore, more energetic than a few MeV do not escape from the disk but are degraded to lower energy radiation. The application of this picture to specific high-energy spectra of active galactic nuclei and quasars as well as high-energy background is explored. A hot accretion disk around a stellar black hole may also account for the positron source in the center of the Milky Way.

Kafatos, M.↗