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NASA Framework for the Ethical Use of Artificial Intelligence (AI)

The NASA Framework for the Ethical Use of Artificial Intelligence (AI) provides six key principles to guide NASA's use of AI. The principles are NASA's AI must be 1. Fair, 2., Explainable and transparent, 3. Accountable, 4. Secure and safe, 5. Human-centric and societally beneficial, and 6. Scientifically and technically robust. The framework describes each ethical AI principle, and then applies that principle to NASA work. The framework also includes a list of questions practitioners should use to guide their AI work. Finally, the framework focuses on concrete, practical considerations for the next five - ten years, while also beginning to lay the foundation for longer-term disruptive change as human-level (or beyond) AI is created.

Artificial Intelligence

The Exploration Ethic: Its Historical-Intellectual Basis. Outlook for Space (1980 - 2000)

Principle components of the exploration ethic are discussed. Attempts were made to justify both the historical and intellectual aspects of the concept. It was noted that intellectual justification is strongly grounded on: (1) the complementarity of objective and normative inquiry as to method, and (2) interdisciplinary alliance of ethics of adaptive systems with contemporary decision sciences, as a theoretical basis. Historical exploration justification was associated with: (1) periods of civilization transition, (2) changes in the process of exploration which cause change in types of rationals used, sponsors involved, and explorers interest, and (3) the incorrectness of proven prior cost/benefit calculations.

Priscoli, J. D.

Screening for Psychopathology Versus Selecting for Suitability: Ethical and Legal Considerations

The current system for psychological selection of U.S. astronauts is divided into two phases: The select-out phase and the select-in phase. The select-out phase screens candidates for psychopathology; candidates who do not meet the baseline psychiatric requirements are immediately disqualified. The select-in phase assesses candidates for suitability to fly short- and long-duration missions. Suitability ratings are given for ten factors found to be critical for short and long-duration space missions. There are qualitative differences in the purpose of the two phases (select-in vs. select-out) and in the nature of the information collected in each phase. Furthermore, there are different logistic, ethical, and legal issues related to a medical or psychiatric (select-out) screening versus a suitability (select-in) psychological screening process . The purpose of this presentation is to contrast the ethical and legal environment surrounding the select-out and select-in phases of the psychological selection system. Issues such as data collection, data storage and management, the federal statutory environment, and personnel training will be discussed. Further, a summary of the new standards for psychological testing is presented, along with their implications for astronaut selection.

Holland, Albert W.

Space Toxicology Challenges and Ethical Considerations

Before delineating specific ways that nanotechnology enterprises might contribute to better management of toxicological risks during spaceflight, I will show how ethical considerations and several theories of justice can be applied to nanotechnology strategic plans. The principles that guide an ethical technical enterprise include autonomy, beneficence, non-maleficence, veracity and justice. Veracity (truth) is the underpinning principle; however, beyond this, proponents of nanotechnology must think carefully about balancing conflicting principles. For example, autonomy must yield to beneficence when fearful individuals simply lack knowledge to appreciate nanotechnology's beneficial advances. Justice is a complex topic upon which I will place six models: utilitarian, distributive, free-exchange/choice, individual dignity (social participation), equity vs. greed, and liberation of the poor. After briefly summarizing each model, I will present what I call an iterative-hybrid model of justice to show specifically how our thinking can be applied to nanotechnology enterprises. Within that broad landscape, I will discuss a single feature: how our early effort to understand health risks of carbon nanotubes fits into the iterative model. Finally, I will suggest ways that nanotechnology might advance our management of toxicological risks during spaceflight, but always with an eye toward how such advances might result in a more just world.

James, John T.

Arm DevSummit Keynote: Environment for Data Engineering in Virtual Reality: Ethical Considerations

Currently, the US Government is going through a large-scale data Transformation effort, where the GSA playbook is guiding all agencies to make their processes data-driven with the help of emerging technologies. To address concerns about algorithm sharing, AI adoption, and vendor lock-in, the NASA Langley Research Center Digital Transformation Group has developed the Environment for Data Engineering in Virtual Reality (EnDEVR), a data science ecosystem that allows users to command and investigate customizable data analyses from a VR environment. The system has been evaluated in the Oculus Rift S and Quest environments, two popular VR systems powered by the ARM architecture. Current and future development will employ several AI capabilities to guide research and automation within the environment and to facilitate algorithm sharing. In this talk, we will discuss the results of an initial ethical investigation and recommended considerations for the use of AI within the system.

Artificial Intelligence

Software engineering ethics

Software engineering ethics is reviewed. The following subject areas are covered: lack of a system viewpoint; arrogance of PC DOS software vendors; violation od upward compatibility; internet worm; internet worm revisited; student cheating and company hiring interviews; computing practitioners and the commodity market; new projects and old programming languages; schedule and budget; and recent public domain comments.

Bown, Rodney L.

The physics, biology, and environmental ethics of making mars habitable

The considerable evidence that Mars once had a wetter, more clement, environment motivates the search for past or present life on that planet. This evidence also suggests the possibility of restoring habitable conditions on Mars. While the total amounts of the key molecules--carbon dioxide, water, and nitrogen--needed for creating a biosphere on Mars are unknown, estimates suggest that there may be enough in the subsurface. Super greenhouse gases, in particular, perfluorocarbons, are currently the most effective and practical way to warm Mars and thicken its atmosphere so that liquid water is stable on the surface. This process could take approximately 100 years. If enough carbon dioxide is frozen in the South Polar Cap and absorbed in the regolith, the resulting thick and warm carbon dioxide atmosphere could support many types of microorganisms, plants, and invertebrates. If a planet-wide martian biosphere converted carbon dioxide into oxygen with an average efficiency equal to that for Earth's biosphere, it would take > 100,000 years to create Earth-like oxygen levels. Ethical issues associated with bringing life to Mars center on the possibility of indigenous martian life and the relative value of a planet with or without a global biosphere.

Exobiology/ethics

Pulmonary Toxicity of Carbon Nanotubes: Ethical Implications and Human Risk Assessment

Presentation viewgraphs review the health considerations of working with and manufacturing Carbon Nanotubes. The inherent toxicity of Single Walled Carbon Nanotubes (SWNT) are reviewed, and how the preparation of the SWNTs are reviewed. The experimental protocol that was used is reviewed, and the results in lungs of rodents are shown. The presentation ends with posing the ethical questions in reference to the manufacture and use of carbon nanotubes.

James, John T.

Space Exploration: Challenges in Medicine, Research, and Ethics

This viewgraph presentation describes the challenges that space exploration faces in terms of medicine, research and ethics. The topics include: 1) Effects of Microgravity on Human Physiology; 2) Radiation; 3) Bone; 4) Behavior and Performance; 5) Muscle; 6) Cardiovascular; 7) Neurovestibular; 8) Food and Nutrition; 9) Immunology and Hematology; 10) Environment; 11) Exploration; 12) Building Block Approach; 13) Exploration Issues; 14) Life Sciences Contributions; 15) Health Care; and 17) Habitability.

Davis, Jeffrey R.

Ethics of large systems

Operations research and management planning methods in relation to philosophical problem of building improved social system

Churchman, C. W.

The lunar community church: Contributions to lunar living and to evolution of ethical and spiritual thinking

Should religious institutions get interested in lunar settlement? Would their participation make positive contributions or would it discourage creative diversity and interfere with science and good technical judgement? Among the spacefaring nations of today, religion is distinctly separated from the governments that plan and pay for space exploration. However, as we move off the Earth, our art and philosophy will follow our science and technology. Spiritual thinking will follow as part of our culture. It is time to consider in what ways this can occur constructively. Transport of religious values to a lunar base may have positive effects in two ways. First, the social structure of a 'community church' as found in today's United States, supports its members psychologically. Mutual psychological and social support will be needed in a lunar community. Second, our space pioneers will experience a unique view of the universe which may, in their philosophical discussions, forge new ideas in the spiritual realm.

Allton, J. H.

Reconsidering the Theological and Ethical Implications of Extraterrestrial Life

As we stand on the threshold of a new millennium, we also find ourselves at the brink of a new and exciting era in space exploration. In fact, this new era has already begun, with the successful landing and exploration of Mars by the Pathfinder mission in July 1997. Pathfinder represents an important scientific accomplishment for NASA because it demonstrated the agency's ability to successfully explore space at a relatively modest price. At the same time, Pathfinder revealed once again the genuine interest and fascination that people all over planet Earth have for space exploration. The recent Pathfinder mission to Mars was only the first in an ambitious series of NASA missions planned for exploration of Mars, Earth's nearest planetary neighbor where extraterrestrial life is a real possibility. In March 1998, the next step in this exploration takes place, when the Mars Global Surveyor--which is already in orbit around Mars--begins photographing and mapping the Martian surface. NASA plans to continue its exploration with additional landers and orbiters taking off for Mars every 26 months, when the paths of Mars and Earth bring them in closer proximity. By the year 2005, NASA hopes to launch a mission that will return martian samples to Earth. And, as early as 2011, astronauts could be rocketing from Earth for the first human landing on the Red Planet. In the distant future, there may be even more grandiose plans, including the possibility of engineering an atmosphere on Mars that could support biological life.

Randolph, Richard O.

Reconsidering the Theological and Ethical Implications of Extraterrestrial Life

As we stand on the threshold of a new millennium, we also find ourselves at the brink of a new and exciting era in space exploration. In fact, this new era has already begun, with the successful landing and exploration of Mars by the Pathfinder mission in July 1997. Pathfinder represents an important scientific accomplishment for NASA because it demonstrated the agency's ability to successfully explore space at a relatively modest price. At the same time, Pathfinder revealed once again the genuine interest and fascination that people all over planet Earth have for space exploration. The Pathfinder mission is just one of several recent events-both scientific and cultural-that reveal this deep and almost unquenchable curiosity about space-and the possibility that there is life "out there." In August 1996, the public was captivated with NASA's announcement that a meteorite from Mars may contain evidence of early microscopic life. Shortly after the NASA announcement, media coverage of the discovery-and public discourse concerning the discovery-turned to an examination of the theological implications of evidence for extraterrestrial, albeit unintelligent, life. To a lesser extent, public reaction to the Hale-Bopp comet in the Spring of 1996 is also suggestive of many persons' deep passion to know more about space.

Randolph, Richard O.

Exploring the Utility-Privacy Trade-Off: Impacts of Semantic and Visit Types Ambiguities on Human Mobility Simulation

Humans are in perpetual movement, constantly traversing buildings, cities, waters, oceans, and countries. Mobility stands out as a major driving force shaping our modern societies. Capturing and explaining human behavior in a world of eight billion distinct mobility agendas is a complex challenge. With the rise of interconnected devices and platforms, such as smartphones, wearables, and point-of-interest data, largescale behavioral data has become more accessible, enabling rich insights into mobility patterns. However, the widespread availability of such data introduces significant ethical challenges. Detailed mobility data can inadvertently reveal sensitive personal information, including individuals' locations, habits, social interactions, and even political or religious affiliations. Beyond privacy breaches, the ethical implications of uncovering and potentially manipulating underlying behavioral patterns demand attention. Striking a balance between the utility of mobility models and the protection of individual privacy is therefore paramount. This paper explores the utility-privacy trade-offs in human mobility modeling, focusing on the impacts of introducing semantic and visit type ambiguities. By systematically examining how these ambiguities affect the fidelity of simulated trajectories and privacy risks, we provide a framework for evaluating ethical and privacy-conscious modeling practices. Our findings emphasize the need for methods that safeguard privacy without undermining the usefulness of mobility models, contributing to the responsible advancement of mobility science in alignment with ethical standards and societal expectations.

Amichi, Licia [ORNL] (ORCID:0000000177631394)

Applications of Decellularized Plant Tissues in Regenerative Medicine and Tissue Engineering

The development of biomaterials capable of supporting complex tissue growth remains a central challenge in regenerative medicine and tissue engineering, particularly in replicating the structural, mechanical, and transport functions of native extracellular matrices. While decellularized animal tissues have demonstrated significant success as scaffolds for tissue engineering, they are still constrained by cost, immunogenicity, and ethical concerns. In recent years, decellularized plant tissues have emerged as a compelling alternative scaffold platform due to their inherent vascular architectures, ethical sourcing, tunable mechanical properties, cytocompatibility, and sustainability. This review summarizes current strategies for the decellularization of plant tissues, including chemical, enzymatic, and physical approaches, and discusses how these methods preserve plant cell wall structure while removing immunogenic components. Advances in surface loading and functionalization, including protein coatings, oxidation, nanoparticle incorporation, peptide conjugation, and bioactive molecule loading, have further enhanced cell adhesion, differentiation, biodegradability, and immunomodulation. Recent applications of decellularized plant scaffolds in cardiac, skeletal muscle, bone, nerve, and wound healing contexts are reviewed, highlighting proof-of-concept successes and remaining challenges. Beyond therapeutic applications, plant-derived scaffolds have also enabled physiologically relevant in vitro models for vascular biology, mechanotransduction, cancer, metabolic tissues, and drug response studies. Collectively, these advances position decellularized plant tissues as versatile, low-cost, and ethically favorable biomaterials with growing relevance for both regenerative medicine and tissue modeling.

59 BASIC BIOLOGICAL SCIENCES

Standards of conduct for NASA employees

'Standards of Conduct' for employees (14 CFR Part 1207) is set forth in this handbook and is hereby incorporated in the NASA Directives System. This handbook incorporates, for the convenience of NASA employees, the regulations now in effect prescribing standards of conduct for NASA employees. These regulations set forth the high ethical standards of conduct required of NASA employees in carrying out their duties and responsibilities. These regulations have been approved by the Office of Government Ethics, Office of Personnel Management. The regulations incorporated in this handbook were first published in the Federal Register on October 21, 1967 (32 FR 14648-14659); Part B concerning the acceptance of gifts, gratuities, or entertainment was extensively revised on January 19, 1976 (41 FR 2631-2633) to clarify and generally to restrict the exceptions to the general rule against the acceptance by a NASA employee from persons or firms doing or seeking business with NASA. Those regulations were updated on January 29, 1985 (50 FR 3887) to ensure conformity to the Ethics in Government Act of 1978 regarding the public financial disclosure statement. These regulations were published in the Federal Register on June 16, 1987 (52 FR 22755-764) and a correction was printed on Sept. 28, 1987 (52 FR 36234).

John E O'Brien