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At least 37 records · Page 2

Type 2 diabetes impairs annulus fibrosus fiber deformation and rotation under disc compression in the University of California Davis type 2 diabetes mellitus (UCD-T2DM) rat model

Abstract Understanding the biomechanical behavior of the intervertebral disc is crucial for studying disease mechanisms and developing tissue engineering strategies for managing disc degeneration. We used synchrotron small-angle X-ray scattering to investigate how changes to collagen behavior contribute to alterations in the disc’s ability to resist compression. Coccygeal motion segments from 6-month-old lean Sprague-Dawley rats ( n=7) and diabetic obese University of California Davis type 2 diabetes mellitus (UCD-T2DM) rats ( n=6, diabetic for 68±7 days) were compressed during simultaneous synchrotron scanning to measure collagen strain at the nanoscale (beamline 7.3.3 of the Advanced Light Source). After compression, the annulus fibrosus was assayed for nonenzymatic cross-links. In discs from lean rats, resistance to compression involved two main energy-dissipation mechanisms at the nanoscale: (1) rotation of the two groups of collagen fibrils forming the annulus fibrosus and (2) straightening (uncrimping) and stretching of the collagen fibrils. In discs from diabetic rats, both mechanisms were significantly impaired. Specifically, diabetes reduced fibril rotation by 31% and reduced collagen fibril strain by 30% (compared to lean discs). The stiffening of collagen fibrils in the discs from diabetic rats was consistent with a 31% higher concentration of nonenzymatic cross-links and with evidence of earlier onset plastic deformations such as fibril sliding and fibril–matrix delamination. These findings suggest that fibril reorientation, stretching, and straightening are key deformation mechanisms that facilitate whole-disc compression, and that type 2 diabetes impairs these efficient and low-energy elastic deformation mechanisms, thereby altering whole-disc behavior and inducing the earlier onset of plastic deformation.

Rosenberg, James L.↗

Three dimensional mean velocity and turbulence characteristics in the annulus wall region of an axial flow compressor rotor passage

The experiment was performed using the rotating hot-wire technique within the rotor blade passage and the stationary hot-wire technique for the exitflow of the rotor blade passage. The measurements reveal the effect of rotation and subsequent flow interactions upon the rotor blade flowfield and wake development in the annulus-wall region. The flow near the rotor blade tips is found to be highly complex due to the interaction of the annulus-wall boundary layer, the blade boundary layers, the tip leakage flow, and the secondary flow. Within the blade passage, this interaction results in an appreciable radial inward flow as well as a defect in the mainstream velocity near the mid-passage. Turbulence levels within this region are very high. This indicates a considerable extent of flow mixing due to the viscous flow interactions. The size and strength of this loss core is found to grow with axial distance from the blade trailing edge. The nature of the rotor blade exit-flow was dominated by the wake development.

Davino, R.↗

Characteristics of the flow in the annulus-wall region of an axial-flow compressor rotor blade passage

Three-dimensional characteristics of the mean velocity and turbulence structure in the annulus-wall region of a moderately loaded compressor rotor have been investigated experimentally by employing triaxial hot-wire probes. Results are presented which indicate that the flow within and downstream of the rotor passage is highly complex due to the interaction of the annulus-wall boundary layer, blade boundary layers, tip leakage flow, and passage secondary flow. An understanding of the reported viscous flow interactions is important for establishing improved aerodynamic design criteria and efficiency, for predicting noise levels, and for determining the stall, surge, vibration, and flutter characteristics of turbomachinery.

Davino, R. M.↗

Stability of fluid flow in a cylindrical annulus

Helical flow in an annulus between two coaxial cylinders is investigated with regard to its stability against the formation of helical vortices of the type known as Taylor's annular vortices. Assuming the annulus to be small and the velocities to vary linearly with radius, it is shown that the problem can be reduced to the classical case of flow between two rotating cylinders. An appropriate stability criterion for helical flows is derived from Rayleigh's stability criterion applicable to such flows.

Ludwieg, H.↗

Laboratory experiments in a baroclinic annulus with heating and cooling on the horizontal boundaries

Experiments have been performed in a cylindrical annulus with horizontal temperature gradients imposed upon the horizontal boundaries and in which the vertical depth was smaller than the width of the annulus. Qualitative observations were made by the use of small, suspended, reflective flakes in the liquid (water). Four basic regimes of flow were observed: (1) axisymmetric flow, (2) deep cellular convection, (3) boundary layer convective rolls, and (4) baroclinic waves. In some cases there was a mix of baroclinic and convective instabilities present. As a 'mean' interior Richardson number was decreased from a value greater than unity to one less than zero, axisymmetric baroclinic instability of the Solberg type was never observed. Rather, the transition was from non-axisymmetric baroclinic waves, to a mix of baroclinic and convective instability, to irregular cellular convection.

Miller, T. L.↗

Laser Doppler velocimeter measurement of annulus wall boundary layer development in a compressor rotor

Detailed measurement of the flow field in the tip region of a compressor rotor was carried out using LDV. The axial and tangential components of relative velocities were measured upstream, inside the passage, and at the exit of the rotor, up to about 20 percent of the blade span from the blade tip. The annulus-wall boundary layer is well behaved at the leading edge and far downstream of the rotor. But inside the passage, complex interactions between the leakage flow and the annulus-wall boundary layer result in unconventional profiles with wide deviations from models employed for analyses.

Lakshminarayana, B.↗

A study of baroclinic instability in a cylindrical annulus with the temperature gradient imposed on the lower surface

Results are presented from experimental and numerical-modeling studies carried out on a rotating thermally driven fluid system in a cylindrical annulus with the horizontal gradient imposed upon the lower horizontal surface. The rotation rate and the temperature difference were varied to construct a regime diagram in thermal Rossby-number/Taylor-number space. It is shown that the curve separating the axisymmetric flow from the wave flow is 'knee-shaped', similar to the conventional side-heated and side-cooled baroclinic annulus. The experimentally observed transition curve agrees well with numerical calculations and the agreement between the predicted and measured wavenumbers is good both near the transition and within the wave regime. Away from the transition curve and well within the wave regime, there is an evolution from larger to smaller wavenumbers as the flow equilibrates, which is well captured by the numerical model for these cases.

Miller, Timothy L.↗

Pressure oscillation in the leakage annulus between a shrouded impeller and its housing due to impeller-discharge-pressure disturbances

The perturbed flow in the leakage path between a shrouded-pump impeller and its housing is analyzed using experiences with the Space Shuttle Main Engine (SSME), high pressure fuel turbopump (HPFTP) wearing-ring seals. Analysis is based on a bulk-flow model which consists of the path-momentum, circumferential momentum, and continuity equations. The pressure oscillations in the leakage annulus are driven by a circumferential variation of the impeller discharge pressure. It is shown that the occurrence and nature of the pressure oscillations depend on the tangential-velocity ratio of the fluid entering the seal, the order of the Fourier coefficient, the closeness of the precessional frequency of the rotating pressure field to the first natural frequency of the fluid annulus, and the clearance of the wearing-ring seal. The results obtained may explain the internal melting observed on SSME HPFTP seal parts.

Childs, D. W.↗

Theoretical analysis of total-pressure loss and airflow distribution for tubular turbojet combustors with constant annulus and liner cross-sectional areas

Compressible and incompressible flow calculations were made of the combustor total-pressure-loss coefficient and liner airflow distribution for tubular turbojet combustors having constant annulus and liner cross-sectional areas along the combustor axis. Information on static and total pressure distribution and liner air-jet entrance angles along the length of the combustor was obtained as an intermediate step in the calculations. The calculations include the effects of heat release, annulus wall friction, and variation in discharge coefficients of the liner wall openings along the combustor. The combustor total-pressure-loss coefficient and liner air-flow distribution are presented graphically in terms of the following dimensionless parameters: (1) combustor reference Mach number, (2) ratio of combustor-exit to inlet total temperature, (3) fraction of total airflow passing through the liner dome, (4) ratio of total open hole area in liner wall to total combustor cross-sectional area, and (5) ratio of liner cross-sectional area to total combustor cross-sectional area.

Graves, Charles C↗

Unsteady Full Annulus Simulations of a Transonic Axial Compressor Stage

Two recent research endeavors in turbomachinery at NASA Glenn Research Center have focused on compression system stall inception and compression system aerothermodynamic performance. Physical experiment and computational research are ongoing in support of these research objectives. TURBO, an unsteady, three-dimensional, Navier-Stokes computational fluid dynamics code commissioned and developed by NASA, has been utilized, enhanced, and validated in support of these endeavors. In the research which follows, TURBO is shown to accurately capture compression system flow range-from choke to stall inception-and also to accurately calculate fundamental aerothermodynamic performance parameters. Rigorous full-annulus calculations are performed to validate TURBO s ability to simulate the unstable, unsteady, chaotic stall inception process; as part of these efforts, full-annulus calculations are also performed at a condition approaching choke to further document TURBO s capabilities to compute aerothermodynamic performance data and support a NASA code assessment effort.

Herrick, Gregory P.↗

Onset of High-Harmonic Fast Wave Propagation in Annulus Geometry

Previous experiments on NSTX have reported high-harmonic fast wave (HHFW) power losses in the scrape-off layer (SOL), with dependencies on the wave parallel wavenumber, plasma density, and magnetic field. This study presents an analysis of HHFW propagation in the SOL plasma, focusing on parasitic coupling to the waveguide mode bounded by the steep gradient pedestal and the outer wall boundary. The analytic and finite element wave models are discussed using a 2D annulus geometry, which serves as a simplified representation of the NSTX-U plasma. The model shows that a minimum radial gap width is required to support wave propagation, analogous to the higher-order modes in coaxial geometries. The impact of several factors, including gap width, wave parallel phasing, and magnetic field strength, on parasitic wave coupling is examined, highlighting the role of the geometric dimension in relation to the wave perpendicular wavelength. The findings suggest that controlling the edge/SOL density profile (gap control) is crucial for mitigating parasitic coupling when the density in front of the antenna exceeds the density cutoff.

Baek, Seung-Gyou [Massachusetts Inst. of Technolog↗

Performance of transonic fan stage with weight flow per unit annulus area of 208 kilograms per second per square meter (42.6 (lb/sec)/sq ft)

Performance was obtained for a 50-cm-diameter compressor designed for a high weight flow per unit annulus area of 208 (kg/sec)/sq m. Peak efficiency values of 0.83 and 0.79 were obtained for the rotor and stage, respectively. The stall margin for the stage was 23 percent, based on equivalent weight flow and total-pressure ratio at peak efficiency and stall.

Urasek, D. C.↗

Performance of transonic fan stage with weight flow per unit annulus area of 198 kilograms per second per square meter (40.6(lb/sec)/sq ft)

The overall and blade-element performance are presented for an air compressor stage designed to study the effect of weight flow per unit annulus area on efficiency and flow range. At the design speed of 424.8 m/sec the peak efficiency of 0.81 occurred at the design weight flow and a total pressure ratio of 1.56. Design pressure ratio and weight flow were 1.57 and 29.5 kg/sec (65.0 lb/sec), respectively. Stall margin at design speed was 19 percent based on the weight flow and pressure ratio at peak efficiency and at stall.

Kovich, G.↗