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At least 37 records · Page 2

Monitoring the state of the human airways by analysis of respiratory sound

A mechanism whereby sound is generated by the motion of vortices in the human lung is described. This mechanism is believed to be responsible for most of the sound which is generated both on inspiration and expiration in normal lungs. Mathematical expressions for the frequencies of sound generated, which depend only upon the axial flow velocity and diameters of the bronchi, are derived. This theory allows the location within the bronchial tree from which particular sounds emanate to be determined. Redistribution of pulmonary blood volume following transition from Earth gravity to the weightless state probably alters the caliber of certain airways and doubtless alters sound transmission properties of the lung. We believe that these changes can be monitored effectively and non-invasively by spectral analysis of pulmonary sound.

Lung/anatomy & histology/physiology

Measurements of Atmospheric Turbulence on Seattle-Alaska Airways

For about the past year, American Airlines has been engaged in obtaining data on various uses of airborne radar under routine operating conditions. This work is under contract to the Navy Department, Bureau of Ships, and includes the investigation of radar as a navigational aid and terrain collision warning device and its use in icing and turbulence detection. In view of the work of the National Advisory Committee for Aeronautics on atmospheric turbulence, the NACA was requested to participate in the tests to the extent of obtaining and evaluating the turbulence data for use in the turbulence-detection phase of the work. Gust measurements and airborne radar observations were consequently obtained in February and March 1947 during routine flights of an American Airlines airplane on the Seattle-Alaska airways. Unfortunately, the weather conditions encountered during the flights gave no well-defined radar echoes and no comparison between radar indications end turbulence could be made. The gust data for the route, however, are of interest from an operational standpoint, and are presented herein for the information of the Navy Department in accordance with previous arrangements.

Funk, Jack

Static Longitudinal Stability of a Tandem-Coupled Bomber-Fighter Airplane Configuration Proposed by All American Airways, Inc.

At the request of the Air Materiel Command an investigation was made in the Langley free-flight tunnel to determine the static longitudinal stability and control characteristics of models coupled together in a tandem configuration proposed by All American Airways, Inc. Force tests were made using 1/20-scale models of B-29 end F-80 airplanes to determine the effects of coupling the fighter to the tail of the bomber. The results of the investigation showed that for the bomber alone the aerodynamic center was 0.21 mean aerodynamic chord behind the center of gravity (stable) but that for the tandem configuration the aerodynamic center was 0.09 mean aerodynamic chord forward of the center of gravity, of the combination (unstable). The elevator effectiveness of the bomber was reduced approximately 50 percent by addition of the fighter. Some recent flight tests made in the free-flight tunnel with models simulating the proposed configuration indicate that the reduction in stability may be minimized by incorporating a hinged coupling permitting freedom in pitch.

Hewes, Donald E.

NASA JetBlue Airways Technical Interchange

The Digital Information Sub-project will hold a Technical Interchange Meeting (TIM) with JetBlue Airways to discuss potential collaboration opportunities as well as discuss upcoming NASA-led demonstrations. This interchange meeting will solicit feedback from JetBlue for consideration of the sub-project in upcoming development and to encourage future participation and collaboration.

Digital Information Platform

Airways and avionics

Terminal and enroute traffic control are summarized along with visual and radio navigation aids.

Source record

British Airways' pre-command training program

Classroom, flight simulator, and in-flight sessions of an airline pilot training program are briefly described. Factors discussed include initial command potential assessment, precommand airline management studies course, precommand course, and command course.

Holdstock, L. F. J.

The organization of airways

An aircraft freed from all contact with the ground during most of the period of its operation, is nevertheless dependent on the provision of proper ground organization. The provision of landing fields scattered over the country for the benefit of civil or military pilots who may arrive from any direction constitutes the first step in making commercial flying possible.

Warner, Edward P

The Propagation of a Liquid Bolus Through an Elastic Tube and Airway Reopening

We use lubrication theory and matched asymptotic expansions to model the quasi-steady propagation of a liquid bridge through an elastic tube. In the limit of small capillary number, asymptotic expressions are found for the pressure drop across the bridge and the thickness of the liquid film left behind, as functions of the capillary number, the thickness of the liquid lining ahead of the bridge and the elastic characteristics of the tube wall. For a given precursor thickness, we find a critical propagation speed, and hence a critical imposed pressure drop, above which the bridge will eventually burst, and hence the tube will reopen.

Howell, Peter D.

Navigating the Airways

Through a licensing agreement with JPL, Hughes Aircraft Company is using the Jet Propulsion Laboratory's (JPL) software GIPSY-OASIS for implementation of the Federal Aviation Administration's Wide Area Augmentation System (WAAS). WAAS will provide precision navigation for commercial airliners in U.S. airspace. JPL's GIPSY-OASIS (GIPSY - GPS-Inferred Positioning System; OASIS - Orbit Analysis and Simulation Software) has been used world-wide to produce the most accurate Global Positioning System (GPS) ephemeredes (satellite position) solutions ever achieved for ground and space users, both in scientific and commercial applications.

Source record

Fluid Mechanics of Capillary-Elastic Instabilities in Microgravity Environment

The aim of this project is to investigate the closure and reopening of lung airways due to surface tension forces, coupled with airway elasticity. Airways are liquid-lined, flexible tubes and closure of airways can occur by a Rayleigh instability of the liquid lining, or an instability of the elastic support for the airway as the surface tension of the air-liquid interface pulls the tube shut, or both. Regardless of the mechanism, the airway is closed because the liquid lining has created a plug that prevents axial gas exchange. In the microgravity environment, surface tension forces dominate lung mechanics and would lead to more prevalent, and more uniformly distributed air-way closure, thereby creating a potential for respiratory problems for astronauts. Once closed the primary option for reopening an airway is by deep inspiration. This maneuver will pull the flexible airways open and force the liquid plug to flow distally by the incoming air stream. Airway reopening depends to a large extent on this plug flow and how it may lead to plug rupture to regain the continuity of gas between the environment and the alveoli. In addition to mathematical modeling of plug flows in liquid-lined, flexible tubes, this work has involved benchtop studies of propagating liquid plugs down tube networks that mimic the human airway tree. We have extended the work to involve animal models of liquid plug propagation in rat lungs. The liquid is radio-opaque and x-ray video imaging is used to ascertain the movement and distribution of the liquid plugs so that comparisons to theory may be made. This research has other uses, such as the delivery of liquids or drugs into the lung that may be used for surfactant replacement therapy or for liquid ventilation.

Grotberg, James B.

Investigations of Pulmonary Epithelial Cell Damage due to Air-Liquid Interfacial Stresses in a Microgravity Environment

Pulmonary airway closure is a potentially dangerous event that can occur in microgravity environments and may result in limited gas exchange for flight crew during long-term space flight. Repetitive airway collapse and reopening subjects the pulmonary epithelium to large, dynamic, and potentially injurious mechanical stresses. During ventilation at low lung volumes and pressures, airway instability leads to repetitive collapse and reopening. During reopening, air must progress through a collapsed airway, generating stresses on the airway walls, potentially damaging airway tissues. The normal lung can tolerate repetitive collapse and reopening. However, combined with insufficient or dysfunctional pulmonary surfactant, repetitive airway collapse and reopening produces severe lung injury. Particularly at risk is the pulmonary epithelium. As an important regulator of lung function and physiology, the degree of pulmonary epithelial damage influences the course and outcome of lung injury. In this paper we present experimental and computational studies to explore the hypothesis that the mechanical stresses associated with airway reopening inflict injury to the pulmonary epithelium.

Gaver, Donald P., III

Computational multiphysics modeling of radioactive aerosol deposition in diverse human respiratory tract geometries

The evaluation of aerosol exposure relies on generic mathematical models that assume uniform particle deposition profiles over the human respiratory tract and do not account for subject-specific characteristics. Here we introduce a hybrid-automated computational workflow that generates personalized particle deposition profiles in 3D reconstructed human airways from computed tomography scans using Computational Fluid and Particle Dynamics simulations. This is the first large-scale study to consider realistic airways variability, where 380 lower and 40 upper human respiratory tract 3D geometries are reconstructed and parameterized. The data is clustered into nine groups using random forest regression. Computational fluid and particle dynamics simulations are conducted on these representative geometries using a realistic heavy-breathing respiratory cycle and radioactive iodine-131 as a source term. Monte Carlo radiation transport simulations are performed to obtain detailed energy deposition maps. Our findings emphasize the importance of personalized studies, as minor respiratory tract variations notably influence deposition patterns rather than global parameters of the lower airways, observing more than 30% variance in the mass deposition fraction.

62 RADIOLOGY AND NUCLEAR MEDICINE