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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Steady-State Mechanical Analysis for Target Assembly in the Material Plasma Exposure eXperiment Facility

The Material Plasma Exposure eXperiment (MPEX) steady-state linear plasma facility is currently under design at Oak Ridge National Laboratory to expose target specimens to fusion divertor regimes. The neutron-irradiated target is actively cooled and remote handled in the MPEX facility for conducting plasma-material–interaction (PMI) experiments. Here, the steady-state stresses in the target and target assembly system are investigated using two-dimensional (2-D) and three-dimensional (3-D) models to provide expected stresses/strains under the heat loads to which various system components would be exposed during MPEX operation. The calculated temperatures from the 2-D axisymmetric mechanical model were found to be in excellent agreement with those from the full 3-D thermohydraulic model, providing a strong model validation. Numerical simulation results for the steady-state mechanical model indicate nonuniform distributions for the temperature, stress, and deformation within the critical components. For the initial design, the deformation results indicate possible gap openings between contacting surfaces below the plasma-facing materials. To reduce the possibility of interfacial gap opening, the target assembly was slightly changed and evaluated using the 2-D stress model. Numerical simulation results indicate that the interfacial gap openings can be minimized without drastically changing the entire target assembly. The stress-strain conditions for the target will be further used to assess the appropriate operation during MPEX experiments and gain insight into materials science phenomena during PMI.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2025

Enhancing the sensitivity to seesaw mechanism predictions in gauged B − L scenarios

New gauge bosons coupled to heavy neutral leptons (HNLs) are simple and well-motivated extensions of the Standard Model. In searches for HNLs in proton fixed-target experiments, we find that a large population of gauge bosons ( Z ′ ) produced by proton bremsstrahlung may decay to HNLs, leading to a significant improvement in existing bounds on the ( m HNL , U α ), where U α represent the mixing between HNL and the active neutrinos with flavor α . We study this possibility in fixed target experiments with the 8 GeV proton beams, including SBND, MicroBooNE, and ICARUS, as well as DUNE and DarkQuest at 120 GeV. We find the projected sensitivities to additional Z ′ -mediated HNL production can bring the seesaw mechanism of the neutrino masses within a broadened experimental reach. Published by the American Physical Society 2025

Capozzi, Francesco (ORCID:0000000161351531)↗
NASA NTRS1999

Effect of viewing distance on the generation of vertical eye movements during locomotion

Vertical head and eye coordination was studied as a function of viewing distance during locomotion. Vertical head translation and pitch movements were measured using a video motion analysis system (Optotrak 3020). Vertical eye movements were recorded using a video-based pupil tracker (Iscan). Subjects (five) walked on a linear treadmill at a speed of 1.67 m/s (6 km/h) while viewing a target screen placed at distances ranging from 0.25 to 2.0 m at 0. 25-m intervals. The predominant frequency of vertical head movement was 2 Hz. In accordance with previous studies, there was a small head pitch rotation, which was compensatory for vertical head translation. The magnitude of the vertical head movements and the phase relationship between head translation and pitch were little affected by viewing distance, and tended to orient the naso-occipital axis of the head at a point approximately 1 m in front of the subject (the head fixation distance or HFD). In contrast, eye velocity was significantly affected by viewing distance. When viewing a far (2-m) target, vertical eye velocity was 180 degrees out of phase with head pitch velocity, with a gain of 0. 8. This indicated that the angular vestibulo-ocular reflex (aVOR) was generating the eye movement response. The major finding was that, at a close viewing distance (0.25 m), eye velocity was in phase with head pitch and compensatory for vertical head translation, suggesting that activation of the linear vestibulo-ocular reflex (lVOR) was contributing to the eye movement response. There was also a threefold increase in the magnitude of eye velocity when viewing near targets, which was consistent with the goal of maintaining gaze on target. The required vertical lVOR sensitivity to cancel an unmodified aVOR response and generate the observed eye velocity magnitude for near targets was almost 3 times that previously measured. Supplementary experiments were performed utilizing body-fixed active head pitch rotations at 1 and 2 Hz while viewing a head-fixed target. Results indicated that the interaction of smooth pursuit and the aVOR during visual suppression could modify both the gain and phase characteristics of the aVOR at frequencies encountered during locomotion. When walking, targets located closer than the HFD (1.0 m) would appear to move in the same direction as the head pitch, resulting in suppression of the aVOR. The results of the head-fixed target experiment suggest that phase modification of the aVOR during visual suppression could play a role in generating eye movements consistent with the goal of maintaining gaze on targets closer than the HFD, which would augment the lVOR response.

NASA Discipline Neuroscience↗
NASA NTRS1977

Adaptation to visual and proprioceptive rearrangement - Origin of the differential effectiveness of active and passive movements

Experiments were conducted to measure and compare the accuracy with which subjects pointed to visual targets before and after an exposure period in which they received systematic proprioceptive misinformation about the locations of visual targets. The crucial factor determining whether adaptation will be elicited is shown to be the presence of a discordance in the positional information being conveyed over two different sensory modalities. Another experiment was carried out to study the effectiveness of active and passive movements in eliciting adaptation when the subjects were exposed to a systematic discordance between the visual and proprioceptive locations of external targets without being permitted sight of their hands. Superiority of active over passive movements in producing adaptation to visual rearrangement is due to the greater accuracy of position sense information about voluntarily moved limbs, partly derived from the contribution of muscle afferent signals.

Lackner, J. R.↗
DOE OSTI2021

A High Separation Factor for 165Er from Ho for Targeted Radionuclide Therapy

Background: Radionuclides emitting Auger electrons (AEs) with low (0.02–50 keV) energy, short (0.0007–40 µm) range, and high (1–10 keV/µm) linear energy transfer may have an important role in the targeted radionuclide therapy of metastatic and disseminated disease. Erbium-165 is a pure AE-emitting radionuclide that is chemically matched to clinical therapeutic radionuclide 177Lu, making it a useful tool for fundamental studies on the biological effects of AEs. This work develops new biomedical cyclotron irradiation and radiochemical isolation methods to produce 165Er suitable for targeted radionuclide therapeutic studies and characterizes a new such agent targeting prostate-specific membrane antigen. Methods: Biomedical cyclotrons proton-irradiated spot-welded Ho(m) targets to produce 165Er, which was isolated via cation exchange chromatography (AG 50W-X8, 200–400 mesh, 20 mL) using alpha-hydroxyisobutyrate (70 mM, pH 4.7) followed by LN2 (20–50 µm, 1.3 mL) and bDGA (50–100 µm, 0.2 mL) extraction chromatography. The purified 165Er was radiolabeled with standard radiometal chelators and used to produce and characterize a new AE-emitting radiopharmaceutical, [165Er]PSMA-617. Results: Irradiation of 80–180 mg natHo targets with 40 µA of 11–12.5 MeV protons produced 165Er at 20–30 MBq·µA−1·h−1. The 4.9 ± 0.7 h radiochemical isolation yielded 165Er in 0.01 M HCl (400 µL) with decay-corrected (DC) yield of 64 ± 2% and a Ho/165Er separation factor of (2.8 ± 1.1) · 105. Radiolabeling experiments synthesized [165Er]PSMA-617 at DC molar activities of 37–130 GBq·µmol−1. Conclusions: A 2 h biomedical cyclotron irradiation and 5 h radiochemical separation produced GBq-scale 165Er suitable for producing radiopharmaceuticals at molar activities satisfactory for investigations of targeted radionuclide therapeutics. This will enable fundamental radiation biology experiments of pure AE-emitting therapeutic radiopharmaceuticals such as [165Er]PSMA-617, which will be used to understand the impact of AEs in PSMA-targeted radionuclide therapy of prostate cancer.

165Er↗
DOE OSTI2022

Measurement of the Ne 18 ( α , p ) Na 21 reaction with the ANASEN active-target detector system at E c . m . = 2.5 – 4 MeV

The 18 Ne(α,p) 21 Na reaction plays a significant role in Type-I X-ray bursts. It is a major path in the breakout from the hot-CNO cycles to the synthesis of heavier elements in the αp- and rp-processes. An experiment to determine the cross section of this reaction was performed with the ANASEN active-target detector system, determining the cross section at energies between 2.5 and 4 MeV in the center-of-mass frame. The measured cross sections for reactions populating the ground state in 21 Na are consistent with results obtained from the time-inverse reaction, but significantly lower than the previously published experimental data of direct measurements. The total cross sections are also compared with those derived from indirect methods and statistical-model calculations. Furthermore, this experiment establishes a new experimental data set on the excitation function of the 18 Ne(α,p) 21 Na reaction, revealing the significance of the excited states' contributions to the total reaction cross section and allowing us to separate the contribution of the (α,2p) reaction. The impact of the measured cross section on thermal reaction rates is discussed.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2023

Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA

The interbacterial deaminase toxin DddA catalyzes cytosine-to-uracil conversion in double-stranded (ds) DNA and enables CRISPR-free mitochondrial base editing, but the molecular mechanisms underlying its unique substrate selectivity have remained elusive. Here, we report crystal structures of DddA bound to a dsDNA substrate containing the 5'-TC target motif. These structures show that DddA binds to the minor groove of a sharply bent dsDNA and engages the target cytosine extruded from the double helix. DddA Phe1375 intercalates in dsDNA and displaces the 5' (-1) thymine, which in turn replaces the target (0) cytosine and forms a noncanonical T–G base pair with the juxtaposed guanine. This tandem displacement mechanism allows DddA to locate a target cytosine without flipping it into the active site. Biochemical experiments demonstrate that DNA base mismatches enhance the DddA deaminase activity and relax its sequence selectivity. On the basis of the structural information, we further identified DddA mutants that exhibit attenuated activity or altered substrate preference. Our studies may help design new tools useful in genome editing or other applications.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

A new hybrid gadolinium nanoparticles-loaded polymeric material for neutron detection in rare event searches

Experiments aimed at direct searches for WIMP dark matter require highly effective reduction of backgrounds and control of any residual radioactive contamination. In particular, neutrons interacting with atomic nuclei represent an important class of backgrounds due to the expected similarity of a WIMP-nucleon interaction, so that such experiments often feature a dedicated neutron detector surrounding the active target volume. In the context of the development of DarkSide-20k detector at INFN Gran Sasso National Laboratory (LNGS), several R&D projects were conceived and developed for the creation of a new hybrid material rich in both hydrogen and gadolinium nuclei to be employed as an essential element of the neutron detector. Thanks to its very high cross-section for neutron capture, gadolinium is one of the most widely used elements in neutron detectors, while the hydrogen-rich material is instrumental in efficiently moderating the neutrons. In this paper results from one of the R&Ds are presented. In this effort the new hybrid material was obtained as a poly(methyl methacrylate) (PMMA) matrix, loaded with gadolinium oxide in the form of nanoparticles. We describe its realization, including all phases of design, purification, construction, characterization, and determination of mechanical properties of the new material.

Dark Matter detectors (WIMPs, axions, etc.)↗
NASA NTRS1971

Experiment M410: Color patch photography

A slate that supported four calibrated color targets was photographed during Gemini 10 mission extravehicular activity to determine if existing outdoor-type color films can reproduce colored objects accurately in the space environment. The experiment resulted in the acquisition of sufficient information to confirm that objects can be photographed in space with good color fidelity by the use of existing materials. Available color film is balanced to the solar spectrum in space, and the effect of ultraviolet energy on film degradation appears to be negligible.

Brinkmann, J. R.↗
NASA NTRS2006

Microgravity and Immunity: Changes in Lymphocyte Gene Expression

Earlier studies had shown that modeled and true microgravity (MG) cause multiple direct effects on human lymphocytes. MG inhibits lymphocyte locomotion, suppresses polyclonal and antigen-specific activation, affects signal transduction mechanisms, as well as activation-induced apoptosis. In this study we assessed changes in gene expression associated with lymphocyte exposure to microgravity in an attempt to identify microgravity-sensitive genes (MGSG) in general and specifically those genes that might be responsible for the functional and structural changes observed earlier. Two sets of experiments targeting different goals were conducted. In the first set, T-lymphocytes from normal donors were activated with antiCD3 and IL2 and then cultured in 1g (static) and modeled MG (MMG) conditions (Rotating Wall Vessel bioreactor) for 24 hours. This setting allowed searching for MGSG by comparison of gene expression patterns in zero and 1 g gravity. In the second set - activated T-cells after culturing for 24 hours in 1g and MMG were exposed three hours before harvesting to a secondary activation stimulus (PHA) thus triggering the apoptotic pathway. Total RNA was extracted using the RNeasy isolation kit (Qiagen, Valencia, CA). Affymetrix Gene Chips (U133A), allowing testing for 18,400 human genes, were used for microarray analysis. In the first set of experiments MMG exposure resulted in altered expression of 89 genes, 10 of them were up-regulated and 79 down-regulated. In the second set, changes in expression were revealed in 85 genes, 20 were up-regulated and 65 were down-regulated. The analysis revealed that significant numbers of MGS genes are associated with signal transduction and apoptotic pathways. Interestingly, the majority of genes that responded by up- or down-regulation in the alternative sets of experiments were not the same, possibly reflecting different functional states of the examined T-lymphocyte populations. The responder genes (MGSG) might play an essential role in adaptation to MG and/or be responsible for pathologic changes encountered in Space and thus represent potential targets for molecular-based countermeasures

Risin, D.↗
DOE OSTI2021

Understanding the effects of neutron scattering for neutron-yield-isotropy measurements at the NIF

Neutron-yield diagnostics at the NIF have been upgraded to include 48 detectors placed around the NIF target chamber to assess the DT-neutron-yield isotropy for inertial confinement fusion experiments. Real-time neutron-activation detectors are used to understand yield asymmetries due to Doppler shifts in the neutron energy attributed to hotspot motion, variations in the fuel and ablator areal densities, and other physics effects. In order to isolate target physics effects, we must understand the contribution due to neutron scattering associated with the different hardware configurations used for each experiment. Here, we present results from several calibration experiments that demonstrate the ability to achieve our goal of 1% or better precision in determining the yield isotropy.

47 OTHER INSTRUMENTATION↗
DOE OSTI2022

Scintillator ageing of the T2K near detectors from 2010 to 2021

The T2K experiment widely uses plastic scintillator as a target for neutrino interactions and an active medium for the measurement of charged particles produced in neutrino interactions at its near detector complex. Over 10 years of operation the measured light yield recorded by the scintillator based subsystems has been observed to degrade by 0.9–2.2% per year. Extrapolation of the degradation rate through to 2040 indicates the recorded light yield should remain above the lower threshold used by the current reconstruction algorithms for all subsystems. This will allow the near detectors to continue contributing to important physics measurements during the T2K-II and Hyper-Kamiokande eras. Additionally, work to disentangle the degradation of the plastic scintillator and wavelength shifting fibres shows that the reduction in light yield can be attributed to the ageing of the plastic scintillator. The long component of the attenuation length of the wavelength shifting fibres was observed to degrade by 1.3–5.4% per year, while the short component of the attenuation length did not show any conclusive degradation.

47 OTHER INSTRUMENTATION↗
DOE OSTI2021

2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography

The genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus has a capping modification at the 5'-untranslated region (UTR) to prevent its degradation by host nucleases. These modifications are performed by the Nsp10/14 and Nsp10/16 heterodimers using S-adenosylmethionine as the methyl donor. Nsp10/16 heterodimer is responsible for the methylation at the ribose 2'-O position of the first nucleotide. To investigate the conformational changes of the complex during 2'-O methyltransferase activity, we used a fixed-target serial synchrotron crystallography method at room temperature. We determined crystal structures of Nsp10/16 with substrates and products that revealed the states before and after methylation, occurring within the crystals during the experiments. Here we report the crystal structure of Nsp10/16 in complex with Cap-1 analog ( m7 GpppA m2'-O ). Inhibition of Nsp16 activity may reduce viral proliferation, making this protein an attractive drug target.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2003

Rigidity Spectra of Protons and Helium as Measured in the First Flight of the ATIC Experiment

ATIC (Advanced Thin Ionization Calorimeter) is a balloon borne experiment designed to measure cosmic ray composition for elements from hydrogen to iron and their energy spectra from 30 GeV to near 100 TeV. It is comprised of a fully active BGO calorimeter, a carbon interaction target, scintillator hodoscopes, and a silicon matrix that is used as a charge detector in the experiment. ATIC had two successful balloon flights in Antarctica: from 28 Dec 2000 to 13 Jan 2001 (ATIC-1) and from 29 Dec 2002 to 18 Jan 2003 (ATIC-2). Preliminary rigidity spectra of protons and helium nuclei and their ratio are presented for the test flight (ATIC-1). Particular attention is given to problems associated with measuring energy.

Zatsepin, V. I.↗
NASA NTRS2005

Effects of ongoing task context and target typicality on prospective memory performance: the importance of associative cueing

Two experiments examined whether prospective memory performance is influenced by contextual cues. In our automatic activation model, any information available at encoding and retrieval should aid recall of the prospective task. The first experiment demonstrated an effect of the ongoing task context; performance was better when information about the ongoing task present at retrieval was available at encoding. Performance was also improved by a strong association between the prospective memory target as it was presented at retrieval and the intention as it was encoded. Experiment 2 demonstrated boundary conditions of the ongoing task context effect, which implicate the association between the ongoing and prospective tasks formed at encoding as the source of the context effect. The results of this study are consistent with predictions based on automatic activation of intentions.

Cues↗
NASA NTRS2003

Exploring Asteroid Interiors: The Deep Interior Mission Concept

Deep Interior is a mission to determine the geophysical properties of near-Earth objects, including the first volumetric image of the interior of an asteroid. Radio reflection tomography will image the 3D distribution of complex dielectric properties within the ~1 km rendezvous target and hence map structural, density or compositional variations. Laser altimetry and visible imaging will provide high-resolution surface topography. Smart surface pods culminating in blast experiments, imaged by the high frame rate camera and scanned by lidar, will characterize active mechanical behavior and structure of surface materials, expose unweathered surface for NIR analysis, and may enable some characterization of bulk seismic response. Multiple flybys en route to this target will characterize a diversity of asteroids, probing their interiors with non-tomographic radar reflectance experiments. Deep Interior is a natural follow-up to the NEARShoemaker mission and will provide essential guidance for future in situ asteroid and comet exploration. While our goal is to learn the interior geology of small bodies and how their surfaces behave, the resulting science will enable pragmatic technologies required of hazard mitigation and resource utilization.

Asphaug, E.↗
DOE OSTI2024

A dynamic Bayesian optimized active recommender system for curiosity-driven partially Human-in-the-loop automated experiments

Optimization of experimental materials synthesis and characterization through active learning methods has been growing over the last decade, with examples ranging from measurements of diffraction on combinatorial alloys at synchrotrons, to searches through chemical space with automated synthesis robots for perovskites. In virtually all cases, the target property of interest for optimization is defined a priori with the ability to shift the trajectory of the optimization based on human-identified findings during the experiment is lacking. Thus, to highlight the best of both human operators and AI-driven experiments, here we present the development of a human–AI collaborated experimental workflow, via a Bayesian optimized active recommender system (BOARS), to shape targets on the fly with human real-time feedback. Here, the human guidance overpowers AI at early iteration when prior knowledge (uncertainty) is minimal (higher), while the AI overpowers the human during later iterations to accelerate the process with the human-assessed goal. We showcase examples of this framework applied to pre-acquired piezoresponse force spectroscopy of a ferroelectric thin film, and in real-time on an atomic force microscope, with human assessment to find symmetric hysteresis loops. It is found that such features appear more affected by subsurface defects than the local domain structure. This work shows the utility of human–AI approaches for curiosity driven exploration of systems across experimental domains.

36 MATERIALS SCIENCE↗
DOE OSTI2026

Radiolytic Gas Generation and Pressure Buildup in a Closed System Containing Mo-99 Solution

This study measured radiolytic gas generation and pressure buildup in a sealed stainless-steel system containing alkaline Mo-99 solution with added sodium nitrate as a hydrogen suppressant. In each of two experiments, approximately 200 Ci of Mo-99 solution was transferred into a closed experimental vessel inside a hot cell, isolated, and monitored for pressure rise caused by gas generation during radioactive decay. After pressure buildup, headspace gas samples were collected and analyzed by mass spectrometry to determine hydrogen and oxygen concentrations. The purpose was to quantify the magnitude of pressure buildup in a closed system and to characterize the gas composition produced by radiolysis of the Mo-99 target solution under representative handling and storage conditions. The two experiments used similar total Mo-99 activity but differed in solution volume, headspace volume, and leak integrity. In the first experiment, 197.5 Ci of Mo-99 in 16.92 mL of solution was loaded into a vessel with a 31.1-mL headspace; a small leak was later identified, and the measured peak pressure of 46 psig was extrapolated to about 70 psig in the absence of leakage. The headspace gas from this experiment contained about 21.4% H2 and 63.4% O2, but the composition was influenced by preferential hydrogen loss through the leak. In the second experiment, 193 Ci of Mo-99 in 5.41 mL of solution with 0.46 g NaNO3 was loaded into a vessel with a larger 42.61 mL headspace, and no detectable leak was observed. This experiment reached a peak pressure of 38 psig, and the measured gas composition was approximately 28.2% H2 and 51.5% O2. Because the second experiment was leak-free, it is considered the more reliable indicator of the true pressure buildup and intrinsic radiolytic gas composition of the Mo-99 solution.

Chemerisov, Sergey D.↗