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NASA NTRS1993

Air Force construction automation/robotics

The Air Force has several missions which generate unique requirements that are being met through the development of construction robotic technology. One especially important mission will be the conduct of Department of Defense (DOD) space activities. Space operations and other missions place construction/repair equipment operators in dangerous environments and potentially harmful situations. Additionally, force reductions require that human resources be leveraged to the maximum extent possible, and more stringent construction repair requirements push for increased automation. To solve these problems, the U.S. Air Force is undertaking a research and development effort at Tyndall AFB, FL, to develop robotic construction/repair equipment. This development effort involves the following technologies: teleoperation, telerobotics, construction operations (excavation, grading, leveling, tool change), robotic vehicle communications, vehicle navigation, mission/vehicle task control architecture, and associated computing environment. The ultimate goal is the fielding of a robotic repair capability operating at the level of supervised autonomy. This paper will discuss current and planned efforts in space construction/repair, explosive ordnance disposal, hazardous waste cleanup, and fire fighting.

Nease, A. D.↗

NASA NTRS2001

Plants, plant pathogens, and microgravity--a deadly trio

Plants grown in spaceflight conditions are more susceptible to colonization by plant pathogens. The underlying causes for this enhanced susceptibility are not known. Possibly the formation of structural barriers and the activation of plant defense response components are impaired in spaceflight conditions. Either condition would result from altered gene expression of the plant. Because of the tools available, past studies focused on a few physiological responses or biochemical pathways. With recent advances in genomics research, new tools, including microarray technologies, are available to examine the global impact of growth in the spacecraft on the plant's gene expression profile. In ground-based studies, we have developed cDNA subtraction libraries of rice that are enriched for genes induced during pathogen infection and the defense response. Arrays of these genes are being used to dissect plant defense response pathways in a model system involving wild-type rice plants and lesion mimic mutants. The lesion mimic mutants are ideal experimental tools because they erratically develop defense response-like lesions in the absence of pathogens. The gene expression profiles from these ground-based studies will provide the molecular basis for understanding the biochemical and physiological impacts of spaceflight on plant growth, development and disease defense responses. This, in turn, will allow the development of strategies to manage plant disease for life in the space environment.

NASA Discipline Plant Biology↗

NASA NTRS2017

Maturation of the Asteroid Threat Assessment Project

As described at IPPW 12 [1], NASA initiated a new research activity focused on Planetary Defense (PD) on October 1, 2014. The overarching function of the Asteroid Threat Assessment Project (ATAP) is to provide capabilities to assess impact damage of any Near-Earth Object (NEO) that could inflict on the Earth. The activity includes four interrelated efforts: Initial Conditions (at the atmospheric entry interface); Entry Modeling (energy deposition in the atmosphere); Hazards (on the surface including winds, over pressures, thermal exposures, craters, tsunami and earthquakes) and Risk (physics-based). This paper outlines progress by ATAP and highlights achievements that are complimentary to activities of interest to the International Planetary Probe community. The ATAPs work is sponsored by NASAs Planetary Defense Coordination Office (PDCO), a part of the agency's Science Mission Directorate [1] Arnold, J. O., et. al., Overview of a New NASA Activity Focused on Planetary Defense, IPPW 12 Cologne Germany, June 15-19. 2015.

Entry and Breakup↗

NASA NTRS2023

Information and Best Practices Related to NASA Nuclear Flight Safety for Space Flights Involving Space Nuclear Systems

The purpose of this handbook is to facilitate a repeatable and robust process that promotes clear and effective interfaces between activities and stakeholders focused on meeting nuclear flight safety requirements for missions utilizing space nuclear systems (SNS), within the context of NASA’s broader nuclear-related activities and interfaces. NPR 8715.26, Nuclear Flight Safety, requires that the NASA project manager “incorporate nuclear flight safety considerations starting with program or project formulation through the point at which the SNS or other radioactive material no longer has the potential to affect Earth’s biosphere.” NASA’s use of SNS inherently involves partnering with other stakeholders to conduct a range of related activities that interface with nuclear flight safety. From a categorical perspective these include: (i) meeting the authorities and licensing requirements for possession and use of nuclear material, as governed by other Federal authorities; (ii) conducting National Environmental Policy Act (NEPA) activities for nuclear-enabled missions; (iii) meeting Federal nuclear launch authorization requirements; (iv) conducting radiological contingency planning activities, including those associated with international commitments; (v) performing risk communication and public outreach activities; and (vi) ensuring decommissioning and disposal strategies reflect National policies and interests. It is the intent of this handbook to promote an effective interface between nuclear flight safety and these interrelated categorical activities. In addition to activities undertaken with partnering agencies, there are individual nuclear-related activities and programs that have a nexus to nuclear flight safety, and these include: (i) applicable NASA Standing Review Boards; (ii) the US Department of Energy nuclear safety activities conducted in partnership with NASA under Memoranda of Understanding; (iii) the Department of Defense’s Range Safety activities; (iv) NASA’s general involvement in interagency and international dialogues regarding nuclear safety; (v) the NASA-administered Interagency Nuclear Safety Review Board; (vi) NASA’s program and project governance activities and nuclear-specific Technical Discipline Team activities under the Office of the Chief Engineer; and others. It is the intent of this handbook to promote effective leveraging of these additional interrelated organizational activities, as appropriate.

Donald Helton↗

NASA NTRS1997

Induction of ceruloplasmin synthesis by IFN-gamma in human monocytic cells

Ceruloplasmin is a 132-kDa glycoprotein abundant in human plasma. It has multiple in vitro activities, including copper transport, lipid pro- and antioxidant activity, and oxidation of ferrous ion and aromatic amines; however, its physiologic role is uncertain. Although ceruloplasmin is synthesized primarily by the liver in adult humans, production by cells of monocytic origin has been reported. We here show that IFN-gamma is a potent inducer of ceruloplasmin synthesis by monocytic cells. Activation of human monoblastic leukemia U937 cells with IFN-gamma increased the production of ceruloplasmin by at least 20-fold. The identity of the protein was confirmed by plasmin fingerprinting. IFN-gamma also increased ceruloplasmin mRNA. Induction followed a 2- to 4-h lag and was partially blocked by cycloheximide, indicating a requirement for newly synthesized factors. Ceruloplasmin induction in monocytic cells was agonist specific, as IL-1, IL-4, IL-6, IFN-alpha, IFN-beta, TNF-alpha, and LPS were completely ineffective. The induction was also cell type specific, as IFN-gamma did not induce ceruloplasmin synthesis in endothelial or smooth muscle cells. In contrast, IFN-gamma was stimulatory in other monocytic cells, including THP-1 cells and human peripheral blood monocytes, and also in HepG2 cells. Ceruloplasmin secreted by IFN-gamma-stimulated U937 cells had ferroxidase activity and was, in fact, the only secreted protein with this activity. Monocytic cell-derived ceruloplasmin may contribute to defense responses via its ferroxidase activity, which may drive iron homeostasis in a direction unfavorable to invasive organisms.

Non-NASA Center↗

NASA NTRSDate not supplied

PLANETARY DEFENSE: FINDINGS AND RECOMMENDATIONS FROM THE NATIONAL ACADEMIES PLANETARY SCIENCE AND ASTROBIOLOGY DECADAL SURVEY 2023 - 2032

The National Academies of Sciences, Engineering, and Medicine was chartered by the NASA Science Mission Directorate (SMD), with support from the National Science Foundation, to conduct a new decadal survey to develop a comprehensive science and mission strategy for planetary science (1). The survey was tasked to determine the current state of knowledge and to identify the most important scientific questions to be addressed in astrobiology and planetary science during the upcoming decade of 2023 - 2032. For the first time, the decadal survey also included and addressed the topic of planetary defense, now recognized as a key element of NASA’s planetary science activities under the direction of NASA’s SMD Planetary Defense Coordination Office. The topic of planetary defense was included in the decadal survey as a dedicated chapter, divided into five sections based on the framework from the U.S. National NEO Preparedness Strategy and Action Plan (2). These sections discussed: NEO Detection, Tracking, and Characterization NEO Modelling, Prediction, and Integration NEO Deflection and Disruption Missions International Cooperation on NEO Preparation NEO Impact Emergency Procedures and Action Protocols Content of these sections included identifying the activities, ground- and space-based assets, facilities, resources, technologies, and missions that should be considered to enable NEO preparedness over the next decade. Supporting inputs to this chapter involved contributions from submitted white papers authored by many members of the NEO science and planetary defense communities. In addition, a planetary defense rapid mission architecture study commissioned by the decadal survey small bodies panel and led by the Jet Propulsion Laboratory examined several different types of in-situ characterization and mitigation demonstration missions. All of this input contributed to the formulation of 42 findings and 11 recommendations that suggest a path forward for increasing our understanding of the NEO population and their associated physical characteristics, modelling the impact probabilities and hazard potential of these objects, and implementing plans to develop and test NEO impact mitigation capabilities. Including planetary defense in the decadal survey has helped sharpen the focus on this international issue and provided key inputs for stakeholders and decision makers to consider when developing future planetary defense-related activities. Such information is vital for developing a long-term integrated planetary defense capability able to protect humanity in the decades to come.

NEO Detection and Characterization↗

NASA NTRS1997

Commercializing Defense Technologies and Helping Defense Firms Succeed in Commercial Markets: A Report on the Objectives, Activities, and Accomplishments of the TAP-IN Program

Technology Access for Product Innovation (TAP-IN), the largest technology deployment project funded by TRP, was competitively selected through a national solicitation for proposals. TAP-IN was created to help companies access and apply defense technologies and help defense-dependent companies enter new commercial markets. Defense technologies included technologies developed by DoD, DOE, NASA, and their contractors. TAP-IN was structured to provide region-based technology access services that were able to draw on technology resources nationwide. TAP-IN provided expert assistance in all stages of the commercialization process from concept through prototype design to capital sourcing and marketing strategy. TAP-IN helped companies locate new technology, identify business partners, secure financing, develop ideas for new products, identify new markets, license technology, solve technical problems, and develop company-specific applications of federal technology. TAP-IN leveraged NASA's existing commercial technology network to create an integrated national network of organizations that assisted companies in every state. In addition to NASA's six regional technology transfer centers (RTTCs), TAP-IN included business and technology development organizations in every state, the Industrial Designers Society of America, and the Federal Laboratory Consortium (FLC).

Source record↗

NASA NTRS1983

AFFTC overview of orbiter-reentry flight-test results

The Air Force Flight Test Center (AFFTC) has been participating in the flight testing of the Space Shuttle since 1976. An independent assessment of the reentry and landing capabilities of the Orbiter was conducted with respect to Department of Defense (DOD) missions. This activity is on-going and reports have been published after each flight. AFFTC participation in this conference is not directly related to the DOD assessment activity, however, and the views presented by myself and other AFFTC authors discuss the technical aspects of testing and the technology emanating from these tests.

Hoey, R. G.↗

NASA NTRS1994

Ionospheric response to the sustained high geomagnetic activity during the March '89 great storm

A simulation was conducted to model the high-latitude ionospheric to the sustaied level of high geomagnetic activity for the great magnetic storm period of March 13-14, 1989. The geomagnetic and solar activity indices and the Defense Meterological Satellite Program (DMSP) F8 and F9 satellite data for particle precipitation and high-latitude convection were used as inputs to a time-dependent ionospheric model (TDIM). The results of the TDIM were compared to both DMSP plasma density data and ground-based total electron content (TEC) measurements for the great storm period as well as with earlier storm observations. The comparisons show that the overall structure of the high-latitude ionosphere was dominated by an increased convection speed within the polar cap that led to increased ion temperatures. In turn, this enhanced the NO(+) density, raised the atomic-to-molecular ion transition height to over 300 km, decreased N(sub m)F(sub 2), increased h(sub m)F(sub 2), and in places either increased n(sub e) at 800 km or slightly decreased it. The morphology of the ionosphere under these extreme conditions was considerably different than that modeled for less distributed intervals. These differences included the character of the dayside tongue of ionization that no longer extended deep into the polar cap. Instead, as a result of the ion heating and consequent reduction in N(sub m)F(sub 2), a large polar hole occupied much of the polar region. This polar hole extended beyond the auroral oval and merged with the night sector midatitude trough. The limitaions associated with the applicability of the TDIM to the geomagnetic conditions present on March 13 and 14 are discussed. The primary limitations of the TDIM derive from the limited temporal resolution of the model input parameters and the lack of suitably dynamic thermospheric specification for the great storm conditions. These limitations leads to midlatitude ionospheric storm phases that do no follow those observed.

Sojka, J. J.↗

NASA NTRS2001

Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases

Many of the biological and pathological effects of nitric oxide (NO) are mediated through cell signaling pathways that are initiated by NO reacting with metalloproteins. More recently, it has been recognized that the reaction of NO with free radicals such as superoxide and the lipid peroxyl radical also has the potential to modulate redox signaling. Although it is clear that NO can exert both cytotoxic and cytoprotective actions, the focus of this overview are those reactions that could lead to protection of the cell against oxidative stress in the vasculature. This will include the induction of antioxidant defenses such as glutathione, activation of mitogen-activated protein kinases in response to blood flow, and modulation of mitochondrial function and its impact on apoptosis. Models are presented that show the increased synthesis of glutathione in response to shear stress and inhibition of cytochrome c release from mitochondria. It appears that in the vasculature NO-dependent signaling pathways are of three types: (i) those involving NO itself, leading to modulation of mitochondrial respiration and soluble guanylate cyclase; (ii) those that involve S-nitrosation, including inhibition of caspases; and (iii) autocrine signaling that involves the intracellular formation of peroxynitrite and the activation of the mitogen-activated protein kinases. Taken together, NO plays a major role in the modulation of redox cell signaling through a number of distinct pathways in a cellular setting.

Non-NASA Center↗

NASA NTRS1991

Aircraft active and passive microwave validation of sea ice concentration from the Defense Meteorological Satellite Program special sensor microwave imager

Results are presented of a series of coordinate special sensor microwave imager (SSM/I) underflights that were carried out during March 1988 with NASA and Navy aircraft over portions of the Bering, Beaufort, and Chukchi seas. NASA DC-8 AMMR data from Bering Sea ice edge crossings were used to verify that the ice edge location, defined as the position of the initial ice bands encountered by the aircraft, corresponds to an SSM/I ice concentration of 15 percent. Direct comparison of SSM/I and aircraft ice concentrations for regions having at least 80 percent aircraft coverage reveals that the SSM/I total ice concentration is lower on average by 2.4 +/-2.4 percent. For multiyear ice, NASA and Navy flights across the Beaufort and Chukchi seas show that the SSM/I algorithm correctly maps the large-scale distribution of multiyear ice: the zone of first-year ice off the Alaskan coast, the large areas of mixed first-year and multiyear ice, and the region of predominantly multiyear ice north of the Canadian archipelago.

Cavalieri, D. J.↗

NASA NTRS1996

Fact Sheet: National Space Policy

For over three decades, the United States has led the world in the exploration and use of outer space. Our achievements in space have inspired a generation of Americans and people throughout the world. We will maintain this leadership role by supporting a strong, stable, and balanced national space program that serves our goals in national security, foreign policy, economic growth, environmental stewardship, and scientific and technical excellence. Access to and use of space are central for preserving peace and protecting US national security as well as civil and commercial interests. The United States will pursue greater levels of partnership and cooperation in national and international space activities and work with other nations to ensure the continued exploration and use of outer space for peaceful purposes. The goals of the US space program are to: (a) Enhance knowledge of the Earth, the solar system, and the universe through human and robotic exploration; (b) Strengthen and maintain the national security of the United States; (c) Enhance the economic competitiveness and scientific and technical capabilities of the United States; (d) Encourage State, local, and private sector investment in, and use of, space technologies; (e) Promote international cooperation to further US domestic, national security, and foreign policies. The United States is committed to the exploration and use of outer space by all nations for peaceful purposes and for the benefit of all humanity. "Peaceful purposes" allow defense and intelligence-related activities in pursuit of national security and other goals. The United States rejects any claims to sovereignty by any nation over outer space or celestial bodies, or any portion thereof, and rejects any limitations on the fundamental right of sovereign nations to acquire data from space. The United States considers the space systems of any nation to be national property with the right of passage through and operations in space without interference. Purposeful interference with space systems shall be viewed as an infringement on sovereign rights. The US Government will maintain and coordinate separate national security and civil space systems where differing needs dictate. All actions undertaken by agencies and departments in implementing the national space policy shall be consistent with US law, regulations, national security requirements, foreign policy, international obligations, and nonproliferation policy. The National Science and Technology Council (NSTC) is the principal forum for resolving issues related to national space policy. As appropriate, the NSTC and NSC will co-chair policy process. This policy will be implemented within the overall resource and policy guidance provided by the President.

Source record↗

DOE OSTI2025

Data Qualification Report: SRNL Glass Composition-Properties (ComPro) Database

The Savannah River National Laboratory Glass Composition-Properties (ComPro) database is an extensive database containing pertinent composition and durability data to support the accelerated clean-up mission at the Defense Waste Processing Facility. The activities described in this data qualification report were performed to support the information contained in the database. There were two objectives of the original data qualification process. The first objective was to review supporting documentation to determine if DOE/RW-0333P Quality Assurance Requirements and Description had been implemented during the original work. If the DOE/RW-0333P Quality Assurance Requirements and Description had not been directly implemented during the original work, the second objective was to determine if the controls that were used were adequate to meet the intent of the DOE/RW-0333P Quality Assurance Requirements and Description. The results of these two objectives and the activities performed to support these decisions are described in this document. An assessment of each dataset was made to determine if the data were RW-0333P Compliant, RW-0333P Equivalent or Non-RW-0333P Compliant. The original data qualification was performed in accordance with E7, Conduct of Engineering Manual, Procedure 3.70, Revision 4, Qualification of Data. The specific method that was used was Equivalent Controls as described in E7, 3.70. Revision 2 of this document adds supporting information for the RW-0333P Compliant datasets added to Revision 3 of the database.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

NASA NTRS1991

The NASA/DOE/DOD nuclear rocket propulsion project - FY 1991 status

NASA has initiated planning and critical technology development for nuclear rocket propulsion systems for Space Exploration Initiative missions to the moon and to Mars. Interagency agreements are being negotiated between NASA, the Department of Energy, and the Department of Defense for joint technology development activities. This paper summarizes the activities of the NASA project planning team in FY 1990 that led to the draft Nuclear Propulsion Project Plan, outlines the FY 1991 Interagency activities, and describes the current status of the project plan.

Clark, John S.↗

NASA NTRS1994

A look into the crystal ball: The next 25 years

The PTTI Planning Meeting was born at about the same time as the atomic definition of the unit of time, the second. This use of the cesium resonance was made possible by advances in quantum electronics during the preceding decade which resulted in commercial availability of cesium, rubidium, and hydrogen clocks and frequency standards. Twenty-five years later these types of clocks still are the backbone of time and frequency applications; together with a variety of crystal oscillators, transmitters, and receivers, as well as signal distribution, conditioning and switching systems, atomic clocks are an essential part of the infrastructure of modern navigation and communication technology. The next 25 years undoubtedly will see a pervasive expansion of PTTI into the infrastructure that supports and leverages industrial, social, environmental, defense, and even individual human activities. Speculation as to what capabilities, services, and personal conveniences may become available will be limited by two factors: the degree to which existing device concepts can be made more affordable and reliable, and the ability to miniaturize for purposes of compatibility with electronic integration. With regard to the latter, history teaches us that the required technological breakthrough is unlikely to originate in existing technology; thus, we may expect a paradigm shift in PTTI device concepts not unlike the shift in the 1960s from vacuum tubes to semiconductors.

Hellwig, Helmut↗

NASA NTRS2015

High-Power, High-Thrust Ion Thruster (HPHTion)

Advances in high-power photovoltaic technology have enabled the possibility of reasonably sized, high-specific power solar arrays. At high specific powers, power levels ranging from 50 to several hundred kilowatts are feasible. Ion thrusters offer long life and overall high efficiency (typically greater than 70 percent efficiency). In Phase I, the team at ElectroDynamic Applications, Inc., built a 25-kW, 50-cm ion thruster discharge chamber and fabricated a laboratory model. This was in response to the need for a single, high-powered engine to fill the gulf between the 7-kW NASA's Evolutionary Xenon Thruster (NEXT) system and a notional 25-kW engine. The Phase II project matured the laboratory model into a protoengineering model ion thruster. This involved the evolution of the discharge chamber to a high-performance thruster by performance testing and characterization via simulated and full beam extraction testing. Through such testing, the team optimized the design and built a protoengineering model thruster. Coupled with gridded ion thruster technology, this technology can enable a wide range of missions, including ambitious near-Earth NASA missions, Department of Defense missions, and commercial satellite activities.

Peterson, Peter Y.↗

NASA NTRS2021

CubeSAT Security Attack Tree Analysis

Once a novelty, small satellites, often referred to as CubeSats, have become important tools for a variety of space activities ranging from exploration to defense. Their relative affordability and short development timeline have made them attractive options to complement larger space vehicles, conduct reconnaissance and other finite tasks. The specialized nature of many CubeSat missions do not make their security any less important as their missions could easily be matters of national security. This paper demonstrates the use of attack tree analysis to assess vulnerabilities of a CubeSat. First, we abstract and build an architectural model of an operational CubeSat. We then create a series of attack trees for the abstracted architecture to illustrate a series of potential attack vectors for small satellites. We conclude by discussing some strategies that could be employed to improve CubeSat resilience.

Santangelo, Andrew↗

DOE OSTI2026

Recurrent acquisition of nuclease-protease pairs in antiviral immunity

Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, otherwise unrelated antiviral immune systems in bacteria. Cell-based and biochemical assays revealed that the nuclease is a proenzyme that cleaves DNA only after activation by its partner protease. Two distinct immune systems, Hachiman and AVAST (antiviral adenosine triphosphatase/nucleoside triphosphatase of the STAND superfamily, Avs), use the same mechanism of proteolytic activation despite their independent evolutionary origins. Examination of nuclease-protease inheritance patterns identified caspase-nuclease (canu) genomic loci that confer antiviral defense in a pathway reminiscent of eukaryotic caspase activation. These results uncover the coordinated activities of pronucleases and their activating proteases within different immune systems and show how coevolution enables defense system innovation.

Tuck, Owen T↗