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At least 343 records · Page 19

Lifetime Extension of the Stainless-Steel Components of the SAVY-4000 Storage Container - 18572

Surveillance of vented, stainless-steel Hagan and SAVY-4000 storage containers with some plutonium materials have revealed evidence of corrosion inside the container. There are ∼3000 items stored in Hagan containers and ∼600 items currently stored in SAVY-4000 containers at TA-55. The Hagan is made of 304L steel while the SAVY is made of 316L and should be less susceptible to corrosion. Given the relatively thin body wall of these containers (nominally 0.762 millimeters), it is essential to understand the effects of corrosion on the lifetime of the containers to ensure worker safety. Studies are being conducted on both container types to determine the relative susceptibility of the two containers to corrosion. This paper will describe the potential cause of the corrosion, the extent of corrosion, the types of corrosion observed, along with the results of accelerating aging experiments. The combined results of the surveillance and lifetime extension studies will be used to predict the container lifetime. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Multiporosity flow in fractured low-permeability rocks: Extension to shale hydrocarbon reservoirs

We presented a multiporosity extension of classical double and triple-porosity fractured rock flow models for slightly compressible fluids. The multiporosity model is an adaptation of the multirate solute transport model of Haggerty and Gorelick (1995) to viscous flow in fractured rock reservoirs. It is a generalization of both pseudo steady state and transient interporosity flow double-porosity models. The model includes a fracture continuum and an overlapping distribution of multiple rock matrix continua, whose fracture-matrix exchange coefficients are specified through a discrete probability mass function. Semianalytical cylindrically symmetric solutions to the multiporosity mathematical model are developed using the Laplace transform to illustrate its behavior. Furthermore, the multiporosity model presented here is conceptually simple, yet flexible enough to simulate common conceptualizations of double and triple-porosity flow. This combination of generality and simplicity makes the multiporosity model a good choice for flow modelling in low-permeability fractured rocks.

58 GEOSCIENCES↗

Matrix Extension Validation of AOCS Ce 2c‐11 for Omega‐3 Polyunsaturated Fatty Acids in Conventional Foods and Dietary Supplements Containing Added Marine Oil

Abstract Marine oils are commonly added to conventional foods and dietary supplements to enhance their contents of omega‐3 polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA; 20:5n‐3) and docosahexaenoic acid (DHA; 22:6n‐3), which have been associated with numerous potential health benefits. This study compared American Oil Chemists’ Society (AOCS) Official Methods Ce 2b‐11 and Ce 2c‐11 for determining EPA and DHA in foods and dietary supplements and found that AOCS Ce 2c‐11 produces significantly higher analyzed values, which could be attributed to a more comprehensive breakdown of the sample matrix and derivatization of fatty acids. Our subsequent food matrix extension validation of AOCS Ce 2c‐11 demonstrated that the method produces true, accurate, sensitive, and precise determinations of EPA, DHA, and total omega‐3 PUFA in foods and dietary supplements containing added marine oil, including those formulated with emulsified and microencapsulated oils. The method detection limits for EPA and DHA were 0.012 ± 0.002 and 0.011 ± 0.003 mg g −1 , respectively (means ± SD). The analyzed contents of EPA (1.26–386 mg serving −1 ), DHA (1.37–563 mg serving −1 ), and total omega‐3 PUFA (2.69–1270 mg serving −1 ) were reported for 27 conventional food and dietary supplement products. Eighteen products declared contents of DHA, EPA + DHA, or total omega‐3 PUFA on product labels, and the analyzed contents of those fatty acids varied from 95 to 162% of label declarations for all but two of the products.

Li, Ziyi↗

Electrochemical Detection of SNP in Human Mitochondrial DNA Using Cyclic Primer Extension with Biotinylated Nucletides and Enzymatic Labeling at Disposable Pencil Graphite Electrodes

Abstract A novel method of SNP typing in human mitochondrial DNA utilizing enzymatic labeling and electrochemical detection at disposable pencil graphite electrodes is described. The procedure is based on amplification of DNA stretches by cyclic primer extension (PEx) of SNP‐specific diagnostic primers in a mixture of biotinylated and natural nucleotides. The diagnostic primers are designed to recognize, by its 3'‐terminal nucleotide, the SNP‐site in target template. Under optimized conditions of the PEx reaction, efficient polymerase synthesis of biotin‐labeled strands takes place only in the case of full complementarity between the diagnostic primer and the target SNP site. There is also benefit from introducing many biotin molecules per extended DNA strand, resulting in another level of signal amplification. After adsorption of biotinylated PEx products at the electrode surface, streptavidin‐alkaline phosphatase conjugate was bound to the biotin tags, 1‐naphthol was enzymatically produced and electrochemically detected. Several critical steps and parameters of the assay, including termination of 3’‐OH ends of residual amplification primers, temperature for annealing of diagnostic primers, relative amount of biotinylated deoxynucleoside triphosphate in the PEx mixture and number of PEx cycles were optimized in this study to attain best SNP resolution, and reduction of time needed for the analysis.

Plucnara, Medard↗

Chain extension epoxide polymerization to well‐defined block polymers using a N‐Al Lewis pair catalyst

Block polyethers comprised of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEG or PEO) segments form the basis of ABA-type PEO-b-PPO-b-PEO poloxamer materials. The inverse architecture with an internal hydrophilic PEO segment flanked by hydrophobic blocks can be difficult to prepare with control of architecture by use of traditional anionic polymerization. These oxyanionic polymerizations are plagued by chain-transfer-to-monomer side reactions that occur with substituted epoxides such as propylene oxide (PO). Herein, we report a new method for the preparation of block polymers through a controlled polymerization involving a N-Al Lewis adduct catalyst and an aluminum alkoxide macroinitiator. The Lewis pair catalyst was able to chain-extend commercial PEO macroinitiators to prepare di-, tri-, and pentablock polyethers with low dispersity and reasonable monomer tolerance. Chain extension was confirmed using size exclusion chromatography and diffusion ordered nuclear magnetic resonance spectroscopy. In conclusion, the resulting block polymers were additionally analyzed with small-angle X-ray scattering to correlate the morphology to molecular architecture.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

An extensible vector toolkit and parts library for advanced engineering of plant genomes

Abstract Plant biotechnology is rife with new advances in transformation and genome engineering techniques. A common requirement for delivery and coordinated expression in plant cells, however, places the design and assembly of transformation constructs at a crucial juncture as desired reagent suites grow more complex. Modular cloning principles have simplified some aspects of vector design, yet many important components remain unavailable or poorly adapted for rapid implementation in biotechnology research. Here, we describe a universal Golden Gate cloning toolkit for vector construction. The toolkit chassis is compatible with the widely accepted Phytobrick standard for genetic parts, and supports assembly of arbitrarily complex T‐DNAs through improved capacity, positional flexibility, and extensibility in comparison to extant kits. We also provision a substantial library of newly adapted Phytobricks, including regulatory elements for monocot and dicot gene expression, and coding sequences for genes of interest such as reporters, developmental regulators, and site‐specific recombinases. Finally, we use a series of dual‐luciferase assays to measure contributions to expression from promoters, terminators, and from cross‐cassette interactions attributable to enhancer elements in certain promoters. Taken together, these publicly available cloning resources can greatly accelerate the testing and deployment of new tools for plant engineering.

42 ENGINEERING↗

Sparticle spectroscopy and dark matter in a U(1) B-L extension of MSSM

We consider a class of SUSY models in which the MSSM gauge group is supplemented with a gauged U(1) B-L symmetry and a global U(1) R symmetry. This extension introduces only electrically neutral states, and the new SUSY partners effectively double the number of states in the neutralino sector that now includes a blino (from B - L) and singlino from a gauge singlet superfield. If the DM density is saturated by a LSP neutralino, the model yields quite a rich phenomenology depending on the DM composition. The LSP relic density constraint provides a lower bound on the stop and gluino masses of about 3 TeV and 4 TeV respectively, which is testable in the near future collider experiments such as HL-LHC.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Heterotic instantons for monad and extension bundles

We consider non-perturbative superpotentials from world-sheet instantons wrapped on holomorphic genus zero curves in heterotic string theory. These superpotential contributions feature prominently in moduli stabilization and large field axion inflation, which makes their presence or absence, as well as their functional dependence on moduli, an important issue. We develop geometric methods to compute the instanton superpotentials for heterotic string theory with monad and extension bundles. Using our methods, we find a variety of examples with a non-vanishing superpotential. In view of standard vanishing theorems, we speculate that these results are likely to be attributed to the non-compactness of the instanton moduli space. We test this proposal, for the case of monad bundles, by considering gauged linear sigma models where compactness of the instanton moduli space can be explicitly checked. In all such cases, we find that the geometric results are consistent with the vanishing theorems. Surprisingly, linearly dependent Pfaffians even arise for cases with a non-compact instanton moduli space. This suggests some gauged linear sigma models with a non-compact instanton moduli space may still have a vanishing instanton superpotential.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Collider and gravitational wave complementarity in exploring the singlet extension of the standard model

We present a dedicated complementarity study of gravitational wave and collider measurements of the simplest extension of the Higgs sector: the singlet scalar augmented Standard Model. We study the following issues: (i) the electroweak phase transition patterns admitted by the model, and the proportion of parameter space for each pattern; (ii) the regions of parameter space that give detectable gravitational waves at future space-based detectors; and (iii) the current and future collider measurements of di-Higgs production, as well as searches for a heavy weak diboson resonance, and how these searches interplay with regions of parameter space that exhibit strong gravitational wave signals. We carefully investigate the behavior of the normalized energy released during the phase transition as a function of the model parameters, address subtle issues pertaining to the bubble wall velocity, and provide a description of different fluid velocity profiles. On the collider side, we identify the subset of points that are most promising in terms of di-Higgs and weak diboson production studies while also giving detectable signals at LISA, setting the stage for future benchmark points that can be used by both communities.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A nonlinear extension of the spin-2 partially massless symmetry

Here, we investigate the possibility of extending the “partially massless” symmetry of a spin-2 field in de Sitter to nonlinear order. To do so, we impose a closure condition on the symmetry transformations. This requirement imposes strong constraints on the form of the nonlinear symmetry while making only minimal assumptions about the form of the nonlinear partially massless action. We find a unique nonlinear extension of the free partially massless symmetry. However, we show that no consistent Lagrangian that contains at most two derivatives of the fields can realize this symmetry.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

An effective formalism for testing extensions to General Relativity with gravitational waves

The recent direct observation of gravitational waves (GW) from merging black holes opens up the possibility of exploring the theory of gravity in the strong regime at an unprecedented level. It is therefore interesting to explore which extensions to General Relativity (GR) could be detected. We construct an Effective Field Theory (EFT) satisfying the following requirements. It is testable with GW observations; it is consistent with other experiments, including short distance tests of GR; it agrees with widely accepted principles of physics, such as locality, causality and unitarity; and it does not involve new light degrees of freedom. The most general theory satisfying these requirements corresponds to adding to the GR Lagrangian operators constructed out of powers of the Riemann tensor, suppressed by a scale comparable to the curvature of the observed merging binaries. The presence of these operators modifies the gravitational potential between the compact objects, as well as their effective mass and current quadrupoles, ultimately correcting the waveform of the emitted GW.

79 ASTRONOMY AND ASTROPHYSICS↗

Distinguishing standard model extensions using monotop chirality at the LHC

Here, we present two minimal extensions of the standard model, each giving rise to baryogenesis. They include heavy color-triplet scalars interacting with a light Majorana fermion that can be the dark matter (DM) candidate. The electroweak charges of the new scalars govern their couplings to quarks of different chirality, which leads to different collider signals. These models predict monotop events at the LHC and the energy spectrum of decay products of highly polarized top quarks can be used to establish the chiral nature of the interactions involving the heavy scalars and the DM. Detailed simulation of signal and standard model background events is performed, showing that top quark chirality can be distinguished in hadronic and leptonic decays of the top quarks.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Radiation Protection Methods for the Interventionalist’s Hands: Use of an Extension Tube

PurposeCumulative radiation exposure to the hands during certain interventional procedures may be high. It is important to decrease the amount of radiation to the operator due to the possibility of deterministic effects. We performed a pilot study to demonstrate a significant decrease in operator dose when using extension tubing (ET) in combination with shielding and collimation during a simulated percutaneous transhepatic cholangiogram (PTC) procedure.MethodsA whole body, anthropomorphic phantom was used to simulate the patient. A Unfors-Xi Survey detector (to measure scatter) supported by a retort stand and trolley was placed in various positions to simulate the position of hands and eyes/thyroid of an interventionalist. Radiation dose was measured simulating left and right-sided PTC punctures with and without a lead shield, and with and without ET.ResultsRegarding the radiation dose to the hands; the use of an ET reduces dose by 54 % in right-sided PTC punctures without a shield and by 91 % if used in combination with a shield. For left-sided PTC punctures, ET reduces hand dose by 75 %. The use of collimation decreases hand dose by approximately 60 %. The use of shielding reduces dose to the eyes/thyroid by 98 %.ConclusionsThe dose to the hands can be significantly reduced with the appropriate use of a shield, ET, and tight collimation. The use of a shield is paramount to reduce dose to the eyes/thyroid. It is important for interventionalists to adhere to radiation protective practice considering the potential deterministic effects during a lifelong career.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Percutaneous CT-Guided Cryoablation as an Alternative Treatment for an Extensive Pelvic Bone Giant Cell Tumor

A giant cell tumor (GCT) is an intermediate grade, locally aggressive neoplasia. Despite advances in surgical and clinical treatments, cases located on the spine and pelvic bones remain a significant challenge. Failure of clinical treatment with denosumab and patient refusal of surgical procedures (hemipelvectomy) led to the use of cryoablation. We report the use of percutaneous CT-guided cryoablation as an alternative treatment, shown to be a minimally invasive, safe, and effective option for a GCT with extensive involvement of the pelvic bones and allowed structural and functional preservation of the involved bones.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Radiology and Enterprise Medical Imaging Extensions (REMIX)

Radiology and Enterprise Medical Imaging Extensions (REMIX) is a platform originally designed to both support the medical imaging-driven clinical and clinical research operational needs of Department of Radiology of The Ohio State University Wexner Medical Center. REMIX accommodates the storage and handling of “big imaging data,” as needed for large multi-disciplinary cancer-focused programs. The evolving REMIX platform contains an array of integrated tools/software packages for the following: (1) server and storage management; (2) image reconstruction; (3) digital pathology; (4) de-identification; (5) business intelligence; (6) texture analysis; and (7) artificial intelligence. These capabilities, along with documentation and guidance, explaining how to interact with a commercial system (e.g., PACS, EHR, commercial database) that currently exists in clinical environments, are to be made freely available.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Bel–Robinson as stress-tensor gradients and their extensions to massive matter

Here, we show that the Bel–Robinson (BR) tensor is—generically, as well as in its original GR setting—an autonomously conserved part of the, manifestly conserved, double gradient of a system’s stress-tensor. This implies its natural extension from GR to matter models, first to (known) massless scalars and vectors, then to massive ones, including tensors. These massive versions are to be expected, given that they arise upon KK reduction of massless $D$ + 1 ones. We exhibit the resulting spin (0,1,2) “massive” BR.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Implicit extensions of an explicit multirate Runge–Kutta scheme

In this work, we propose a new method that extends conservative explicit multirate methods to implicit explicit-multirate methods. We develop extensions of order one and two with different stability properties on the implicit side. The method is suitable for time-stepping adaptive mesh refinement PDE discretizations with different degrees of stiffness. A numerical example with an advection-diffusion problem illustrates the new method's properties.

97 MATHEMATICS AND COMPUTING↗