SEARCH · Engineering Papers

Results for “changes in human systems”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19

All sources NASA NTRS DOE OSTI

NASA NTRSDate not supplied

A Cost Modeling Approach for Entry Systems Analysis of Human Mars Missions

Cost is one of the biggest obstacles to sending humans to Mars. However, spacecraft costs are typically not estimated until after the preliminary vehicle and mission concepts have been designed. By automating the cost estimation process, the effect of any change in vehicle or mission design on the mission cost can be determined more efficiently. This paper describes an extension to the tool Systems Analysis for Planetary Entry, Descent, and Landing which integrates the cost modeling software System Estimation and Evaluation of Resources-Hardware with a number of systems analysis tools. This new method is used to analyze several trade spaces of an entry vehicle for human Mars missions utilizing a Hypersonic Inflatable Aerodynamic Decelerator and provide preliminary results. Key findings include quantifying how ballistic coefficient, main engine specific impulse, and thrust to weight ratio affect the cost of the vehicle and how the payload per lander and number of landers affects the cost of a campaign to Mars.

Paul D Friz↗

NASA NTRSDate not supplied

Establishing Trust in NASA’s Artemis Program Computer-Human Interface (CHI) Implementation

The NASA Artemis program will return humans to the moon. This time, with the help of commercial and international partners, the program’s objective is a permanent moon base. The moon base infrastructure, including an orbiting moon station and moon surface assets, will be developed for astronauts to stay for the long haul to learn to live and work on another planet in preparation for an eventual Humans-to-Mars mission. As the roundtrip communication delays increase in deep space exploration, more onboard systems autonomy and functionality will be needed to maintain and control the vehicle or habitat. These mission constraints will change the current Earth-based spacecraft ground control support approach that will demand more safe, efficient, and effective Computer-Human Interface (CHI) control. For Artemis, CHI is defined as the elements that the crew interfaces with-audio, video, lighting, and crew controls. Understanding how CHI will need to evolve to support deep space missions will be critical for the Artemis program-especially crew controls which is the focus of this paper. How does NASA ensure crew controls are reliable to control complex systems and prevent a catastrophic event due to human error-especially when the astronauts could be physiologically and/or psychologically impaired? NASA’s approach to mitigating catastrophic hazards in human spaceflight system development such as crew controls is through a holistic system engineering and Human System Integration methodology that embraces NASA’s Human-Rating Requirements-ensuring human performance characteristics to control/safely recover the crew from hazardous situations within the human interface design are considered. This paper discusses, at a high level, CHI for the Artemis program. Next, a discussion of what it means to human-rate a space system crew controls and how trust in the human-computer interface begins with the NASA human rating requirements. Finally, a discussion on how systems engineering, and the human system integration process ensures that crew control implementation incorporates the NASA human-rating requirements.

Human-Rating↗

DOE OSTI2024

Projecting Changes in the Frequency and Magnitude of Ozone Pollution Events Under Uncertain Climate Sensitivity

Abstract Climate change is projected to worsen ozone pollution over many populated regions, with larger impacts at higher concentrations. More intense and frequent ozone episodes risk setbacks to human health and environmental policy achievements. However, assessing these changes is complicated by uncertain climate sensitivity, closely related to climate model response, and internal variability in simulations projecting climate's influence on air quality. Here, leveraging a global modeling framework that one‐way couples a human activity model, an Earth system model of intermediate complexity, and an atmospheric chemistry model, we investigate the role of climate sensitivity in climate‐induced changes to high ozone pollution episodes in the United States using multiple greenhouse gas emissions scenarios, representations of climate sensitivity, and initial condition members. We bias correct and evaluate historical model simulations, identifying modeled and observed O 3 episodes using extreme value theory, and extend the approach to projections of mid‐ and end‐century climate impacts. Results show that the influence of climate sensitivity can be as significant as that of greenhouse gas emissions scenario absent precursor emissions changes. Climate change is projected to increase the magnitude of the highest annually occurring O 3 concentrations by over 2.3 ppb on average across the U.S. at mid‐century under a high climate sensitivity and moderate emissions scenario, but the increase is limited to less than 0.3 ppb under lower climate sensitivity. Further, we show that areas in the U.S. currently meeting air quality standards risk being pushed into non‐compliance due to a climate‐induced increase in frequency of high ozone days.

Environmental Sciences & Ecology↗

DOE OSTI2020

Microbiomes Reduce Their Host’s Sensitivity to Interspecific Interactions

Description of the Earth’s microbiota has recently undergone a phenomenal expansion that has challenged basic assumptions in many areas of biology, including hominid evolution, human gastrointestinal and neurodevelopmental disorders, and plant adaptation to climate change. By using the classic model system of freshwater phytoplankton that has been drawn upon for numerous foundational theories in ecology, we show that microbiomes, by facilitating their host population, can also influence between-species interactions among their eukaryotic hosts. Between-species interactions, including competition for resources, has been a central tenet in the field of ecology because of its implications for the diversity and composition of communities and how this in turn shapes ecosystem functioning.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1988

Vestibular-related neuroscience and manned space flight

The effects of weightlessness on the human vestibular system are examined, reviewing the results of recent investigations. The functional, neurophysiological, and neurochemical changes which occur during adaptation to weightlessness are discussed; theoretical models proposed to explain the underlying mechanism are outlined; and particular attention is given to the author's experiments on squirrel monkeys. There, good correlations were found between (1) the recovery of locomotor balance function in the acute compensation phase after unilateral labyrinthectomy and (2) the bilateral imbalance in the optical density of GABA-like immunoreactivity.

Igarashi, Makoto↗

NASA NTRS2022

Separating Propulsive Mass and Energy for Space Applications

Initially and traditionally, space access and in-space propulsion utilized combustion and expulsion of chemical “fuels” carried on board, with performance governed by the rocket equation. These chemicals produced energy, and after combustion, constituted the propulsive mass/momentum. The best such chemicals in terms of Isp that are deemed safe engineering/mission wise are hydrogen and oxygen, producing some 450 seconds of Isp. There are more reactive chemicals, such as fluorine, which have higher Isp, but also have serious safety issues. Propulsion in atmospheres can ingest atmospheric constituents (aka “airbreathing propulsion”) which provide additional propulsive mass when heated and a component of the combustion/energy generation process. This utilization of non-stored/carried propulsive mass provides partial separation of propulsive mass and energy and produces higher Isp. The other approach to separating propulsive mass and energy is to, either on board or added from offboard, supply additional energy, such as from nuclear or solar sources. This is the approach for fission nuclear thermal and electric propulsion, which can provide an Isp in excess of 800 seconds of Isp. Other processes or in addition to thermal expansion, such as electro-magnetics, can be employed to increase exit velocity and Isp. Separating propulsive mass and energy for space faring is commonly referred to as a means to circumvent the rocket equation and is capable of producing major benefits for the development of commercial deep space and space faring in general including affordable fast transits to mitigate the human health impacts of galactic cosmic radiation (GCR) and microG. The key to higher than chemical Isp, beyond H2-O2, and beyond the radiated energy and systems limitations of solar for space faring, is a light weight, high energy density source, either on board or via utilization of energy beaming to the vehicle. Traditional energy sources include chemical, heat, electrics, mechanical, photons, and nuclear. Propulsive mass can be carried on board, sourced beyond the surface of Earth via in-situ resource utilization (ISRU), and includes harvesting from atmospheres. High Isp via electromagnetic related propulsive mass acceleration requires sufficient ionization and conductivity. The major metrics for space propulsion are costs, safety, Isp, weight, and thrust level, the latter dependent upon mission requirements. High thrust for human missions is needed to reduce time exposed to radiation and microG and high thrust is required for space access. Costs of space access are reducing via reusability, printing manufacture, and robotization of manufacturing and operation. Chemical rockets provide high thrust from the expansion of the heated mass constituents at high mass flow. The other high thrust propulsion approach is magnetohydrodynamics (MHD), which, in addition to high thrust, has a high Isp of over 2,000 seconds of Isp. The VASIMIR engine offers some 5,000 seconds of Isp at high thrust [ref. 3]. Electric propulsion cycles are capable of Isp much higher than that but at low thrust levels using available energy sources. With cost as a major metric, reusable rockets and improved manufacturing and operations are rapidly greatly lowering the costs of space access, which could provide/supply in space fuel depots and affordable chemical propulsion for the desired human fast transits (e.g., some 200-day round trips to Mars). The other option for fast transits is VASIMIR, given a nuclear on-board energy source that has the requisite many megawatts of power and an alpha, kgs of weight/kW of energy produced, on the order of one (i.e., a light weight, high energy density energy source). The purpose of this report is to examine the options beyond traditional rocket engines, where propulsive mass and energy are combined, specifically the separation of propulsive mass and energy. This report considers the spectrum of advanced energetics, sources of propulsive mass, conductivity enhancement approaches, energy beaming possibilities, and candidate propulsion cycles. Suggestions are made for various combinatorial, system level, beyond traditional combustion rocket, space propulsion approaches for human deep space missions given the changing conditions of increased knowledge of deep space resources for ISRU, revolutionary energetics, and technology advancements writ large.

Dennis M. Bushnell↗

DOE OSTI2021

Mathematical model of a personalized neoantigen cancer vaccine and the human immune system

Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4 + and CD8 + T cells. Multiple successful clinical applications of cancer vaccines have shown good safety and efficacy. Despite the notable progress, significant challenges remain in obtaining consistent immune responses across heterogeneous patient populations, as well as various cancers. We present a mechanistic mathematical model describing key interactions of a personalized neoantigen cancer vaccine with an individual patient’s immune system. Specifically, the model considers the vaccine concentration of tumor-specific antigen peptides and adjuvant, the patient’s major histocompatibility complexes I and II copy numbers, tumor size, T cells, and antigen presenting cells. We parametrized the model using patient-specific data from a clinical study in which individualized cancer vaccines were used to treat six melanoma patients. Model simulations predicted both immune responses, represented by T cell counts, to the vaccine as well as clinical outcome (determined as change of tumor size). This model, although complex, can be used to describe, simulate, and predict the behavior of the human immune system to a personalized cancer vaccine.

60 APPLIED LIFE SCIENCES↗

NASA NTRS2019

Exploring Human Factors Issues for Urban Air Mobility Operations

Urban air mobility (UAM) is currently receiving increased attention in the aviation literature as a new entrant into the airspace. Although the introduction of UAM offers the potential for significant benefits, it also creates the potential for fundamental change to the current air traffic management system. Several concepts are being explored to enable the development of a safe and efficient UAM system for near, mid and far term operations. A concept of operations for near term operations proposes several assumptions. Concepts for roles and responsibilities of human operators such as air traffic controllers propose different degrees of involvement. Identifying and exploring human factors issues is therefore a critical next step in the forward progression of concept development. A human-in-the-loop air traffic control simulation was used to investigate the effect of UAM traffic density and changes in current airspace routes and communication procedures on subjective controller workload and efficiency-related task performance. Findings indicate that although subjective workload was manageable for low density operations, medium and high density operations led to unmanageable levels of workload, leading to refusals to allow more vehicles into controlled airspace. By implementing a letter of agreement, verbal communications were reduced which were associated with reduced workload. Optimized routes were also associated with reduced workload and increased performance efficiency. Although these adjustments can positively support controller performance, workload still remained high during the high density UAM traffic scenarios. It is therefore suggested that, in order for UAM operation to become scalable, human operators will be required to work differently compared to current air traffic controllers. Future research should focus on the level and type of human operator or controller involvement and mated systems, to ensure safety and efficiency within UAM operations.

Air Traffic Management↗

NASA NTRS1993

Endocrine and metabolic changes in payload specialist (L-1)

The endocrine system plays an important role in the adaptation to unusual environments by secreting hormones to control metabolism. Since human beings have long evolved on the surface of the Earth under a gravity environment, the weightless environment must be quite unusual for them. The purpose of this experiment is to study the mechanisms of human adaptation to a weightless environment from endocrine and metabolic changes. Our study plan is focused on four major physiological changes which were reported during past space flights or which may be expected to occur under that condition: (1) hormone and metabolic changes associated with fluid shift; (2) bone demineralization and muscle atrophy; (3) altered circadian rhythm; and (4) stress reaction during space flight.

Matsui, Nobuo↗

NASA NTRS2004

A Software Architecture for Semiautonomous Robot Control

A software architecture has been developed to increase the safety and effectiveness with which tasks are performed by robots that are capable of functioning autonomously but sometimes are operated under control by humans. The control system of such a robot designed according to a prior software architecture has no way of taking account of how the environment has changed or what parts of a task were performed during an interval of control by a human, so that errors can occur (and, hence, safety and effectiveness jeopardized) when the human relinquishes control. The present architecture incorporates the control, task-planning, and sensor-based-monitoring features of typical prior autonomous-robot software architectures, plus features for updating information on the environment and planning of tasks during control by a human operator in order to enable the robot to track the actions taken by the operator and to be ready to resume autonomous operation with minimal error. The present architecture also provides a user interface that presents, to the operator, a variety of information on the internal state of the robot and the status of the task.

Kortenkamp, David↗

NASA NTRSDate not supplied

Cross-Scale and Cross-Interface Processes and Arctic Amplification

The Arctic is a dynamic region, demonstrated by its remarkable internal variability and rapid response to anthropogenic climate change over the last 40 years. Actionable predictions and projections hold significant value for managing both natural and human systems. The value of these model outputs only grows in a warmer, less icy Arctic. However, substantial gaps exist in our understanding of cross-scale and cross-interface (air-sea ice-ocean) interactions that limit our predictive capabilities. Studies dating back at least 40 years provide evidence that the evolution of the Arctic climate system is sensitive to these cross-scale and cross-interface interactions. This presentation summarizes our understanding of cross-scale and cross-interface interactions relevant to the Arctic’s response to anthropogenic climate change—Arctic Amplification. The presentation emphasizes the influence of surface-type dependent turbulent flux exchanges of heat and moisture, the rectification of episodic atmospheric heat transport events on time-averaged changes, local and remote feedback interactions, and cross-seasonal energy transfers. The presentation concludes with a summary of knowledge gaps and discusses potential pathways for accelerating our understanding of the Arctic climate system.

Patrick C. Taylor↗

NASA NTRSDate not supplied

The Importance of Cross-Scale and Cross-Interface Processes on Arctic Amplification

The Arctic is a dynamic region, demonstrated by its remarkable internal variability and rapid response to anthropogenic climate change over the last >40 years. Actionable predictions and projections hold significant value for managing both natural and human systems. The value of these model outputs only grows in a warmer, less icy Arctic. However, substantial gaps exist in our understanding of cross-scale and cross-interface (air-sea ice-ocean) interactions that limit our predictive capabilities. Studies dating back at least 40 years provide evidence that the evolution of the Arctic climate system is sensitive to these cross-scale and cross-interface interactions. This presentation summarizes our understanding of cross-scale and cross-interface interactions relevant to the Arctic’s response to anthropogenic climate change—Arctic Amplification. The presentation emphasizes the influence of surface-type dependent turbulent flux exchanges of heat and moisture, the rectification of episodic atmospheric heat transport events on time-averaged changes, local and remote feedback interactions, and cross-seasonal energy transfers. The presentation concludes with a summary of knowledge gaps and discusses potential pathways for accelerating our understanding of the Arctic climate system.

Patrick C Taylor↗

NASA NTRSDate not supplied

Cross-Scale and Cross-Interface Processes and Arctic Amplification

Patrick C. Taylor↗

NASA NTRS2017

Effects of Simulated Microgravity on a Host-Pathogen System

While it has been shown that decades of astronauts and cosmonauts can suffer from illnesses both during and after spaceflight, the underlying causes are still poorly understood, due in part to the fact that there are so many variables to consider when investigating the human immune system in a complex environment. Invertebrates have become popular models for studying human disease because they are cheap, highly amenable to experimental manipulation, and have innate immune systems with a high genetic similarity to humans. Fruit flies (Drosophila melanogaster) have been shown to experience a dramatic shift in immune gene expression following spaceflight, but are still able to fight off infections when exposed to bacteria. However, the common bacterial pathogen Serratia marcescens was shown to become more lethal to fruit flies after being cultured in space, suggesting that not only do we need to consider host changes in susceptibility, but also changes in the pathogen itself after spaceflight conditions. Being able to simulate spaceflight conditions in a controlled environment on the ground gives us the ability to not only evaluate the effects of microgravity on the host immune system, but also how the microorganisms that cause immune disorders are being affected by these drastic environmental shifts. In this study, I use a ground-based simulated microgravity environment to examine the genetic changes associated with increased S. marcescens virulence in order to understand how microgravity is affecting this pathogen, as well as how these genetic changes influence and interact with the host immune system. This study will provide us with more directed approaches to studying the effects of spaceflight on human beings, with the ultimate goal of being able to counteract immune dysfunction in future space exploration.

Immunology↗

NASA NTRS2017

Studying the Effect of Radiation in the Context of Deep Space Travel

Bhattacharya, Sharmila↗

NASA NTRSDate not supplied

The Partial Gravity of the Moon and Mars Appears Insufficient to Maintain Human Health

Astronauts who spend many weeks or months in space in microgravity suffer serious health problems including muscle atrophy, cardiovascular deconditioning, bone calcium loss, impaired vision, and immune system changes. The debilitating effects of weightlessness were first demonstrated on the early Skylab, Salyut, and Mir missions, but it was then hoped that countermeasures including in-flight exercise and resistance training could reduce most of these problems. Similar effects are anticipated in the partial gravity of the Moon and Mars. Direct evidence of the long-term effects of partial gravity on humans is not yet available, but indirect evidence suggests that partial gravity exposure below 0.4 g will be insufficient to maintain musculoskeletal and cardiopulmonary conditioning over the long term. Some studies show a strong correlation between heart rate, oxygen consumption, net metabolic rate, and simulated gravity from 0 to 1 g. Exposure to moon and Mars gravities will probably cause less severe physiological deconditioning than microgravity, but the benefit of partial gravity seems likely to be roughly proportional to the level of gravity experienced. As in microgravity, exercise countermeasures seem useful but insufficient to preserve all physiological systems as they would be in Earth gravity.

Harry W. Jones↗

NASA NTRS2009

Satellite Contributions to Global Change Studies

By providing a global view with a level playing field (no region missed because of unfavorable surface conditions or political boundaries), satellites have made major contributions to improved monitoring and understanding of our constantly changing planet. The global view has allowed surprising realizations like the relative sparsity of lightning strikes over oceans and the large-scale undulations on the massive Antarctic ice sheet. It has allowed the tracking of all sorts of phenomena, including aerosols, both natural and anthropogenic, as they move with the atmospheric circulation and impact weather and human health. But probably nothing that the global view allows is more important in the long term than its provision. of unbiased data sets to address the issue of global change, considered by many to be among the most important issues facing humankind today. With satellites we can monitor atmospheric temperatures at all latitudes and longitudes, and obtain a global average that lessens the likelihood of becoming endlessly mired in the confusions brought about by the certainty of regional differences. With satellites we can monitor greenhouse gases such as CO2 not just above individual research stations but around the globe. With satellites we can monitor the polar sea ice covers, as we have done since the late 1970s, determining and quantifying the significant reduction in Arctic sea ice and the slight growth in Antarctic sea ice over that period, With satellites we can map the full extent and changes in the Antarctic stratospheric ozone depletions that were first identified from using a single ground station; and through satellite data we have witnessed from afar land surface changes brought about by humans both intentionally, as with wide-scale deforestation, and unintentionally, as with the decay of the Aral Sea. The satellite data are far from sufficient for all that we need in order to understand the global system and forecast its changes, as we also need sophisticated climate models, in situ process studies, and data sets that extend back well before the introduction of satellite technology. Nonetheless, the repetitive, global view provided by satellites is contributing in a major way to our improved recognition of how the Earth im changing, a recognition that is none too soon in view of the magnitude of the impacts that humans can now have.

Parkinson, Claire L.↗

NASA NTRS2010

Applied Meteorology Unit (AMU) Quarterly Report

By providing a global view with a level playing field (no region missed because of unfavorable surface conditions or political boundaries), satellites have made major contributions to improved monitoring and understanding of our constantly changing planet. The global view has allowed surprising realizations like the relative sparsity of lightning strikes over oceans and the large-scale undulations on the massive Antarctic ice sheet. It has allowed the tracking of all sorts of phenomena, including aerosols, both natural and anthropogenic,as they move with the atmospheric circulation and impact weather and human health. But probably nothing that the global view allows is more important in the long term than its provision of unbiased data sets to address the issue of global change, considered by many to be among the most important issues facing humankind today. With satellites we can monitor atmospheric temperatures at all latitudes and longitudes, and obtain a global average that lessens the likelihood of becoming endlessly mired in the confusions brought about by the certainty of regional differences. With satellites we can monitor greenhouse gases such as CO2 not just above individual research stations but around the globe. With satellites we can monitor the polar sea ice covers, as we have done since the late 1970s, determining and quantifying the significant reduction in Arctic sea ice and the slight growth in Antarctic sea ice over that period. With satellites we can map the full extent and changes in the Antarctic stratospheric ozone depletions that were first identified from a single ground station; and through satellite data we have witnessed from afar land surface changes brought about by humans both intentionally, as with wide-scale deforestation, and unintentionally, as with the decay of the Aral Sea. The satellite data are far from sufficient for all that we need in order to understand the global system and forecast its changes, as we also need sophisticated climate models, in situ process studies, and data sets that extend back well before the introduction of satellite technology. Nuomthc)cmm, the repetitive, global view provided by satellites is contributing in a major way to our improved recognition of how the Earth is changing, a recognition that is none too soon in view of the magnitude of the impacts that humans can now have.

Bauman, William↗