Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “causality”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 343 records · Page 19
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus

Causal transcripts at genomic loci associated with type 2 diabetes (T2D) are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin-resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, LOC157273, located 175 kilobases from PPP1R3B, which encodes a key protein regulating insulin-mediated hepatic glycogen storage in humans. We hypothesized that LOC157273 regulates expression of PPP1R3B in human hepatocytes. We tested our hypothesis using Stellaris fluorescent in situ hybridization to assess subcellular localization of LOC157273; small interfering RNA (siRNA) knockdown of LOC157273, followed by RT-PCR to quantify LOC157273 and PPP1R3B expression; RNA-seq to quantify the whole-transcriptome gene expression response to LOC157273 knockdown; and an insulin-stimulated assay to measure hepatocyte glycogen deposition before and after knockdown. We found that siRNA knockdown decreased LOC157273 transcript levels by approximately 80%, increased PPP1R3B mRNA levels by 1.7-fold, and increased glycogen deposition by >50% in primary human hepatocytes. An A/G heterozygous carrier (vs. three G/G carriers) had reduced LOC157273 abundance due to reduced transcription of the A allele and increased PPP1R3B expression and glycogen deposition. We show that the lncRNA LOC157273 is a negative regulator of PPP1R3B expression and glycogen deposition in human hepatocytes and a causal transcript at an insulin-resistant T2D risk locus.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Mechanism Across Scales: A Holistic Modeling Framework Integrating Laboratory and Field Studies for Microbial Ecology

Over the last century, leaps in technology for imaging, sampling, detection, high-throughput sequencing, and -omics analyses have revolutionized microbial ecology to enable rapid acquisition of extensive datasets for microbial communities across the ever-increasing temporal and spatial scales. The present challenge is capitalizing on our enhanced abilities of observation and integrating diverse data types from different scales, resolutions, and disciplines to reach a causal and mechanistic understanding of how microbial communities transform and respond to perturbations in the environment. This type of causal and mechanistic understanding will make predictions of microbial community behavior more robust and actionable in addressing microbially mediated global problems. To discern drivers of microbial community assembly and function, we recognize the need for a conceptual, quantitative framework that connects measurements of genomic potential, the environment, and ecological and physical forces to rates of microbial growth at specific locations. We describe the Framework for Integrated, Conceptual, and Systematic Microbial Ecology (FICSME), an experimental design framework for conducting process-focused microbial ecology studies that incorporates biological, chemical, and physical drivers of a microbial system into a conceptual model. Through iterative cycles that advance our understanding of the coupling across scales and processes, we can reliably predict how perturbations to microbial systems impact ecosystem-scale processes or vice versa. We describe an approach and potential applications for using the FICSME to elucidate the mechanisms of globally important ecological and physical processes, toward attaining the goal of predicting the structure and function of microbial communities in chemically complex natural environments.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

The relationship between below average cognitive ability at age 5 years and the child’s experience of school at age 9

Background At age 5, while only embarking on their educational journey, substantial differences in children’s cognitive ability will already exist. The aim of this study was to examine the causal association between below average cognitive ability at age 5 years and child-reported experience of school and self-concept, and teacher-reported class engagement and emotional-behavioural function at age 9 years. Methods This longitudinal cohort study used data from 7,392 children in the Growing Up in Ireland Infant Cohort, who had completed the Picture Similarities and Naming Vocabulary subtests of the British Abilities Scales at age 5. Principal components analysis was used to produce a composite general cognitive ability score for each child. Children with a general cognitive ability score more than 1 standard deviation (SD) below the mean at age 5 were categorised as ‘Below Average Cognitive Ability’ (BACA), and those scoring above this as ‘Typical Cognitive Development’ (TCD). The outcomes of interest, measured at age 9, were child-reported experience of school, child’s self-concept, teacher-reported class engagement, and teacher-reported emotional behavioural function. Binary and multinomial logistic regression models were used to examine the association between BACA and these outcomes. Results Compared to those with TCD, those with BACA had significantly higher odds of never liking school [Adjusted odds ratio (AOR) 1.82, 95% CI 1.37–2.43, p < 0.001], of being picked on (AOR 1.27, 95% CI 1.09–1.48) and of picking on others (AOR 1.53, 95% CI 1.27–1.84). They had significantly higher odds of experiencing low self-concept (AOR 1.20, 95% CI 1.02–1.42) and emotional-behavioural difficulties (AOR 1.34, 95% CI 1.10–1.63, p = 0.003). Compared to those with TCD, children with BACA had significantly higher odds of hardly ever or never being interested, motivated and excited to learn (AOR 2.29, 95% CI 1.70–3.10). Conclusion Children with BACA at school-entry had significantly higher odds of reporting a negative school experience and low self-concept at age 9. They had significantly higher odds of having teacher-reported poor class engagement and problematic emotional-behavioural function at age 9. The findings of this study suggest BACA has a causal role in these adverse outcomes. Early childhood policy and intervention design should be cognisant of the important role of cognitive ability in school and childhood outcomes.

Bowe, Andrea K.↗
DOE OSTI2023

Seven governing principles in biology

In physical science such as physics and chemistry, there are governing principles that are universal and applicable to all relevant systems, including energy conservation, entropy increase, uncertainty principle in quantum mechanics, and chemical equilibrium. However, what are governing principles in biology that are unique to all living systems? After collecting opinions and thoughts from diverse scientists and engineers all over the world, I summarize seven governing principles or laws in biology: central dogma, evolution, biological robustness, regeneration, reproduction, development, and causality. Some of these are not necessarily unique in biological systems from a reductionist’s point of view (e.g., causality), and others are applicable predominantly to eukaryotes (e.g., reproduction and development). Notably, many engineering systems have mimicked biological systems to enhance their performance. In this perspective article, I discuss these principles to better understand the rules of life and help construct improved engineering systems that we can use and control in an ethical, safe, and rational way.

Moon, Tae Seok↗
DOE OSTI2022

Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants and are associated with human disease. Canonically, many PAHs induce toxicity via activation of the aryl hydrocarbon receptor (AHR) pathway. While the interaction between PAHs and the AHR is well-established, understanding which AHR-regulated transcriptional effects directly result in observable phenotypes and which are adaptive or benign is important to better understand PAH toxicity. Retene is a frequently detected PAH in environmental sampling and has been associated with AHR2-dependent developmental toxicity in zebrafish, though its mechanism of toxicity has not been fully elucidated. To interrogate transcriptional changes causally associated with retene toxicity, we conducted whole-animal RNA sequencing at 48 hours post-fertilization after exposure to eight retene concentrations. The concentrations were selected to produce effects ranging from no phenotype to mortality and malformations in 100% of animals at 5 days post-fertilization. We identified a concentration-response relationship between retene teratogenicity and differential gene expression in both number of DEGs and magnitude of expression change. Elevated expression of cyp1a at retene concentrations below the threshold for teratogenicity suggested that while cyp1a expression is a sensitive biomarker of AHR activation, it may be too sensitive to serve as a biomarker of AHR-dependent teratogenicity. Genes differentially expressed at only non-teratogenic concentrations were enriched for transforming growth factor-ß (TGF-ß) signaling pathway disruption while DEGs identified at only teratogenic concentrations were significantly enriched for response to xenobiotic stimulus and reduction-oxidation reaction activity. DEGs which spanned both non-teratogenic and teratogenic concentrations showed similar disrupted biological processes to those unique to teratogenic concentrations, indicating these processes were disrupted at low exposure concentrations. Gene co-expression network analysis identified several gene modules, including those associated with PAHs and AHR2 activation. One, Module 7, was strongly enriched for AHR2-associated genes and contained the strongest responses to retene. Benchmark concentration (BMC) of Module 7 genes identified a median BMC of 7.5 µM, nearly the highest retene concentration with no associated teratogenicity, supporting the hypothesis that Module 7 genes are largely responsible for retene toxicity.

Toxin, Zebrafish, Retene, Transcriptomics, network↗
DOE OSTI2024

The safety of magnetic resonance imaging contrast agents

Gadolinium-based contrast agents are increasingly used in clinical practice. While these pharmaceuticals are verified causal agents in nephrogenic systemic fibrosis, there is a growing body of literature supporting their role as causal agents in symptoms associated with gadolinium exposure after intravenous use and encephalopathy following intrathecal administration. Gadolinium-based contrast agents are multidentate organic ligands that strongly bind the metal ion to reduce the toxicity of the metal. The notion that cationic gadolinium dissociates from these chelates and causes the disease is prevalent among patients and providers. We hypothesize that non-ligand-bound (soluble) gadolinium will be exceedingly low in patients. Soluble, ionic gadolinium is not likely to be the initial step in mediating any disease. The Kidney Institute of New Mexico was the first to identify gadolinium-rich nanoparticles in skin and kidney tissues from magnetic resonance imaging contrast agents in rodents. In 2023, they found similar nanoparticles in the kidney cells of humans with normal renal function, likely from contrast agents. We suspect these nanoparticles are the mediators of chronic toxicity from magnetic resonance imaging contrast agents. This article explores associations between gadolinium contrast and adverse health outcomes supported by clinical reports and rodent models.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Female “Paradox” in Atrial Fibrillation—Role of Left Truncation Due to Competing Risks

Female sex in patients with atrial fibrillation (AF) is a controversial and paradoxical risk factor for stroke—controversial because it increases the risk of stroke only among older women of some ethnicities and paradoxical because it appears to contradict male predominance in cardiovascular diseases. However, the underlying mechanism remains unclear. We conducted simulations to examine the hypothesis that this sex difference is generated non-causally through left truncation due to competing risks (CR) such as coronary artery diseases, which occur more frequently among men than among women and share common unobserved causes with stroke. We modeled the hazards of stroke and CR with correlated heterogeneous risk. We assumed that some people died of CR before AF diagnosis and calculated the hazard ratio of female sex in the left-truncated AF population. In this situation, female sex became a risk factor for stroke in the absence of causal roles. The hazard ratio was attenuated in young populations without left truncation and in populations with low CR and high stroke incidence, which is consistent with real-world observations. This study demonstrated that spurious risk factors can be identified through left truncation due to correlated CR. Female sex in patients with AF may be a paradoxical risk factor for stroke.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

GW190814's Secondary Component with Mass 2.50–2.67 M ⊙ as a Superfast Pulsar

Using Stergioulas's RNS code for investigating fast pulsars with Equation of States (EOSs) on the causality surface (where the speed of sound equals that of light) of the high-density EOS parameter space satisfying all known constraints from both nuclear physics and astrophysics, we show that one possible explanation for the GW190814's secondary component of mass (2.50-2.67) M ⊙ is that it is a super-fast pulsar spinning faster than 971 Hz about 42% below its Kepler frequency. If confirmed, it would be the fastest pulsar with the highest mass observed presently. There is a large and physically allowed EOS parameter space below the causality surface where pulsars heavier than 2.50 M ⊙ are supported if they can rotate even faster with critical frequencies depending strongly on the high-density behavior of nuclear symmetry energy.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Constraining aerosol–cloud adjustments by uniting surface observations with a perturbed parameter ensemble

Abstract. Aerosol–cloud interactions (ACIs) are the largest source of uncertainty in inferring the magnitude of future warming consistent with the observational record. The effective radiative forcing due to ACI (ERFaci) is dominated by liquid clouds and is composed of two terms: the change in cloud albedo due to redistributing liquid over a larger number of cloud droplets (Nd) and the change in cloud macrophysical properties due to changes in cloud microphysics. These terms are, respectively, referred to as the radiative forcing due to ACI (RFaci) and aerosol–cloud adjustments. While the magnitude of RFaci is uncertain, its sign is confidently negative and results in a cooling in the historical record. In contrast, the adjustment of cloud liquid water path (LWP) to enhanced Nd and associated radiative forcing is uncertain in sign. Increased LWP in response to increased Nd is consistent with precipitation suppression, while decreased LWP in response to increased Nd is consistent with enhanced evaporation from cloud top. Observational constraints of these processes are poor in part because of causal ambiguity in the relationship between Nd and LWP. To better understand this relationship, precipitation (P), Nd, and LWP surface observations from the Eastern North Atlantic (ENA) atmospheric observatory are combined with the output from a perturbed parameter ensemble (PPE) hosted in the Community Atmosphere Model version 6 (CAM6). This allows for causal interpretation of observed covariability. Observations of precipitation and cloud from ENA constrain the range of possible LWP aerosol–cloud adjustments relative to the prior from the PPE by 15 %, resulting in a global value that is confidently positive (a historical cooling) ranging from 2.1 to 6.9 g m−2. It is found that observed covariability between Nd and LWP is dominated by coalescence scavenging and that this observed covariability is not strongly related to aerosol–cloud adjustments.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1973

Critique of fluid theory of magnetospheric phenomena

It is pointed out that the fluid theory has been successful in magnetospheric problems (such as the shape of the magnetopause) which involve basic considerations such as the conservation of particles, of momentum, and of energy, but that it is inadequate for other problems (such as the energization of auroral particles). Difficulties arise from the fact that it is not always possible to specify 'a volume of plasma' because particles do not remain as neighbors. Misuse of the fluid theory has led to a number of fallacies, such as the idea that the causal order of physical events in cosmic electrodynamics is the reverse of that in the familiar laboratory electrodynamics. This mistaken idea comes from a confusion of a mathematical sequence of calculations with the causal order. A plea is made for a common sense approach to magnetospheric and auroral problems wherein the fluid theory is used whenever it can, but where it is not expected to be adequate for all occasions.

Heikkila, W. J.↗
NASA NTRS1976

A correlation polarimeter for noise-like signals

Optimum estimation (tracking) of the polarization plane of a linearly polarized electromagnetic wave is determined when the signal is a narrow-band Gaussian random process with a polarization plane angle which is also a Gaussian random process. This model is compared to previous work and is applicable to space communication. The estimator performs a correlation operation similar to an amplitude-comparison monopulse angle tracker, giving the name correlation polarimeter. Under large signal-to-noise ratio (SNR), the estimator is causal. Performance of the causal correlation polarimeter is evaluated for arbitrary SNR. Optimum precorrelation filtering is determined. With low SNR, the performance of this system is far better than that of previously developed systems. Practical implementation is discussed. A scheme is given to reduce the effect of linearly polarized noise.

Ohlson, J. E.↗
NASA NTRS1977

Noncausal propagation in spin-0 theories with external field interactions

The two-component Sakata-Taketani (ST) spin-0 theory and the single-component Klein-Gordon theory are obtained from the five-component Duffin-Kemmer-Petiau (DKP) theory with six types of external field interactions by means of a Peirce decomposition. Whereas the DKP equation manifests the covariance, the ST equation manifests the causal properties. In particular, the presence of noncausal wave propagation when there is coupling to a second-rank tensor field is apparent from the form of the ST equation, in which the coefficients of all the space derivatives depend on the external field. The results indicate that the causal properties of higher-spin equations should also be obvious when they are expressed in 2(2J + 1)-component Schroedinger form

Guertin, R. F.↗
NASA NTRS1977

Noncausal effects in relativistic wave equations

Manifestly covariant wave equations describing particles with a unique mass and spin can, for certain types of external-field interactions, possess noncausal solutions. The paper reports a procedure for applying Pierce decomposition of all six couplings expressed in the Duffin-Kemmer-Petiau spin-0 formula. This treatment converts the equation to a form in which the causal properties are apparent. The conditions under which the causal properties of higher-spin equations can be made manifest are discussed.

Guertin, R. F.↗
NASA NTRS1980

Transmitted sound field due to an impulsive line acoustic source bounded by a plate followed by a vortex sheet

The propagation of sound due to a line acoustic source in the moving stream across a semiinfinite vortex sheet which trails from a rigid plate is examined in a linear theory for the subsonic case. A solution for the transmitted sound field is obtained with the aid of multiple integral transforms and the Wiener-Hopf technique for both the steady state (time harmonic) and initial value (impulsive source) situations. The contour of inverse transform and hence the decomposition of the functions are determined through causality and radiation conditions. The solution obtained satisfies causality and the full Kutta conditions. The transmitted sound field is composed of two waves in both the stady state and initial value problems. One is the wave scattered from the edge of the plate which is associated with the bow wave and the instability wave. These waves exist in the downstream sectors. The other is the wave transmitted through the vortex sheet which is also associated with the instability wave. Regional divisions of the transmitted sound field are identified.

Miura, T.↗
NASA NTRS1982

Candidate Species Selection and Controlled Environment Injuries

Research was undertaken to attempt to identify the causal agents for intumescences that develop on many different species of plants in controlled environments. Concentration and filtration procedures were not successful in identifying any particular compounds. The injury was found to develop, even though the atmosphere for the plants is filtered through activated charcoal, potassium permanganate, or is subjected to catalytic combustion at 450 C. Thus, the causal agent is apparently either an oxidized compound or specific element, or the result of some unrecognized variation in physical conditions around the plants. The research has demonstrated that the injury is controlled to a significant extent by temperature. Growing temperatures of 20 degrees and 25 degrees C resulted in serious injury on plants, but temperatures of 30 C resulted in very little injury.

Tibbitts, T. W.↗
NASA NTRS1985

Management behavior, group climate and performance appraisal at NASA

The relationships among manager behavior, group climate and managerial effectiveness are examined. Survey data were collected from 435 GM14-15 managers and their subordinates at NASA concerning management practices and perceptions of the group environment. Performance ratings of managers were obtained from their superiors. The results strongly supported a causal model in which subordinates' climate perceptions mediate the effects of manager behavior on performance. That is, the development of group climate provides the process through which the effects of manager practices may be understood. Analyses also revealed that the function performed by a manager and his group (e.g., research) influenced the specific nature of the causal dynamics. Some implications of the results for management training and development are discussed.

Manderlink, G.↗
NASA NTRS1988

A methodology for the synthesis of robust feedback systems

A new methodology is developed for the synthesis of linear, time-variant (LTI) controllers for multivariable LTI systems. The resulting closed-loop system is nominally stable and exhibits a known level of performance. In addition, robustness of the feedback system is guaranteed, i.e., stability and performance are retained in the presence of multiple unstructured uncertainty blocks located at various points in the feedback loop. The design technique is referred to as the Causality Recovery Methodology (CRM). The CRM relies on the Youla parameterization of all stabilizing compensators to ensure nominal stability of the feedback system. A frequency-domain inequality in terms of the structured singular value mu defines the robustness specification. The optimal compensator, with respect to the mu condition, is shown to be noncausal in general. The aim of the CRM is to find a stable, causal transfer function matrix that approximates the robustness characteristics of the optimal solution. The CRM, via a series of infinite-dimensional convex programs, produces a closed-loop system whose performance robustness is at least as good as that of any initial design. The algorithm is approximated by a finite dimensional process for the purposes of implementation. Two numerical examples confirm the potential viability of the CRM concept; however, the robustness improvement comes at the expense of increased computational burden and compensator complexity.

Milich, David Albert↗
NASA NTRS1987

Predictive monitoring research: Summary of the PREMON system

Traditional approaches to monitoring are proving inadequate in the face of two important issues: the dynamic adjustment of expectations about sensor values when the behavior of the device is too complex to enumerate beforehand, and the selective but effective interpretation of sensor readings when the number of sensors becomes overwhelming. This system addresses these issues by building an explicit model of a device and applying common-sense theories of physics to model causality in the device. The resulting causal simulation of the device supports planning decisions about how to efficiently yet reliably utilize a limited number of sensors to verify correct operation of the device.

Doyle, Richard J.↗