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At least 343 records · Page 19

Human Mars Mission Performance Crew Taxi Profile

This timeline was generated on the Integrated Mission Program (IMP). All burn events over 2 seconds are finite with IMP solving a two point boundary value setup for begin burn time, burn time and control angles. Perigee and apogee shown above are mean orbital values. Significant events are listed. Each finite thrust event has two lines. The first is the beginning time showing the initial conditions, thrust and ISP used. The second has the end burn conditions and the delta v and time of burn. This case is an abort from the 750 x 750 phasing abort, using the taxi's main engines. An abort using the Reaction Control System (RCS) was also investigated but required a large increase in RCS propellant and was abandoned.

Duaro, Vince A.↗

Shuttle Reference Data

This collection of shuttle reference data contains the following information: shuttle abort history, shuttle abort modes, abort decisions, space shuttle rendezvous maneuvers, space shuttle main engines, space shuttle solid rocket boosters, hold-down posts, SRB (solid rocket boosters) ignition, electrical power distribution, hydraulic power units, thrust vector control, SBR rate gyro assemblies, SBR separation and Space Shuttle Super Super Light Weight Tank (SLWT).

Source record↗

Structure of an anti-HIV-1 hammerhead ribozyme complex with a 17-mer DNA substrate analog of HIV-1 gag RNA and a mechanism for the cleavage reaction: 750 MHz NMR and computer experiments

The structure of an anti-HIV-1 ribozyme-DNA abortive substrate complex was investigated by 750 MHz NMR and computer modeling experiments. The ribozyme was a chimeric molecule with 30 residues-18 DNA nucleotides, and 12 RNA residues in the conserved core. The DNA substrate analog had 17 residues. The chimeric ribozyme and the DNA substrate formed a shortened ribozyme-abortive substrate complex of 47 nucleotides with two DNA stems (stems I and III) and a loop consisting of the conserved core residues. Circular dichroism spectra showed that the DNA stems assume A-family conformation at the NMR concentration and a temperature of 15 degrees C, contrary to the conventional wisdom that DNA duplexes in aqueous solution populate entirely in the B-form. It is proposed that the A-family RNA residues at the core expand the A-family initiated at the core into the DNA stems because of the large free energy requirement for the formation of A/B junctions. Assignments of the base H8/H6 protons and H1' of the 47 residues were made by a NOESY walk. In addition to the methyl groups of all T's, the imino resonances of stems I and III and AH2's were assigned from appropriate NOESY walks. The extracted NMR data along with available crystallographic data, were used to derive a structural model of the complex. Stems I and III of the final model displayed a remarkable similarity to the A form of DNA; in stem III, a GC base pair was found to be moving into the floor of the minor groove defined by flanking AT pairs; data suggest the formation of a buckled rhombic structure with the adjacent pair; in addition, the base pair at the interface of stem III and the loop region displayed deformed geometry. The loop with the catalytic core, and the immediate region of the stems displayed conformational multiplicity within the NMR time scale. A catalytic mechanism for ribozyme action based on the derived structure, and consistent with biochemical data in the literature, is proposed. The complex between the anti HIV-1 gag ribozyme and its abortive DNA substrate manifests in the detection of a continuous track of A.T base pairs; this suggests that the interaction between the ribozyme and its DNA substrate is stronger than the one observed in the case of the free ribozyme where the bases in stem I and stem III regions interact strongly with the ribozyme core region (Sarma, R. H., et al. FEBS Letters 375, 317-23, 1995). The complex formation provides certain guidelines in the design of suitable therapeutic ribozymes. If the residues in the ribozyme stem regions interact with the conserved core, it may either prevent or interfere with the formation of a catalytically active tertiary structure.

NASA Discipline Exobiology↗

Sea State and Weather Capability for NASA's Constellation Program

Marine weather and related parameters such as wind, ocean wave height and period, air temperature, sea surface temperature, visibility, and potential for icing are critical to the design, operation, and safety of crewed space vehicles. The National Aeronautics and Space Administration's (NASA's) Constellation Program requires detailed assessment of marine weather related parameters that may be encountered during launch, abort, landing, and crew rescue operations for the crewed Axes/Orion space vehicles. This information is required for both space vehicle design and operational purposes. The space vehicles must be designed such that they cam withstand the environment they are likely to encounter. The crewed Axes/Orion space vehicles will launch from NASA's Kennedy Space Center (KSC), Florida for both International Space Station (ISS) missions with 51.6deg inclination orbits and lunar missions with approximately 280 inclination orbits. Since both missions will fly ever the Atlantic Ocean on ascent to orbit and will fly over the Pacific Ocean on descent from orbit, an unlikely but possible emergency abort could require parachuting the Orion capsule and crew into the ocean. This situation could potentially put the crew in an isolated and hazardous environment for severn hours while they await rescue. Therefore, abort, landing, and crew rescue elements of the Constellation Program must address weather related parameters on a global scale. This paper describes buoy measurement data, sea surface temperature satellite data, and sea state computer model data that are being utilized by the Constellation Program to address these design and operational issues.

Barbre, R. E.↗

Sea State and Weather Assessment Capability for NASA's Constellation Program

Marine weather and related parameters such as wind, ocean wave height and period, air temperature, sea surface temperature, visibility, and potential for icing are critical to the design, operation, and safety of crewed space vehicles. The National Aeronautics and Space Administration's (NASA's) Constellation Program requires detailed assessment of marine weather related parameters that may be encountered during launch, abort, landing, and crew rescue operations for the crewed Ares/Orion space vehicles. This information is required for both space vehicle design and operational purposes. The space vehicles must be designed such that they can withstand the environment they are likely to encounter. The crewed Ares/Orion space vehicles will launch from NASA's Kennedy Space Center (KSC), Florida for both International Space Station (ISS) missions with 51.6 o inclination orbits and lunar missions with approximately 28 inclination orbits. Since both missions will fly over the Atlantic Ocean on ascent to orbit and will fly over the Pacific Ocean on descent from orbit, an unlikely but possible emergency abort could require parachuting the Orion capsule and crew into the ocean. This situation could potentially put the crew in an isolated and hazardous environment for several hours while they await rescue. Therefore, abort, landing, and crew rescue elements of the Constellation Program must address weather related parameters on a global scale. This paper describes buoy measurement data, sea surface temperature satellite data, and sea state computer model data that are being utilized by the Constellation Program to address these design and operational issues.

Barbre, B. J.↗

Apollo Guidance, Navigation, and Control (GNC) Hardware Overview

This viewgraph presentation reviews basic guidance, navigation and control (GNC) concepts, examines the Command and Service Module (CSM) and Lunar Module (LM) GNC organization and discusses the primary GNC and the CSM Stabilization and Control System (SCS), as well as other CSM-specific hardware. The LM Abort Guidance System (AGS), Control Electronics System (CES) and other LM-specific hardware are also addressed. Three subsystems exist on each vehicle: the computer subsystem (CSS), the inertial subsystem (ISS) and the optical subsystem (OSS). The CSS and ISS are almost identical between CSM and LM and each is designed to operate independently. CSM SCS hardware are highlighted, including translation control, rotation controls, gyro assemblies, a gyro display coupler and flight director attitude indicators. The LM AGS hardware are also highlighted and include the abort electronics assembly and the abort sensor assembly; while the LM CES hardware includes the attitude controller assembly, thrust/translation controller assemblies and the ascent engine arming assemble. Other common hardware including the Orbital Rate Display - Earth and Lunar (ORDEAL) and the Crewman Optical Alignment Sight (COAS), a docking aid, are also highlighted.

Interbartolo, Michael↗

Contributions of TetrUSS to Project Orion

The NASA Constellation program has relied heavily on Computational Fluid Dynamics simulations for generating aerodynamic databases and design loads. The Orion Project focuses on the Orion Crew Module and the Orion Launch Abort Vehicle. NASA TetrUSS codes (GridTool/VGRID/USM3D) have been applied in a supporting role to the Crew Exploration Vehicle Aerosciences Project for investigating various aerodynamic sensitivities and supplementing the aerodynamic database. This paper provides an overview of the contributions from the TetrUSS team to the Project Orion Crew Module and Launch Abort Vehicle aerodynamics, along with selected examples to highlight the challenges encountered along the way. A brief description of geometries and tasks will be discussed followed by a description of the flow solution process that produced production level computational solutions. Four tasks conducted by the USM3D team will be discussed to show how USM3D provided aerodynamic data for inclusion in the Orion aero-database, contributed data for the build-up of aerodynamic uncertainties for the aero-database, and provided insight into the flow features about the Crew Module and the Launch Abort Vehicle.

Mcmillin, Susan N.↗

Co-op Student Work Report

Projects: (1) Boeing Launch Abort Analysis My first project for the summer was analyzing the Boeing CCDev Vehicle's abort aerodynamics using an inviscid solver (CART3D). The goal of the project was to develop the grid and CFD inputs necessary to use CART3D as a quick tool for investigating loading trends at various points along abort trajectories. As a supplementary task, I analyzed a few cases and compared them to the aerodatabase from the last generation geometry. (2) My second project for the summer dealt with investigating how heating changes as the height of a protuberance on top of a flat plate changes. The goal of this investigation is to better understand how to properly model heating on and around a protuberance. This is one of the biggest challenges when designing a re ]entry vehicle because very small changes in the shape and conditions leading up to a protuberance, not to mention the protuberance geometry, will greatly impact the local heating.

Powell, Jessica M.↗

Potential Cislunar and Interplanetary Proving Ground Excursion Trajectory Concepts

NASA has been investigating potential translunar excursion concepts to take place in the 2020s that would be used to test and demonstrate long duration life support and other systems needed for eventual Mars missions in the 2030s. These potential trajectory concepts could be conducted in the proving ground, a region of cislunar and near-Earth interplanetary space where international space agencies could cooperate to develop the technologies needed for interplanetary spaceflight. Enabled by high power Solar Electric Propulsion (SEP) technologies, the excursion trajectory concepts studied are grouped into three classes of increasing distance from the Earth and increasing technical difficulty: the first class of excursion trajectory concepts would represent a 90-120 day round trip trajectory with abort to Earth options throughout the entire length, the second class would be a 180-210 day round trip trajectory with periods in which aborts would not be available, and the third would be a 300-400 day round trip trajectory without aborts for most of the length of the trip. This paper provides a top-level summary of the trajectory and mission design of representative example missions of these three classes of excursion trajectory concepts.

asteroids↗

Comparison of Surface Pressure Fluctuations from Flight and Wind Tunnel Tests on the Orion Multi-Purpose Crew Vehicle

Transonic and supersonic wind-tunnel test of scaled-models are used to predict the surface pressure fluctuations on aerospace vehicles. An outstanding question is how good are such tests? The present paper attempts to answer this question for the Multi-Purpose Crew Vehicle by comparing data from the Ascent Abort-2 (AA2) flight test with those measured in two different scaled-model wind tunnel tests (WTT) 51AS and 134AS. A sensor by sensor and a Mach by Mach comparisons of spectra of surface pressure fluctuations are presented for nominal ascent part of flight. Spectra measured over a large part of the vehicle surface were found to be dominated by the wake vortices shed from the four Abort Motor nozzles situated on the upper part of the Launch Abort System. It was found that the shapes of the scaled-up spectra from WTTs were very close to those measured in the flight, but the levels, for the most part, were found to be lower than the flight data. The highest differences were from the regions of complex flows where wakes from the adjacent nozzles interacted with the free-stream flow. There the WTT predicted levels were consistently 2dB to 6dB lower than the flight data, across all spectral bands. Another region of significant under-prediction was the local separated flow region at the Fillet-Ogive junction. The accuracy of the sharp spectral peaks from regions along a nozzle axis was found to be dependent on the fidelity of the model. The model in the 51AS WTT used a simplified contour, which resulted in a large under prediction of the spectral peak by 1dB to 10dB. A limited number of data from 134AS, where the model accurately captured all features of the nozzles of the flight vehicle, however; showed that the under prediction was lower: 1-2dB. The fluctuation spectra on the large protuberance of the Umbilical Cover was found to be reasonably well-predicted by 134AS WTT, which meticulously reproduced a scaled-down shape of this protuberance. Such information will help to determine the margins to be applied to wind-tunnel data to create flight environments.

MPCV↗

Overview of Integrated Random Vibration Testing of the NASA Orion Crew Survival Suit

The launch ascent and abort random vibration environments from NASA’s Orion spacecraft drove the need to test the NASA Orion Crew Survival Suit as an integrated system with exposure to the design levels. In order to properly characterize component responses, a series of integrated tests were designed to incorporate the interaction between a crew member, suit, seat, and the attenuation system. The first Development Test (2017) included human subjects, and was performed with early development seat and suit components, and low level inputs. It provided a baseline for frequency response and behavior of the integrated system. The next two tests, Development Test (2019) and Qualification Test (2020), used manikin surrogates to represent the crew member and increasing levels of component hardware fidelity in order to test to higher input levels. Testing was performed at NASA Johnson Space Center (JSC) and Kennedy Space Center (KSC) Vibration Labs and provided the input levels required to represent the ascent and abort vehicle profiles as well as recorded component response behavior from accelerometer instrumentation and high speed cameras. Inspection of the suit and related components showed that for all seat orientations, and input environments, no damage occurred. Additional pre and post-test checks confirmed the functionality of all suited hardware. Response data of the suited components generally showed heavy attenuation across most of the tested frequency range. Transmissibility plots showed some amplification of components at lower frequency ranges. Overall this series of integrated tests showed that 1) the use of surrogate manikins in the tests were adequate for representing crew in a vibration environment, 2) full vibration levels for ascent and abort were heavily attenuated in the suit components and were non-damaging, and 3) the suit and related components are qualified for the Orion random vibration environments.

Jeffrey D Suhey↗

Overview of Integrated Random Vibration Testing of the NASA Orion Crew Survival Suit

The launch ascent and abort random vibration environments from NASA’s Orion spacecraft drove the need to test the NASA Orion Crew Survival Suit as an integrated system with exposure to the design levels. In order to properly characterize component responses, a series of integrated tests were designed to incorporate the interaction between a crew member, suit, seat, and the attenuation system. The first Development Test (2017) included human subjects, and was performed with early development seat and suit components, and low level inputs. It provided a baseline for frequency response and behavior of the integrated system. The next two tests, Development Test (2019) and Qualification Test (2020), used manikin surrogates to represent the crew member and increasing levels of component hardware fidelity in order to test to higher input levels. Testing was performed at NASA Johnson Space Center (JSC) and Kennedy Space Center (KSC) Vibration Labs and provided the input levels required to represent the ascent and abort vehicle profiles as well as recorded component response behavior from accelerometer instrumentation and high speed cameras. Inspection of the suit and related components showed that for all seat orientations, and input environments, no damage occurred. Additional pre and post-test checks confirmed the functionality of all suited hardware. Response data of the suited components generally showed heavy attenuation across most of the tested frequency range. Transmissibility plots showed some amplification of components at lower frequency ranges. Overall this series of integrated tests showed that 1) the use of surrogate manikins in the tests were adequate for representing crew in a vibration environment, 2) full vibration levels for ascent and abort were heavily attenuated in the suit components and were non-damaging, and 3) the suit and related components are qualified for the Orion random vibration environments.

Jeffrey Suhey↗

Analysis and Results from a Flush Airdata Sensing System in Close Proximity to Firing Rocket Nozzles

This paper presents information regarding the nosecap Flush Airdata Sensing (FADS) system on Orion’s Pad Abort 1 (PA-1) vehicle. The purpose of the nosecap FADS system was to test whether or not useful data could be obtained from a FADS system if it was placed in close proximity to firing rocket nozzles like the Attitude Control Motor (ACM) nozzles on the PA-1 Launch Abort System. The nosecap FADS system used pressure measurements from a series of pressure ports which were arranged in a cruciform pattern and flush with the surface of the vehicle to estimate values of angle of attack, angle of sideslip, Mach number, impact pressure, and freestream static pressure. This paper will present the algorithms employed by the FADS system along with the development of the calibration datasets and a comparison of the final results to the Best Estimated Trajectory (BET) data for PA-1. Also presented in this paper is a Computational Fluid Dynamics (CFD) study to explore the impact of the ACM on the nosecap FADS system. The comparison of the nosecap FADS system results to the BET and the CFD study showed that more investigation is needed to quantify the impact of the firing rocket motors on the FADS system.

Flush Air Data Sensing System↗

Analysis and Results from a Flush Airdata Sensing (FADS) System in Close Proximity to Firing Rocket Nozzles

This presentation presents information regarding the nose-cap flush airdata sensing (FADS) system on Orion's Pad Abort 1 (PA-1) vehicle. The purpose of the nose-cap FADS system was to test whether or not useful data could be obtained from a FADS system if it was placed in close proximity to firing rockets nozzles like the attitude control motor (ACM) nozzles on the PA-1 launch abort system (LAS). The nose-cap FADS systems use pressure measurements from a series of pressure ports which are arranged in a cruciform pattern and flush with the surface of the vehicle to estimate values of angle of attack, angle of side-slip, Mach number, impact pressure and free-stream static pressure.

Pad Abort 1↗

Mapping brucellosis risk in Kenya and its implications for control strategies in sub-Saharan Africa

In Sub-Saharan Africa (SSA), effective brucellosis control is limited, in part, by the lack of long-term commitments by governments to control the disease and the absence of reliable national human and livestock population-based data to inform policies. Therefore, we conducted a study to establish the national prevalence and develop a risk map for Brucella spp. in cattle to contribute to plans to eliminate the disease in Kenya by the year 2040. We randomly generated 268 geolocations and distributed them across Kenya, proportionate to the area of each of the five agroecological zones and the associated cattle population. Cattle herds closest to each selected geolocation were identified for sampling. Up to 25 cattle were sampled per geolocation and a semi-structured questionnaire was administered to their owners. We tested 6,593 cattle samples for Brucella immunoglobulin G (IgG) antibodies using an Enzyme-linked immunosorbent assay (ELISA). We assessed potential risk factors and performed spatial analyses and prevalence mapping using approximate Bayesian inference implemented via the integrated nested Laplace approximation (INLA) method. The national Brucella spp. prevalence was 6.8% (95% CI: 6.2–7.4%). Exposure levels varied significantly between agro-ecological zones, with a high of 8.5% in the very arid zone with the lowest agricultural potential relative to a low of 0.0% in the agro-alpine zone with the highest agricultural potential. Additionally, seroprevalence increased with herd size, and the odds of seropositivity were significantly higher for females and adult animals than for males or calves. Similarly, animals with a history of abortion, or with multiple reproductive syndromes had higher seropositivity than those without. At the herd level, the risk of Brucella spp. transmission was higher in larger herds, and herds with a history of reproductive problems such as abortion, giving birth to weak calves, or having swollen testes. Geographic localities with high Brucella seroprevalence occurred in northern, eastern, and southern regions of Kenya all primarily characterized by semi-arid or arid agro-ecological zones dominated by livestock pastoralism interspersed with vast areas with mixed livestock-wildlife systems. The large spatial extent of our survey provides compelling evidence for the widespread geographical distribution of brucellosis risk across Kenya in a manner easily understandable for policymakers. Our findings can provide a basis for risk-stratified pilot studies aiming to investigate the cost-effectiveness and efficacy of singular and combined preventive intervention strategies that seek to inform Kenya’s Brucellosis Control Policy.

60 APPLIED LIFE SCIENCES↗

Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery

Arboviruses are a diverse group of insect-transmitted pathogens that pose global public health challenges. Identifying evolutionarily conserved host factors that combat arbovirus replication in disparate eukaryotic hosts is important as they may tip the balance between productive and abortive viral replication, and thus determine virus host range. Here, we exploit naturally abortive arbovirus infections that we identified in lepidopteran cells and use bacterial effector proteins to uncover host factors restricting arbovirus replication. Bacterial effectors are proteins secreted by pathogenic bacteria into eukaryotic hosts cells that can inhibit antimicrobial defenses. Since bacteria and viruses can encounter common host defenses, we hypothesized that some bacterial effectors may inhibit host factors that restrict arbovirus replication in lepidopteran cells. Thus, we used bacterial effectors as molecular tools to identify host factors that restrict four distinct arboviruses in lepidopteran cells. By screening 210 effectors encoded by seven different bacterial pathogens, we identify several effectors that individually rescue the replication of all four arboviruses. We show that these effectors encode diverse enzymatic activities that are required to break arbovirus restriction. We further characterize Shigella flexneri-encoded IpaH4 as an E3 ubiquitin ligase that directly ubiquitinates two evolutionarily conserved proteins, SHOC2 and PSMC1, promoting their degradation in insect and human cells. We show that depletion of either SHOC2 or PSMC1 in insect or human cells promotes arbovirus replication, indicating that these are ancient virus restriction factors conserved across invertebrate and vertebrate hosts. Collectively, our study reveals a novel pathogen-guided approach to identify conserved antimicrobial machinery, new effector functions, and conserved roles for SHOC2 and PSMC1 in virus restriction.

59 BASIC BIOLOGICAL SCIENCES↗

CREW SAFETY AND SURVIVAL ASPECTS OF THE LUNAR-LANDING MISSION

Some of the safety and survival aspects of the manned lunar-landing mission are examined. The conditions requiring abort to the earth, lunar orbit, and lunar surface are determined. Some of the possible design requirements to permit abort to lunar orbit or surface are indicated. Lunar orbital and surface survival kits are described, and the stationing of such kits in lunar orbit and at the intended landing site is proposed.

Safety↗

Empire. a study of early manned interplanetary missions final report, may 26 - nov. 25, 1962

This report summarizes the investigations and results of the EMPIRE Study Program undertaken by Aeronutronic Division of Ford Motor Company for the Future Projects Office, Marshall Space Flight Center, under Contract NAS8-5025. The dual planet flyby missions of the Crocco and Symmetric trajectory classes are discussed. The Crocco mission with an August 1971 launch window requires an interplanetary injection velocity increment of i0.i km/sec, has a return velocity of 13.5 km/sec, and takes approximately 400 days. The Symmetric mission with a July 1970 launch window has an injection velocity increment of 5.3 km/sec, a return velocity of 15.8 km/sec, and takes approximately 630 days. Additional results of the trajectory studies and abort trajectories are reported. The guidance and navigation subsystem, midcourse corrections, and planetary approach corrections are discussed. A detailed analysis of the reentry phase of EMPIRE includes consideration of an Apollo-type, a Drag Brake, and a lifting-type reentry vehicle to return the six-man crew at mission completion or in an aborted condition. The High L/D reentry vehicle is used in the missions considered. The various technological areas required for design criteria are developed and several spacecraft designs are considered. The all chemical propulsion Crocco system is discarded due to weight, complexity, and cost. The nuclear injected Crocco is treated in a similar manner. The lower energy injection for the Symmetric Mission leads to the feasibility of a nuclear injected vehicle with an Earth orbit weight of about 180,000 kilograms (400,000 pounds) before interplanetary transit. In addition, two chemical symmetric vehicles are treated. Conservative radiation exposures are derived, for the 630 day mission, of less than 200 REM and a polyethelene radiation shelter is designed. Scientific aspects of the missions are discussed. Mission Success Probabilities are presented for the various missions considered and for Saturn C-5, Nova, and Super-Nova Earth launch vehicles in light of possible development. The need for acceleration of nuclear rocket engine developments and auxiliary power developments is indicated. Definition of a larger nuclear engine of the order of 200,000 pounds thrust and about 800 seconds burning time or 50,000 pound thrust and 3600 seconds burning time is indicated for the Symmetric Mission in 1970 (energy requirements are higher in 1972 and for later launch due to the less favorable position of Mars)_ Immediate development of this advanced nuclear propulsion capability is recommended. A Development Plan and Funding Schedule is given for the 1970 launch window pinpointing the critical development areas and indicating a total program cost of $12.6 billion independent of other programmed R&D costs. In conclusion, technological feasibility for an early manned dual planet Mars-Venus flyby is believed to be demonstrated in this study. Several areas of accelerated development and experimental confirmation of theory are pinpointed. The necessary funding and development of Nova or orbital operations capability with Saturn C-5's is required. The 1970 launch window appears to offer the least expensive Symmetric Mission for several years into the 1980's.

F. P. Dixon↗