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At least 343 records · Page 19

All sources NASA NTRS DOE OSTI

NASA NTRS2015

Determination of Roles of Microgravity and Ionizing Radiation on the Reactivation of Epstein-Barr Virus In Vitro

Astronauts experience symptomatic and asymptomatic herpes virus reactivation during spaceflight. We have shown increases in reactivation of Epstein-Barr virus (EBV), cytomegalovirus (CMV) and varicella zoster virus (VZV) and shedding in body fluids (saliva and urine) in astronauts during space travel. Alterations in immunity, increased stress hormone levels, microgravity, increased radiation, and other conditions unique to spaceflight may promote reactivation of latent herpes viruses. Unique mechanico-physico forces associated with spaceflight can have profound effects on cellular function, especially immune cells. In space flight analog studies such as Antarctica, bed rest studies, and NASA's undersea habitat (Aquarius), reactivation of these viruses occurred, but to a lesser extent than spaceflight. Spaceflight analogs model some spaceflight factors, but none of the analogs recreates all factors experienced in space. Most notably, microgravity and radiation are not included in many analogs. Stress, processed through the HPA axis and SAM systems, induces viral reactivation. However, the respective roles of microgravity and increased space radiation levels or if any synergy exists are not known. Therefore, we studied the effect of modeled space radiation and/or microgravity, independent of the immune system on the changes in cellular gene expression that results in viral (EBV) reactivation. The effects of modeled microgravity and low shear on EBV replication and cellular and EBV gene expression were studied in human B-lymphocyte cell cultures. Latently infected B-lymphocytes were propagated in the rotating wall bioreactor and irradiated with the various dosages of gamma irradiation. At specific time intervals following exposure to modeled microgravity, the cells and supernatant were harvested and reactivation of EBV were assessed by measuring EBV and gene expression, DNA methylation, and infectious virus production.

Mehta, Satish K↗

NASA NTRS1999

Sustained Partial Sleep Deprivation: Effects on Immune Modulation and Growth Factors

The vulnerability to medical emergencies is greatest in space where there are real limits to the availability or effectiveness of ground based assistance. Moreover, astronaut safety and health maintenance will be of increasing importance as we venture out into space for extended periods of time. It is therefore critical to understand the mechanisms of the regulatory physiology of homeostatic systems (sleep, circadian, neuroendocrine, fluid and nutritional balance) and the key roles played in adaptation. This synergy project has combined aims of the "Human Performance Factors, Sleep and Chronobiology Team"; the "Immunology, Infection and Hematology Team"; and the "Muscle Alterations and Atrophy Team", to broadly address the effects of long term sleep reduction, as is frequently encountered in space exploration, on neuroendocrine, neuroimmune and circulating growth factors. Astronaut sleep is frequently curtailed to averages of between 4- 6.5 hours per night. There is evidence that this amount of sleep is inadequate for maintaining optimal daytime functioning. However, there is a lack of information concerning the effects of chronic sleep restriction, or reduction, on regulatory physiology in general, and there have been no controlled studies of the cumulative effects of chronic sleep reduction on neuroendocrine and neuroimmune parameters. This synergy project represents a pilot study designed to characterize the effects of chronic partial sleep deprivation (PSD) on neuroendocrine, neuroimmune and growth factors. This project draws its subjects from two (of 18) conditions of the larger NSBRI project, "Countermeasures to Neurobehavioral Deficits from Cumulative Partial Sleep Deprivation During Space Flight", one of the projects on the "Human Performance Factors, Sleep and Chronobiology Team ". For the purposes of this study, to investigate the effects of chronic sleep loss on neuroendocrine and neuroimmune function, we have focused on the two extreme sleep conditions from this larger study: a 4.2 hour per night condition, and a 8.2 hour per night condition. During space flight, muscle mass and bone density are reduced, apparently due to loss of GH and IGF-I, associated with microgravity. Since >70% of growth hormone (GH) is secreted at night in normal adults, we hypothesized that the chronic sleep restriction to 4 hours per night would reduce GH levels as measured in the periphery. In this synergy project, in collaboration with the "Muscle Alterations and Atrophy Team ", we are measuring insulin-like growth factor-I (IGF-I) in peripheral circulation to test the prediction that it will be reduced by chronic sleep restriction. In addition to stress modulation of immune function, recent research suggests that sleep is also involved. While we all have the common experience of being sleepy when suffering from infection, and being susceptible to infection when not getting enough sleep, the mechanisms involved in this process are not understood and until recently have gone largely overlooked. We believe that the immune function changes seen in spaceflight may also be related to the cumulative effects of sleep loss. Moreover, in space flight, the possibility of compromised immune function or of the reactivation of latent viruses are serious potential hazards for the success of long term missions. Confined living conditions, reduced sleep, altered diet and stress are all factors that may compromise immune function, thereby increasing the risks of developing and transmitting disease. Medical complications, which would not pose serious problems on earth, may be disastrous if they emerged in space.

Mullington, Janet M.↗

DOE OSTI2021

Analysis of basic airflow configurations for separate sensible and latent cooling systems with indoor air recirculation

Separate sensible and latent cooling (SSLC) is a technology with efficiency and comfort advantages over conventional cooling systems used for space conditioning of buildings. Using multiple cooling processes at different temperatures allows SSLC to save energy by raising the evaporation temperature of the sensible cooling process. In this paper, all possible airflow configurations of SSLC systems are enumerated under the following constraints: exactly two heat exchangers are used, and air is recirculated to the conditioned space (no exhaust or outdoor air treatment). Seven designs are identified, with varying free operating variables, and each is modeled. Analysis reveals that several configurations are equivalent, and there is only one unique basic airflow SSLC configuration: the one with the sensible and latent heat exchangers placed in series. The efficiency of the SSLC system is compared against that of the conventional system. Under standard conditions, an SSLC system can improve the coefficient of performance by 14.8%. In addition to the numerical simulation, the optimal operating condition of the basic air configuration of the SSLC system is derived analytically. The basic SSLC system is shown to offer the highest performance improvement when the outdoor temperature is relatively cool and the space sensible heat ratio is high.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

NASA NTRS1987

Fluoride salts and container materials for thermal energy storage applications in the temperature range 973 to 1400 K

Multicomponent fluoride salt mixtures were characterized for use as latent heat of fusion heat storage materials in advanced solar dynamic space power systems with operating temperatures in the range of 973 to 1400 K. The melting points and eutectic composition for many systems with published phase diagrams were verified, and several new eutectic compositions were identified. Additionally, the heats of fusion of several binary and ternary eutectics and congruently melting intermediate compounds were measured by differential scanning calorimetry. The extent of corrosion of various metals by fluoride melts was estimated from thermodynamic considerations, and equilibrium conditions inside a containment vessel were calculated as functions of the initial moisture content of the salt and free volume above the molten salt. Preliminary experimental data on the corrosion of commercial, high-temperature alloys in LiF-19.5CaF2 and NaF-27CaF2-36MgF2 melts are presented and compared to the thermodynamic predictions.

Misra, Ajay K.↗

NASA NTRS1987

Fluoride salts and container materials for thermal energy storage applications in the temperature range 973 - 1400 K

Misra, Ajay K.↗

NASA NTRS2018

Estimating Software Reliability for Space Launch Vehicles in Probabilistic Risk Assessment (PRA)

It is acutely recognized in the Probabilistic Risk assessment (PRA) field that software plays a defining role in overall system reliability for all modern systems across a wide variety of industries. Regardless if the software is embedded firmware for working components or elements, part of a Human-Machine-Interface, or automated command and control logic, the success of the software to fulfill its function under nominal and off-nominal environments will be a dominant contributor to system reliability. It is also recognized that software reliability prediction and estimation is one of the more challenging and questionable aspects of any PRA or system analyses due to the nature of software and its integration with physics based systems. Irrespective of this dichotomy, any incorporation of software reliability methods requires that the contributions are accountable, quantitative, and tractable. This paper provides a brief overview of software reliability methods, establishes some minimum requirements that the methods should incorporate for completeness, and provides a logic structure for applying software reliability. Model resolution will be discussed that supports current testing plans and trade studies. We will provide initial recommendations for use in the NASA PRA and present a future dynamic option for software and PRA. Space Launch Vehicle Software is recognized to be reliable in static conditions, yet relatively vulnerable to a set of failure modes in changing environments/flight phases. Two quantitative methods were chosen to incorporate software reliability into a Space Launch Vehicle PRA accounting for phase adjustments. One method predicts latent software failure using statistical methods, and the second provides estimates of coding errors and software operating system failures based on test and historical data, respectively. Software uncertainty will also be discussed. We determined that recommendations for PRA software reliability should be modeled at the software module level where multiple software components compose a module and combinations of the software architecture can lead to a functional failure.

Novack, Steven↗

NASA NTRS2018

Estimating Software Reliability for Space Launch Vehicles in Probabilistic Risk Assessment (PRA)

It is acutely recognized in the Probabilistic Risk Assessment (PRA) field that software plays a defining role in overall system reliability for all modern systems across a wide variety of industries. Regardless of whether the software is embedded firmware for working components or elements, part of a Human-Machine-Interface, or automated command and control logic, the success of the software to fulfill its function under nominal and off-nominal environments will be a dominant contributor to system reliability. It is also recognized that software reliability prediction and estimation is one of the more challenging and questionable aspects of any PRA or system analyses due to the nature of software and its integration with physics based systems. Irrespective of this dichotomy, any incorporation of software reliability methods requires that the contributions are accountable, quantitative, and tractable. This paper provides a brief overview of software reliability methods, establishes some minimum requirements that the methods should incorporate for completeness, and provides a logic structure for applying software reliability. Model resolution will be discussed that supports current testing plans and trade studies. We will provide initial recommendations for use in the National Aeronautics and Space Administration (NASA) PRA and present a future dynamic option for software and PRA. Space Launch Vehicle software is recognized to be reliable in static conditions, yet relatively vulnerable to a set of failure modes in changing environments/flight phases. Two quantitative methods were chosen to incorporate software reliability into a Space Launch Vehicle PRA accounting for phase adjustments. One method predicts latent software failure using statistical methods, and the second provides estimates of coding errors and software operating system failures based on test and historical data. Software uncertainty will also be discussed. It is determined that recommendations for PRA software reliability should be modeled at the software module level where multiple software components compose a module and combinations of the software architecture can lead to a functional failure.

Steven D. Novack↗

NASA NTRSDate not supplied

ES2Vec: Earth Science Metadata Suggestions and Analogical Reasoning

As the volume of text-based Earth science research grows, it is increasingly possible to discover latent relationships in the literature. However, traditional methodologies are restricted by limited computational capabilities and intractable problem spaces. Advancements in natural language processing (NLP) have allowed us to use an extensive Earth science corpus to create a domain-specific word vector model, Es2Vec, which we have used to surface latent relationships between Earth science concepts and generate improved keyword tags. Earth science metadata keyword assignment is a challenging problem. Dataset curators select appropriate keywords from the Global Change Master Directory (GCMD) set of keywords. The keywords an are integral part of the search and discovery of these datasets. Hence, the selection of keywords is crucial to increasing the discoverability of datasets. Utilizing machine learning techniques, we provide users with automated keyword suggestions to complement manual selection. We trained a machine learning model that leverages the semantic embedding ability of Word2Vec models to process abstracts and suggest relevant keywords. A user interface tool we built to assist data curators in the assignment of such keywords is also described.

word vectors↗

NASA NTRS2002

Passive and Active Microwave Remote Sensing of Precipitation and Latent Heating Distributions in the Tropics from TRMM

Passive and active microwave remote sensing data are analyzed to identify signatures of precipitation and vertical motion in tropical convection. A database of cloud/radiative model simulations is used to quantify surface rain rates and latent heating profiles that are consistent with these signatures. At satellite footprint-scale (approximately 10 km), rain rate and latent heating estimates are subject to significant random errors, but by averaging the estimates in space and time, random errors are substantially reduced, Bias errors have been minimized by improving the microphysics in the supporting cloud/radiative model simulations, and by imposing a consistent definition of remotely-sensed and model-simulated convective/stratiform rain coverage. Remotely-sensed precipitation and latent heating distributions in the tropics are derived from Tropical Rainfall Measuring Mission (TRMM) and Special Sensor Microwave/ Imager (SSM/ I) sensor data. The prototype Version 6 TRMM passive microwave algorithm typically yields average heating profiles with maxima between 6 and 7 km altitude for organized mesoscale convective systems. Retrieved heating profiles for individual convective systems are compared to coincident estimates based upon a combination of dual-Doppler radar and rawinsonde data. Also, large-scale latent heating distributions are compared to estimates derived from a simpler technique that utilizes observations of surface rain rate and stratiform rain proportion to infer vertical heating structure. Results of these tests will be presented at the conference.

Olson, William S.↗

NASA NTRS2004

Precipitation and Latent Heating Distributions from Satellite Passive Microwave Radiometry: Evaluation of Estimates Using Independent Data - Part 2

Rainfall rate estimates from space-borne k&ents are generally accepted as reliable by a majority of the atmospheric science commu&y. One-of the Tropical Rainfall Measuring Mission (TRh4M) facility rain rate algorithms is based upon passive microwave observations fiom the TRMM Microwave Imager (TMI). Part I of this study describes improvements in the TMI algorithm that are required to introduce cloud latent heating and drying as additional algorithm products. Here, estimates of surface rain rate, convective proportion, and latent heating are evaluated using independent ground-based estimates and satellite products. Instantaneous, OP5resolution estimates of surface rain rate over ocean fiom the improved TMI algorithm are well correlated with independent radar estimates (r approx. 0.88 over the Tropics), but bias reduction is the most significant improvement over forerunning algorithms. The bias reduction is attributed to the greater breadth of cloud-resolving model simulations that support the improved algorithm, and the more consistent and specific convective/stratiform rain separation method utilized. The bias of monthly, 2.5 deg. -resolution estimates is similarly reduced, with comparable correlations to radar estimates. Although the amount of independent latent heating data are limited, TMI estimated latent heating profiles compare favorably with instantaneous estimates based upon dual-Doppler radar observations, and time series of surface rain rate and heating profiles are generally consistent with those derived from rawinsonde analyses. Still, some biases in profile shape are evident, and these may be resolved with: (a) additional contextual information brought to the estimation problem, and/or; (b) physically-consistent and representative databases supporting the algorithm. A model of the random error in instantaneous, 0.5 deg-resolution rain rate estimates appears to be consistent with the levels of error determined from TMI comparisons to collocated radar. Error model modifications for non-raining situations will be required, however. Sampling error appears to represent only a fraction of the total error in monthly, 2S0-resolution TMI estimates; the remaining error is attributed to physical inconsistency or non-representativeness of cloud-resolving model simulated profiles supporting the algorithm.

Yang, Song↗

NASA NTRS2001

Consequences of contamination of the spacecraft environment: immunologic consequences

Long-term space voyages pose numerous known and unknown health hazards, to the human immune system. Well-studied clinical examples of secondary immunodeficiencies created on Earth, lead one to predict that the conditions of prolonged space flight would weaken the human immune responses that normally hold infection and cancer in check. From evidence gathered from humans flown for prolonged periods in space and from human models of space flight studied on Earth it is reasonable to suspect that space travelers to the planet Mars would experience a weakening of immunity. Subtle defects of immune cell structure and function have been observed in astronauts, such as weakening of specific T-lymphocyte recall of specific antigens. Ground-based models also have demonstrated alterations of immune function, such as the elevation of neuroendocrine immune system messengers, interleukin-6, and soluble tumor necrosis factor-alpha receptor in sleep deprivation. Since severe immune compromise the clinical consequences of reactivation of latent virus infections and the development of cancer, has yet to be seen in space flight or in the Earth models, it is extremely important to begin to quantify early changes in immunity to predict the development of immune system collapse with poor clinical outcomes. This approach is designed to validate a number of surrogate markers that will predict trouble ahead. Inherent in this research is the development of countermeasures to reduce the risks of infection and cancer in the first humans going to Mars.

Non-NASA Center↗

NASA NTRS1993

An observational search for CO2 ice clouds on Mars

CO2 ice clouds were first directly identified on Mars by the Mariner 6 and 7 infrared spectrometer limb scans. These observations provided support for early theoretical modeling efforts of CO2 condensation. Mariner 9 IRIS temperature profiles of north polar hood clouds were interpreted as indicating that these clouds were composed of H2O ice at lower latitudes and CO2 ice at higher latitudes. The role of CO2 condensation on Mars has recently received increased attention because (1) Kasting's model results indicated that CO2 cloud condensation limits the magnitude of the proposed early Mars CO2/H2O greenhouse, and (2) Pollack el al.'s GCM results indicated that the formation of CO2 ice clouds is favorable at all polar latitudes during the fall and winter seasons. These latter authors have shown that CO2 clouds play an important role in the polar energy balance, as the amount of CO2 contained in the polar caps is constrained by a balance between latent heat release, heat advected from lower latitudes, and thermal emission to space. The polar hood clouds reduce the amount of CO2 condensation on the polar caps because they reduce the net emission to space. There have been many extensive laboratory spectroscopic studies of H2O and CO2 ices and frosts. In this study, we use results from these and other sources to search for the occurrence of diagnostic CO2 (and H2O) ice and/or frost absorption features in ground based near-infrared imaging spectroscopic data of Mars. Our primary goals are (1) to try to confirm the previous direct observations of CO2 clouds on Mars; (2) to determine the spatial extent, temporal variability, and composition (H2O/CO2 ratio) of any clouds detected; and (3) through radiative transfer modeling, to try to determine the mean particle size and optical depth of polar hood clouds, thus, assessing their role in the polar heat budget.

Bell, James F., III↗

NASA NTRS2011

Immune System Dysregulation and Herpesvirus Reactivation Persist During Long-Duration Spaceflight

This poster presentation reviews a study that is designed to address immune system dysregulation and the risk to crewmembers in long duration exploration class missions. This study will address these objectives: (1) Determine the status of adaptive immunity physiological stress, viral immunity, latent herpesvirus reactivation in astronauts during 6 month missions to the International Space Station; (2) determine the clinical risk related to immune dysregulation for exploration class spaceflight; and (3) determine an appropriate monitoring strategy for spaceflight-associated immune dysfunction that could be used for the evaluation of countermeasures. The study anticipates 17 subjects, and for this presentation, (midpoint study data) 10 subjects are reviewed.

Crucian, B. E.↗

NASA NTRS2002

Letting Our Cells Do the Fighting: Flight-Induced Changes in the Immune Response

The organisms that make us ill, such as bacteria, viruses, and fungi, are like attacking armies. We now know a great deal more about this unseen world of microscopic invaders. Fortunately for us, the human immune system is ever vigilant against them. Microorganisms such as bacteria, viruses, and fungi occupy almost every corner of the Earth, and even parts of the human body. Some organisms are beneficial to us, helping to produce milk, cheese or yogurt. Others are potentially harmful, yet we don#t always develop illnesses from them; they are kept in check by the sentinels of our immune system. Our immune system is routinely challenged by these organisms every day. When the immune response is diminished, our ability to fight off these "bugs" is lowered. And that's when we become ill. Space flight presents a challenge to the immune system. Scientists believe that the stressful conditions of space flight - launch into orbit, adapting to microgravity, heavy workloads, and isolation from family and friends, to name but a few - reduce the astronauts' immunity. This immune suppression makes them more susceptible to common illnesses from bacteria and to re-infections from latent viruses in the body. In addition, risk of spreading illness in the confined environment of the Space Shuttle is high. Understanding changes in immune function will help scientists develop ways to keep astronauts healthy in space. This knowledge can also benefit earthbound populations. This experiment will give scientists insight into the immune system by comparing how certain cells of astronauts' innate immune system - the first line of defense against invaders - function after flight compared to before flight.

Pierson, Duane↗

NASA NTRS2008

Validation of Procedures for Monitoring Crewmember Immune Function

There is ample evidence to suggest that space flight leads to immune system dysregulation. This may be a result of microgravity, confinement, physiological stress, radiation, environment or other mission-associated factors. The clinical risk (if any) from prolonged immune dysregulation during exploration-class space flight has not yet been determined, but may include increased incidence of infection, allergy, hypersensitivity, hematological malignancy or altered wound healing. Each of the clinical events resulting from immune dysfunction has the potential to impact mission critical objectives during exploration-class missions. To date, precious little in-flight immune data has been generated to assess this phenomenon. The majority of recent flight immune studies have been post-flight assessments, which may not accurately reflect the in-flight status of immunity as it resolves over prolonged flight. There are no procedures currently in place to monitor immune function or its effect on crew health. The objective of this Supplemental Medical Objective (SMO) is to develop and validate an immune monitoring strategy consistent with operational flight requirements and constraints. This SMO will assess immunity, latent viral reactivation and physiological stress during both short and long duration flights. Upon completion, it is expected that any clinical risks resulting from the adverse effects of space flight on the human immune system will have been determined. In addition, a flight-compatible immune monitoring strategy will have been developed with which countermeasures validation could be performed. This study will determine, to the best level allowed by current technology, the in-flight status of crewmembers' immune systems. The in-flight samples will allow a distinction between legitimate in-flight alterations and the physiological stresses of landing and readaptation which are believed to alter R+0 assessments. The overall status of the immune system during flight (activation, deficiency, dysregulation) and the response of the immune system to specific latent virus reactivation (known to occur during space flight) will be thoroughly assessed. The first in-flight activity for integrated immunity very recently occurred during the STS-120 Space Shuttle mission. The protocols functioned well from a technical perspective, and accurate in-flight data was obtained from 1 Shuttle and 2 ISS crewmembers. Crew participation rates for the study continue to be robust.

Crucian, Brian↗

NASA NTRS1984

Determination of monthly mean humidity in the atmospheric surface layer over oceans from satellite data

A simple statistical technique is described to determine monthly mean marine surface-layer humidity, which is essential in the specification of surface latent heat flux, from total water vapor in the atmospheric column measured by space-borne sensors. Good correlation between the two quantities was found in examining the humidity soundings from radiosonde reports of mid-ocean island stations and weather ships. The relation agrees with that obtained from satellite (Seasat) data and ship reports averaged over 2 deg areas and a 92-day period in the North Atlantic and in the tropical Pacific. The results demonstrate that, by using a local regression in the tropical Pacific, total water vapor can be used to determine monthly mean surface layer humidity to an accuracy of 0.4 g/kg. With a global regression, determination to an accuracy of 0.8 g/kg is possible. These accuracies correspond to approximately 10 to 20 W/sq m in the determination of latent heat flux with the bulk parameterization method, provided that other required parameters are known.

Liu, W. T.↗

NASA NTRS1980

Flexible body stability analysis of Space Shuttle ascent flight control system by using lambda matrix solution techniques

A lambda matrix solution technique is being developed to perform an open loop frequency analysis of a high order dynamic system. The procedure evaluates the right and left latent vectors corresponding to the respective latent roots. The latent vectors are used to evaluate the partial fraction expansion formulation required to compute the flexible body open loop feedback gains for the Space Shuttle Digital Ascent Flight Control System. The algorithm is in the final stages of development and will be used to insure that the feedback gains meet the design specification.

Bown, R. L.↗

NASA NTRS2000

ISS Fiber Optic Failure Investigation Root Cause Report

In August of 1999, Boeing Corporation (Boeing) engineers began investigating failures of optical fiber being used on International Space Station flight hardware. Catastrophic failures of the fiber were linked to a defect in the glass fiber. Following several meetings of Boeing and NASA engineers and managers, Boeing created and led an investigation team, which examined the reliability of the cable installed in the U.S. Lab. NASA Goddard Space Flight Center's Components Technologies and Radiation Effects Branch (GSFC) led a team investigating the root cause of the failures. Information was gathered from: regular telecons and other communications with the investigation team, investigative trips to the cable distributor's plant, the cable manufacturing plant and the fiber manufacturing plant (including a review of build records), destructive and non-destructive testing, and expertise supplied by scientists from Dupont, and Lucent-Bell Laboratories. Several theories were established early on which were not able to completely address the destructive physical analysis and experiential evidence. Lucent suggested hydrofluoric acid (HF) etching of the glass and successfully duplicated the "rocket engine" defect. Strength testing coupled with examination of the low strength break sites linked features in the polyimide coating with latent defect sites. The information provided below explains what was learned about the susceptibility of the pre-cabled fiber to failure when cabled as it was for Space Station and the nature of the latent defects.

Leidecker, Henning↗