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At least 343 records · Page 19

A simulator evaluation of the use of spoilers on a light aircraft

A fixed-base flight simulator was used to evaluate wing spoilers for longitudinal flight path control on a modified Cessna Cardinal aircraft. Spoilers which generated the proper pitching moment to maintain aircraft trim C sub L constant could be used as an effective descent rate control. More than 100 simulated ILS approaches were flown by evaluation pilots using both conventional methods and spoiler descent rate control. Three spoiler control schemes were evaluated during the ILS approaches. Using the spoilers for control, instrument approaches could be flown smoothly and precisely with constant airspeed and pitch attitude. While the spoilers could adequately control ILS approaches, a spoiler system with greater authority would be desirable for use in visual approaches.

Brainerd, C. H.↗

Landing approach evaluation of an integrated CRT display for general aviation aircraft

A flight director adaptable to general aviation aircraft was evaluated for the landing approach task in a twin turbojet business aircraft. The flight director combined aircraft heading, pitch and roll atitude, and ILS (Instrument Landing System) signals into a single picture on a small cathode ray tube (CRT) to give the pilot an integrated picture of the aircraft situation. The display is unique in that it presents the information on a CRT and gives quasi-command signals to the pilot. The particular display investigated was a preproduction version of the Kaiser Model FP-50 flight director. Approaches made with visual references only, with a conventional ILS displacement instrument, and with the CRT display were compared in terms of tracking performance and pilot workload. Tracking performance of three research pilots using the CRT display was superior to that using the conventional ILS instrument and comparable to that under VFR conditions. Pilot workload (based on pilot comments) was not clearly decreased.

Talbot, P. D.↗

Investigation of fuselage acoustic treatment for a twin-engine turboprop aircraft in flight and laboratory tests

A flight and laboratory study of sidewall acoustic treatment for cabin noise control is described. In flight, cabin noise levels were measured at six locations with three treatment configurations. Noise levels from narrow-band analysis are reduced to one-third octave format and used to calculate insertion loss, IL, defined as the reduction of interior noise associated with the addition of a treatment. Laboratory tests used a specially constructed structural panel modeled after the propeller plane section of the aircraft sidewall, and acoustic treatments representing those used in flight. Lab measured transmission loss and absorption values were combined using classical acoustic procedures to obtain a prediction of IL. Comparison with IL values measured in flight for the boundary layer component of the noise indicated general agreement.

Mixson, J. S.↗

Simulator evaluation of a remotely piloted vehicle lateral landing task using a visual display

A simulator evaluation of a remotely piloted research vehicle was conducted at NASA Ames Research Center's Dryden Flight Research Facility to determine the utility of a visual display when studying the influence of changes in the lateral stick gearing gains during landing approaches. The test vehicle used in this study was a highly maneuverable aircraft technology (HiMAT) aircraft, which is a 0.44 scale version of an envisioned small, single seat fighter airplane. Handling qualities ratings and comments obtained from pilots using a simulated visual display of a runway scene and a simulated instrument landing system (ILS) display were compared with the results of actual flight tests. The visual display was found to provide an adequate representation of the test vehicle in a visual landing approach, and it improved the roll response cues provided to the pilot. The handling qualities ratings and comments for flight and simulation visual landing approaches correlated well. The ILS simulation results showed reduced correlation compared with the flight results for ILS approaches. Handling qualities criteria for remotely piloted research vehicles are also discussed in this paper.

Sarrafian, S. K.↗

Simulator evaluation of a remotely piloted vehicle lateral landing task using a visual display

A simulator evaluation of a remotely piloted research vehicle was conducted at NASA Ames Research Center's Dryden Flight Research Facility to determine the utility of a visual display when studying the influence of changes in the lateral-stick gearing gains during landing approaches. The test vehicle used in this study was a highly maneuverable aircraft technology (HiMAT) aircraft, which is a 0.44-scale version of an envisioned small, single-seat fighter airplane. Handling qualities ratings and comments obtained from pilots using a simulated visual display of a runway scene and a simulated instrument landing system (ILS) display were compared with the results of actual flight tests. The visual display was found to provide an adequate representation of the test vehicle in a visual landing approach, and it improved the roll response cues provided to the pilot. The handling qualities ratings and comments for flight and simulation visual landing approaches correlated well. The ILS simulation results showed reduced correlation compared with the flight results for ILS approaches. Handling qualities criteria for remotely piloted research vehicles are also discussed in this paper.

Sarrafian, S. K.↗

Industry liaison section implementation plan

The Industry Liaison Section is a new function of the Army/NASA Aircrew-Aircraft Integration (AAAI) Program that is intended to bridge an existing gap between Government developers (including contractors) and outside organizations who are potential users of products and services developed by the AAAI Program. Currently in its sixth year, the Program is experiencing considerable pull from industry and other government organizations to disseminate products. Since the AAAI Program's charter is exploratory and research in nature, and satisfying proper dissemination requirements is in conflict with the rapid prototyping approach utilized by the design team, the AAAI Program has elected to create an Industry Liaison Section (ILS) to serve as the Program's technology transfer focal point. The process by which the ILS may be established, organized and managed is described, including the baseline organizational structure, duties, functions, authority, responsibilities, relations and policies and procedures relevant to the conduct of the ILS.

Lakowske, Stephen↗

Effect of spaceflight on lymphocyte proliferation and interleukin-2 production

In this study, inguinal lymp node lymphocytes from rats flown on the Cosmos 2044 mission were tested for proliferation and interleukin-2 (IL-2) production. Cells cultured with mitogenic lectins, phorbol ester, and calcium ionophore, or T-cell mitogen and lymphokine, were assayed for DNA synthesis by (H-3) thymidine incorporation. Lymphocytes incubated with a T-cell mitogen alone also were tested for IL-2 production. Proliferation of lymphocytes from flight rats was not significantly different from controls for any of the mitogens tested. Furthermore, lymph node lymphocytes from control and flown rats produced similar amounts of IL-23. Thus microgravity may act on lymphocytes in a tissue-specific manner, a new finding that could impact on the evaluation of spaceflight effects on immunocompetence.

Nash, Patricia V.↗

Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets

This portion of the study quantified the effects of a 12-day space shuttle mission (Space Transport System-108/UF-1) on body and lymphoid organ masses, activation marker expression, cytokine secretion, and erythrocyte and thrombocyte characteristics in C57BL/6 mice. Animals in flight (Flt group) had 10-12% lower body mass compared with ground controls housed either in animal enclosure modules or under standard vivarium conditions (P < 0.001) and the smallest thymus and spleen masses. Percentages of CD25(+) lymphocytes, CD3(+)/CD25(+) T cells, and NK1.1(+)/CD25(+) natural killer cells from Flt mice were higher compared with both controls (P < 0.05). In contrast, CD71 expression was depressed in the Flt and animal enclosure module control mice compared with vivarium control animals (P < 0.001). Secretion of interferon-gamma, IL-2, and IL-4, but not tumor necrosis factor-alpha and IL-5, by splenocytes from Flt mice was decreased relative to either one or both ground controls (P < 0.05). Flt mice also had high red blood cell and thrombocyte counts compared with both sets of controls; low red blood cell volume and distribution width, percentage of reticulocytes, and platelet volume were also noted (P < 0.05) and were consistent with dehydration. These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions.

Flight Experiment↗

Induction of ceruloplasmin synthesis by IFN-gamma in human monocytic cells

Ceruloplasmin is a 132-kDa glycoprotein abundant in human plasma. It has multiple in vitro activities, including copper transport, lipid pro- and antioxidant activity, and oxidation of ferrous ion and aromatic amines; however, its physiologic role is uncertain. Although ceruloplasmin is synthesized primarily by the liver in adult humans, production by cells of monocytic origin has been reported. We here show that IFN-gamma is a potent inducer of ceruloplasmin synthesis by monocytic cells. Activation of human monoblastic leukemia U937 cells with IFN-gamma increased the production of ceruloplasmin by at least 20-fold. The identity of the protein was confirmed by plasmin fingerprinting. IFN-gamma also increased ceruloplasmin mRNA. Induction followed a 2- to 4-h lag and was partially blocked by cycloheximide, indicating a requirement for newly synthesized factors. Ceruloplasmin induction in monocytic cells was agonist specific, as IL-1, IL-4, IL-6, IFN-alpha, IFN-beta, TNF-alpha, and LPS were completely ineffective. The induction was also cell type specific, as IFN-gamma did not induce ceruloplasmin synthesis in endothelial or smooth muscle cells. In contrast, IFN-gamma was stimulatory in other monocytic cells, including THP-1 cells and human peripheral blood monocytes, and also in HepG2 cells. Ceruloplasmin secreted by IFN-gamma-stimulated U937 cells had ferroxidase activity and was, in fact, the only secreted protein with this activity. Monocytic cell-derived ceruloplasmin may contribute to defense responses via its ferroxidase activity, which may drive iron homeostasis in a direction unfavorable to invasive organisms.

Non-NASA Center↗

Potentiation of lymphocyte proliferative responses by nickel sulfide

Crystalline nickel sulfide (NiS) induced a spleen cell proliferation that resembles a mixed lymphocyte reaction (MLR). It depended on cell-cell interaction, induced high levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) and the responding cell subpopulation was composed of CD4+ T lymphocytes. Furthermore, the proliferation was inhibited in a dose-dependent manner by magnesium. Crystalline NiS also increased significantly the spleen cell proliferative response to concanavalin A (Con A) and lipopolysaccharide (LPS) with magnesium potentiating the combined effects of crystalline NiS and mitogens. Interestingly, crystalline NiS did not show any effect on the induction of IL-2 by Con A. The results described herein suggest that crystalline NiS can potentiate both antigenic (MLR) and mitogenic (Con A and LPS) proliferative responses in vitro. Crystalline NiS appears to potentiate these responses by acting in the form of ionic nickel on several intracellular targets for which magnesium ions have different noncompetitive interactions. The effects of magnesium on the potentiating action of crystalline NiS are different depending upon the type of primary stimulatory signal for proliferation (mitogenic or antigenic).

NASA Discipline Cell Biology↗

Lunar Oxygen Production and Metals Extraction Using Ionic Liquids

Initial results indicate that ionic liquids are promising media for the extraction of oxygen from lunar regolith. IL acid systems can solubilize regolith and produce water with high efficiency. IL electrolytes are effective for water electrolysis, and the spent IL acid media are capable of regeneration.

Marone, Matthew↗

An Illumination Correction ALgorithm on Landsat-TM Data

In this paper, a new illumination correction model, the rotation model, is introduced. The model is based on the empirical correlation between reflectance and the illumination condition (IL). The model eliminates the dependency of reflectance on IL through rotating the data in IL-reflectance space. This model is compared with widely used cosine model and C model over a sample forest region. We found that the newly developed rotation model consistently performs best on both atmospheric uncorrected and corrected Landsat images. Index Terms Landsat, illumination correction, change detection, LEDAPS

Tan, Bin↗

Ionic Liquids Enabling Revolutionary Closed-Loop Life Support

Minimizing resupply from Earth is essential for future long duration manned missions. The current oxygen recovery system aboard the International Space Station is capable of recovering approximately 50% of the oxygen from metabolic carbon dioxide. For long duration manned missions, a minimum of 75% oxygen recovery is targeted with a goal of greater than 90%. Theoretically, the Bosch process can recover 100% of oxygen, making it a promising technology for oxygen recovery for long duration missions. However, the Bosch process produces elemental carbon which ultimately fouls the catalyst. Once the catalyst performance is compromised, it must be replaced resulting in undesired resupply mass. Based on the performance of a Bosch system designed by NASA in the 1990's, a three year Martian mission would require approximately 1315 kg (2850 lbs) of catalyst resupply. It may be possible to eliminate catalyst resupply with a fully regenerable system using an Ionic Liquid (IL)-based Bosch system. In 2016, we reported the feasibility of using ILs to produce an iron catalyst on a copper substrate and to regenerate the iron catalyst by extracting the iron from the copper substrate and product carbon. Additionally, we described a basic system concept for an IL-based Bosch. Here we report the results of efforts to scale catalyst preparation, catalyst regeneration, and to scale the carbon formation processing rate of a single reactor.

Brown, Brittany R.↗

Ionic Liquids Enabling Revolutionary Closed-Loop Life Support

Minimizing resupply from Earth is essential for future long duration manned missions. The current oxygen recovery system aboard the International Space Station is capable of recovering approximately 50% of the oxygen from metabolic carbon dioxide. For long duration manned missions, a minimum of 75% oxygen recovery is targeted with a goal of greater than 90%. Theoretically, the Bosch process can recover 100% of oxygen, making it a promising technology for oxygen recovery for long duration missions. However, the Bosch process produces elemental carbon which ultimately fouls the catalyst. Once the catalyst performance is compromised, it must be replaced resulting in undesired resupply mass. Based on the performance of a Bosch system designed by NASA in the 1990's, a three year Martian mission would require approximately 1315 kg (2850 lbs) of catalyst resupply. It may be possible to eliminate catalyst resupply with a fully regenerable system using an Ionic Liquid (IL)-based Bosch system. In 2016, we reported the feasibility of using ILs to produce an iron catalyst on a copper substrate and to regenerate the iron catalyst by extracting the iron from the copper substrate and product carbon. Additionally, we described a basic system concept for an IL-based Bosch. Here we report the results of efforts to scale catalyst preparation, to scale catalyst regeneration, and to scale the carbon formation processing rate of a single reactor.

Brown, Brittany R.↗

Analysis of Interlaminar Damage in Refractory Composites by In-Situ Micro-X-Ray Computed Tomography

Refractory composites are relevant for hot-structure applications on re-entry vehicles. To develop optimized high-performance hot structures, accurate material property data is required. Material properties that often limit design in two-dimensional (2-D) composites are interlaminar strengths. A better understanding of the failure mechanisms for interlaminar shear (ILS), interlaminar tension (ILT), and curved-beam interlaminar tension (CB-ILT) tests can provide insight on improving the design and fabrication of refractory composites. In-situ tests were performed to capture the progressive failure in American Society for Testing and Materials (ASTM) sized ILS (ASTM D3846), ILT (ASTM D7291), and CB-ILT (ASTM D6415) specimens. The present study investigates the change in material behavior by examining the macro porosity change in in-situ ILS tests, the mesoscale and inter-ply porosity changes in flatwise in-situ ILT tests and the change in per-ply delamination in in-situ CB-ILT tests.

In-situ Damage Characterization↗

Investigation of electrode-electrolyte interfaces to enable non-flammable Li-ion batteries operating up to 125°C with liquid electrolyte

Non-flammable and high-temperature stable ionic liquid (IL)-based electrolytes could eliminate catastrophic battery failures and improve battery safety, but their poor electrochemical interaction with the LiNi x Mn y Co z O 2 (NMC) family of cathodes is a long-standing problem due to severe parasitic reactions at high temperature. Understanding surface and bulk structural mechanisms of NMC-type cathodes at elevated operational temperature is of paramount importance to facilitate stable electrochemical performance. Here, we report a non-flammable phosphonium IL-based cell chemistry that offers stable electrode-electrolyte interfaces, leading to electrochemical performance up to 125°C and high-temperature safety. We combine electrochemistry with multimodal X-ray spectroscopy methods to understand interfaces at elevated temperature (100°C). This nanoscale understating enables a proof-of-concept high-temperature cylindrical cell (14500), and the design achieves an average Coulombic efficiency of ≈99.5% up to 300 cycles at 100°C. The results ascertain the significance of depth-dependent degradation at the interface, guiding room-temperature Li-ion technology toward extreme-temperature applications.

36 MATERIALS SCIENCE↗

Understanding Gas Solubility of Pure Component and Binary Mixtures within Multivalent Ionic Liquids from Molecular Simulations

Understanding the molecular-level solubility of CO 2 and its mixtures is essential to the progress of gas treating technologies. Herein, we use grand canonical Monte Carlo simulations to study the single component gas absorption of SO 2 , N 2 , CH 4 , and H 2 , and binary mixtures of CO 2 /SO 2 , CO 2 /N 2 , CO 2 /CH 4 , and CO 2 /H 2 of varying mole fractions within multivalent ionic liquids (ILs). Our results highlight the importance of the free volume effect and the anion effect when interpreting the absorption behavior of these mixtures, similar to the behavior of CO 2 found in our previous study. The deviation of the gas solubility between the pure component absorption versus the binary absorption, as well as the solubility selectivity, highlight the importance of the relative affinity of gas species within a mixture to the different anions. Further, the absorption selectivity within a specific IL system can be predicted based on the relative gas affinity to the anion.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

How do deer respiratory epithelial cells weather the initial storm of SARS-CoV-2 WA1/2020 strain?

The potential infectivity of severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) in animals raises a public health and economic concern, particularly the high susceptibility of white-tailed deer (WTD) to SARS-CoV-2. The disparity in the disease outcome between humans and WTD is very intriguing, as the latter are often asymptomatic, subclinical carriers of SARS-CoV-2. To date, no studies have evaluated the innate immune factors responsible for the contrasting SARS-CoV-2-associated disease outcomes in these mammalian species. A comparative transcriptomic analysis in primary respiratory epithelial cells of human (HRECs) and WTD (Deer-RECs) infected with the SARS-CoV-2 WA1/2020 strain was assessed throughout 48 h post inoculation (hpi). Both HRECs and Deer-RECs were susceptible to virus infection, with significantly ( P < 0.001) lower virus replication in Deer-RECs. The number of differentially expressed genes (DEG) gradually increased in Deer-RECs but decreased in HRECs throughout the infection. The ingenuity pathway analysis of DEGs further identified that genes commonly altered during SARS-CoV-2 infection mainly belong to cytokine and chemokine response pathways mediated via interleukin-17 (IL-17) and nuclear factor-κB (NF-κB) signaling pathways. Inhibition of the NF-κB signaling in the Deer-RECs pathway was predicted as early as 6 hpi. The findings from this study could explain the lack of clinical signs reported in WTD in response to SARS-CoV-2 infection as opposed to the severe clinical outcomes reported in humans. IMPORTANCE. This study demonstrated that human and white-tailed deer primary respiratory epithelial cells are susceptible to the SARS-CoV-2 WA1/2020 strain infection. However, the comparative transcriptomic analysis revealed that deer cells could limit viral replication without causing hypercytokinemia by downregulating IL-17 and NF-κB signaling pathways. Identifying differentially expressed genes in human and deer cells that modulate key innate immunity pathways during the early infection will lead to developing targeted therapies toward preventing or mitigating the “cytokine storm” often associated with severe cases of coronavirus disease 19 (COVID-19). Moreover, results from this study will aid in identifying novel prognostic biomarkers in predicting SARS-CoV-2 adaption and transmission in deer and associated cervids.

60 APPLIED LIFE SCIENCES↗