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At least 343 records · Page 19

Noninvasive stress testing - Methodology for elimination of the phonocardiogram

Measurement by systolic time intervals (STI) of cardiac responses requires extremely careful recording during actual stress test performance. Previous work indicated no significant changes in the pulse transmission time (PTT) during exercise and other challenges. Since external STI depend on the carotid pulse offset by the PTT as an aortic curve equivalent, stable PTT implies that timing of the carotid upstroke and the carotid incisura would respectively track the pre-ejection period and the aortic incisura. In ten subjects, STIs were recorded at supine rest, sitting, standing, during prompt and sustained squatting and during isometric and dynamic exercise. The results demonstrated the tracking of both points. Coefficients of correlation and of determination were uniformly high for all challenges except isometric handgrip (IHG). Since left ventricular ejection time is obtained directly from the pulse curve, with the exception of IHG, STI responses during stress testing can be measured without a phonocardiogram.

Spodick, D. H.↗

X-ray and radio emission from the compact galaxy III Zw 2

X-rays from the compact galaxy III Zw 2 have been detected with the rotating modulation collimator on board SAS 3. The (2-10-keV) flux is (4.3 + or - 0.5) by 10 to the -11th power erg/sq cm per sec, which corresponds to a luminosity of 1.4 by 10 to the 45th power erg/s at 530 Mpc. Subsequent radio observations between 1.46 and 90 GHz were made at the NRAO Very Large Array and 36-foot (11-m) installations. The radio spectrum rises sharply toward higher frequencies and, below about 100 GHz, is indicative of a self-absorbed synchrotron spectrum from an extremely compact, rapidly evolving object.

Schnopper, H. W.↗

On the mean meridional mass motions of the stratosphere and mesosphere

Using a simplified, approximate 'Lagrangian-mean' dynamical formulation, the mean meridional mass circulation of the stratosphere and mesosphere is discussed. Under solstice conditions, it is shown that this Lagrangian-mean circulation may be inferred, as a first approximation, from the Eulerian-mean diabatic heating. Diabatic heating rates for the solstices, originally derived by Murgatroyd and Goody (1958), result in Lagrangian-mean rising motion at the tropical tropopause, subsidence across the extra-tropical tropopause, and a very strong summer-to-winter pole flow in the mesosphere. This circulation is exactly that obtained by Murgatroyd and Singleton (1961) for the solstices. Those authors, however, attempted to identify this circulation as the Eulerian-mean motion, and were later criticized for their neglect of the meridional eddy heat flux in the calculation, which proved to be extremely important in the winter hemisphere. The present study, nevertheless, indicates that Murgatroyd and Singleton's circulation may in fact be representative of actual air parcel motions in the stratosphere and mesosphere.

Dunkerton, T.↗

A pristine eucrite-like gabbro from Descartes and its exotic kindred

A coarse-grained plagioclase-pyroxene gabbro (61224,6) with a cumulate texture suggestive of a slowly cooled plutonic rock was recovered from the 4-10 mm fraction of an Apollo 16 soil. The rock is uncommonly poor in feldspar and rich in Na for a lunar highlands lithology. Trace element analyses show extremely low siderophile element concentrations which confirm the pristine character indicated by the texture. The composition of 61224,6 is compared with those of 3 other pristine, exceptionally mafic, nonmare gabbros and of certain eucrites. 61224,6 and the three other gabbros have notable chemical differences but share relatively high ratios of Ti/Sm and Sc/Sm which suggest a possible genetic relationship. We conclude that 61224,6 represents a Na-rich cumulate from a layered intrusion within the highlands crust.

Marvin, U. B.↗

X-ray Activity in Pre-main Sequence Stars

X-ray findings and their interpretation with respect to winds and surface activity of pre-main sequence stars are summarized. Some recent optical and radio observations supporting the X-ray evidence for giant flares on PMS stars are discussed. The unusual properties of PMS/T Tauri stars were for many years primarily attributed to their strong winds. Numerous lines of evidence are outlined herein indicating that PMS stars also have enhanced surface activity, including extremely strong individual flares.

Feigelson, E. D.↗

Solid rocket motor aft field joint flow field analysis

An efficient Navier-Stokes analysis was successfully applied to simulate the complex flow field in the vicinity of a slot in a solid rocket motor with segment joints. The capability of the computer code to resolve the flow near solid surfaces without using a wall function assumption was demonstrated. In view of the complex nature of the flow field in the vicinity of the slot, this approach is considered essential. The results obtained from these calculations provide valuable design information, which would otherwise be extremely difficult to obtain. The results of the axisymmetric calculations indicate the presence of a region of reversed axial flow at the aft-edge of the slot and show the over-pressure in the slot to be only about 10 psi. The results of the asymmetric calculations indicate that a pressure asymmetry more than two diameters downstream of the slot has no noticeable effect on the flow field in the slot. They also indicate that the circumferential pressure differential caused in the slot due to failure of a 15 deg section of the castable inhibitor will be approximately 1 psi.

Sabnis, Jayant S.↗

C-band scatterometer measurements of a tallgrass prairie

C-band (4.75 GHz) scatterometer measurements were made of a tallgrass prairie in an attempt to determine the relationship between (1) the backscattering coefficient and different expressions of soil moisture and (2) the backscattering coefficient and various canopy parameters. A moderately strong correlation and partial correlation between the backscattering coefficient and leaf water potential indicates the capability of C-band measurements to detect extremes in the water status of prairie vegetation under shallow soil conditions. Site differences due to burn treatments appeared to be sufficient to cause significant differences in the sensitivity of the backscattering coefficient to soil moisture. The site differences could not be removed by any known expression of soil moisture.

Martin, Robert D., Jr.↗

Surface electrons in inverted layers of p-HgCdTe

Anodic oxide passivation of p-type HgCdTe generates an inversion layer. Extremely high Hall mobility data for electrons in this layer indicated the presence of a two-dimensional electron gas. This is verified by use of the Shubnikov-de Haas effect from 1.45 to 4.15 K. Data are extracted utilizing a numerical second derivative of dc measurement. Three sub-bands are detected. Their relative occupancies are in excellent agreement with theory and with experimental results obtained on anodic oxide as accumulation layers of n-type HgCdTe. The effective mass derived is comparable to what was expected.

Schacham, Samuel E.↗

Emission lines and winds from T Tauri stars

Strong emission lines and excess optical continuum emission are only seen in T Tauri stars when a circumstellar disk is present, as indicated by IR excess emission. Thus, it appears that the extreme emission and winds of T Tauri stars are probably driven by disk accretion.

Hartmann, L.↗

The dynamical settling of warped disks and angular momentum transport in galaxies

We present results of three-dimensional, hydrodynamic models of gaseous disks settling in a nonspherical potential. As the gas settles, differential precession creates a warped disk similar to the warps seen in spiral galaxies. A logarithmic potential, indicative of a massive halo, seems to induce warps more extreme than those produced by a l/r potential with a quadrupole distortion.

Fisher, P.↗

1919+479: Big WAT in a poor cluster

New x-ray, optical, and redshift data are presented for the cluster of galaxies associated with the giant, 1 Mpc diameter, wide-angle tailed (WAT) radio galaxy 1919+479. The ROSAT Position-Sensitive Proportional Counter (PSPC) pointed observation shows an x-ray peak on the WAT and elongated diffuse emission tracing the galaxy distribution. In addition, an asymmetric extension of emission exists between the tails of the WAT. The fitting of a Raymond-Smith thermal model to the x-ray spectra suggests an approximately = 2 keV temperature intracluster medium (ICM). The cooling time and irregular morphology rule out a cluster-wide cooling flow. The x-ray luminosity and temperature are consistent with the velocity dispersion, 480 km/s, estimated from 31 galaxy velocities. However, this velocity distribution is significantly non-Gaussian, which along with the x-ray morphology, suggests incomplete virialization in the cluster. Substructure analysis does not reveal significant clumping in the velocities/positions; but, the spatial distribution of galaxies is very elongated. Also, the cD galaxy producing the WAT does not have a significant radial peculiar velocity with respect to the cluster centroid. These characteristics are consistent with a merger scenario in which a subcluster has crossed the cluster core in the plane of the sky and has dispersed. We compare this cluster with the post-merger cluster Abell 2634 (Pinkney et al., 1993), containing the prototype WAT, and with a recent N-Body/Hydro simulation of merging clusters. The similarities indicate that the cluster 1919+479 may be the poor extreme of a class of clusters in which the bulk motion in the ICM, caused by a subcluster merger, in shaping the central WAT.

Pinkney, Jason↗

Aerodynamic Shape Optimization Using A Real-Number-Encoded Genetic Algorithm

A new method for aerodynamic shape optimization using a genetic algorithm with real number encoding is presented. The algorithm is used to optimize three different problems, a simple hill climbing problem, a quasi-one-dimensional nozzle problem using an Euler equation solver and a three-dimensional transonic wing problem using a nonlinear potential solver. Results indicate that the genetic algorithm is easy to implement and extremely reliable, being relatively insensitive to design space noise.

Holst, Terry L.↗

Assessing Dual Sensor Enhanced Flight Vision Systems to Enable Equivalent Visual Operations

Flight deck-based vision system technologies, such as Synthetic Vision (SV) and Enhanced Flight Vision Systems (EFVS), may serve as a revolutionary crew/vehicle interface enabling technologies to meet the challenges of the Next Generation Air Transportation System Equivalent Visual Operations (EVO) concept - that is, the ability to achieve the safety of current-day Visual Flight Rules (VFR) operations and maintain the operational tempos of VFR irrespective of the weather and visibility conditions. One significant challenge lies in the definition of required equipage on the aircraft and on the airport to enable the EVO concept objective. A motion-base simulator experiment was conducted to evaluate the operational feasibility, pilot workload and pilot acceptability of conducting straight-in instrument approaches with published vertical guidance to landing, touchdown, and rollout to a safe taxi speed in visibility as low as 300 ft runway visual range by use of onboard vision system technologies on a Head-Up Display (HUD) without need or reliance on natural vision. Twelve crews evaluated two methods of combining dual sensor (millimeter wave radar and forward looking infrared) EFVS imagery on pilot-flying and pilot-monitoring HUDs as they made approaches to runways with and without touchdown zone and centerline lights. In addition, the impact of adding SV to the dual sensor EFVS imagery on crew flight performance, workload, and situation awareness during extremely low visibility approach and landing operations was assessed. Results indicate that all EFVS concepts flown resulted in excellent approach path tracking and touchdown performance without any workload penalty. Adding SV imagery to EFVS concepts provided situation awareness improvements but no discernible improvements in flight path maintenance.

Kramer, Lynda J.↗

Preservation of Lipid Biomarkers Under Prolonged and Extreme Hyperaridity in Atacama Desert Soils

Molecular biomarkers are the most direct biosignatures of life on early Earth and a key target in the search for life on Mars. Lipid biomarkers are of particular interest given their ability to survive oxidative degradation and record microbial presence and activity of microorganisms that occurred billions of years ago (Eigenbrode, 2008). Environmental conditions that suspend biotic and abiotic degradative processes prior to lithification can lead to enhanced biomolecular preservation over geological time-scales. The hyperarid core of the Atacama Desert in northern Chile offers a unique environment to investigate lipid biomarker taphonomy under extreme and prolonged dryness. We investigated the accumulation and degree of preservation of lipid biomarkers in million-year-old hyperarid soils where primarily abiotic conditions influence their taphonomy. Soils were extracted and free and membrane bound lipids were analyzed across a vertical profile of 2.5 meters in the Yungay hyper-arid core of the Atacama Desert. Due to the extremely low inventory of biomass in Atacama soils, samples were collected by scientists wearing cleanroom suits to minimize anthropogenic contamination during sampling. Fatty acids were found to be well preserved in Yungay soils, and were most abundant in the clay-rich soils at approx.2 m depth (approx.750 ng of fatty acid methyl ester/g of soil). These buried clays layers were fluvially deposited approximately 2 million years ago, and have been excluded from exposure to rainwater and modern surficial processes since their emplacement (Ewing et al., 2008). Monocarboxylic fatty acid, monohydroxy fatty acid, glycerol tetraether, and n-alkane hydrocarbon content was found to change with depth. Lipid biomarker content in deeper soil layers is suggestive of soils having been formed at a time when environmental conditions were capable of supporting active microbial communities and plants. In short, total lipid extracts reveal a remarkable degree of lipid biomarker preservation even in the oldest soils analyzed (ca. 2 Myr) indicating that typical diagenetic processes of lipid destruction are arrested under extreme dryness. This result has implications for the search for molecular biomarkers on Mars, which could have experienced millions to billions of years of extreme hyperaridity.

Lipid Biomarkers↗

Bioverse: A Comprehensive Assessment of the Capabilities of Extremely Large Telescopes to Probe Earth-like O 2 Levels in Nearby Transiting Habitable-zone Exoplanets

Molecular oxygen is a strong indicator of life on Earth and may indicate biological processes on exoplanets too. Recent studies proposed that Earth-like O 2 levels might be detectable on nearby exoplanets using high-resolution spectrographs on future extremely large telescopes (ELTs). However, these studies did not consider constraints like relative velocities, planet occurrence rates, and target observability. We expanded on past studies by creating a homogeneous catalog of 286,391 main-sequence stars within 120 pc using Gaia DR3 and used the Bioverse framework to simulate the likelihood of finding nearby transiting Earth analogs. We also simulated a survey of M dwarfs within 20 pc accounting for η ⊕ estimates, transit probabilities, relative velocities, and target observability to determine how long ELTs and theoretical 50–100 m ground-based telescopes need to observe to probe for Earth-like O 2 levels with an R = 100,000 spectrograph. This would only be possible within 50 yr for up to ~21% of nearby M-dwarf systems if a suitable transiting habitable-zone Earth analog was discovered, assuming signals from every observable partial transit from each ELT can be combined. If so, Earth-like O 2 levels could be detectable on TRAPPIST-1 d–g within 16–55 yr, respectively, and about half that time with an R = 500,000 spectrograph. These results have important implications for whether ELTs can survey nearby habitable-zone Earth analogs for O 2 via transmission spectroscopy. Our work provides the most comprehensive assessment to date of the ground-based capabilities to search for life beyond the solar system.

79 ASTRONOMY AND ASTROPHYSICS↗

Small-aperture infrared photometry of Seyfert 1 galactic nuclei

Multiaperture infrared photometry of the nuclei of five Seyfert 1 galaxies is presented. When apertures approaching the seeing limit were used, it was found that all of the nuclei have observed power law energy distributions with F(nu) proportional to 1/nu sq from 1.25 to 3.45 micron. After correcting for reddening, the spectral indices had a range of alpha = 1.4-1.9. These results are supported through infrared imaging of one of the program galaxies, and they demonstrate the importance of properly isolating the nuclear component from the stellar disk through the use of extremely small apertures. Although the nature of the infrared emissions cannot be determined, results indicate that a common energy source exists among the observed galaxies.

Simons, D. A.↗

Changing Trends in Drought Patterns over the Northeastern United States Using Multiple Large Ensemble Datasets

Since the infamous extreme drought of the 1960s, the climate of the northeastern United States (NEUS) has generally trended toward warmer and wetter conditions. Nonetheless, there is mounting evidence that short-term droughts will continue to pose a significant risk for this region. To better explore the processes governing events such as these, climate models have adopted more complex representations of the fully coupled atmosphere–land–ocean–sea ice system; however, large uncertainties in future projections still persist, with internal variability necessitating large ensembles to understand trends in both rare and high-impact extreme events such as rapidly developing droughts (a term here that includes flash droughts developing on monthly scales). In this study, seven large ensemble (LE) models are employed to answer the outstanding question: How are the frequency and character of drought in the NEUS changing under a warming climate? We find that most LE models indicate the NEUS will experience a long-term wetting trend with more “extremely wet” months, but also more frequent short-term extreme droughts. These changes are associated with increasing precipitation, atmospheric water demand, and climate variability. We also conclude that discrepant trends in precipitation and evapotranspiration variability will lead to increasing anticorrelation of these variables, which is relevant to the intensification of rapidly developing drought, particularly in the spring season. These changes are associated with an increase in evapotranspiration from plants, brought by an earlier emergence of the growing season and denser vegetation.

54 ENVIRONMENTAL SCIENCES↗

Anaerobic Fungal Mevalonate Pathway Genomic Biases Lead to Heterologous Toxicity Underpredicted by Codon Adaptation Indices

Anaerobic fungi are emerging biotechnology platforms with genomes rich in biosynthetic potential. Yet, the heterologous expression of their biosynthetic pathways has had limited success in model hosts like E. coli. We find one reason for this is that the genome composition of anaerobic fungi like P. indianae are extremely AT-biased with a particular preference for rare and semi-rare AT-rich tRNAs in E coli, which are not explicitly predicted by standard codon adaptation indices (CAI). Native P. indianae genes with these extreme biases create drastic growth defects in E. coli (up to 69% reduction in growth), which is not seen in genes from other organisms with similar CAIs. However, codon optimization rescues growth, allowing for gene evaluation. In this manner, we demonstrate that anaerobic fungal homologs such as PI.atoB are more active than S. cerevisiae homologs in a hybrid pathway, increasing the production of mevalonate up to 2.5 g/L (more than two-fold) and reducing waste carbon to acetate by ~90% under the conditions tested. This work demonstrates the bioproduction potential of anaerobic fungal enzyme homologs and how the analysis of codon utilization enables the study of otherwise difficult to express genes that have applications in biocatalysis and natural product discovery.

60 APPLIED LIFE SCIENCES↗