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Escape zone depths λ' for true-secondary electrons and photoelectrons from pure CdTe and CdTe with a Ba film of thickness θ ≤ 1 monolayer have been estimated for the first time. It is shown that upon a decrease of the work function of the surface by 2 eV, the value of λ' increases by 1.2–1.3 times.
The sensitivity of convective clouds to aerosols and their interactions with environment, combined with limited observational constraints in parameterizations, introduces significant uncertainties in atmospheric models. Here, this study investigates the dependence of convective cloud microphysical properties on environmental conditions using a synergistic approach that combines unique observations from the TRACER and ESCAPE field campaigns, machine learning techniques, and parcel model simulations with a super-droplet microphysics scheme. A random forest algorithm identifies in-situ vertical velocity (w), temperature (T), and surface fine-mode aerosol mass concentration as the three most important environmental conditions influencing cloud properties including liquid water content (LWC), number concentration for particles with D max < 50 μm (N c ,<50), 50 μm ≤ D max ≤ 3000 μm (N c,50–3000 ), and droplet effective diameter (D e ). Results show that LWC, N c,<50 , and N c,50–3000 significantly increase with w in updrafts. Across w bins, as T decreases, LWC, D e , and N c,50–3000 increase, while N c,<50 decreases, which are closely linked to the distance above cloud bases. Warmer cloud bases yield higher LWC, greater N c,50–3000 , and smaller N c,<50 , while polluted environments produce greater N c,<50 . Parcel model simulations successfully replicate these observed dependencies. The simulation results indicate that warmer cloud bases enhance condensation generating larger droplets, and differences in droplet sizes are then amplified through collision-coalescence, resulting in a greater N c,50–3000 . Polluted conditions result in a greater N c,<50 primarily due to enhanced cloud condensation nuclei activation despite increased collision-coalescence rates compared to pristine conditions. This study provides observed quantitative patterns characterizing cloud microphysical properties as a function of key environmental parameters, offering valuable constraints for improving physics parameterizations and numerical models.
The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from neutralizing antibodies through various mechanisms. Mutations that are distant from the antibody binding site can lead to escape, probably by changing the conformation or dynamics of Env; however, these changes are difficult to identify and define mechanistically. Here we describe a network analysis-based approach to identify potential allosteric immune evasion mechanisms using three known HIV-1 Env gp120 protein structures from two different clades, B and C. First, correlation and principal component analyses of molecular dynamics (MD) simulations identified a high degree of longdistance coupled motions that exist between functionally distant regions within the intrinsic dynamics of the gp120 core, supporting the presence of long-distance communication in the protein. Then, by integrating MD simulations with network theory, we identified the optimal and suboptimal communication pathways and modules within the gp120 core. The results unveil both strain-dependent and -independent characteristics of the communication pathways in gp120. We show that within the context of three structurally homologous gp120 cores, the optimal pathway for communication is sequence sensitive, i.e. a suboptimal pathway in one strain becomes the optimal pathway in another strain. Yet the identification of conserved elements within these communication pathways, termed inter-modular hotspots, could present a new opportunity for immunogen design, as this could be an additional mechanism that HIV-1 uses to shield vulnerable antibody targets in Env that induce neutralizing antibody breadth.
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41. Despite low maximum inhibition plateaus, often below 50% inhibitory concentrations, the breadth of CAP248-2B significantly correlated with donor plasma. Site-directed mutagenesis, X-ray crystallography, and negative-stain electron microscopy 3D reconstructions revealed how CAP248-2B recognizes a cleavage-dependent epitope that includes the gp120 C terminus. While this epitope is distinct, it overlapped in parts of gp41 with the epitopes of broadly neutralizing antibodies PGT151, VRC34, 35O22, 3BC315, and 10E8. CAP248-2B has a conformationally variable paratope with an unusually long 19 amino acid light chain third complementarity determining region. Two phenylalanines at the loop apex were predicted by docking and mutagenesis data to interact with the viral membrane. Neutralization by CAP248-2B is not dependent on any single glycan proximal to its epitope, and low neutralization plateaus could not be completely explained by N- or O-linked glycosylation pathway inhibitors, furin co-transfection, or pre-incubation with soluble CD4. Viral escape from CAP248-2B involved a cluster of rare mutations in the gp120-gp41 cleavage sites. Simultaneous introduction of these mutations into heterologous viruses abrogated neutralization by CAP248-2B, but enhanced neutralization sensitivity to 35O22, 4E10, and 10E8 by 10-100-fold. Altogether, this study expands the region of the HIV-1 gp120-gp41 quaternary interface that is a target for broadly neutralizing antibodies and identifies a set of mutations in the gp120 C terminus that exposes the membrane-proximal external region of gp41, with potential utility in HIV vaccine design.
Convective updrafts are one of the main characteristics of convective clouds, responsible for the convective mass flux and the redistribution of energy and condensate in the atmosphere. During the early stages of their lifecycle, convective clouds experience rapid cloud-top ascent manifested by a decrease in the geostationary IR brightness temperature (𝑇𝐵 𝐼𝑅 ). Under the assumption that the convective cloud top behaves like a black body, the ascent rate of the convective cloud top can be estimated as ($\frac{∂𝑇𝐵_{𝐼𝑅}}{∂𝑡}$), and it can be used to infer the near cloud-top convective updraft. The temporal resolution of the geostationary IR measurements and non-uniform beam-filling effects can influence the convective updraft estimation. However, the main shortcoming until today was the lack of independent verification of the strength of the convective updraft. Here, Doppler radar observations from the ESCAPE and TRACER field experiments provide independent estimates of the convective updraft velocity at higher spatiotemporal resolution throughout the convective core column and can be used to evaluate the updraft velocity estimates from the IR cooling rate for limited samples. Isolated convective cells were tracked with dedicated radar (RHIs and PPIs) scans throughout their lifecycle. Radial Doppler velocity measurements near the convective cloud top are used to provide estimates of convective updrafts. These data are compared with the geostationary IR and VIS channels (from the GOES satellite) to characterize the convection evolution and lifecycle based on cloud-top cooling rates.
We derive the escape velocity profile for an Einasto density field in an accelerating universe and demonstrate its physical viability by comparing theoretical expectations to both light-cone data generated from N -body simulations and archival data on 20 galaxy clusters. We demonstrate that the projection function ($g(\beta)$) is deemed physically viable only for the theoretical expectation that includes a cosmology-dependent term. Using simulations, we show that the inferred velocity anisotropy is more than 6σ away from the expected value for the theoretical profile that ignores the acceleration of the universe. In the archival data, we constrain the average velocity anisotropy parameter of a sample of 20 clusters to be $\beta ={0.248}_{-0.360}^{+0.164}$ at the 68% confidence level. Finally, we briefly discuss how our analytic model may be used as a novel cosmological probe based on galaxy clusters.
Galaxies represent one of the preferred candidate sources to drive the reionization of the universe. Even as gains are made in mapping the galaxy UV luminosity density to z>6, significant uncertainties remain regarding the conversion to the implied ionizing emissivity. The relevant unknowns are the Lyman-continuum (LyC) photon production efficiency ξ{sub ion} and the escape fraction f {sub esc}. As we show here, the first of these unknowns is directly measurable in z = 4–5 galaxies based on the impact the Hα line has on the observed IRAC fluxes. By computing a LyC photon production rate from the implied Hα luminosities for a broad selection of z = 4–5 galaxies and comparing this against the dust-corrected UV-continuum luminosities, we provide the first-ever direct estimates of the LyC photon production efficiency ξ{sub ion} for the z⩾4 galaxy population. We find log{sub 10} ξ{sub ion}/[Hz erg{sup −1}] to have a mean value of 25.27{sub −0.03}{sup +0.03} and 25.34{sub −0.02}{sup +0.02} for sub-L* z = 4–5 galaxies adopting Calzetti and SMC dust laws, respectively. Reassuringly, both derived values are consistent with the standard assumed ξ{sub ion}'s in reionization models, with a slight preference for higher ξ{sub ion}'s (by ∼0.1 dex) adopting the SMC dust law. High values of ξ{sub ion} (∼25.5–25.8 dex) are derived for the bluest galaxies (β<−2.3) in our samples, independent of dust law and consistent with results for a z = 7.045 galaxy. Such elevated values of ξ{sub ion} would have important consequences, indicating that f {sub esc} cannot be in excess of 13% for standard assumptions about the faint-end cut-off to the LF and the clumping factor.
We search for escaping helium from the hot super-Earth 55 Cnc e by taking high-resolution spectra of the 1083 nm line during two transits using Keck/NIRSPEC. We detect no helium absorption down to a 90% upper limit of 250 ppm in excess absorption or 0.27 mÅ in equivalent width. This corresponds to a mass-loss rate of less than ∼10{sup 9} g s{sup −1} assuming a Parker wind model with a plausible exosphere temperature of 5000–6000 K, although the precise constraint is heavily dependent on model assumptions. We consider both hydrogen- and helium-dominated atmospheric compositions and find similar bounds on the mass-loss rate in both scenarios. Our hydrodynamical models indicate that if a lightweight atmosphere exists on 55 Cnc e, our observations would have easily detected it. Together with the nondetection of Lyα absorption by Ehrenreich et al., our helium nondetection indicates that 55 Cnc e either never accreted a primordial atmosphere in the first place or lost its primordial atmosphere shortly after the dissipation of the gas disk.
One-dimensional treatment of the escape of a gas into a vacuum
Simulation operation of gemini launch escape system, showing the launch sequence and pilot role in an abort action
Inviscid supersonic flow around a hemisphere- cylinder at escape velocity is analyzed throughout the shock layer, with reference to reentry aerodynamics
Escape of helium from earth atmosphere
Theory of star escape during collision of galaxies
Effect of thermal escape on neutral hydrogen distribution in upper atmosphere
Elevator-type emergency escape system evacuates personnel from tall structures, especially when the possibility of explosion or fire exists. The system consists of a spike shaped rescue cabin which descends along a vertical guide cable, penetrates the dome shaped roof of an underground blast shelter and stops in a deceleration bed of granular material.
Flight simulated subsonic off-pad landing and escape maneuvers for vertically launched hypersonic glider - pilot performance and safety requirements
Thermal escape of neutral hydrogen and distribution in Earth thermosphere, noting collision in transition regions