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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 343 records · Page 19

All sources NASA NTRS DOE OSTI

NASA NTRS2023

Implementation of A Drone Delivery System for Healthcare in Mexico: International Precedents and Domestic Considerations

One of the Mexican healthcare system’s principal problems is providing access to its rural communities. Drone delivery has repeatedly proven to be a compelling and cost-effective solution to this problem elsewhere, yet there is currently no scholarship connecting global developments in drone technology to problems in the Mexican healthcare system. This paper is to outline lessons learned from drone systems in several countries, providing information on the potential target communities, technical drone and nest specs, goods of delivery, and regulation of a drone system for healthcare in Mexico.

Drone↗

DOE OSTI2016

Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2016

Delivery Ring Lattice Modifications for Transitionless Deceleration

A portion of the remnant Tevatron program infrastruc- ture at Fermilab is being reconfigured to be used for the generation and delivery of proton and muon beams for new high-precision particle physics experiments. With the 8 GeV Booster as its primary source, the Mu2e exper- iment will receive 8.9 GeV/c bunched beam on target, after being stored and slow spilled from the Delivery Ring (DR) -- a refurbished debuncher ring from Tevatron anti- proton production. For the Muon g-2 experiment, the DR will be tuned for 3.1 GeV/c to capture muons off of a target before sending them to this experiment's Storage Ring. The apertures in the beam transport systems are optimized for the large muon beams of this lower-energy experiment. In order to provide further flexibility in the operation of the DR for future possible low-energy, high- intensity particle physics experiments (REDTOP[1], for example) and detector development, investigations are underway into the feasibility of decelerating beams from its maximum kinetic energy of 8 GeV level to lower en- ergies, down to 1-2 GeV. In this paper we look at possi- ble lattice modifications to the DR to avoid a transition crossing during the deceleration process. Hardware re- quirements and other operational implications of this scheme will also be discussed.

43 PARTICLE ACCELERATORS↗

DOE OSTI2017

Laser beam delivery at ELI-NP

The Laser Beam Delivery (LBD) system technical design report covers the interface between the High Power Laser System (HPLS) and the experiments, together with the pulse quality management. Here, the laser transport part of the LBD has a number of subsystems as follows: the beam transport lines for the six main outputs of HPLS, the additional short and long pulses and the synchronization system including the timing of the laser pulses with the Gamma Beam System (GBS) and the experiments on femtosecond timescale. Pulse quality management, discussed further here, consist in the generation and delivery of multiple HPLS pulses, coherent combining of the HPLS arms, laser pulse diagnostics on target, laser beam dumps, shutters and output energy adaption.

42 ENGINEERING↗

DOE OSTI2019

Compositions and methods for the delivery of oxygen

H--NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H--NOX proteins comprise mutations that impart altered O.sub.2 or NO ligand-binding relative to the corresponding wild-type H--NOX domain, and are operative as physiologically compatible mammalian blood O.sub.2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H--NOX proteins for the treatment of any condition for which delivery of O.sub.2 is beneficial.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2020

Novel, Simplified Air Delivery System Design Gets Commercialized

Typical air delivery systems require contractors to design systems that are complex, difficult to integrate into the framing and structural components of a home, and often do not meet the optimization demands of newer energy-efficient homes. This complex process can be a burden to already strained construction labor costs. However, a new technology simplifies duct system design to improve comfort and eliminate sources of installation error for residential air delivery systems.

Building America↗

DOE OSTI2020

Novel, Simplified Air Delivery System Design Gets Commercialized

30 DIRECT ENERGY CONVERSION↗

DOE OSTI2022

Modelica-json: Transforming energy models to digitize the control delivery process

Building simulation models are typically not used to generate the documentation required for bidding and project delivery of commercial building systems, or for their semantic modeling and commissioning. This paper presents a software tool that aids in digitizing the control delivery process, spanning simulation during design to implementation and formal verification during commissioning. The tool can generate from Modelica models digital documentation of control sequences. This digital documentation, along with other project drawings and specifications can be used for project bidding. It can also be used for implementation of control sequences through machineto-machine translation to commercial legacy control products, for which we are currently developing the proposed ASHRAE Standard 231P based on the presented work. Moreover, as-installed control sequences can be formally verified against the design specification, and a semantic model in Brick can be exported to aid in configuration of building analytics and fault detection. The paper presents what we believe is the first translation of a Modelica-implemented control sequence to a native implementation on a commercial control platform, using the webCTRL product line from Automated Logic. The paper also shows how a webCTRL implementation can be formally verified against its Modelica specification. These use cases have all been demonstrated with a prototype implementation that is now being further developed.

Wetter, Michael↗

DOE OSTI2019

OPTIMIZATION OF INTRA-CITY FREIGHT MOVEMENT WITH NEW DELIVERY METHODS

The purpose of this study is to develop a methodology for modeling intra-city freight delivery tours using innovative modes and alternative last mile delivery scenarios to determine potential energy savings in Columbus, Ohio. This study is part of the Department of Energy (DOE)’s SMART (Systems and Modeling for Accelerated Research in Transportation) Mobility Multi-Modal Freight Pillar. It is a partnership with the Oak Ridge National Laboratory, Idaho National Laboratory, National Renewable Energy Laboratory, United Parcel Service – Columbus, Ohio, and the Mid-Ohio Regional Planning Commission.

Moore, Amy↗

DOE OSTI2023

CRITICAL FUNCTION ASSURANCE: Understanding Critical Function and Critical Function Delivery is Foundational for Meaningful ICS Security Improvement and Policy Efforts

Modern life is enabled by a complex and interdependent web of critical functions, including energy, communications, transportation, food, and water. Automation has significantly reduced or replaced human interactions in the delivery of these functions, resulting in a web of goods and services that are made available 24/7 only through unique and intentional deployments of microprocessors, software, and firmware technologies. The prospect of cyber-enabled sabotage of these processes disrupts traditional risk determination models. Critical Function Assurance (CFA) is a foundational approach to identifying, prioritizing, and mitigating the risk that is inherent in the delivery of critical functions that depend on digital technology. It provides rapid focus to what matters most and illuminates elements and areas of risk that otherwise are often overlooked. This focus enables effective application of available security resources and optimizes security strategy and policy efforts. This paper introduces CFA to decision makers and risk executives (including CEOs, COOs, CFOs, and CISOs) whose organizations support and deliver the critical functions that underpin national defense, societal health and safety, and a vibrant economy.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

DOE OSTI2017

Separable Organic Evaluation: Waste Feed Delivery Impacts - 17563

The potential for separable organic materials to separate out from Hanford tank waste requires consideration for future Waste Feed Delivery operations. Separable organic materials are organic compounds of very limited solubility in bulk waste that can form a separate phase or layer. If the organic materials bound to waste separates during mixing and transfer operations, the feed batch would be disqualified under the Hanford Tank Waste Treatment and Immobilization Plant (WTP) waste acceptance criteria for 'no visible immiscible layer.' Sample data and process history were used to identify tanks with the potential to contain separable organic materials. Centrifuge testing was performed on available archived tank samples and on waste simulants developed to mimic characteristics of the archived tank samples. A separable layer formed during centrifuge testing of archived samples 241-C-204, 241-SY-102, and for all developed simulants tested. Due to the formation of a separable organic layer during the centrifugation studies, an impact assessment was performed. This impact assessment identified forty-four potential tanks of concern regarding the release of organic material bound to solids during waste disturbing activities. A Hanford Tank Waste Operations Simulator model run was modified to trace the origin of each batch to the WTP. The outputs of the model run indicated that a separable organic layer would form during High Level Waste Feed Delivery operations and would cascade to all tanks containing or receiving significant amounts of organic solvents/diluents. Hence, there is a potential for a ripple effect across the feed batches. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2019

Unlocking the Vault - Accelerated Delivery Through the Application of Innovation and Collaboration - 19011

The Pile Fuel Cladding Silo (PFCS) at Sellafield was built in 1949/50 to receive and store fuel cladding from reprocessing of Windscale Pile fuel; it has been used to store this material and other waste from the UK nuclear programme ever since. The Silo is unsuitable for indefinite storage; this along with uncertainty in the make-up and condition of the inventory combine to rank the facility alongside the most hazardous in Western Europe. Sellafield Ltd, began working with its supply chain partners Bechtel Cavendish Nuclear Solutions (BCNS - a joint venture between Bechtel Inc and Cavendish Nuclear Ltd) in 2012, to execute a suite of projects to create an access route to the waste and a capability to retrieve waste from the silo for the first time ever. However, the challenge of providing this capability, while maintaining ongoing safe storage of the waste, and underpinning future performance of both the silo and the waste packages for many hundreds of years, proved to be too much for traditional Sellafield Ltd delivery models. With both cost and schedule forecasts doubling from initial estimates, a new approach was clearly required. The team recognised that success would require all of the experience and expertise of each organisation working together to a common goal. Therefore, significant effort was expended to build a collaborative team environment into which an innovative approach to both the engineering of what was provided and the delivery methods for doing it could be launched. Focussing on collaborative culture in which innovation and fit for purpose thinking were encouraged has completely rebuilt stakeholder confidence. The project is now almost complete; 17 months ahead of schedule and British Pounds 100 m less than the approved cost. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2024

Delivery-Risk-Aware Flexibility Scheduling and Dispatch for Aggregated Flexible Loads

Flexible loads like smart thermostats and water heaters can shift energy consumption and provide flexibility to the grid. However, this flexibility is dependent on occupant behavior and can lead to delivery risk, which causes utilities and grid operations to consider them as unreliable for purposes of grid operation. To date, they have not been well integrated into wholesale electricity markets or ancillary service offerings. With proper consideration of uncertainty and risk, these resources can be one of the most cost-effective sources of flexibility. This work uses stochastic optimization to quantify and bid flexibility from a fleet of flexible resources while considering their delivery risk.

DER↗

DOE OSTI2024

Energy storage-based packetized delivery of electricity

Systems and methods for Energy Storage-based Packetized Delivery of Electricity (ES-PDE) are disclosed that are radically different from the operation of today's grid. Using ES-PDE, the loads are powered by the energy storage systems (ESS) the majority of the time and only receive packets of electricity periodically to charge the ESSs. Therefore, the grid operators can schedule the delivery of electricity packets to utilize the existing grid infrastructure. Since the customers are powered by the co-located ESSs they are not impacted by the grid operation in short term. Therefore, when grid outages occur, the customers still have power for some time, giving the grid more time to be fully restored.

Nguyen, Tu Anh↗

DOE OSTI2024

Immolative cell-penetrating complexes for nucleic acid delivery to the lung

There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.

Blake, Tim R.↗

DOE OSTI2019

Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery

Nanomedicine is a promising, noninvasive approach to reduce atherosclerotic plaque burden. However, drug delivery is limited without the ability of nanocarriers to sense and respond to the diseased microenvironment. Here, nanomaterials are developed from peptide amphiphiles (PAs) that respond to the increased levels of matrix metalloproteinases 2 and 9 (MMP2/9) or reactive oxygen species (ROS) found within the atherosclerotic niche. A pro-resolving therapeutic, Ac2-26, derived from annexin-A1 protein, is tethered to PAs using peptide linkages that cleave in response to MMP2/9 or ROS. By adjusting the molar ratios and processing conditions, the Ac2-26 PA can be co-assembled with a PA containing an apolipoprotein A1-mimetic peptide to create a targeted, therapeutic nanofiber (ApoA1-Ac226 PA). The ApoA1-Ac2-26 PAs demonstrate release of Ac2-26 within 24 h after treatment with MMP2 or ROS. The niche-responsive ApoA1-Ac2-26 PAs are cytocompatible and reduce macrophage activation from interferon gamma and lipopolysaccharide treatment, evidenced by decreased nitric oxide production. Interestingly, the linkage chemistry of ApoA1-Ac2-26 PAs significantly affects macrophage uptake and retention. Taken together, these findings demonstrate the potential of PAs to serve as an atheroma niche-responsive nanocarrier system to modulate the inflammatory microenvironment, with implications for atherosclerosis treatment.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2023

Overcoming Barriers Associated with Oral Delivery of Differently Sized Fluorescent Core‐Shell Silica Nanoparticles

Oral delivery, while a highly desirable form of nanoparticle-drug administration, is limited by challenges associated with overcoming several biological barriers. Here, in this study, the authors study how fluorescent and poly(ethylene glycol)-coated (PEGylated) core-shell silica nanoparticles sized 5 to 50 nm interact with major barriers including intestinal mucus, intestinal epithelium, and stomach acid. From imaging fluorescence correlation spectroscopy studies using quasi-total internal reflection fluorescence microscopy, diffusion of nanoparticles through highly scattering mucus is progressively hindered above a critical hydrodynamic size around 20 nm. By studying Caco-2 cell monolayers mimicking the intestinal epithelia, it is observed that ultrasmall nanoparticles below 10 nm diameter (Cornell prime dots, [C’ dots]) show permeabilities correlated with high absorption in humans from primarily enhanced passive passage through tight junctions. Particles above 20 nm diameter exclusively show active transport through cells. After establishing C’ dot stability in artificial gastric juice, in vivo oral gavage experiments in mice demonstrate successful passage through the body followed by renal clearance without protein corona formation. Results suggest C’ dots as viable candidates for oral administration to patients with a proven pathway towards clinical translation and may generate renewed interest in examining silica as a food additive and its effects on nutrition and health.

36 MATERIALS SCIENCE↗

DOE OSTI2023

Breast tumor-targeted drug delivery via polymer nanocarriers: Endogenous and exogenous strategies

Breast cancer, one of the most common types of cancer worldwide, has a high degree of malignancy while lacking efficient treatments. The off-target events frequently occurring in drug administration have been a major obstacle, which causes severe side effects to patients and reduces the therapeutic efficacy. An ideal medication should precisely target the specific site with precise control over concentration and duration. In recent years, there has been immense progress in polymer nanocarriers that demonstrate great potential in the targeted delivery. These nanocarriers are constructed from materials sensitive to a wide range of endogenous (e.g., pH, enzyme, redox) and exogenous stimuli (e.g., light, ultrasound, magnetic waves), driving cargo release to the targeted tissue or cells. Here, we elucidate the mechanism of current targeting strategies and the engineering methods to construct these targeting systems or to improve their targeting efficiency. Here we capture the recent progress in the targeted nanocarriers derived from polymers which span hydrogels and micelles, demonstrating their design and applications in chemo, hyperthermia, immuno, and gene therapies.

36 MATERIALS SCIENCE↗