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NASA NTRS2010

DigitalHuman (DH): An Integrative Mathematical Model ofHuman Physiology

Mathematical models and simulation are important tools in discovering the key causal relationships governing physiological processes and improving medical intervention when physiological complexity is a central issue. We have developed a model of integrative human physiology called DigitalHuman (DH) consisting of -5000 variables modeling human physiology describing cardiovascular, renal, respiratory, endocrine, neural and metabolic physiology. Users can view time-dependent solutions and interactively introduce perturbations by altering numerical parameters to investigate new hypotheses. The variables, parameters and quantitative relationships as well as all other model details are described in XML text files. All aspects of the model, including the mathematical equations describing the physiological processes are written in XML open source, text-readable files. Model structure is based upon empirical data of physiological responses documented within the peer-reviewed literature. The model can be used to understand proposed physiological mechanisms and physiological interactions that may not be otherwise intUitively evident. Some of the current uses of this model include the analyses of renal control of blood pressure, the central role of the liver in creating and maintaining insulin resistance, and the mechanisms causing orthostatic hypotension in astronauts. Additionally the open source aspect of the modeling environment allows any investigator to add detailed descriptions of human physiology to test new concepts. The model accurately predicts both qualitative and more importantly quantitative changes in clinically and experimentally observed responses. DigitalHuman provides scientists a modeling environment to understand the complex interactions of integrative physiology. This research was supported by.NIH HL 51971, NSF EPSCoR, and NASA

Hester, Robert L.↗
NASA NTRS2004

Precipitation of Secondary Phases from the Dissolution of Silicate Glasses

Basaltic and anorthositic glasses were subjected to aqueous weathering conditions in the laboratory where the variables were pH, temperature, glass composition, solution composition, and time. Leached layers formed at the surfaces of glasses followed by the precipitation of X-ray amorphous iron and titanium oxides in acidic and neutral solutions at 25 C over time. Glass under oxidative hydrothermal treatments at 150 C yielded a three-layered surface; which included an outer smectite layer, a Fe-Ti oxide layer and an innermost thin leached layer. The introduction of Mg into solutions facilitated the formation of phyllosilicates. Aqueous hydrothermal treatment of anorthositic glasses (high Ca, low Ti) at 200 C readily formed smectite, whereas, the basaltic glasses (high Ti) were more resistant to alteration and smectite was not observed. Alkaline hydrothermal treatment at 2000e produced zeolites and smectites; only smectites formed at 200 C in neutral solutions. These mineralogical changes, although observed under controlled conditions, have direct applications in interpreting planetary (e.g., meteorite parent bodies) and terrestrial aqueous alteration processes.

Ming, Douglas W.↗
NASA NTRS2002

Major Effects of Nonmetallic Inclusions on the Fatigue Life of Disk Superalloy Demonstrated

The fatigue properties of modern powder metallurgy disk alloys can vary because of the different steps of materials and component processing and machining. Among these variables, the effects of nonmetallic inclusions introduced during the powder atomization and handling processes have been shown to significantly degrade low-cycle fatigue life. The levels of inclusion contamination have, therefore, been reduced to less than 1 part per million in state-of-the-art nickel disk powder-processing facilities. Yet the large quantities of compressor and turbine disks weighing from 100 to over 1000 lb have enough total volume and surface area for these rare inclusions to still be present and limit fatigue life. The objective of this study was to investigate the effects on fatigue life of these inclusions, as part of the Crack Resistant Disk Materials task within the Ultra Safe Propulsion Project. Inclusions were carefully introduced at elevated levels in a nickel-base disk superalloy, U720, produced using powder metallurgy processing. Multiple strain-controlled fatigue tests were then performed on extracted test specimens at 650 C. Analyses were performed to compare the low-cycle fatigue lives and failure initiation sites as functions of inclusion content and fatigue conditions. Powder of the nickel-base superalloy U720 was atomized in argon at Special Metals Corporation, Inc., using production-scale high-cleanliness powder-processing facilities and handling practices. The powder was then passed through a 270-mesh screen. One portion of this powder was set aside for subsequent consolidation without introduced inclusions. Two other portions of this powder were seeded with alumina inclusions. Small, polycrystalline soft (Type 2) inclusions of about 50 mm diameter were carefully prepared and blended into one powder lot, and larger hard (Type 1) inclusions of about 150 mm mean diameter were introduced into the other seeded portion of powder. All three portions of powder were then sealed in separate containers, hot isostatically pressurized, extruded, forged into subscale disks, and heat treated. Low-cycle-fatigue specimens were then extracted, machined, and tested. Fatigue tests were performed at 650 C in closed-loop servohydraulic testing machines using induction heating and axial extensometers. All tests were continued to failure, and fractographic evaluations were performed on all specimens to determine the crack initiation sites. A large majority of the failures in specimens with introduced inclusions occurred at cracks initiating from inclusions at the specimen surface, as shown for each type of inclusion in the following bar chart. The inclusions significantly reduced fatigue life from unseeded material levels, as shown in the bar chart. These effects were found to depend on the strain range, strain ratio, and inclusion size. Tests at lower strain ranges and higher strain ratios resulted in larger effects of inclusions on life. Inclusion effects on life were thereby maximized in tests at the lowest strain range of 0.6 percent and the most positive strain ratio of 0.5. Under these conditions, small Type 2 inclusions reduced life substantially-- about 20 times, whereas large Type 1 inclusions dramatically reduced life 100 times. These results clearly demonstrate that it is essential to include the effects of inclusions for realistic predictions of disk fatigue life. Important issues, including temperature dependence, crack initiation versus propagation, surface treatments, realistic disk features and machining, and realistic disk spin testing will be addressed to accurately model inclusion effects on disk fatigue life. Fatigue life varied from well over 105 cycles for no inclusions to a little over 103 cycles for 100-micrometer inclusions. A single crack initiating at a surface-connected seeded inclusion caused failure in each case.

Gabb, Timothy P.↗
NASA NTRS2023

Multiphysics Modeling of Electrode Dissolution under Hydrodynamic Conditions in Low Conductivity Water

Efficient plug-flow electrochemical reactors are characterized by their ability to effectively convert species with significant ionic strength and/or with the assistance of a well-behaved electrolyte. Because of the classic electroconductivity requirement, electrochemical reactors are not particularly attractive options for applications with low-conductivity conditions, especially for low-pressure feeds. However, these reactors can still find application in dedicated processes such as ultra-clean water conditioning and biological-coupled separation systems. Consequently, a multi-physics model was developed using COMSOL Multiphysics to characterize different reactor-design conditions based on the Tertiary Current Distribution which accounts for the effects of expected variations in electrolyte composition and ionic strength on the electrochemical process, as well as solution resistance and electrode kinetics. The modelling framework presented here employs single-phase laminar fluid flow, the Nernst-Planck equation, the water-based electroneutrality condition, and concentration-dependent overpotentials. This investigation particularly explores the electrolysis process of “anodic dissolution,” in which elemental species dissociate from the solid matrix of the electrode and enter the liquid phase of the electrolyte as soluble ions. The reactor configuration of interest has a rectangular parallel-electrode design and is operated galvanostatically. A series of parametric studies are carried out to inspect the response of the system when hydrodynamic, kinetic, and geometric conditions are changed. The parametric sweep resulted in variable effluent concentrations and system voltage, which reveal underlaying optimization patterns for electrode dissolution in low conductivity water.

Multiphysics↗
NASA NTRS1977

Thermionic converter performance with oxide collectors

Thermionic converters using a variety of metal oxide collector surfaces have been fabricated and tested. Both work function and power output data are presented and evaluated. Oxides of barium, strontium, zinc, tungsten and titanium have been incorporated into a variable spacing converter. Tungsten oxide was found to give the highest converter performance and to furnish oxygen for the emitter at the same time. Oxygenated emitters operate at reduced cesium pressure with an increase in electrode spacing. Electron spectroscopy for chemical analysis (ESCA) performed on several tungsten oxide collectors showed cesium penetration of the oxide layer, possibly forming a cesium tungstate bronze. Titanium oxide showed high performance but did not furnish oxygen for the emitter; strontium oxide, in the form of a sprayed layer, appeared to dissociate in the presence of cesium. Sprayed coatings of barium and zinc oxides produced collector work functions of about 1.3 eV, but had excessive series resistance. Lanthanum hexaboride, in combination with oxygen introduced through a silver tube, and cesium produced a low work function collector and better than average performance.

Lieb, D.↗
NASA NTRS1985

Structure-property characterization of rheocast and VADER processed IN-100 superalloy

Two recent solidification processes have been applied in the production of IN-100 nickel-base superalloy: rheocasting and vacuum arc double electrode remelting (VADER). A detailed microstructural examination has been made of the products of these two processes; associated tensile strength and fatigue crack propagation (FCP) rate at an elevated temperature were evaluated. In rheocasting, processing variables that have been evaluated include stirring speed, isothermal stirring time and volume fraction solid during isothermal stirring. VADER processed IN-100 was purchased from Special Metals Corp., New Hartford, NY. As-cast ingots were subjected to hot isostatic pressing (HIP) and heat treatment. Both rheocasting and VADER processed materials yield fine and equiaxed spherical structures, with reduced macrosegregation in comparison to ingot materials. The rheocast structures are discussed on the basis of the Vogel-Doherty-Cantor model of dendrite arm fragmentation. The rheocast ingots evaluated were superior in yield strength to both VADER and commercially cast IN-100 alloy. Rheocast and VADER ingots may have higher crack propagation resistance than P/M processed material.

Cheng, J. J. A.↗
NASA NTRS1978

Martian canyons and African rifts: Structural comparisons and implications

The resistant parts of the canyon walls of the Martian rift complex Valled Marineris were used to infer an earlier, less eroded reconstruction of the major roughs. The individual canyons were then compared with individual rifts of East Africa. When measured in units of planetary radius, Martian canyons show a distribution of lengths nearly identical to those in Africa, both for individual rifts and for compound rift systems. A common mechanism which scales with planetary radius is suggested. Martian canyons are significantly wider than African rifts. The overall pattern of the rift systems of Africa and Mars are quite different in that the African systems are composed of numerous small faults with highly variable trend. On Mars the trends are less variable; individual scarps are straighter for longer than on earth. This is probably due to the difference in tectonic histories of the two planets: the complex history of the earth and the resulting complicated basement structures influence the development of new rifts. The basement and lithosphere of Mars are inferred to be simple, reflecting a relatively inactive tectonic history prior to the formation of the canyonlands.

Frey, H. V.↗
NASA NTRS1934

Tank tests of a family of flying-boat hulls

This report presents towing tests made in the N.A.C.A. tank of a parent form and five variations of a flying-boat hull. The beams of two of the derived forms were made the same as that of the parent and the lengths changed by increasing and decreasing the spacing of stations. The lengths of the two others of the derived forms were made the same as that of the parent while the beams were changed by increasing and decreasing the spacing of buttocks, all other widths being changed in proportion. The remaining derived form has the same length and beam as the parent, but the lines of the forebody were altered to give a planing bottom with no longitudinal curvature forward of the step. The test data were analyzed to determine the minimum resistance and the angle at which it occurs for all speeds and loads. The results of this analysis are given in the form of non dimensional curves for each model. The effect of variation in over-all size, as indicated by a "complete" test on any given hull, is pointed out. The effect of changing length alone by the spacing of buttocks, as well as the effects of the changes in length-beam ratio and longitudinal curvature that result from these operations are discussed. The difficulties encountered in interpreting test results of systematic families derived by the method used are emphasized. Further studies are suggested in which changes in the variable under consideration would not be obscured by secondary changes in other important variables.

Shoemaker, James M↗
NASA NTRS1991

Design of a blade-stiffened composite panel with a hole

A procedure is developed analytically to design and produce an optimized stiffened panel with a centrally located hole. The PASCO panel-buckling analysis and sizing code is employed with the Engineering Analysis Language (EAL) code for finite-element analysis to optimize the design variables. Important design considerations are stiffener height and ply thicknesses in the skin and the stiffener laminates. The EAL code calculates the maximum strains around the hole boundary, and the resulting constraints are combined with the buckling constraint developed by the PASCO code. Cooptimization of the two codes is effected until convergence on the optimal solution is achieved. Results of the analytical procedure are experimentally verified by applying a compressive end-load to graphite-fiber laminated plates with center holes. The experimental results support the analytical procedure, and it is found that for the same weight, the soft-skin designs tested are found to have the best tolerance characteristics and resistance to failure.

Nagendra, S.↗
NASA NTRS2007

Loss-of-Control-Inhibitor Systems for Aircraft

Systems to provide improved tactile feedback to aircraft pilots are being developed to help the pilots maintain harmony between their control actions and the positions of aircraft control surfaces, thereby helping to prevent loss of control. A system of this type, denoted a loss-of-control-inhibitor system (LOCIS) can be implemented as a relatively simple addition to almost any pre-existing flight-control system. The LOCIS concept offers at least a partial solution to the problem of (1) keeping a pilot aware of the state of the control system and the aircraft and (2) maintaining sufficient control under conditions that, as described below, have been known to lead to loss of control. Current commercial aircraft exhibit uneven responses of primary flight-control surfaces to aggressive pilot control commands, leading to deterioration of pilots ability to control their aircraft. In severe cases, this phenomenon can result in loss of control and consequent loss of aircraft. For an older aircraft equipped with a purely mechanical control system, the loss of harmony between a pilot s command action and the control- surface response can be attributed to compliance in the control system (caused, for example, by stretching of control cables, flexing of push rods, or servo-valve distortion). In a newer aircraft equipped with a fly-by-wire control system, the major contributions to loss of harmony between the pilot and the control surfaces are delays attributable to computer cycle time, control shaping, filtering, aliasing, servo-valve distortion, and actuator rate limiting. In addition, a fly-by-wire control system provides no tactile feedback that would enable the pilot to sense such features of the control state as surface flutter, surface jam, position limiting, actuator rate limiting, and control limiting imposed by the aircraft operational envelope. Hence, for example, when a pilot is involved in aggressive closed-loop maneuvering, as when encountering a wake-vortex upset on final landing approach, the control-surface delay can lead to loss of control. Aggressive piloting can be triggered and exacerbated by control-system anomalies, which the pilot cannot diagnose because of the lack of symptoms caused by the absence of feedback through the controls. The purpose served by a LOCIS is to counteract these adverse effects by providing real-time feedback that notifies the pilot that the aircraft is tending to lag the pilot s commands. A LOCIS (see figure) includes cockpit control input-position sensors, control-surface output-position sensors, variable dampers (for example, shock absorbers containing magneto-rheological fluids such that the damping forces can be varied within times of the order of milliseconds by varying applied magnetic fields) attached to the cockpit control levers, electromagnet coils to apply the magnetic fields, and feedback control circuits to drive the electromagnet coils. The feedback control gains are chosen so that the current applied to each electromagnet coil results in a damping force that increases in a suitable nonlinear manner (e.g., exponentially) with the difference between the actual and commanded positions of the affected control surface. The increasing damping force both alerts the pilot to the onset of a potentially dangerous situation and resists the pilot s effort to command a control surface to change position at an excessive rate

AHarrah, Ralph C.↗
NASA NTRS2007

The Cosmic Battery Revisited

We reinvestigate the generation and accumulation of magnetic flux in optically thin accretion flows around active gravitating objects. The source of the magnetic field is the azimuthal electric current associated with the Poynting-Robertson drag on the electrons of the accreting plasma. This current generates magnetic field loops which open up because of the differential rotation of the flow. We show through simple numerical simulations that what regulates the generation and accumulation of magnetic flux near the center is the value of the plasma conductivity. Although the conductivity is usually considered to be effectively infinite for the fully ionized plasmas expected near the inner edge of accretion disks, the turbulence of those plasmas may actually render them much less conducting due to the presence of anomalous resistivity. We have discovered that if the resistivity is sufficiently high throughout the turbulent disk while it is suppressed interior to its inner edge, an interesting steady-state process is established: accretion carries and accumulates magnetic flux of one polarity inside the inner edge of the disk, whereas magnetic diffusion releases magnetic flux of the opposite polarity to large distances. In this scenario, magnetic flux of one polarity grows and accumulates at a steady rate in the region inside the inner edge and up to the point of equipartition when it becomes dynamically important. We argue that this inward growth and outward expulsion of oppositely-directed magnetic fields that we propose may account for the approx. 30 min cyclic variability observed in the galactic microquasar GRS1915+105.

Contopoulos, Ioannis↗
NASA NTRS1975

Duct wall impedance control as an advanced concept for acoustic impression

Models and tests on an acoustic duct liner system which has the property of controlled-variable acoustic impedance are described. This is achieved by a novel concept which uses the effect of steady air flow through a multi-layer, locally reacting, resonant-cavity absorber. The scope of this work was limited to a 'proof of concept.' The test of the concept was implemented by means of a small-scale, square-section flow duct facility designed specifically for acoustic measurements, with one side of the duct acoustically lined. The test liners were designed with the aid of previously established duct acoustic theory and a semi-empirical impedance model of the liner system. Over the limited range tested, the liner behaved primarily as predicted, exhibiting significant changes in resistance and reactance, thus providing the necessary concept validation.

Dean, P. D.↗
NASA NTRS2017

Improving Satellite Compatible Microdevices to Study Biology in Space

The technology for biology in space lags far behind the gold standard for biological experiments on Earth. To remedy this disparity, the Rothschild lab works on proof of concept, prototyping, and developing of new sensors and devices to further the capabilities of biology research on satellites. One such device is the PowerCell Payload System. One goal for synthetic biology in aiding space travel and colonization is to genetically engineer living cells to produce biochemicals in space. However, such farming in space presupposes bacteria retain their functionality post-launch, bombarded by radiation, and without the 1G of Earth. Our questions is, does a co-culture of cyanobacteria and protein-synthesizing bacteria produce Earth-like yields of target proteins? Is the yield sensitive to variable gravitational forces? To answer these questions, a PowerCell Payload System will spend 1 year aboard the German Aerospace Center's Euglena and Combined Regenerative Organic-food Production In Space (Eu:CROPIS) mission satellite. The PowerCell system is a pair of two 48-well microfluidic cards, each well seeded with bacteria. The system integrates fluidic, thermal, optical, electronic, and control systems to germinate bacteria spores, then measure the protein synthesized for comparison to parallel experiments conducted on the Earth. In developing the PowerCell Payload, we gained insight into the shortcomings of biology experiments on satellites. To address these issues, we have started three new prototyping projects: 1) The development of an extremely stable and radiation resistant cell-free system, allowing for the construction of proteins utilizing only cell components instead of living cells. This can be lyophilized on a substrate, like paper. (2) Using paper as a microfluidic platform that is flexible, stable, cheap, and wicking. The capillary action eliminates the need for pumps, reducing volume, mass, and potential failing points. Electrodes can be printed on the paper to sense for biochemicals. (3) Developing a modular, semi-autonomous microfluidic device that can be easily adapted for a variety of common biological experiments. This versatility will allow for quicker and cheaper experimentation. These improvements to satellite experiment platforms have the potential to radically increase the return from NASA's biological and field studies with reduced development time, mass, and cost with increased robustness data and interpretation.

biology in spac↗
NASA NTRS1986

Comparative oceanography of coastal lagoons

The hypothesis that physical lagoon characteristics and variability depend on the channel connecting the lagoon to the adjacent coastal ocean is evaluated. The geographical, hydrological, and oceanographic characteristics of 10 lagoon systems are described and analyzed; these oceanographic features are utilized to classify the lagoon systems. Choked lagoons (Laguna Joyuda, Coorong, Lake St.Lucia, Gippsland Lakes, Lake Songkla/Thale Luang/Thale Noi, and Lagoa dos Patos) are prevalent on coasts with high wave energy and low tidal range; restricted lagoons (Lake Pontchartrain and Laguna de Terminos) are located on low/medium wave energy coasts with a low tidal range; and leaky lagoons (Mississippi Sound and Belize Lagoon/Chetumal Bay) are connected to the ocean by wide tidal passes that transmit oceanic effects into the lagoon with a minimum of resistance. The data support the hypothesis that the nature of the connecting channel controls system functions.

Kjerfve, Bjorn↗
NASA NTRS2004

Reliability-Based Life Assessment of Stirling Convertor Heater Head

Onboard radioisotope power systems being developed and planned for NASA's deep-space missions require reliable design lifetimes of up to 14 yr. The structurally critical heater head of the high-efficiency Stirling power convertor has undergone extensive computational analysis of operating temperatures, stresses, and creep resistance of the thin-walled Inconel 718 bill of material. A preliminary assessment of the effect of uncertainties in the material behavior was also performed. Creep failure resistance of the thin-walled heater head could show variation due to small deviations in the manufactured thickness and in uncertainties in operating temperature and pressure. Durability prediction and reliability of the heater head are affected by these deviations from nominal design conditions. Therefore, it is important to include the effects of these uncertainties in predicting the probability of survival of the heater head under mission loads. Furthermore, it may be possible for the heater head to experience rare incidences of small temperature excursions of short duration. These rare incidences would affect the creep strain rate and, therefore, the life. This paper addresses the effects of such rare incidences on the reliability. In addition, the sensitivities of variables affecting the reliability are quantified, and guidelines developed to improve the reliability are outlined. Heater head reliability is being quantified with data from NASA Glenn Research Center's accelerated benchmark testing program.

Shah, Ashwin R.↗
NASA NTRS1990

Inducing optimally directed non-routine designs

Non-routine designs are characterized by the creation of new variables and thus an expansion of the design space. These differ from routine designs in that the latter are restricted to a fixed set of variables and thus a pre-defined design space. In previous papers, the 1stPRINCE non-routine design methodology that expands the design space in such a way that optimal trends dictate the direction and form of this expansion is described. How inductive techniques can determine these optimal trends are examined. The induction techniques in 1stPRINCE utilize constraint information from monotonicity analysis to determine how to mutate the design space. The process observes the constraint information of mutated designs and induces trends from those constraints. Application of 1stPRINCE to a beam under flexural load leads to an optimally directed tapered beam. An interesting application of 1stPRINCE to determine the optimally directed shape of a spinning square block such that resistance to spinning is minimized leads to the discovery of a circular wheel.

Cagan, Jonathan↗
NASA NTRS1944

Gas Jets

A brief summary of the contents of this paper is presented here. In part I the differential equations of the problem of a gas flow in two dimensions is derived and the particular integrals by which the problem on jets is solved are given. Use is made of the same independent variables as Molenbroek used, but it is found to be more suitable to consider other functions. The stream function and velocity potential corresponding to the problem are given in the form of series. The investigation on the convergence of these series in connection with certain properties of the functions entering them forms the subject of part II. In part III the problem of the outflow of a gas from an infinite vessel with plane walls is solved. In part IV the impact of a gas jet on a plate is considered and the limiting case where the jet expands to infinity changing into a gas flow is taken up in more detail. This also solved the equivalent problem of the resistance of a gaseous medium to the motion of a plate. Finally, in part V, an approximate method is presented that permits a simpler solution of the problem of jet flows in the case where the velocities of the gas (velocities of the particles in the gas) are not very large.

Chaplygin, S.↗
NASA NTRS1997

Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles

In the present study of rats, we examined the role, during 2 wk of hindlimb suspension, of growth hormone/insulin-like growth factor I (GH/IGF-I) administration and/or brief bouts of resistance exercise in ameliorating the loss of myonuclei in fibers of the soleus muscle that express type I myosin heavy chain. Hindlimb suspension resulted in a significant decrease in mean soleus wet weight that was attenuated either by exercise alone or by exercise plus GH/IGF-I treatment but was not attenuated by hormonal treatment alone. Both mean myonuclear number and mean fiber cross-sectional area (CSA) of fibers expressing type I myosin heavy chain decreased after 2 wk of suspension compared with control (134 vs. 162 myonuclei/mm and 917 vs. 2,076 micron2, respectively). Neither GH/IGF-I treatment nor exercise alone affected myonuclear number or fiber CSA, but the combination of exercise and growth-factor treatment attenuated the decrease in both variables. A significant correlation was found between mean myonuclear number and mean CSA across all groups. Thus GH/IGF-I administration and brief bouts of muscle loading had an interactive effect in attenuating the loss of myonuclei induced by chronic unloading.

NASA Center ARC↗