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At least 325 records · Page 18

Identifying Candidate Biomarkers of Ionizing Radiation in Human Pulmonary Microvascular Lumens Using Microfluidics—A Pilot Study

The microvasculature system is critical for the delivery and removal of key nutrients and waste products and is significantly damaged by ionizing radiation. Single-cell capillaries and microvasculature structures are the primary cause of circulatory dysfunction, one that results in morbidities leading to progressive tissue and organ failure and premature death. Identifying tissue-specific biomarkers that are predictive of the extent of tissue and organ damage will aid in developing medical countermeasures for treating individuals exposed to ionizing radiation. In this pilot study, we developed and tested a 17 µL human-derived microvascular microfluidic lumen for identifying candidate biomarkers of ionizing radiation exposure. Through mass-spectrometry-based proteomics, we detected 35 proteins that may be candidate early biomarkers of ionizing radiation exposure. This pilot study demonstrates the feasibility of using humanized microfluidic and organ-on-a-chip systems for biomarker discovery studies. A more elaborate study of sufficient statistical power is needed to identify candidate biomarkers and test medical countermeasures of ionizing radiation.

59 BASIC BIOLOGICAL SCIENCES↗

Deforestation reshapes land-surface energy-flux partitioning

Land-use and land-cover change significantly modify local land-surface characteristics and water/energy exchanges, which can lead to atmospheric circulation and regional climate changes. In particular, deforestation accounts for a large portion of global land-use changes, which transforms forests into other land cover types, such as croplands and grazing lands. Many previous efforts have focused on observing and modeling land–atmosphere–water/energy fluxes to investigate land–atmosphere coupling induced by deforestation. However, interpreting land–atmosphere–water/energy-flux responses to deforestation is often complicated by the concurrent impacts from shifts in land-surface properties versus background atmospheric forcings. In this study, we used 29 paired FLUXNET sites, to improve understanding of how deforested land surfaces drive changes in surface-energy-flux partitioning. Each paired sites included an intact forested and non-forested site that had similar background climate. We employed transfer entropy, a method based on information theory, to diagnose directional controls between coupling variables, and identify nonlinear cause–effect relationships. Transfer entropy is a powerful tool to detective causal relationships in nonlinear and asynchronous systems. The paired eddy covariance flux measurements showed consistent and strong information flows from vegetation activity (gross primary productivity (GPP)) and physical climate (e.g. shortwave radiation, air temperature) to evaporative fraction (EF) over both non-forested and forested land surfaces. More importantly, the information transfers from radiation, precipitation, and GPP to EF were significantly reduced at non-forested sites, compared to forested sites. We then applied these observationally constrained metrics as benchmarks to evaluate the Energy Exascale Earth System Model (E3SM) land model (ELM). ELM predicted vegetation controls on EF relatively well, but underpredicted climate factors on EF, indicating model deficiencies in describing the relationships between atmospheric state and surface fluxes. Moreover, changes in controls on surface energy flux partitioning due to deforestation were not detected in the model. We highlight the need for benchmarking model simulated surface-energy fluxes and the corresponding causal relationships against those of observations, to improve our understanding of model predictability on how deforestation reshapes land surface energy fluxes.

54 ENVIRONMENTAL SCIENCES↗

Cloud Overlapping Detection Algorithm Using Solar and IR Wavelengths With GOSE Data Over ARM/SGP Site

One of the most perplexing problems in satellite cloud remote sensing is the overlapping of cloud layers. Although most techniques assume a 1-layer cloud system in a given retrieval of cloud properties, many observations are affected by radiation from more than one cloud layer. As such, cloud overlap can cause errors in the retrieval of many properties including cloud height, optical depth, phase, and particle size. A variety of methods have been developed to identify overlapped clouds in a given satellite imager pixel. Baum el al. (1995) used CO2 slicing and a spatial coherence method to demonstrate a possible analysis method for nighttime detection of multilayered clouds. Jin and Rossow (1997) also used a multispectral CO2 slicing technique for a global analysis of overlapped cloud amount. Lin et al. (1999) used a combination infrared, visible, and microwave data to detect overlapped clouds over water. Recently, Baum and Spinhirne (2000) proposed 1.6 and 11 microns. bispectral threshold method. While all of these methods have made progress in solving this stubborn problem, none have yet proven satisfactory for continuous and consistent monitoring of multilayer cloud systems. It is clear that detection of overlapping clouds from passive instruments such as satellite radiometers is in an immature stage of development and requires additional research. Overlapped cloud systems also affect the retrievals of cloud properties over the ARM domains (e.g., Minnis et al 1998) and hence should identified as accurately as possible. To reach this goal, it is necessary to determine which information can be exploited for detecting multilayered clouds from operational meteorological satellite data used by ARM. This paper examines the potential information available in spectral data available on the Geostationary Operational Environmental Satellite (GOES) imager and the NOAA Advanced Very High Resolution Radiometer (AVHRR) used over the ARM SGP and NSA sites to study the capability of detecting overlapping clouds

Kawamoto, Kazuaki↗

ISS Ammonia Leak Detection Through X-Ray Fluorescence

Ammonia leaks are a significant concern for the International Space Station (ISS). The ISS has external transport lines that direct liquid ammonia to radiator panels where the ammonia is cooled and then brought back to thermal control units. These transport lines and radiator panels are subject to stress from micrometeorites and temperature variations, and have developed small leaks. The ISS can accommodate these leaks at their present rate, but if the rate increased by a factor of ten, it could potentially deplete the ammonia supply and impact the proper functioning of the ISS thermal control system, causing a serious safety risk. A proposed ISS astrophysics instrument, the Lobster X-Ray Monitor, can be used to detect and localize ISS ammonia leaks. Based on the optical design of the eye of its namesake crustacean, the Lobster detector gives simultaneously large field of view and good position resolution. The leak detection principle is that the nitrogen in the leaking ammonia will be ionized by X-rays from the Sun, and then emit its own characteristic Xray signal. The Lobster instrument, nominally facing zenith for its astrophysics observations, can be periodically pointed towards the ISS radiator panels and some sections of the transport lines to detect and localize the characteristic X-rays from the ammonia leaks. Another possibility is to use the ISS robot arm to grab the Lobster instrument and scan it across the transport lines and radiator panels. In this case the leak detection can be made more sensitive by including a focused 100-microampere electron beam to stimulate X-ray emission from the leaking nitrogen. Laboratory studies have shown that either approach can be used to locate ammonia leaks at the level of 0.1 kg/day, a threshold rate of concern for the ISS. The Lobster instrument uses two main components: (1) a microchannel plate optic (also known as a Lobster optic) that focuses the X-rays and directs them to the focal plane, and (2) a CCD (charge coupled device) focal plane detector that reads out the position and energy of the X-rays, allowing a determination of the leak location. The effective area of the detection system is approximately 2 cm(exp2) at 1 keV. The Lobster astrophysics instrument, designed for monitoring the sky for Xray transients, gives high sensitivity along with large field of view (30×30deg) and good spatial resolution (1 arc min). This offers a significant benefit for detecting ISS ammonia leaks, since the goal is to localize small leaks as efficiently as possible.

Camp, Jordan↗

Aerosol and Cloud Detection Using Machine Learning Algorithms and Space-Based Lidar Data

Clouds and aerosols play a significant role in determining the overall atmospheric radiation budget, yet remain a key uncertainty in understanding and predicting the future climate system. In addition to their impact on the Earth’s climate system, aerosols from volcanic eruptions, wildfires, man-made pollution events, and dust storms are hazardous to aviation safety and human health. Space-based lidar systems provide critical information about the vertical distributions of clouds and aerosols that greatly improve our understanding of the climate system. However, daytime data from backscatter lidars, such as the Cloud-Aerosol Transport System (CATS) on the International Space Station (ISS), must be averaged during science processing at the expense of spatial resolution to obtain sufficient signal-to-noise ratio (SNR) for accurately detecting atmospheric features. For example, 50% of all atmospheric features reported in daytime operational CATS data products require averaging to 60 km for detection. Furthermore, the single-wavelength nature of the CATS primary operation mode makes accurately typing these features challenging in complex scenes. This paper presents machine learning (ML) techniques that, when applied to CATS data, enable detection of atmospheric features during daytime operations with a horizontal resolution of 5 km compared to the 60 km horizontal resolution often required for daytime CATS data. A Convolutional Neural Network (CNN) trained using CATS standard data products also demonstrated the potential for improved cloud-aerosol discrimination compared to the operational CATS algorithms for cloud edges and complex near-surface scenes during daytime.

lidar↗

Aerosol and Cloud Detection Using Machine Learning Algorithms and Space-Based Lidar Data

Clouds and aerosols play a significant role in determining the overall atmospheric radiation budget, yet remain a key uncertainty in understanding and predicting the future climate system. In addition to their impact on the Earth’s climate system, aerosols from volcanic eruptions, wildfires, man-made pollution events and dust storms are hazardous to aviation safety and human health. Space-based lidar systems provide critical information about the vertical distributions of clouds and aerosols that greatly improve our understanding of the climate system. However, daytime data from backscatter lidars, such as the Cloud-Aerosol Transport System (CATS) on the International Space Station (ISS), must be averaged during science processing at the expense of spatial resolution to obtain sufficient signal-to-noise ratio (SNR) for accurately detecting atmospheric features. For example, 50% of all atmospheric features reported in daytime operational CATS data products require averaging to 60 km for detection. Furthermore, the single-wavelength nature of the CATS primary operation mode makes accurately typing these features challenging in complex scenes. This paper presents machine learning (ML) techniques that, when applied to CATS data, (1) increased the 1064 nm SNR by 75%, (2) increased the number of layers detected (any resolution) by 30%, and (3) enabled detection of 40% more atmospheric features during daytime operations at a horizontal resolution of 5 km compared to the 60 km horizontal resolution often required for daytime CATS operational data products. A Convolutional Neural Network (CNN) trained using CATS standard data products also demonstrated the potential for improved cloud-aerosol discrimination compared to the operational CATS algorithms for cloud edges and complex near-surface scenes during daytime.

lidar↗

Particle Acceleration and Pitch-angle Evolution in Relativistic Turbulence

Synchrotron radiation detected from relativistic astrophysical objects such as pulsar-wind nebulae and jets from active galactic nuclei depends on the magnetic fields and the distribution functions of energetic electrons in these systems. Relativistic magnetically dominated turbulence has been recognized as an efficient mechanism for structure formation and nonthermal particle acceleration in these environments. Recent numerical simulations of relativistic turbulence have provided insights into the energy distribution functions of accelerated electrons. Much less is currently understood about their pitch angle distributions, which are crucial for accurately interpreting the spectra of synchrotron radiation. We perform a detailed case study of the pitch angle distributions formed during the process of turbulent acceleration for B 0 /δB 0 = 10 and $\tilde{σ}$ 0 ~40, where B0 is the uniform component of the magnetic field, δB0 is the fluctuating component, and $\tilde{σ}$ 0 is the plasma magnetization based on the magnetic fluctuations. We find that even minimal numerical noise can cause substantial pitch angle scattering, but we demonstrate techniques for overcoming the numerical challenges associated with the evolution of very small pitch angles. Our numerical results are consistent with the phenomenological considerations found in C. Vega et al. (2024a, 2025).

79 ASTRONOMY AND ASTROPHYSICS↗

Relativistic gas accretion onto supermassive black hole binaries from inspiral through merger

Accreting supermassive black hole binaries are powerful multimessenger sources emitting both gravitational and electromagnetic (EM) radiation. Understanding the accretion dynamics of these systems and predicting their distinctive EM signals is crucial to informing and guiding upcoming efforts aimed at detecting gravitational waves produced by these binaries. To this end, accurate numerical modeling is required to describe both the spacetime and the magnetized gas around the black holes. In this paper, we present two key advances in this field of research. First, we have developed a novel 3D general relativistic magnetohydrodynamics (GRMHD) framework that combines multiple numerical codes to simulate the inspiral and merger of supermassive black hole binaries starting from realistic initial data and running all the way through merger. Throughout the evolution, we adopt a simple but functional prescription to account for gas cooling through photon emission. Next, we have applied our new computational method to follow the time evolution of a circular, equal-mass, nonspinning black hole binary for ∼200 orbits, starting from a separation of 20⁢𝑟 𝑔 and reaching the postmerger evolutionary stage of the system. We have shown how mass continues to flow toward the binary even after the binary “decouples” from its surrounding disk, but the accretion rate onto the black holes diminishes. We have identified how the minidisks orbiting each black hole are slowly drained and eventually dissolve as the binary compresses. We confirm previous findings that the system’s luminosity decreases by a factor of a few during inspiral; however, we observe an abrupt increase by ∼50% in this quantity at the time of merger, likely accompanied by an equally abrupt change in spectrum. Lastly, we have demonstrated that during the inspiral, fluid ram pressure regulates the fraction of the magnetic flux transported to the binary that attaches to the black holes’ horizons.

Accretion disk & black-hole plasma↗

Nuclear and Chemical Sciences Division: Investment Strategy 2023

The mission of the Nuclear and Chemical Sciences (NACS) Division within the Physical and Life Sciences (PLS) Directorate is to advance scientific understanding, capabilities, and technologies in nuclear and particle physics, radiochemistry, forensic science, and isotope systems to support LLNL’s national security mission. NACS Division personnel conduct a diverse range of research activities in particle physics, nuclear physics, radiation detection, nuclear measurements, chemical and nuclear forensic science, nuclear and radiochemistry, isotope geochemistry, and environmental science. These areas are leveraged to address evolving national security challenges. Scientific research provides the foundation for addressing these challenges, and it is also the principal means of attracting, training, and retaining staff scientists who can deliver solutions across the Laboratory’s mission space. The overarching strategy is to position the NACS Division at the nexus between fundamental nuclear and chemical science research and nuclear security applications. This approach will support efforts to recruit, train, and retain top-flight scientists and engineers who will play a key role in executing the Laboratory’s core nuclear security missions, while also enhancing LLNL’s reputation as a center for innovative scientific research. This document describes the strategic vision that will be used to guide key investments aimed at enabling NACS scientists to lead new efforts and meet future challenges.

07 ISOTOPE AND RADIATION SOURCES↗

Coincidence probabilities for spacecraft gravitational wave experiments - Massive coalescing binaries

Massive coalescing binary systems are candidate sources of gravitational radiation in the millihertz frequency band accessible to spacecraft Doppler tracking experiments. This paper discusses signal processing and detection probability for waves from coalescing binaries in the regime where the signal frequency increases linearly with time, i.e., 'chirp' signals. Using known noise statistics, thresholds with given false alarm probabilities are established for one- and two-spacecraft experiments. Given the threshold, the detection probability is calculated as a function of gravitational wave amplitude for both one- and two-spacecraft experiments, assuming random polarization states and under various assumptions about wave directions. This allows quantitative statements about the detection efficiency of these experiments and the utility of coincidence experiments. In particular, coincidence probabilities for two-spacecraft experiments are insensitive to the angle between the directions to the two spacecraft, indicating that near-optical experiments can be done without constraints on spacecraft trajectories.

Tinto, Massimo↗

Radiation imaging apparatus

A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

Anger, Hal O.↗

Eddy Current System for Detection of Cracking Beneath Braiding in Corrugated Metal Hose

In this paper an eddy current system for the detection of partially-through-the-thickness cracks in corrugated metal hose is presented. Design criteria based upon the geometry and conductivity of the part are developed and applied to the fabrication of a prototype inspection system. Experimental data are used to highlight the capabilities of the system and an image processing technique is presented to improve flaw detection capabilities. A case study for detection of cracking damage in a space shuttle radiator retract flex hoses is also presented.

Wincheski, Buzz↗

Low-Noise MMIC Amplifiers for 120 to 180 GHz

Three-stage monolithic millimeter-wave integrated-circuit (MMIC) amplifiers capable of providing useful amounts of gain over the frequency range from 120 to 180 GHz have been developed as prototype low-noise amplifiers (LNAs) to be incorporated into instruments for sensing cosmic microwave background radiation. There are also potential uses for such LNAs in electronic test equipment, passive millimeter- wave imaging systems, radar receivers, communication receivers, and systems for detecting hidden weapons. The main advantage afforded by these MMIC LNAs, relative to prior MMIC LNAs, is that their coverage of the 120-to-180-GHz frequency band makes them suitable for reuse in a wider variety of applications without need to redesign them. Each of these MMIC amplifiers includes InP transistors and coplanar waveguide circuitry on a 50- mthick chip (see Figure 1). Coplanar waveguide transmission lines are used for both applying DC bias and matching of input and output impedances of each transistor stage. Via holes are incorporated between top and bottom ground planes to suppress propagation of electromagnetic modes in the substrate. On the basis of computational simulations, each of these amplifiers was expected to operate with a small-signal gain of 14 dB and a noise figure of 4.3 dB. At the time of writing this article, measurements of noise figures had not been reported, but on-chip measurements had shown gains approaching their simulated values (see Figure 2).

Pukala, David↗

Three MMIC Amplifiers for the 120-to-200 GHz Frequency Band

Closely following the development reported in the immediately preceding article, three new monolithic microwave integrated circuit (MMIC) amplifiers that would operate in the 120-to-200-GHz frequency band have been designed and are under construction at this writing. The active devices in these amplifiers are InP high-electron-mobility transistors (HEMTs). These amplifiers (see figure) are denoted the LSLNA150, the LSA200, and the LSA185, respectively. Like the amplifiers reported in the immediately preceding article, the LSLNA150 (1) is intended to be a prototype of low-noise amplifiers (LNAs) to be incorporated into spaceborne instruments for sensing cosmic microwave background radiation and (2) has potential for terrestrial use in electronic test equipment, passive millimeter-wave imaging systems, radar receivers, communication receivers, and systems for detecting hidden weapons. The HEMTs in this amplifier were fabricated according to 0.08- m design rules of a commercial product line of InP HEMT MMICs at HRL Laboratories, LLC, with a gate geometry of 2 fingers, each 15 m wide. On the basis of computational simulations, this amplifier is designed to afford at least 15 dB of gain, with a noise figure of no more than about 6 dB, at frequencies from 120 to 160 GHz. The measured results of the amplifier are shown next to the chip photo, with a gain of 16 dB at 150 GHz. Noise figure work is ongoing. The LSA200 and the LSA185 are intended to be prototypes of transmitting power amplifiers for use at frequencies between about 180 and about 200 GHz. These amplifiers have also been fabricated according to rules of the aforesaid commercial product line of InP HEMT MMICs, except that the HEMTs in these amplifiers are characterized by a gate geometry of 4 fingers, each 37 m wide. The measured peak performance of the LSA200 is characterized by a gain of about 1.4 dB at a frequency of 190 GHz; the measured peak performance of the LSA185 is characterized by a gain of about 2.7 dB at a frequency of 181 GHz. The measured gain results of each chip are shown next to their respective photos.

Samoska, Lorene↗

The Far Ultraviolet M-dwarf Evolution Survey. I. The Rotational Evolution of High-energy Emissions

M-dwarf stars are prime targets for exoplanet searches because of their close proximity and favorable properties for both planet detection and characterization. However, the potential habitability and atmospheric characterization of these exoplanetary systems depends critically on the history of high-energy stellar radiation from X-rays to NUV, which drive atmospheric mass loss and photochemistry in the planetary atmospheres. With the Far Ultraviolet M-dwarf Evolution Survey, we have assessed the evolution of the FUV radiation, specifically eight prominent emission lines, including Lyα, of M-dwarf stars with stellar rotation period and age. We demonstrate tight power-law correlations between the spectroscopic FUV features, and measure the intrinsic scatter of the quiescent FUV emissions. The luminosity evolution with rotation of these spectroscopic features is well-described by a broken power law, saturated for fast rotators, and decays with increasing Rossby number, with a typical power-law slope of −2, although likely shallower for Lyα. Our regression fits enable FUV emission-line luminosity estimates relative to bolometric from known rotation periods to within ∼0.3 dex, across eight distinct UV emission lines, with possible trends in the fit parameters as a function of source layer in the stellar atmosphere. Our detailed analysis of the UV luminosity evolution with age further shows that habitable-zone planets orbiting lower-mass stars experience much greater high-energy radiative exposure relative the same planets orbiting more massive hosts. Around early- to mid-M dwarfs, these exoplanets, at field ages, accumulate up to 10–20× more EUV energy, relative to modern Earth. Moreover, the bulk of this UV exposure likely takes place within the first Gyr of the stellar lifetime.

J Sebastian Pineda↗

Yeast Strain Development and Hardware Testing in Preparation of a Lunar BioSensor

With Artemis missions underway, it is clear we are going back to the Moon to stay. Before sending Astronauts for long-duration missions, it is crucial to understand the technological and biomedical countermeasures needed to protect them before they get there. We can use knowledge gained from biological CubeSats to guide the next generation of experiments to support human habitation on the Moon. Lunar Explorer Instrument for space biology Applications (LEIA) is NASA’s latest BioSensor, adapted BioSentinel, the only CubeSat to travel Beyond Low Earth Orbit. BioSentinel launched on Artemis I and is currently >50 million kilometers from Earth (as of July 2024). LEIA aims to identify biological responses to the Lunar environment, which unprotected against would pose a threat to astronauts (cancer, cardiovascular disease, neurological impairment). The suite of instruments within LEIA detects Lunar radiation using two on-board radiation sensors (ARES charged particle detector, Mini-Fast Neutron Detector), then monitors real-time biological responses to the Lunar environment via an autonomous microfluidic system, fit with 3-LED emitter and detector boards and the alamarBlue metabolic indicator dye. LEIA will use a genetic approach in addition to synthetic biology to test counter-measure production in space, with the goal to inform and protect astronauts for future Moon missions. We have conducted preliminary tests in preparation for launch to the anticipated South Pole of the Moon, optimizing the biology (strain down-selection, desiccation tolerance, radiation sensitivity) and improving the hardware (including a blue LED to detect the beta-carotene countermeasure product). Our team will discuss these findings in several parts – an overview of the LEIA mission (Mark Settles), adapting flexible CubeSat platforms for deep-space applications (Sergio Santa Maria, Kira Rienecker), developing new technologies to support LEIA ground studies (Chinmayee Govinda Raj), and yeast strain development and hardware testing in preparation for LEIA (presented here).

synthetic biology↗

Interpretation of epsilon Aurigae. II - Infrared excess, secondary light variations, and plausible formation of a planetary system

Infrared excess based on the disk model proposed in a previous paper was computed. It was found that the disk alone will emit infrared radiation below the margin of detection. However, if individual condensations are present, the combined result of the disk proper and the condensations yields results of infrared excesses that are consistent with observations. The presence of condensations also makes the secondary light variation understandable. An elementary theory is developed that analyzes such light variations. The result of the analysis yields the size of the orbit of the condensation around the secondary component.

Huang, S.-S.↗

Remote Pulsed Laser Raman Spectroscopy System for Detecting Qater, Ice, and Hydrous Minerals

For exploration of planetary surfaces, detection of water and ice is of great interest in supporting existence of life on other planets. Therefore, a remote Raman spectroscopy system was demonstrated at NASA Langley Research Center in collaboration with University of Hawaii for detecting ice-water and hydrous minerals on planetary surfaces. In this study, a 532 nm pulsed laser is utilized as an excitation source to allow detection in high background radiation conditions. The Raman scattered signal is collected by a 4-inch telescope positioned in front of a spectrograph. The Raman spectrum is analyzed using a spectrograph equipped with a holographic super notch filter to eliminate Rayleigh scattering, and a holographic transmission grating that simultaneously disperses two spectral tracks onto the detector for higher spectral range. To view the spectrum, the spectrograph is coupled to an intensified charge-coupled device (ICCD), which allows detection of very weak Stokes line. The ICCD is operated in gated mode to further suppress effects from background radiation and long-lived fluorescence. The sample is placed at 5.6 m from the telescope, and the laser is mounted on the telescope in a coaxial geometry to achieve maximum performance. The system was calibrated using the spectral lines of a Neon lamp source. To evaluate the system, Raman standard samples such as calcite, naphthalene, acetone, and isopropyl alcohol were analyzed. The Raman evaluation technique was used to analyze water, ice and other hydrous minerals and results from these species are presented.

Garcia, Christopher S.↗