Stress for a stressed out heart: Classic cardiac PET findings in takotsubo cardiomyopathy
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We report that field theories place one or more degrees of freedom at every point in space. Hilbert spaces describing quantum field theories, or their finite-dimensional discretizations on lattices, therefore have large amounts of structure: they are isomorphic to the tensor product of a smaller Hilbert space for each lattice site or point in space. Local field theories respecting this structure have interactions which preferentially couple nearby points. The emergence of classicality through decoherence relies on this framework of tensor-product decomposition and local interactions. We explore the emergence of such lattice structure from Hilbert-space considerations alone. We point out that the vast majority of finite-dimensional Hilbert spaces cannot be isomorphic to the tensor product of Hilbert-space subfactors that describes a lattice theory. A generic Hilbert space can only be split into a direct sum corresponding to a basis of state vectors spanning the Hilbert space, we consider setups in which the direct sum is naturally decomposed into two pieces. We define a notion of direct-sum locality which characterizes states and decompositions compatible with Hamiltonian time evolution. Finally, we illustrate these notions for a toy model that is the finite-dimensional discretization of the quantum-mechanical double-well potential. We discuss their relevance in cosmology and field theory, especially for theories which describe a landscape of vacua with different spacetime geometries.
We propose a new class of method for solving nonlinear systems of equations, which, among other things, has four nice features: (i) it is inspired by the mathematical property of damped oscillators, (ii) it can be regarded as a simple extension to the Newton-Raphson (NR) method, (iii) it has the same local convergence as the NR method does, (iv) it has a significantly wider convergence region or the global convergence than that of the NR method. In this article, we present the evidence of these properties, applying our new method to some examples and comparing it with the NR method.
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Rapid compression machines (RCMs) are widely used to investigate gas phase reaction kinetics of various kind of fuels at application relevant conditions. In principle, the operation of an RCM is based on the idea of compressing a homogenous pre-mixed fuel-air mixture by a piston. Usually creviced pistons ensure a homogenous adiabatic core in the center of the reaction chamber which permits the assumption of an isentropic relation between the measured pressure and gas temperature. Despite the ideal core gas compression, non-ideal effects such as heat loss, differences in the compression behavior, and ultimately non-standardized design and operation of rapid compression machines lead to different experimental results in different facilities at nominally the same end of compression conditions. In this study ignition delay times of ethanol are investigated at four different conditions in five independent RCMs. As expected, the raw results of the different facilities indeed show notable differences at the same end of compression conditions. However, according to the adiabatic core hypothesis the agreement between kinetic simulations and experiments should be consistent for all facilities provided that the facility effects are correctly accounted for. To elaborate upon this hypothesis, a kinetic mechanism is optimized to reflect the experimental results of all facilities. In the end, the optimized mechanism predicts all experimental data within the expected uncertainty. This confirms the reliability of RCM experiments for kinetic investigations and the validity of the effective volume approach in simulating RCM data.
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Urban heat island (UHI) could have significant impact on building energy consumption by increasing space cooling demand and decreasing space heating demand. However, the impact of UHI on building energy use was understudied due to challenges associated with defining UHI-induced temperature change and evaluating building energy use. In this paper, we reviewed the existing literature to understand the quantitative impact of UHI on building energy, which is represented by the difference in energy consumption of a representative building in urban and rural areas. The previous studies found that UHI could result in a median increase of 19.0% in cooling energy consumption and a median decrease of 18.7% in heating energy consumption. Moreover, the reported UHI impact showed strong spatial variation within and among cities; the impact on cooling energy use ranges between 10% and 120% while the impact on heating ranges between 3% and 45%. Building on the previous studies, the future research could extend the study of UHI impact in four ways: 1) exploring the spatial pattern of the UHI impact within a city by considering the intra-city variation of UHI intensity and building characteristics; 2) investigating the inter-city variation of the UHI impact and the influence of different characteristics such as geographical location, city size, and development stage; 3) expanding studies in developing countries where rapid urbanization is expected in the next few decades; and 4) projecting UHI impact with future patterns of urbanization and climate change.
Many U.S. cities are implementing policies to reduce greenhouse gas (GHG) emissions of their buildings. These range from building energy benchmarking and disclosure to building performance standards (BPS) that require buildings to meet specific targets of energy use or emissions. The City of Seattle adopted a climate action plan in 2013 that set a goal of zero net GHG emissions in the road transportation, buildings, and waste sectors by 2050, with a number of near and long term actions. Seattle implemented mandatory building tune-ups in 2016, applying to commercial buildings larger than 50,000 sqft. Building tune-ups1 involve assessment and implementation of operational and maintenance (O + M) improvements to achieve energy and water efficiency, such as changes to thermostat set points or adjusting lighting or irrigation schedules. Seattle's tune-ups program covered 27 such improvements in HVAC, lighting, domestic hot water, and envelope systems.
Highlights: • Heat health-related Google search term frequency increased during heatwave events. • Google data correlated well with validated syndromic heat health indicators. • A similar timeliness was seen between daily Google and syndromic data in England. • Google search data could be of benefit in monitoring heat-related morbidity. One of the implications of climate change is a predicted increase in frequent and severe heatwaves. The impact of heatwaves on the health of the population is captured through real-time syndromic healthcare surveillance systems monitored daily in England during the summer months. Internet search data could potentially provide improved timeliness and help to assess the wider population health impact of heat by capturing a population sub-group who are symptomatic but do not seek healthcare. A retrospective observational study was carried out from June 2013 to September 2017 in England to compare daily trends in validated syndromic surveillance heat-related morbidity indicators against symptom-based heatwave related Google search terms. The degree of correlation was determined with Spearman correlation coefficients and lag assessment was carried out to determine timeliness. Daily increases in frequency in Google search terms during heatwave events correlated well with validated syndromic indicators. Correlation coefficients between search term frequency and syndromic indicators from 2013 to 2017 were highest with the telehealth service NHS 111 (range of 0.684–0.900 by search term). Lag analysis revealed a similar timeliness between the data sources, suggesting Google data did not provide a delayed or earlier signal in the context of England's syndromic surveillance systems. This work highlights the potential benefits for countries which lack established public health surveillance systems to monitor heat-related morbidity and the use of internet search data to assess the wider population health impact of exposure to heat.
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To prospectively determine whether multiparametric magnetic resonance imaging (mpMRI)–based staging is a more accurate independent predictor of outcome than traditional clinical variables for patients undergoing brachytherapy and external beam radiation therapy.
In the search for a sustainable approach for software ecosystems that supports experimental and observational science (EOS) across Oak Ridge National Laboratory (ORNL), we conducted a survey to understand the current and future landscape of EOS software and data. This paper describes the survey design we used to identify significant areas of interest, gaps, and potential opportunities, followed by a discussion on the obtained responses. The survey formulates questions about project demographics, technical approach, and skills required for the present and the next five years. Here, the study was conducted among 38 ORNL participants between June and July of 2021 and followed the required guidelines for human subjects training. We plan to use the collected information to help guide a vision for sustainable, community-based, and reusable scientific software ecosystems that need to adapt effectively to: (i) the evolving landscape of heterogeneous hardware in the next generation of instruments and computing (e.g. edge, distributed, accelerators), and (ii) data management requirements for data-driven science using artificial intelligence.
Here we report the automatic detection of 11 transients (7 possible supernovae and 4 active galactic nuclei candidates) within the Zwicky Transient Facility fourth data release (ZTF DR4), all of them observed in 2018 and absent from public catalogs. Among these, three were not part of the ZTF alert stream. Our transient mining strategy employs 41 physically motivated features extracted from both real light curves and four simulated light curve models (SN Ia, SN II, TDE, SLSN-I). These features are input to a k-D tree algorithm, from which we calculate the 15 nearest neighbors. After pre-processing and selection cuts, our dataset contained approximately a million objects among which we visually inspected the 105 closest neighbors from seven of our brightest, most well-sampled simulations, comprising 89 unique ZTF DR4 sources. Our result illustrates the potential of coherently incorporating domain knowledge and automatic learning algorithms, which is one of the guiding principles directing the SNAD team. It also demonstrates that the ZTF DR is a suitable testing ground for data mining algorithms aiming to prepare for the next generation of astronomical data.
The Born-Oppenheimer potentials for QCD with light quarks include adjoint-hadron potentials that are repulsive at short distances and heavy-hadron-pair potentials that approach thresholds at large distances. The adjoint-hadron potentials must connect smoothly to the heavy-hadron-pair potentials at intermediate distances. We identify exotic hidden-heavy hadrons as bound states and resonances in adjoint-hadron potentials that cross below a heavy-hadron-pair threshold before approaching it. This explains why many exotic hidden-charm and hidden-bottom hadrons have energies near heavy-hadron-pair thresholds. The remarkable properties of some exotic hidden-heavy mesons can be explained by fine tunings of adjoint-meson energies in QCD.