SEARCH · Engineering Papers
Results for “PrIMe”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Towards the $C^{p^\prime}$-Regularity Conjecture in Higher Dimensions
Not Available
Grid-Forming Wind: Getting Ready for Prime Time With and Without Inverters
Variable wind power is one of the fastest-growing energy-generation technologies, harnessing the energy of wind, both on land and at sea. During the past decade, the global share of wind power has grown tremendously, and wind power is evolving into a major contributor to electricity supplies in many countries. In this journey, wind is also becoming a source of reliability services to the grid, which has required grid-supporting functions originally provided by synchronous generators, enabling very high levels of instantaneous penetration (ranging from 60 to 70% in some power systems). To get beyond this, a fundamental shift is required to address challenges associated with the transition to a grid with only a few remaining (or even without any) conventional synchronous generators while achieving a minimum acceptable level of stability.
Photovoltaic System Fault Detection and Diagnostics using Laterally Primed Adaptive Resonance Theory Neural Network.
Abstract not provided.
Prime focus wide-field corrector designs with lossless atmospheric dispersion correction
Wide-Field Corrector designs are presented for the Blanco and Mayall telescopes, the CFHT and the AAT. The designs are Terezibh-style, with 5 or 6 lenses, and modest negative optical power. They have 2.2-3 degree fields of view, with curved and telecentric focal surfaces suitable for fiber spectroscopy. Some variants also allow wide-field imaging, by changing the last WFC element. Apart from the adaptation of the Terebizh design for spectroscopy, the key feature is a new concept for a 'Compensating Lateral Atmospheric Dispersion Corrector', with two of the lenses being movable laterally by small amounts. This provides excellent atmospheric dispersion correction, without any additional surfaces or absorption. A novel and simple mechanism for providing the required lens motions is proposed, which requires just 3 linear actuators for each of the two moving lenses.
Redox priming promotes Aurora A activation during mitosis
Explore the source record for details and available documents.
Erratum for Smith et al., Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8 + T Cells
Volume 7, no. 3, doi:10.1128/mBio.00473-16, 2016. For transparency, the legend to Fig. 7 has been revised to include additional information that was inadvertently omitted. Below is the corrected version.
PRIME: Protein Representation Inference for Mutation Evaluation
Protein language machine learning models built upon existing ESM-2 model developed by Evolutionary Scale (evolutionaryscale.ai) and an in-house protein language model based on the BERT model developed by Google. The code also includes model training scripts and saved checkpoints from our own training using publicly available SARS-CoV-2 protein sequences.
Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets—the V2 apex and fusion peptide (FP). Selection criteria included i) high expression and ii) infectious function, so that trimer neutralization sensitivity can be profiled in pseudovirus (PV) assays. Initially, we boosted the expression of 17 candidate trimers by truncating gp41 and introducing a gp120-gp41 SOS disulfide to prevent gp120 shedding. "Repairs" were made to fill glycan holes and eliminate other strain-specific aberrations. A new neutralization assay allowed PV infection when our standard assay was insufficient. Trimers with exposed V3 loops, a target of non-NAbs, were discarded. To try to increase V2-sensitivity, we removed clashing glycans and modified the C-strand. Notably, a D167N mutation improved V2-sensitivity in several cases. Glycopeptide analysis of JR-FL trimers revealed near complete sequon occupation and that filling the N197 glycan hole was well-tolerated. In contrast, sequon optimization and inserting/removing glycans at other positions frequently had global "ripple" effects on glycan maturation and sequon occupation throughout the gp120 outer domain and gp41. V2 MAb CH01 selectively bound to trimers with small high mannose glycans near the base of the V1 loop, thereby avoiding clashes. Knocking in a rare N49 glycan was found to perturb gp41 glycans, increasing FP NAb sensitivity—and sometimes improving expression. Finally, a biophysical analysis of VLPs revealed that i) ~25% of particles bear Env spikes, ii) spontaneous particle budding is high and only increases 4-fold upon Gag transfection, and iii) Env+ particles express ~30–40 spikes. Taken together, we identified 7 diverse trimers with a range of sensitivities to two targets to allow rigorous testing of immunofocusing vaccine concepts.
SPE-4-prime Calculations on Sympathetic detonation and Preliminary Confinement [Slides]
Peak pressure is very low compared with input pressures that lead to detonation in most explosives (> 100 MPa). As an illustration, Gibbs and Popolato data for PETN at density 1.4 g/cc shows a 500 MPa shock transits to detonation only after a run distance of > 10 mm. The above data are consistent with the RP-83 design - the PETN in the detonator gets a real whack from the EBW to achieve prompt initiation. 500 MPa is 5 kilobar, which is a low pressure in the shock initiation arena. The 4 MPa input pressure is 0.04 kilobar, which is very low. After traveling through the intervening geologic media, the pressure will arrive as a ramp rather than a shock, which is much less effective at initiating explosives. In fact, a compression wave may desensitize the explosive. The most sensitive HE, the PETN in the detonator, is shielded by the mass of ANFO and the pentolite boosters, and so the pressure input to the detonator will be significantly less than that experienced by the ANFO. An additional factor is that the abandoned charge was thermally compromised, and the effect of the somewhat elevated temperature on the PETN and the SHANFO is most likely to desensitize them. This has been observed at LLNL with PETN, and the manufacturer of the SHANFO is the source of the information on its response to temperature. The only possibility posited by one of us is failure of the geologic media resulting in a puncture / perforation of the SHANFO charge. If sufficient shear energy were put into this charge, it could conceivably initiate. This is difficult to quantify and seems like a remote possibility, and at any rate is outside the expected behavior of the geologic media as I understand the problem. Information on the effect of temperature on SHANFO is in the enclosed report that analyzes the failure of SPE 4. I think there are additional possibilities that were not evaluated in the report, but it does provide some useful data on SHANFO sensitivity at elevated temperatures. I don't know if you have seen it, so I enclose a copy. PETN (Jon L. Maienschein, PhD Director, LLNL Energetic Materials Center)
PLUG REMOVAL INSPECTION AND MEASUREMENT EQUIPMENT (PRIME) PERFORMANCE CRITERIA FOR SIMULATED PIPELINE PLUGS FOR WTP PROCESS PIPING: A FOCUSED SURVEY OF LITERATURE AND KNOWLEDGEABLE PERSONNEL
Explore the source record for details and available documents.
Genetic Analysis of Ca 2+ Priming in Arabidopsis Guard Cell Stomatal Closure in Response to the Drought Hormone Abscisic Acid
A primary objective of modern agriculture and biofuel production is to utilize arable land to its fullest potential. However, sub-optimal growing conditions—arising from abiotic stresses such as drought, soil salinity, low humidity, cold, and heat—reduce crop yield and quality. Optimal yield under both stressed and non-stressed conditions requires the plant to activate coping mechanisms at a level commensurate with the severity of the drought stress. The osmotic sensors and associated regulatory mechanisms that initiate drought- and salt-tolerance responses in plants are largely unknown. This research aimed to identify and characterize these initial sensory components.
Correlative Microscopy of Alpha Prime Precipitation in Neutron-Irradiated Fe-Cr-Al Alloys
Fe-Cr-Al alloys are currently being considered for accident tolerant light water reactor fuel cladding applications due to their superior high temperature oxidation and corrosion resistance compared to Zr-based alloys. This work represents the current state-of-the-art on both techniques for analysis of α' precipitate microstructures and the processes and mechanisms governing its formation in neutron-irradiated Fe-Cr-Al alloys.