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At least 325 records · Page 18

Water Dynamics in Cancer Cells: Lessons from Quasielastic Neutron Scattering

The severity of the cancer statistics around the globe and the complexity involving the behavior of cancer cells inevitably calls for contributions from multidisciplinary areas of research. As such, materials science became a powerful asset to support biological research in comprehending the macro and microscopic behavior of cancer cells and untangling factors that may contribute to their progression or remission. The contributions of cellular water dynamics in this process have always been debated and, in recent years, experimental works performed with Quasielastic neutron scattering (QENS) brought new perspectives to these discussions. In this review, we address these works and highlight the value of QENS in comprehending the role played by water molecules in tumor cells and their response to external agents, particularly chemotherapy drugs. In addition, this paper provides an overview of QENS intended for scientists with different backgrounds and comments on the possibilities to be explored with the next-generation spectrometers under construction.

60 APPLIED LIFE SCIENCES↗

Observation and Modeling of Dynamic Fracture Behaviors of Battery Cell Under Impact Loading Using Enhanced Representative Volume Element Concept

The burgeoning electric automobile industry has increased interest in battery safety. Battery cells experience significant mechanical stress during operation, including the impact of accidents and vibrations from driving. The potential for thermal runaway reactions in battery cells raises safety concerns. Although numerous researchers have defined the dynamic behavior of battery cells and proposed numerical models to describe it, few studies have focused on the high-strain rate mechanical impact phase correlated with the onset of fracture. In this study, we describe the dynamic behavior of pouch battery cells and propose a modeling method to study their mechanical failure under impact situations. Impact tests are conducted at various velocities and heights. To overcome numerical issues commonly encountered under rapid deformation scenarios, a new finite element model is developed based on the representative volume element model. The proposed approach efficiently simulates continuous crack propagation and brittleness behavior during impact by permitting the individual behavior of the cell components. Therefore, engineers can reliably design safer electric vehicle battery cells by measuring the properties of the cell components.

ENERGY STORAGE↗

Evaluation of HVAC & refrigeration system fault behaviors and impacts: A systematic review

Achieving the goals of green buildings critically depends on the fault-free operation of heating, ventilation and air conditioning and refrigeration (HVAC&R) systems. However, faults frequently occur in these systems, causing a range of negative consequences, including increased energy consumption, diminished operational performance, compromised indoor environmental quality, higher operational costs, and shortened system lifespan. The evaluation of fault behaviors and impacts plays a critical role in revealing fault characteristics and consequently supports many research areas, including the design of the high-performance equipment, development of fault detection and diagnostics (FDD) and robust control approaches, as well as the enhancement of maintenance decision-making activities. This paper systematically reviews 112 research publications that reported the analysis and evaluation of fault behaviors and impacts in HVAC&R systems over the past thirty years. Here, we designed a review approach to address five crucial research questions, namely: 1) the objectives of analysis and evaluation of fault behaviors and impacts, 2) data sources, 3) equipment/system types and fault types, 4) evaluation methods including evaluation measures and associated metrics, and 5) challenges and future directions in the research on evaluating of fault behaviors and impacts. In-depth discussions on these questions help bridge the gap between the evaluation of fault behaviors and impacts and their practical applications, such as the development of high-performance systems, fault models, FDD methods, and maintenance decision-making tools within the HVAC&R FDD domain.

Chen, Yimin [Oak Ridge National Laboratory (ORNL),↗

2006 Greater Triangle Household Travel Survey

The Greater Triangle Household Travel Survey was a comprehensive study of travel behavior throughout the 12-county Research Triangle Region, including all portions of Chatham, Durham, Franklin, Granville, Johnston, Lee, Orange, Person, Wake, and Vance counties, the eastern portion of Harnett County, and the southern portion of Nash County. The primary objective of this survey effort was to document demographic and travel behavior characteristics of regional travelers in order to update the current regional model and to develop a new, more robust travel demand model for the 12-county region. The 2006 survey was conducted in association with NuStats' DataSource and Louis Berger Group and was sponsored by the Capital Area Metropolitan Planning Organization, the Durham-Chapel Hill-Carrboro Metropolitan Planning Organization, the Triangle Transit Authority, and the North Carolina Department of Transportation. The project was conducted over an eleven-month period from August 2005 through June 2006. The survey utilized standard household travel survey methods, in which all household members from 5,107 households were asked to record all trips for a specified 24-hour period using a specially designed travel log on a non-holiday weekday.

1Hz data↗

Behavioral Health Program Element

The project goal is to develop behavioral health prevention and maintenance system for continued crew health, safety, and performance for exploration missions. The basic scope includes a) Operationally-relevant research related to clinical cognitive and behavioral health of crewmembers; b) Ground-based studies using analog environments (Antarctic, NEEMO, simulations, and other testbeds; c) ISS studies (ISSMP) focusing on operational issues related to behavioral health outcomes and standards; d) Technology development activities for monitoring and diagnostic tools; and e) Cross-disciplinary research (e.g., human factors and habitability research, skeletal muscle, radiation).

Leveton, Lauren B.↗

Effect of Boundary-Layer Bleed Hole Inclination Angle and Scaling on Flow Coefficient Behavior

Phase II data results of the Fundamental Inlet Bleed Experiments study at NASA Glenn Research Center are presented which include flow coefficient behavior for 21 bleed hole configurations. The bleed configurations are all round holes with hole diameters ranging from 0.795 to 6.35 mm, hole inclination angles from 20deg to 90deg, and thickness-to-diameter ratios from 0.25 to 2.0. All configurations were tested at a unit Reynolds number of 2.46 10(exp 7)/m and at discrete local Mach numbers of 1.33, 1.62, 1.98, 2.46, and 2.92. Interactions between the design parameters of hole diameter, hole inclination angle, and thickness-to-diameter as well as the interactions between the flow parameters of pressure ratio and Mach number upon the flow coefficient are examined, and a preliminary statistical model is proposed. An existing correlation is also examined with respect to this data.

Eichorn, Michael B.↗

Deformation mechanisms of NiAl cyclicly deformed near the brittle-to-ductile transformation temperature

One of the ongoing challenges of the aerospace industry is to develop more efficient turbine engines. Greater efficiency entails reduced specific strength and larger temperature gradients, the latter of which means higher operating temperatures and increased thermal conductivity. Continued development of nickel-based superalloys has provided steady increases in engine efficiency and the limits of superalloys have probably not been realized. However, other material systems are under intense investigation for possible use in high temperature engines. Ceramic, intermetallic, and various composite systems are being explored in an effort to exploit the much higher melting temperatures of these systems. NiAl is considered a potential alternative to conventional superalloys due to its excellent oxidation resistance, low density, and high melting temperature. The fact that NiAl is the most common coating for current superalloy turbine blades is a tribute to its oxidation resistance. Its density is one-third that of typical superalloys and in most temperature ranges its thermal conductivity is twice that of common superalloys. Despite these many advantages, NiAl requires more investigation before it is ready to be used in engines. Binary NiAl in general has poor high-temperature strength and low-temperature ductility. On-going research in alloy design continues to make improvements in the high-temperature strength of NiAl. The factors controlling low temperature ductility have been identified in the last few years. Small, but reproducible ductility can now be achieved at room temperature through careful control of chemical purity and processing. But the mechanisms controlling the transition from brittle to ductile behavior are not fully understood. Research in the area of fatigue deformation can aid the development of the NiAl system in two ways. Fatigue properties must be documented and optimized before NiAl can be applied to engineering systems. More importantly though, probing the deformation mechanisms operating in fatigue will lead to a better understanding of NiAl's unique characteristics. Low cycle fatigue properties have been reported on binary NiAl in the past year, yet those studies were limited to two temperature ranges: room temperature and near 1000 K. Eventually, fatigue property data will be needed for a wide range of temperatures and compositions. The intermediate temperature range near the brittle-to-ductile transition was chosen for this study to ascertain whether the sharp change occurring in monotonic behavior also occurs under cyclic conditions. An effort was made to characterize the dislocation structures which evolved during fatigue testing and comment on their role in the deformation process.

Antolovich, Stephen D.↗

Designing Nuclear Fuels with a Multi-Principal Element Alloying Approach

Previous research has shown that multi-principal element alloys (MPEAs) using chromium, molybdenum, niobium, tantalum, titanium, vanadium, and zirconium can form stable body-centered-cubic (BCC) structures across a large temperature region (25°C to 1000°C). This is the same crystal structure as γ-uranium (U), which has shown desirable thermal and irradiation behavior in previous alloy fuel research. It is hypothesized then that the MPEA alloying approach can be used to produce a stable BCC uranium-bearing alloy and to retain its stability throughout anticipated operating regimes of power-producing reactors. Candidate elements were assessed using Monte Carlo N-Particle (MCNP) analysis to determine uranium densities necessary to make the alloy an economically viable fuel compared to conventional fuel forms. Following neutronic considerations, materials property databases and empirical predictors were used to determine the compositions with a high potential to form a BCC solid solution alloy. The final four alloys were MoNbTaU 2 , MoNbTiU 2 , NbTaTiU 2 , and NbTaVU 2 , which were cast using arc melting of raw elemental foils and chunks. Characterization of the fabricated alloys included scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and transmission electron microscopy. The results showed a two-phase system with a U-rich matrix phase surrounding the refractory precipitates. The U phase was found to contain varying concentrations of the alloying elements and was a BCC γ-U phase. These results warrant further research to identify ideal compositions for use as an advanced alloy fuel.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

An operational approach to long-duration mission behavioral health and performance factors

NASA's participation in nearly 10 yr of long-duration mission (LDM) training and flight confirms that these missions remain a difficult challenge for astronauts and their medical care providers. The role of the astronaut's crew surgeon is to maximize the astronaut's health throughout all phases of the LDM: preflight, in flight, and postflight. In support of the crew surgeon, the NASA-Johnson Space Center Behavioral Health and Performance Group (JSC-BHPG) has focused on four key factors that can reduce the astronaut's behavioral health and performance. These factors are defined as: sleep and circadian factors; behavioral health factors; psychological adaptation factors; and human-to-system interface (the interface between the astronaut and the mission workplace) factors. Both the crew surgeon and the JSC-BHPG must earn the crewmember's trust preflight to encourage problem identification and problem solving in these four areas. Once on orbit, the crew medical officer becomes a valuable extension of the crew surgeon and BHPG on the ground due to the crew medical officer's constant interaction with crewmembers and preflight training in these four factors. However, the crew surgeon, BHPG, and the crew medical officer need tools that will help predict, prevent, monitor, and respond to developing problems. Objective data become essential when difficult mission termination decisions must be made. The need for behavioral health and performance tool development creates an environment rich for collaboration between operational healthcare providers and researchers. These tools are also a necessary step to safely complete future, more autonomous exploration-class space missions.

Review↗

Multi-Modal Characterization of Nuclear Fuels and Materials at the Idaho National Laboratory Materials & Fuels Complex

The Idaho National Laboratory (INL) leads cutting-edge research pertaining to the advancement of nuclear reactor technologies, including nuclear fuels and materials. The INL Irradiated Materials Characterization Laboratory (IMCL), Electron Microscopy Laboratory (EML), and future Sample Preparation Laboratory (SPL) are available to the nuclear research community to assess the behavior of nuclear fuels and materials, efficiently and comprehensively characterizing from the engineering to atomistic scale. The IMCL is a unique, 12,000-square-foot facility located at the INL Materials and Fuels Complex designed for analysis of irradiated materials. The facility operates advanced characterization instruments that are sensitive to vibration, temperature, and electromagnetic interference in modular radiological shielding and confinement systems, granting researchers the ability to assess the microstructural, chemical, mechanical and thermophysical properties of nuclear materials, especially irradiated fuels. The EML is dedicated to advanced characterization of materials with optical and electron microscopy tools, including scanning electron microscopy/focused-ion beam (SEM/FIB) and transmission electron microscopy (TEM). Upon construction, the SPL will be a 3 story, 49,000 sq. ft facility, that is the most modern reactor structural materials testing and analysis facility in the world, designed to investigate reactor structural materials in support of life-extension programs and development of advanced reactor concepts, including mechanical testing and advanced characterization capabilities. This presentation will showcase some of the main capabilities available at both IMCL, EML, and SPL, specifically illustrating how these characterization techniques are incorporated into multi-modal characterization work scopes to elucidate the degradation of nuclear structural materials and irradiated fuels.

36 MATERIALS SCIENCE↗

Combustion of Gaseous Fuels Under Reduced-Gravity Conditions

The need for an improved understanding of fires is becoming critically important with increased space travel and utilization. While the control of fires in low-gravity environments is not well understood, it is known that buoyancy significantly affects flame behavior and characteristics. The objective of this research is to gain a more fundamental understanding of fires, and to quantify flame behavior under reduced-gravity levels. Non-premixed flames of gaseous fuels are considered in this study because they are relatively simple and easy to control, yet embody mechanisms found in all types of combustion processes ranging from uncontrolled fires to practical combustion systems. This paper presents some recent results from microgravity studies of these flames. In addition, the potential usefulness of lunar- and Martian-based laboratories is discussed in order to understand the characteristics and behavior of fires in reduced-gravity environments.

Bahadori, M. Yousef↗

Parameter-Varying Hydrodynamic Model of a Single Vane in a Variable-Geometry Oscillating Surge Wave Energy Converter

This paper presents a preliminary study on the parameter-varying hydrodynamic modeling of an individual vane of a variable-geometry oscillating surge wave energy converter (VGOSWEC). The WEC design incorporates controlled surfaces that can modify their orientation relative to the wave motion, reducing hydrodynamic pressure and related loads. This research focuses on characterizing the behavior of the oscillating WEC using a simplified model and three methods for achieving a continuous parameter-varying model: coarse hydrodynamic parameters, interpolation of hydrodynamic parameters, and a fitting function. The results of this study contribute to the understanding of parameter-varying hydrodynamic effects in variable geometry oscillating WECs. The findings provide insights into the potential for reducing structural loads and improving the overall performance of such devices. Further research and development in this area could lead to advancements in WEC technologies, enabling their integration into the competitive energy market.

analytical models↗

Parameter-Varying Hydrodynamic Model of a Single Vane in a Variable-Geometry Oscillating Surge Wave Energy Converter: Preprint

This paper presents a study on the time-varying hydrodynamic modeling of an individual flap of a variable geometry oscillating surge wave energy converter (VGOSWEC). The WEC design incorporates controlled surfaces that can modify their orientation relative to the wave motion, reducing hydrodynamic pressure and related loads. This research focuses on characterizing the behavior of the oscillating WEC using a simplified model and three methods for achieving a continuous time-variant model: discrete hydrodynamic parameters, interpolation of hydrodynamic parameters, and a fitting function. The results of this study contribute to the understanding of time-varying hydrodynamic effects in variable geometry oscillating WECs. The findings provide insights into the potential for reducing structural loads and improving the overall performance of such devices. Further research and development in this area could lead to advancements in WEC technologies, enabling their integration into the competitive energy market.

HYDRO ENERGY,TIDAL AND WAVE POWER↗

Effect of the Addition of a Low Equivalent Stress Mechanism to the Analysis of Geomechanical Behavior of the SPR West Hackberry Site

Sandia National Laboratories has long used the Munson-Dawson (M-D) model to predict the geomechanical behavior of salt caverns used to store oil at the Strategic Petroleum Reserve (SPR). Salt creep causes storage caverns to deform inward, thus losing volume. This loss of volume affects the salt above and around the caverns, puts stresses and strains on borehole casings, and creates surface subsidence which affects surface infrastructure. Therefore, accurate evaluation of salt creep behavior drives decisions about cavern operations. Parameters for the M-D model are typically fit against laboratory creep tests, but nearly all historic creep tests have been performed at equivalent stresses of 8 MPa or higher. Creep rates at lower equivalent stresses are very slow, such that tests take months or years to run, and the tests are sensitive to small temperature perturbations (<0.1°C). A recent collaboration between US and German researchers, recently characterized the creep behavior at low equivalent (deviatoric) stresses (<8 MPa) of salt from the Waste Isolation Pilot Plant. In addition, the M-D model was recently extended to include a low stress creep “mechanism”. This paper details new simulations of SPR caverns that use this extended M-D model, called the M-D Viscoplastic model. The results show that the inclusion of low stress creep significantly alters the prediction of steady-state cavern closure behavior and indicate that low stress creep is the dominant displacement mechanism at the dome scale. The implications for evaluating cavern and well integrity are demonstrated by investigating three phenomena: the extent of stress changes around the cavern; the predicted vertical strains applied to wellbore casings; and the evaluation of oscillating stress changes around the cavern due to oil sale cycles and their potential effect on salt fatigue.

58 GEOSCIENCES↗

Geomagnetism of earth's core

Instrumentation, analytical methods, and research goals for understanding the behavior and source of geophysical magnetism are reviewed. Magsat, launched in 1979, collected global magnetometer data and identified the main terrestrial magnetic fields. The data has been treated by representing the curl-free field in terms of a scalar potential which is decomposed into a truncated series of spherical harmonics. Solutions to the Laplace equation then extend the field upward or downward from the measurement level through intervening spaces with no source. Further research is necessary on the interaction between harmonics of various spatial scales. Attempts are also being made to analytically model the main field and its secular variation at the core-mantle boundary. Work is also being done on characterizing the core structure, composition, thermodynamics, energetics, and formation, as well as designing a new Magsat or a tethered satellite to be flown on the Shuttle.

Benton, E. R.↗

Crack Growth Behavior in the Threshold Region for High Cycle Fatigue Loading

The research results described in this paper presents a new understanding of the behavior of fatigue crack growth in the threshold region. It is believed by some crack growth experts that the ASTM load shedding test method does not produce true or valid threshold properties. The concern involves the observed fanning of threshold region da/dN data plots for some materials in which the low R-ratio data fans out or away from the high R-ratio data. This data fanning or elevation of threshold values is obviously caused by an increase in crack closure in the low R-ratio tested specimens. This increase in crack closure is assumed by some investigators to be caused by a plastic wake on the crack surfaces that was created during the load shedding test phase. This study shows that the increase in crack closure is the result of an extensive occurrence of crack bifurcation behavior in some materials, particularly in aluminum alloys, when the crack tip cyclic yield zone size becomes less than the grain size of the alloy. This behavior is related to the high stacking fault energy (SFE) property of aluminum alloys which results in easier slip characteristics. Therefore, the particular fanning behavior in aluminum alloys is a function of intrinsic dislocation property of the materials and that the fanned data represents valid material properties. However, for corrosion sensitive steel alloys used in this study the fanning was caused by a build-up of iron oxide at the crack tip from fretting corrosion.

Forman, Royce G.↗

Space environmental effects on polymer composites: Research needs and opportunities

The long-term performance of polymer-based composites in the space environment is discussed. Both thermoset and thermoplastic matrix composites are included in this discussion. Previous efforts on the space environmental effects on composites are briefly reviewed. Focus of this review is placed on the effects of hygrothermal stresses, atomic oxygen, ultraviolet (UV), and space debris/micrometeoroid impacts along with the potential synergism. Potential approaches to estimating the residual strength of polymer composites after exposure to atomic oxygen erosion or space debris/micrometeoroid impact are evaluated. New ground-based data are then utilized to illustrate the effects of atomic oxygen and thermal cycling on the failure behavior of polymer composites. Finally, research needs, challenges, and opportunities in the field of space environmental effects on composite materials are highlighted.

Jang, Bor Z.↗

A prototype Upper Atmospheric Research Collaboratory (UARC)

The National Collaboratory concept has great potential for enabling 'critical mass' working groups and highly interdisciplinary research projects. We report here on a new program to build a prototype collaboratory using the Sondrestrom Upper Atmospheric Research Facility in Kangerlussuaq, Greenland and a group of associated scientists. The Upper Atmospheric Research Collaboratory (UARC) is a joint venture of researchers in upper atmospheric and space science, computer science, and behavioral science to develop a testbed for collaborative remote research. We define the 'collaboratory' as an advanced information technology environment which enables teams to work together over distance and time on a wide variety of intellectual tasks. It provides: (1) human-to-human communications using shared computer tools and work spaces; (2) group access and use of a network of information, data, and knowledge sources; and (3) remote access and control of instruments for data acquisition. The UARC testbed is being implemented to support a distributed community of space scientists so that they have network access to the remote instrument facility in Kangerlussuaq and are able to interact among geographically distributed locations. The goal is to enable them to use the UARC rather than physical travel to Greenland to conduct team research campaigns. Even on short notice through the collaboratory from their home institutions, participants will be able to meet together to operate a battery of remote interactive observations and to acquire, process, and interpret the data.

Clauer, C. R.↗