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At least 307 records · Page 17

Design, Development, and Flight Evaluation of Pilot Displays and Long-Track Control for Wake Surfing Applications

From April to May 2017, the National Aeronautics and Space Administration Armstrong Flight Research Center completed a series of flights with a trail C-20A airplane surfing in the wake of a Gulfstream III airplane using a commercially available datalink as the primary communication between the two aircraft. The purpose of this test was to characterize the aerodynamic benefits received by the trail airplane flying in the upwash portion of the wake generated from the lead airplane. Lateral and vertical relative position to the wake were automatically controlled through an experimental programmable autopilot on the C-20A airplane. Long-track, the separation distance between the two aircraft, was maintained by test pilots managing throttle position using customized cockpit displays. These displays provided the pilots with throttle cues for maintaining long-track position and situational awareness of the wake vortex relative to the position of the trail airplane. Flight testing demonstrated the ability of the pilots to use these displays to maintain a safe long-track distance, but found there to be trades between tracking performance and the frequency of throttle motion. The wake awareness display provided the pilots with adequate situational awareness of the wake vortex during the flight experiment. This paper presents a summary of the design, development, and flight evaluation of the pilot displays and long-track control.

aircraft↗

Wavefront Control Toolbox for James Webb Space Telescope Testbed

We have developed a Matlab toolbox for wavefront control of optical systems. We have applied this toolbox to the optical models of James Webb Space Telescope (JWST) in general and to the JWST Testbed Telescope (TBT) in particular, implementing both unconstrained and constrained wavefront optimization to correct for possible misalignments present on the segmented primary mirror or the monolithic secondary mirror. The optical models implemented in Zemax optical design program and information is exchanged between Matlab and Zemax via the Dynamic Data Exchange (DDE) interface. The model configuration is managed using the XML protocol. The optimization algorithm uses influence functions for each adjustable degree of freedom of the optical mode. The iterative and non-iterative algorithms have been developed to converge to a local minimum of the root-mean-square (rms) of wavefront error using singular value decomposition technique of the control matrix of influence functions. The toolkit is highly modular and allows the user to choose control strategies for the degrees of freedom to be adjusted on a given iteration and wavefront convergence criterion. As the influence functions are nonlinear over the control parameter space, the toolkit also allows for trade-offs between frequency of updating the local influence functions and execution speed. The functionality of the toolbox and the validity of the underlying algorithms have been verified through extensive simulations.

Shiri, Ron↗

Effects of primary rotor parameters on flapping dynamics

The effects of flapping dynamics of four main rotor design features that influence the agility, stability, and operational safety of helicopters are studied. The parameters include flapping hinge offset, flapping hinge restraint, pitch-flap coupling, and blade lock number. First, the flapping equations of motion are derived that explicitly contain the design parameters. The dynamic equations are then developed for the tip-path plane, and the influence of individual and combined variations in the design parameters determined. The steady state flapping response is examined with respect to control input and aircraft angular rate which leads to a feedforward control law for control decoupling through cross feed, and a feedback control law to decouple the steady state flapping response. The condition for achieving perfect decoupling of the flapping response due to aircraft pitch and roll rates without using feedback control is also found for the hover case. It is indicated that the frequency of the regressing flapping mode of the rotor system can become low enough to require consideration in the assessment of handling characteristics.

Chen, R. T. N.↗

The application of parallel kinetic simulations to laser and electron transport through plasmas (Final technical report)

This is a final report for the grant entitled, “The application of parallel kinetic simulations to laser and electron transport through plasmas”. The objectives of this grant were to significantly advance the fundamental understanding of the nonlinear optics of plasmas and electron transport in high-energy-density laboratory plasmas (HEDLP), including conditions of relevance to Inertial Fusion Energy (IFE). The ultimate goal was to use the understanding to determine how to fully control laser plasma interactions. The primary research tools were our own kinetic particle-in-cell software, OSIRIS, that includes kinetic physics and can run effectively on leadership class computing facilities. Therefore, one objective was to ensure that OSIRIS in continually improved so that it was more accurate and could effectively utilize state-of-the-art computing facilities. Another objective was to attract and train young researchers into the field of high energy density plasma physics. To meet the research objectives, the funds from this proposal were used to conduct research on stimulated Raman scattering (SRS) and enhance our PIC software OSIRIS. It was found that small normalized magnetic fields can in some cases mitigate SRS and that speckles can mutually interact through SRS. It was also found that it is possible for instabilities drive near quarter critical (e.g., the high frequency hybrid instability-HFHI) can generate light waves that propagate back down a density gradient where they can rescatter into the HFHI at 1/16 of the original quarter critical density.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

CsrA-mediated regulation of a virulence switch in Acinetobacter baumannii

CsrA is an RNA binding protein that functions as a global regulator in bacteria. We demonstrate that, in Acinetobacter baumannii, CsrA acts as a positive regulator of the switch from virulent (VIR-O) to avirulent (AV-T) subpopulations. This regulation is mediated, in part, by CsrA interfering with Rho-dependent termination in the mRNA leader region of the ABUW_1645 gene, encoding the primary TetR-type transcriptional regulator that drives cells from the VIR-O to the AV-T state. We demonstrate that CsrA directly binds to the ABUW_1645 mRNA leader region and interferes with Rho binding. We identify three small RNAs (sRNAs) designated CsrB, CsrC, and CsrD that bind to CsrA and inhibit its activity. Individual overexpression of each sRNA greatly decreased the rate of VIR-O to AV-T switching. Individual deletions of each sRNA increased the frequency of VIR-O to AV-T switching, with loss of CsrB giving the highest increase at 2.4-fold. The expression of each sRNA was strongly dependent on the GacA response regulator and the expression of each sRNA was higher in VIR-O cells than in AV-T variants. Furthermore, this regulation provides a mechanism for the differential control of CsrA activity between VIR-O and AV-T variants.

59 BASIC BIOLOGICAL SCIENCES↗

Separation of airborne and structureborne noise radiated by plates constructed of conventional and composite materials with applications for prediction of interior noise paths in propeller driven aircraft

The anticipated application of advanced turboprop propulsion systems and use of composite materials in primary structure is expected to increase the interior noise of future aircraft to unacceptability high levels. The absence of technically and economically feasible noise source-path diagnostic tools has been a primer obstacle in the development of efficient noise control treatments for propeller driven aircraft. A new diagnostic method which permits the separation and prediction of the fully coherent airborne and structureborne components of the sound radiated by plates or thin shells has been developed. Analytical and experimental studies of the proposed method were performed on plates constructed of both conventional and composite materials. The results of the study indicate that the proposed method can be applied to a variety of aircraft materials, could be used in flight, and has fewer encumbrances than the other diagnostic tools currently available. The study has also revealed that the noise radiation of vibrating plates in the low frequency regime due to combined airborne and structureborne inputs possesses a strong synergistic nature. The large influence of the interaction between the airborne and structureborne terms has been hitherto ignored by researchers of aircraft interior noise problems.

Mcgary, M. C.↗

Pressure and Thrust Measurements of a High-Frequency Pulsed Detonation Tube

This paper describes measurements of a small-scale, high-frequency pulsed detonation tube. The device utilized a mixture of H2 fuel and air, which was injected into the device at frequencies of up to 1200 Hz. Pulsed detonations were demonstrated in an 8-inch long combustion volume, at about 600 Hz, for the quarter wave mode of resonance. The primary objective of this experiment was to measure the generated thrust. A mean value of thrust was measured up to 6.0 lb, corresponding to H2 flow based specific impulse of 2970 s. This value is comparable to measurements in H2-fueled pulsed detonation engines (PDEs). The injection and detonation frequency for this new experimental case was much higher than typical PDEs, where frequencies are usually less than 100 Hz. The compact size of the device and high frequency of detonation yields a thrust-per-unit-volume of approximately 2.0 pounds per cubic inch, and compares favorably with other experiments, which typically have thrust-per-unit-volume of order 0.01 pound per cubic inch. This much higher volumetric efficiency results in a potentially much more practical device than the typical PDE, for a wide range of potential applications, including high-speed boundary layer separation control, for example in hypersonic engine inlets, and propulsion for small aircraft and missiles.

Nguyen, N.↗

Space Shuttle cloud detection and earth feature classification experiment

The Feature Identification and Location Experiment (FILE) that is being designed for the detection and classification of four primary earth features (water, vegetation, bare land, and the clouds-snow-ice class) is described. Consideration is given to the FILE classification technology concept and the FILE instrument, which will use two solid-state CCD cameras operating at 0.65 and 0.85-micron center frequency wavelengths, with the camera outputs being functions of the earth surface material radiance. The classification is based on camera output radiance ratio values. The preliminary analysis of the data collected on the STS 41-G mission is discussed. The results demonstrated the suitability of using the two-channel-ratio detection technology and a simple (y = mx) algorithm to autonomously classify the four earth surface features. The technology is especially attractive as a cloud sensor, where, in advance of or during a mission, a threshold value for cloud cover percentage can be programmed and/or adaptively modified for use in the control of other remote sensors.

Sivertson, W. E., Jr.↗

Throttling Characteristics of the RL10 Derivative Common Extensible Cryogenic Engine -- Demo 1.6 and 1.7 Test Results

The Common Extensible Cryogenic Engine (CECE) is a deep throttling cryogenic Lunar Module Descent Engine (LMDE) technology development demonstrator based on the Pratt & Whitney Rocketdyne (PWR) RL10 engine. Previous testing on this engine occurred during 2006 as Demo 1.0, then Demo 1.5 in 2007, Demo 1.6 in 2008 and finally Demo 1.7 in 2010. A review of Demo 1.0, 1.5, and preliminary results of 1.6 were reported in previous JANNAF papers. Demo 1.6 was tested at the PWR E-6 test facility in November 2008. The primary goal of this series was to mitigate low frequency combustion instability observed at low power levels. To mitigate the chug, the Demo 1.6 injector was modified from the previous configurations to include an approximately 0.050 inch thick teflon-type spray-on insulation to reduce heat transfer to the LOX manifold, which was believed to be a significant contributor to the low power instability. In addition, gaseous helium injection into the LOX manifold was used as a means to stabilize the system. Also explored in this test series was mitigation for a low power 1 Hz fuel system oscillation caused by sub-critical hydrogen boiling in the chamber cooling jacket. Reduced area gas venturis were utilized to avoid the 1 Hz fuel-size oscillation by keeping the cooling jacket supercritical down to lower engine power levels. Demo 1.7 began testing in March 2010. Its primary objectives were to demonstrate closed loop control capability on mixture ratio and chamber pressure, start to lower power levels and increased throttling ramp rates. Secondary test objectives that are discussed include multiple engine starts, higher mixture ratio excursions and additional time at low power level. While the complete test series and data reduction is not yet complete for Demo 1.7, an overview and up-to-date status is provided.

Devine, Matthew K.↗

Advanced Electrical Materials and Components Being Developed

All aerospace systems require power management and distribution (PMAD) between the energy and power source and the loads. The PMAD subsystem can be broadly described as the conditioning and control of unregulated power from the energy source and its transmission to a power bus for distribution to the intended loads. All power and control circuits for PMAD require electrical components for switching, energy storage, voltage-to-current transformation, filtering, regulation, protection, and isolation. Advanced electrical materials and component development technology is a key technology to increasing the power density, efficiency, reliability, and operating temperature of the PMAD. The primary means to develop advanced electrical components is to develop new and/or significantly improved electronic materials for capacitors, magnetic components, and semiconductor switches and diodes. The next important step is to develop the processing techniques to fabricate electrical and electronic components that exceed the specifications of presently available state-of-the-art components. The NASA Glenn Research Center's advanced electrical materials and component development technology task is focused on the following three areas: 1) New and/or improved dielectric materials for the development of power capacitors with increased capacitance volumetric efficiency, energy density, and operating temperature; 2) New and/or improved high-frequency, high-temperature soft magnetic materials for the development of transformers and inductors with increased power density, energy density, electrical efficiency, and operating temperature; 3) Packaged high-temperature, high-power density, high-voltage, and low-loss SiC diodes and switches.

Schwarze, Gene E.↗

Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy

Significant opportunities remain for pharmacologically enhancing the clinical effectiveness of proton and carbon ion-based radiotherapies to achieve both tumor cell radiosensitization and normal tissue radioprotection. We investigated whether pretreatment with the hydroxamate-based histone deacetylase inhibitors (HDACi) SAHA (vorinostat), M344, and PTACH impacts radiation-induced DNA double-strand break (DSB) induction and repair, cell killing, and transformation (acquisition of anchorage-independent growth in soft agar) in human normal and tumor cell lines following gamma ray and light ion irradiation. Treatment of normal NFF28 primary fibroblasts and U2OS osteosarcoma, A549 lung carcinoma, and U87MG glioma cells with 5–10 µM HDACi concentrations 18 h prior to cesium-137 gamma irradiation resulted in radiosensitization measured by clonogenic survival assays and increased levels of colocalized gamma-H2AX/53BP1 foci induction. We similarly tested these HDACi following irradiation with 200 MeV protons, 290 MeV/n carbon ions, and 350 MeV/n oxygen ions delivered in the Bragg plateau region. Unlike uniform gamma ray radiosensitization, effects of HDACi pretreatment were unexpectedly cell type and ion species-dependent with C-12 and O-16 ion irradiations showing enhanced G0/G1-phase fibroblast survival (radioprotection) and in some cases reduced or absent tumor cell radiosensitization. DSB-associated foci levels were similar for proton-irradiated DMSO control and SAHA-treated fibroblast cultures, while lower levels of induced foci were observed in SAHA-pretreated C-12 ion-irradiated fibroblasts. Fibroblast transformation frequencies measured for all radiation types were generally LET-dependent and lowest following proton irradiation; however, both gamma and proton exposures showed hyperlinear transformation induction at low doses (≤25 cGy). HDACi pretreatments led to overall lower transformation frequencies at low doses for all radiation types except O-16 ions but generally led to higher transformation frequencies at higher doses (>50 cGy). The results of these in vitro studies cast doubt on the clinical efficacy of using HDACi as radiosensitizers for light ion-based hadron radiotherapy given the mixed results on their radiosensitization effectiveness and related possibility of increased second cancer induction.

59 BASIC BIOLOGICAL SCIENCES↗

Collisional quenching of atoms and molecules on spacecraft thermal protection surfaces

Preliminary results of a research program to determine energy partitioning in spacecraft thermal protection materials due to atom recombination at the gas-surface interface are presented. The primary focus of the research is to understand the catalytic processes which determine heat loading on Shuttle, Aeroassisted OTV, and NASP thermal protection surfaces in nonequilibrium flight regimes. Highly sensitive laser diagnostics based on laser-induced fluorescence and resonantly-enhanced multiphoton ionization spectroscopy are used to detect atoms and metastable molecules. At low temperatures, a discharge flow reactor is employed to measure deactivation/recombination coefficients for O-atoms, N-atoms, and O2. Detection methods are presented for measuring O-atoms, O2 and N2, and results for deactivation of O2 and O-atoms on reaction-cured glass and Ni surfaces. Both atom recombination and metastable product formation are examined. Radio-frequency discharges are used to produce highly dissociated beams of atomic species at energies characteristic of the surface temperature. Auger electron spectroscopy is employed as a diagnostic of surface composition in order to accurately define and control measurement conditions.

Marinelli, W. J.↗

Extended ecosystem signatures with application to Eos synergism requirements

The primary objective is to define the advantages of synergistically combining optical and microwave remote sensing measurements for the determination of biophysical properties important in ecosystem modeling. This objective was approached in a stepwise fashion starting with ground-based observations of controlled agricultural and orchard canopies and progressing to airborne observations of more natural forest ecosystems. This observational program is complemented by a parallel effort to model the visible reflectance and microwave scattering properties of composite vegetation canopies. The goals of the modeling studies are to verify our basic understanding of the sensor-scene interaction physics and to provide the basis for development of inverse models optimized for retrieval of key biophysical properties. These retrieval algorithms can then be used to simulate the expected performance of various aspects of Eos including the need for simultaneous SAR and HIRIS observations or justification for other (non-synchronous) relative timing constraints and the frequency, polarization, and angle of incidence requirements for accurate biophysical parameter extractions. This program completed a very successful series of truck-mounted experiments, made remarkable progress in development and validation of optical reflectance and microwave scattering models for vegetation, extended the scattering models to accommodate discontinuous and periodic canopies, developed inversion approaches for surface and canopy properties, and disseminated these results widely through symposia and journal publications. In addition, the third generation of the computer code for the microwave scattering models was provided to a number of other US, Canadian, Australian, and European investigators who are currently presenting and publishing results using the MIMICS research code.

Ulaby, Fawwaz T.↗

NASA SETI microwave observing project: Sky Survey element

The SETI Sky Survey Observing Program is one of two complimentary strategies that NASA plans to use in its microwave Search for Extraterrestrial Intelligence (SETI). The primary objective of the sky survey is to search the entire sky over the frequency range of 1.0 to 10.0 GHz for evidence of narrow band signals of extraterrestrial intelligent origin. Frequency resolutions of 30 Hz or narrower will be used across the entire band. Spectrum analyzers with upwards of ten million channels are required to keep the survey time approximately 6 years. Data rates in excess of 10 megabits per second will be generated in the data taking process. Sophisticated data processing techniques will be required to determine the ever changing receiver baselines, and to detect and archive potential SETI signals. Existing radio telescopes, including several of NASA's Deep Space Network (DSN) 34 meter antennas located at Goldstone, CA and Tidbinbilla, Australia will be used for the observations. The JPL has the primary responsibility to develop and carry out the sky survey. In order to lay the foundation for the full scale SETI Sky Survey, a prototype system is being developed at the JPL. The system will be installed at the new 34-m high efficiency antenna at the Deep Space Station (DSS) 13 research and development station, Goldstone, CA, where it will be used to initiate the observational phase of the NASA SETI Sky Survey. It is anticipated that the early observations will be useful to test signal detection algorithms, scan strategies, and radio frequency interference rejection schemes. The SETI specific elements of the prototype system are: (1) the Wide Band Spectrum Analyzer (WBSA); a 2-million channel fast Fourier transformation (FFT) spectrum analyzer which covers an instantaneous bandpass of 40 MHz; (2) the signal detection processor; and (3) the SETI Sky Survey Manager, a network-based C-language environment that provides observatory control, performs data acquisition and analysis algorithms. A high level description of the prototype hardware and software systems will be given and the current status of the system development will be reported.

Klein, M. J.↗

Outgrowth of erlotinib-resistant subpopulations recapitulated in patient-derived lung tumor spheroids and organoids

A model that recapitulates development of acquired therapeutic resistance is needed to improve oncology drug development and patient outcomes. To achieve this end, we established methods for the preparation and growth of spheroids from primary human lung adenocarcinomas, including methods to culture, passage, monitor growth, and evaluate changes in mutational profile over time. Primary lung tumor spheroids were cultured in Matrigel® with varying concentrations of erlotinib, a small molecule kinase inhibitor of epidermal growth factor receptor (EGFR) that is ineffective against KRAS mutant cells. Subtle changes in spheroid size and number were observed within the first two weeks of culture. Spheroids were cultured for up to 24 weeks, during which time interactions between different cell types, movement, and assembly into heterogeneous organoid structures were documented. Allele-specific competitive blocker PCR (ACB-PCR) was used to quantify low frequency BRAF V600E, KRAS G12D, KRAS G12V, and PIK3CA H1047R mutant subpopulations in tumor tissue residue (TR) samples and cultured spheroids. Mutant subpopulations, including multiple mutant subpopulations, were quite prevalent. Twelve examples of mutant enrichment were found in eight of the 14 tumors analyzed, based on the criteria that a statistically-significant increase in mutant fraction was observed relative to both the TR and the no-erlotinib control. Of the mutants quantified in erlotinib-treated cultures, PIK3CA H1047 mutant subpopulations increased most often (5/14 tumors), which is consistent with clinical observations. Thus, this ex vivo lung tumor spheroid model replicates the cellular and mutational tumor heterogeneity of human lung adenocarcinomas and can be used to assess the outgrowth of mutant subpopulations. Spheroid cultures with characterized mutant subpopulations could be used to investigate the efficacy of lung cancer combination therapies.

59 BASIC BIOLOGICAL SCIENCES↗

Thermal motion of the STIS optical bench

Various tests have been done of the Space Telescope Imaging Spectrograph (STIS) using internal wavecals to measure thermal motion of the spectral format on the detectors. In most cases, the spectral format moves less than the specification not to exceed 0.2 pixels per hour. Primary causes of the motion are (1) changes to the thermal design dictated by the warmer Aft Shroud environment and (2) on-orbit power cycling of Multi-Anode Microchannel Arrays (MAMA) electronics to minimize the effects of radiation hits on the MAMA detectors. The rear portion of the STIS optical bench is too warm to be held at a constant temperature by internal heaters. Electronics swing in temperature with an orbital and daily frequency. The thermal drift of the optical formats is not negligible, but is well behaved in most circumstances. The observer is advised to examine the trade-off between the most accurate wavelengths with best spectral/spatial resolutions versus increased overheads that directly affect the observing times. A long term concern is that the Aft Shroud thermal environment is predicted to heat up as much as one Centigrade degree per year. Progressively more of the bench would move out of thermal control. Thus the external cooler for STIS, being considered for the Third Servicing Mission is of major importance to the long term operation of STIS.

Gull, Theodore R.↗

"Land-Cover Conversion in Amazonia, The Role of ENV" Ironment and Substrate composition in Modifying SOI

LBA research from the first phase of LBA focused on three broad categories: 1) mapping land cover and quantifying rates of change, persistence of pasture, and area of recovering forest; 2) evaluating the role of environmental factors and land-use history on soil biogeochemistry; and 3) quantifying the natural and human controls on stream nutrient concentrations. The focus of the research was regional, concentrating primarily in the state of RondBnia, but also included land-cover mapping in the vicinity of Maraba, Para, and Manaus, Amazonas. Remote sensing analysis utilized Landsat Thematic Mapper (TM) and Multispectral Scanner (MS S) data to map historical patterns of land-cover change. Specific questions addressed by the remote sensing component of the research included: 1) what is the areal extent of dominant land-cover classes? 2) what are the rates of change of dominant land cover through processes of deforestation, disturbance and regeneration? and 3) what are the dynamic properties of each class that characterize temporal variability, duration, and frequency of repeat disturbance? Biogeochemical analysis focused on natural variability and impacts of land-use/land-cover changes on soil and stream biogeochemical properties at the regional scale. An emphasis was given to specific soil properties considered to be primary limiting factors regionally, including phosphorus, nitrogen, base cations and cation-exchange properties. Stream sampling emphasized the relative effects of the rates and timing of land-cover change on stream nutrients, demonstrating that vegetation conversion alone does not impact nutrients as much as subsequent land use and urbanization.

Roberts, Dar A.↗

Demonstration of Active Combustion Control

The primary objective of this effort was to demonstrate active control of combustion instabilities in a direct-injection gas turbine combustor that accurately simulates engine operating conditions and reproduces an engine-type instability. This report documents the second phase of a two-phase effort. The first phase involved the analysis of an instability observed in a developmental aeroengine and the design of a single-nozzle test rig to replicate that phenomenon. This was successfully completed in 2001 and is documented in the Phase I report. This second phase was directed toward demonstration of active control strategies to mitigate this instability and thereby demonstrate the viability of active control for aircraft engine combustors. This involved development of high-speed actuator technology, testing and analysis of how the actuation system was integrated with the combustion system, control algorithm development, and demonstration testing in the single-nozzle test rig. A 30 percent reduction in the amplitude of the high-frequency (570 Hz) instability was achieved using actuation systems and control algorithms developed within this effort. Even larger reductions were shown with a low-frequency (270 Hz) instability. This represents a unique achievement in the development and practical demonstration of active combustion control systems for gas turbine applications.

Lovett, Jeffrey A.↗