Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “population count”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 307 records · Page 17

Growth and inactivation of Listeria monocytogenes in sterile extracts of fruits and vegetables: Impact of the intrinsic factors pH, sugar and organic acid content

Intrinsic characteristics of fresh produce, such as pH, water activity, acid content and nutrient availability are critical factors in determining the survival and growth of Listeria monocytogenes (Lm). In this study, sterile fresh produce juice was used to analyze Lm growth potential among 14 different commodities and to identify physicochemical characteristics in those juices that affect Lm growth. Significant growth of Lm was observed in juices with pH ≥5.6 and low acidity (0.04–0.07 % titratable acidity (TA)) (cantaloupe, carrot, celery, green pepper, parsley, and romaine lettuce), slight reduction of Lm was observed in juices with pH 4.1 (tomato) and pH 3.9 (mango), and no Lm counts were recovered from juices with pH ≤3.8 and high acidity (0.28–1.17 % TA) (apple, blueberry, grape, peach, and pineapple). Although these acidic fruit juices possessed a high sugar content, the pH and acidity of produce juice seemed to be the primary determinants for Lm growth. The neutralization of acidic juices (i.e., Fuji and Gala apple, blueberry, grape, mango, pineapple, peach, and tomato) enabled Lm growth at 37 °C in all juices except for Gala apple and peach. Strong decline in Lm populations in Gala apple, grape and peach juices might be linked to sensitivity to organic acids, such as malic acid. As a result, Lm populations significantly decreased in pH-neutral (7.6) cauliflower juice, suggesting that potential antilisterial substances may play a role in Lm decline in cauliflower juice.

60 APPLIED LIFE SCIENCES↗

A search for diffuse band profile variations in the rho Ophiuchi cloud

High signal-to-noise profiles of the broad diffuse interstellar band at 4430 A were obtained on the 2.2-m telescope at the Mauna Kea Observatory, using the newly-developed pulse-counting multi-anode microchannel array detector system in an effort to determine whether the band profile varies with mean grain size as expected if the band is produced by absorbers embedded in grain lattices. The lack of profile variability over several lines of sight where independent evidence indicates that the mean grain size varies shows that lambda 4430 is probably not formed by the same grains that are responsible for interstellar extinction at visible wavelengths. The possibility that this band is created by a population of very small ( approximately 100 A) grains is still viable, as is the hypothesis that it has a molecular origin.

Snow, T. P.↗

Dwarf elliptical galaxies

Dwarf elliptical (dE) galaxies, with blue absolute magnitudes typically fainter than M(sub B) = -16, are the most numerous type of galaxy in the nearby universe. Tremendous advances have been made over the past several years in delineating the properties of both Local Group satellite dE's and the large dE populations of nearby clusters. We review some of these advances, with particular attention to how well currently availiable data can constrain (a) models for the formation of dE's, (b) the physical and evolutionary connections between different types of galaxies that overlap in the same portion of the mass-spectrum of galaxies, (c) the contribution of dE's to the galaxy luminosity functions in clusters and the field, (d) the star-forming histories of dE's and their possible contribution to faint galaxy counts, and (e) the clustering properties of dE's. In addressing these issues, we highlight the extent to which selection effects temper these constraints, and outline areas where new data would be particularly valuable.

Ferguson, Henry C.↗

Mars Pathfinder Near-Field Rock Distribution Re-Evaluation

We have completed analysis of a new near-field rock count at the Mars Pathfinder landing site and determined that the previously published rock count suggesting 16% cumulative fractional area (CFA) covered by rocks is incorrect. The earlier value is not so much wrong (our new CFA is 20%), as right for the wrong reason: both the old and the new CFA's are consistent with remote sensing data, however the earlier determination incorrectly calculated rock coverage using apparent width rather than average diameter. Here we present details of the new rock database and the new statistics, as well as the importance of using rock average diameter for rock population statistics. The changes to the near-field data do not affect the far-field rock statistics.

Haldemann, A. F. C.↗

Quantification of Juniperus Ashei Pollen Production for the Development of Forecasting Models

Juniperus ashei pollen is considered one of the most allergenic species of Cupressaceae in North America. Juniperus ashei is distributed throughout central Texas, Northern Mexico, the Arbuckle Mountains of south central Oklahoma, and the Ozark Mountains of northern Arkansas and southwestern Missouri. The large amount of airborne pollen that J. ashei produces affects inhabitants of cities and towns adjacent to juniper woodland areas and because juniper pollen can be transported over long distances, it affects populations that are far away. In order to create a dynamic forecast system for allergy and asthma sufferers, pollen production must be estimated. Estimation of pollen production requires the estimation of male cone production. Two locations in the Arbuckle Mountains of Oklahoma and 4 locations in the Edwards Plateau region of Texas were chosen as sampling sites. Trees were measured to determine approximate size. Male to female ratio was determined and pollen cone production was estimated using a qualitative scale from 0 to 2. Cones were counted from harvested 1/8 sections of representative trees. The representative trees were measured and approximate surface area of the tree was calculated. Using the representative tree data, the number of cones per square meter was calculated for medium production (1) and high production (2) trees. These numbers were extrapolated to calculate cone production in other trees sampled. Calibration was achieved within each location's sub-plot by counting cones on 5 branches collected from 5 sides of both high production and medium production trees. The total area sampled in each location was 0.06 hectare and total cone production varied greatly from location to location. The highest production area produced 5.8 million cones while the lowest production area produced 72,000 cones. A single representative high production tree in the Arbuckle Mountains produced 1.38 million cones. The number of trees per location was relatively uniform, but the number of high cone production trees varied greatly. Although there is great diversity in the locations making it difficult to determine which factors are most important, cone production was well correlated with certain stand characteristics including trunk diameter.

Bunderson, L. D.↗

Investigation of microorganisms in cannabis after heating in a commercial vaporizer

There are concerns about microorganisms present on cannabis materials used in clinical settings by individuals whose health status is already compromised and are likely more susceptible to opportunistic infections from microbial populations present on the materials. Most concerning is administration by inhalation where cannabis plant material is heated in a vaporizer, aerosolized, and inhaled to receive the bioactive ingredients. Heating to high temperatures is known to kill microorganisms including bacteria and fungi; however, microbial death is dependent upon exposure time and temperature. It is unknown whether the heating of cannabis at temperatures and times designated by a commercial vaporizer utilized in clinical settings will significantly decrease the microbial loads in cannabis plant material. To assess this question, bulk cannabis plant material supplied by National Institute on Drug Abuse (NIDA) was used to assess the impact of heating by a commercial vaporizer. Initial method development studies using a cannabis placebo spiked with Escherichia coli were performed to optimize culture and recovery parameters. Subsequent studies were carried out using the cannabis placebo, low delta-9 tetrahydrocannabinol (THC) potency and high THC potency cannabis materials exposed to either no heat or heating for 30 or 70 seconds at 190°C. Phosphate-buffered saline was added to the samples and the samples agitated to suspend the microorganism. Microbial growth after no heat or heating was evaluated by plating on growth media and determining the total aerobic microbial counts and total yeast and mold counts. Overall, while there were trends of reductions in microbial counts with heating, these reductions were not statistically significant, indicating that heating using standard vaporization parameters of 70 seconds at 190°C may not eliminate the existing microbial bioburden, including any opportunistic pathogens. When cultured organisms were identified by DNA sequence analyses, several fungal and bacterial taxa were detected in the different products that have been associated with opportunistic infections or allergic reactions including Enterobacteriaceae, Staphylococcus, Pseudomonas, and Aspergillus.

59 BASIC BIOLOGICAL SCIENCES↗

Measurements of Pion and Muon Nuclear Capture at Rest on Argon in the LArIAT Experiment

We report the measurement of the final-state products of negative pion and muon nuclear capture at rest on argon by the LArIAT experiment at the Fermilab Test Beam Facility. We measure a population of isolated MeV-scale energy depositions, or blips, in 296 LArIAT events containing tracks from stopping low-momentum pions and muons. The average numbers of visible blips are measured to be 0.74 ± 0.19 and 1.86 ± 0.17 near muon and pion track endpoints, respectively. The 3.6⁢𝜎 statistically significant difference in blip content between muons and pions provides the first demonstration of a new method of pion-muon discrimination in neutrino liquid argon time projection chamber experiments. LArIAT Monte Carlo simulations predict substantially higher average blip counts for negative muon (1.22 ± 0.08) and pion (2.34 ± 0.09) nuclear captures. We attribute this difference to geant4’s inaccurate simulation of the nuclear capture process.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Triton's cratering record and its time of capture

Recent impact crater counts on the Voyager 2 high resolution images of Triton have resulted in a more accurate crater size/frequency distribution down to about 3 km diameter. These counts reveal a size/frequency distribution characterized by a differential -4 slope. This is consistent with the observation that there are no craters larger than 27 km diameter on the 20 percent of Triton viewed at resolutions capable of detecting them. A -4 slope is deficient in large craters and at the very low crater density on Triton no craters larger than about 30 km are expected on just 20 percent of the satellite. The Triton size distribution is significantly different from the differential -3 slope of the fresh crater population on Miranda, but both show leading/trailing asymmetries. Since Miranda is in prograde orbit this crater population is probably due to objects in heliocentric orbit, i.e., comets. If this crater population is due to comets, then the significantly different crater population on Triton is probably due to some other population of impacting objects. The most likely origin of these objects is planetesimals in planetocentric orbits. Because Triton is in retrograde orbit, objects in prograde planetocentric orbits will also produce a leading/trailing asymmetry. If the Triton craters are largely the result of objects in planetocentric orbit, then where are the comet craters that should be there if they have a differential -3 distribution function as inferred from the Miranda fresh crater population? The most likely answer is that they are there, but at such a low density that they can not be distinguished from the planetocentric population. An upper bound on this density can be estimated by determining the density of a crater population with a differential -3 slope where no craters larger than 27 km would be expected on the 20 percent of Triton viewed by Voyager at resolutions sufficient to detect them. This density is at the density of the largest crater. At this density the number of craters in size bins greater than 27 km is less than 1 for a -3 distribution function. The observed size distribution, the upper limit of the hypothetical comet crater size distribution, and the difference between the observed and the hypothetical comet crater populations is shown.

Strom, R. G.↗

Far-Infrared Extragalactic Surveys: Past, Present, and Future

As much as one third of the luminosity of the local universe is emitted in the far infrared. In order to understand the history of energy release in the universe, it is crucial to characterize this rest-frame far-infrared contribution from the present back to the era of initial galaxy formation. Over the redshift range from 0 to 10, this energy is received in the 80 micrometers to 1 mm spectral region. In the 1980's the Infrared Astronomy Satellite (IRAS) all-sky survey provided the first comprehensive view of the far infrared emission from the local universe. The diffuse background measurements by Cosmic Background Explorer Satellite (COBE) have provided constraints on the integral contributions from the high redshift universe. In the past five years, submillimeter measurements made using the SCUBA instrument have revealed powerful high redshift sources. To develop a clear history of energy release in the universe, we need numbers and redshifts of representative populations of energetically important objects. The near future will bring the Space Infrared Telescope Facility Multiband Imaging Photometer (SIRTF)(MIPS) survey, which will cover about 100 square degrees at wavelengths out to 160 micrometers, providing a large sample of energetically important galaxies out to z of approx.3. In 2005, the Japanese IRIS survey will provide a 160 micrometers full sky survey, which will provide larger samples of the high z galaxy populations and will find intrinsically rare high luminosity objects. The SPIRE instrument on the FIRST facility will extend these surveys to longer wavelengths, providing a view of the universe at higher redshifts in three spectral bands. A concept for an all-sky submillimeter survey is under development, called the Survey of Infrared Cosmic Evolution (SIRCE). With a 2 m cryogenic telescope, it can map the entire sky to the confusion limit in the 100 to 500 micrometers range in six months. This survey will provide photometric redshifts, number counts, and will find the most luminous objects in the universe. In the next decade, the opening of the submillimeter, combined with the near infrared capability of NGST will provide us with a clear picture of energy release in the early universe.

Moseley, Samuel H., Jr.↗

Influence of Coronal Abundance Variations

The PI of this project was Jeff Scargle of NASA/Ames. Co-I's were Alma Connors of Eureka Scientific/Wellesley, and myself. Part of the work was subcontracted to Eureka Scientific via SAO, with Vinay Kashyap as PI. This project was originally assigned grant number NCC2-1206, and was later changed to NCC2-1350 for administrative reasons. The goal of the project was to obtain, derive, and develop statistical and data analysis tools that would be of use in the analyses of high-resolution, high-sensitivity data that are becoming available with new instruments. This is envisioned as a cross-disciplinary effort with a number of "collaborators" including some at SA0 (Aneta Siemiginowska, Peter Freeman) and at the Harvard Statistics department (David van Dyk, Rostislav Protassov, Xiao-li Meng, Epaminondas Sourlas, et al). We have developed a new tool to reliably measure the metallicities of thermal plasma. It is unfeasible to obtain high-resolution grating spectra for most stars, and one must make the best possible determination based on lower-resolution, CCD-type spectra. It has been noticed that most analyses of such spectra have resulted in measured metallicities that were significantly lower than when compared with analyses of high- resolution grating data where available (see, e.g., Brickhouse et al., 2000, ApJ 530,387). Such results have led to the proposal of the existence of so-called Metal Abundance Deficient, or "MAD" stars (e.g., Drake, J.J., 1996, Cool Stars 9, ASP Conf.Ser. 109, 203). We however find that much of these analyses may be systematically underestimating the metallicities, and using a newly developed method to correctly treat the low-counts regime at the high-energy tail of the stellar spectra (van Dyk et al. 2001, ApJ 548,224), have found that the metallicities of these stars are generally comparable to their photospheric values. The results were reported at the AAS (Sourlas, Yu, van Dyk, Kashyap, and Drake, 2000, BAAS 196, v32, #54.02), and at the conference on Statistical Challenges in Modem Astronomy (Sourlas, van Dyk, Kashyap, Drake, and Pease, 2003, SCMA 111, Eds. E.D.Feigelson, G.J.Babu, New York:Springer, p489-490). We also described the limitations of one of the most egregiously misused and misapplied statistical tests in astrophysical literature, the F-test for verifying model components (Protassov, van Dyk, Connors, Kashyap, and Siemiginowska, 2002, ApJ, 571,545). Indeed, a search through the ApJ archives turned up 170 papers in the 5 previous years that used the F-test explicitly in some form or the other, and with the vast majority of them not using it correctly! Indeed, looking at just 4 issues of the ApJ in 2001, we found 13 instances of its use, of which nine were demonstrably incorrect. Clearly, it is difficult to understate the importance of this issue. We also worked on speeding up Bayes Blocks and Sparse Bayes Blocks algorithms to make them more tractable for large searches. We also supported staistics students and postdocs in both explicit physics- model-based (spectra with tens of thousands of atomic lines) and "model-free" -- i.e. non-parametric or semi-parametric -- algorithms. Work on using more of the latter is just beginning; while using multi-scale methods for Poisson imaging has come to hition. In fact, "An Image Restoration Technique with Error Estimates", by D. Esch, A. Connors, M. Karovska, and D. van Dyk, was published by ApJ (Esch et a1.2004, ApJ, 610, 1213). The code has been delivered to M. Karovska for CXC; and is available for beta-testing upon request. The other large project we worked on was on the self-consistent modeling of logN-logs curves in the Poisson limit. logN-logs curves are a fundamental tool in the study of source populations, luminosity functions, and cosmological parameters. However, their determination is hampered by statistical effects such as the Eddington bias, incompleteness due to detection efficiency, faint source flux fluctuations, etc. We have develed a new and powerful method using the full Poisson machinery that allows us to model the logN-logs distribution of X-ray sources in a self-consistent manner. Because we properly account for all the above statistical effects, our modeling is valid over the full range of the data, and not just for strong sources, as is normally done. Using a Bayesian approach and modeling the fluxes with known functional forms such as simple or broken power-laws, and conditioning the expected photon counts on the fluxes, the background contamination, effective area, detector vignetting, and detection probability, we can delve deeply into the low counts regime and extend the usefulness of medium sensitivity surveys such as ChAMP by orders of magnitude. The built-in flexibility of the algorithm also allows a simultaneous analysis of multiple datasets. We have applied this analysis to a set a Chandra observations (Sourlas, Kashyap, Zezas, van Dyk, 2004, HEAD #8, #16.32)

Scargle, Jeffrey D.↗

Effects of vessel traffic and ocean noise on gray whale stress hormones

Human use of marinescapes is rapidly increasing, especially in populated nearshore regions where recreational vessel traffic can be dense. Marine animals can have a physiological response to such elevated human activity that can impact individual health and population dynamics. To understand the physiological impacts of vessel traffic on baleen whales, we investigated the adrenal stress response of gray whales (Eschrichtius robustus) to variable vessel traffic levels through an assessment of fecal glucocorticoid metabolite (fGC) concentrations. This analysis was conducted at the individual level, at multiple temporal scales (1–7 days), and accounted for factors that may confound fGC: sex, age, nutritional status, and reproductive state. Data were collected in Oregon, USA, from June to October of 2016–2018. Results indicate significant correlations between fGC, month, and vessel counts from the day prior to fecal sample collection. Furthermore, we show a significant positive correlation between vessel traffic and underwater ambient noise levels, which indicates that noise produced by vessel traffic may be a causal factor for the increased fGC. This study increases knowledge of gray whale physiological response to vessel traffic and may inform management decisions regarding regulations of vessel traffic activities and thresholds near critical whale habitats.

59 BASIC BIOLOGICAL SCIENCES↗

Determination of parameters for hypervelocity dust grains encountered in near-Earth space

Primarily interest was in the determination of the population of micrometeoroids and space debris and interpretation of the hole size in a thin film or in a micropore foam returned from space with theoretical calculations describing the event. In order to augment the significance of the theoretical calculations of the impact event, an experiment designed to analyze the charge production due to hypervelocity impacts on thin films also produced data which described the penetration properties of micron and sub-micron sized projectiles. The thin film penetration sites in the 500 A and 1000 A aluminum films were counted and a size distribution function was derived. In the case of the very smallest dust grains, there were no independent measurements of velocities like that which existed for the larger dust grains (d(sub p) is less than or equal to 1 micron). The primary task then became to assess the relationship between the penetration hole and the particle diameter of the projectile which made the hole. The most promising means to assess the measure of the diameters of impacting grains came in the form of comparing cratering mechanics to penetration mechanics. Future experimentation will produce measurements of the cratering as opposed to the penetrating event. Particles encountered by surfaces while being flown in space will degrade that surface in a systematic manner even when the impact is with small hypervelocity particles, d(sub p) is less than or equal to 10 microns. Though not to a degree which would precipitate a catastrophic failure of a system, the degradation of the materials comprising the interconnected system will occur. It is the degradation of the optical system and the subsequent embrittlement of other materials that can lead to degradation if not to failure. It is to this end that research was conducted to compare the primary consequences for experiments which will be flown to those which have been returned.

Tanner, William G.↗

ROSAT PSPC observations of two X-ray-faint early-type galaxies: NGC 4365 and NGC 4382

We present the results of ROSAT Positive Sensitive Proportional Counter (PSPC) observations of the two early-type galaxies NGC 4365 and NGC 4382. These galaxies are among those observed with Einstein to have the lowest X-ray to optical flux ratios of early-type galaxies. The PSCP data show that for radii r greater than 50 arcsec the radial distributions of the X-ray surface brightness are consistent with the optical distributions of King (1978). We also find that these galaxies have X-ray spectra significantly different from those observed in X-ray-bright ellipticals, with a relative excess of counts detected in the softest spectral channels. This confirms earlier Einstein results. The characteristics of the ROSAT PSPC do not allow us to discriminate between possible spectral models. If we adopt a two-component thermal model on the grounds of physical plausibility, we find that the spectral data can be fitted with a very soft optically thin component, with kT approximately 0.2 keV, and a hard component with kT greater than (1.0-1.5) keV. The hard component has a luminosity consistent with that expected from the integrated emission of a population of low mass-X-ray binaries in these galaxies; the nature of the very soft component is more speculative. Candidates include the coronal emission of late-type stars, supersoft X-ray sources, RS CVn, and perhaps a hot Interstellar Medium (ISM). Alternatively, the spectal data may be fitted with a 0.6-1 keV bremsstrahlung spectrum (expontential plus Gaunt), and may suggest the presence of a totally new population of X-ray sources.

Fabbiano, G.↗

Recent Advances in Video Meteor Photometry

One of the most common (and obvious) problems with video meteor data involves the saturation of the output signal produced by bright meteors, resulting in the elimination of such meteors from photometric determinations. It is important to realize that a "bright" meteor recorded by intensified meteor camera is not what would be considered "bright" by a visual observer - indeed, many Generation II or III camera systems are saturated by meteors with a visual magnitude of 3, barely even noticeable to the untrained eye. As the relatively small fields of view (approx.30 ) of the camera systems captures at best modest numbers of meteors, even during storm peaks, the loss of meteors brighter than +3 renders the determination of shower population indices from video observations even more difficult. Considerable effort has been devoted by the authors to the study of the meteor camera systems employed during the Marshall Space Flight Center s Leonid ground-based campaigns, and a calibration scheme has been devised which can extend the useful dynamic range of such systems by approximately 4 magnitudes. The calibration setup involves only simple equipment, available to amateur and professional, and it is hoped that use of this technique will make for better meteor photometry, and move video meteor analysis beyond the realm of simple counts.

Swift, Wesley R.↗

Radiative dynamics and delayed emission in pure and doped InP/ZnSe/ZnS quantum dots

We have used time-correlated single photon counting to elucidate the radiative dynamics of InP/ZnSe/ZnS core/shell/shell quantum dots (QDs) that differ in the amount and distribution of excess indium. Stoichiometric QDs having an In:P atom ratio very near unity exhibit simple luminescence kinetics. The photoluminescence (PL) rises with the 40 ps instrument response function and exhibits a decay that is close to a single exponential with a time constant that decreases from 32 to 28 ns with increasing shell thickness. QDs having excess indium (In:P ratio of 1.15–1.63) show a significant component of a slower rise time assigned to transient population of indium-based hole traps in the ZnSe shell. They also have a slower PL decay, attributed to an equilibrium between these traps, which are optically dark, and the emissive valence-band state. This results in a radiative lifetime that increases from 32 to 48 ns with increasing shell thickness. Different treatments of the InP cores prior to shell deposition result in different core/shell interfaces as indicated by resonance Raman spectroscopy, as well as differences in the amplitude and timescale of the slow PL rise and the PL decay time. These are interpreted in terms of different radial distributions of the indium-based hole traps, which can be related to differences in the interfacial lattice strain.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

The Seyfert II nature of the IRAS source FSC 10214+4724

We have observed the rest-frame optical and UV spectra of the luminous, high redshift Infrared Astronomy Satellite (IRAS) source FSC 10214+4724. We find the optical emission lines to be characterized by ratios similar to those found in Seyfert II galaxies. We support the conclusion of previous work that the UV emission lines are similar to those attributed to Active Galactic Nuclei (AGN) rather than to star formation. The ratio H alpha/H beta greater than or equal to 20 (2 sigma lower limit) implies substantial reddening of the narrow line region with A(sub V) greater than 5.5, sufficient to hide a broad line region in our H alpha observations. Given this large inferred reddening and the strength of the UV continuum and emission lines, we conclude (as have others) that simple screen models of reddening are not appropriate for this object. These properties are very similar to those of the infrared luminous galaxies at lower redshift, suggesting that FSC 10244+4724 is the luminous extreme of the same population. We also present H band (1.6 micrometer) imaging polarimetry observations and find that the rest-frame optical emission is unpolarized (P = 3.2% +/- 22.0%). This deep image of the field shows FSC 10214+4724 to possess an unresolved core, with several companions located within 10 sec of the point source. We find it unlikely that this group of objects is physically associated with FSC 10214+4724 at z = 2.3, and we argue that their magnitudes and colors are more consistant with those expected with those expected for galaxies in a foreground group. While galaxy number counts would suggest that such a projection has a low probability of being observed randomly, a foreground group might gravitational lens the z = 2.3 source, making such random statistics inappropriate, and contribute to the large observed luminosity of FSC 10214+4724. Comparison of H band images taken on two occasions one year apart show that FSC 10214+4724 had varied by 0.16 +/- 0.03 mag relative to a nearby star during that time. The UV-optical emission line spectra, the bright dereddened continuum magnitude (K less than 12) of the unresolved core, its extremely large bolometric luminosity, strong UV polarization, and possible variability all suggest that FSC 10214+4724 harbors an obscured AGN. Given that we observe no spectral features attributable to star formation, it appears either that star formation in FSC 10214+4724 is more highly obscured at optical and UV wavelengths than the narrow line region of the AGN, or that the AGN (rather than star formation) dominates the large luminosity of this object.

Elston, Richard↗

Mathematical model of a personalized neoantigen cancer vaccine and the human immune system

Cancer vaccines are an important component of the cancer immunotherapy toolkit enhancing immune response to malignant cells by activating CD4 + and CD8 + T cells. Multiple successful clinical applications of cancer vaccines have shown good safety and efficacy. Despite the notable progress, significant challenges remain in obtaining consistent immune responses across heterogeneous patient populations, as well as various cancers. We present a mechanistic mathematical model describing key interactions of a personalized neoantigen cancer vaccine with an individual patient’s immune system. Specifically, the model considers the vaccine concentration of tumor-specific antigen peptides and adjuvant, the patient’s major histocompatibility complexes I and II copy numbers, tumor size, T cells, and antigen presenting cells. We parametrized the model using patient-specific data from a clinical study in which individualized cancer vaccines were used to treat six melanoma patients. Model simulations predicted both immune responses, represented by T cell counts, to the vaccine as well as clinical outcome (determined as change of tumor size). This model, although complex, can be used to describe, simulate, and predict the behavior of the human immune system to a personalized cancer vaccine.

60 APPLIED LIFE SCIENCES↗